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Emerging progress:photochemical transformation of nitroso compounds

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Science China Chemistry 2025年第1期68卷 118-133页

作者： ze-Le Chen qiang-qiang Li Armido Studer Jun Xuan Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials School of Chemistry&Chemical EngineeringAnhui UniversityHefei 230601China Organisch-Chemisches Institut Universitat MünsterMunster 48149Germany

Nitroso compounds have emerged as highly valuable reaction partners or reagents in organic synthesis due to their rich *** versatile profile of these compounds allows them to function as electrophiles,nucleophiles,diradicals,and radical acceptors in diverse *** recent years,notable progress has been made in harnessing photochemical reactions with nitroso compounds to prepare N,O-containing structures using mild and eco-friendly *** nitroso compounds like nitrosoarenes,acyloxy nitroso compounds,N-nitrosoamines and nitrites have received significant attention for their ability to introduce NO moieties into complex molecules that are otherwise difficult to *** this review,we provide an overview of the recent advancements in the visible light-induced conversion of nitroso compounds,with particular emphasis on their role as bifunctional reagents and acceptors of radicals,carbenes and nitrenes.

关键词： nitroso compounds photochemistry radical reaction carbene transformation nitrosoarenes

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Dual-functional microneedle with programmatic regulation of macrophage for autoimmune psoriasis treatment

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Nano Research 2024年第8期17卷 7436-7448页

作者： ze qiang zhao Bo Zhi Chen Jia Li Gan Yun Hao Feng Ling Liang Lingyun Yu Zi Yi Wang Samin Abbaszadeh Mohammad-Ali Shahbazi Ruixing Yu Xin Dong Guo State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Beijing Laboratory of Biomedical Materials College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China China-Japan Friendship Hospital Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100029China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China Department of Pharmaceutical Biomaterials School of PharmacyZanjan University of Medical SciencesZanjan 45139-56184Iran Department of Biomaterials and Biomedical Technology University Medical Center GroningenUniversity of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands W.J.Kolff Institute for Biomedical Engineering and Materials Science University of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands

Modulating the immune microenvironment to establish sustained positive feedback within immune pathways represents a promising avenue for the treatment of ***,the precise and efficient delivery of therapeutic systems to the subcutaneous basal layer to modulate immune disorders is a major challenge in the treatment of autoimmune *** this project,we introduce a dual-functional microneedle(DF-MN)designed to combine MNs with multiple release kinetics and immunotherapy,the programmed treatment is achieved through segmented design of the MN structure,realizing the unification of rapid and long-lasting treatment of autoimmune *** vivo imaging results showed that GelMA@M-CSF showed fluorescent signals after 5 days of delivery to subcutaneous tissues,whereas HA@IL-13 showed minimal fluorescent signals after 2 *** multistage release behavior of MNs and the diffusion mechanism of drugs were explained at the molecular level,in combination with coarse-grained molecular ***,DF-MN can successfully induce macrophage reprogramming in vitro and ameliorate overall symptoms in a psoriasis mice model,suggesting that it has the potential to be an effective strategy for the treatment of psoriasis and portends to be a transformative platform for the treatment of other autoimmune diseases.

关键词： microneedle psoriasis M2 macrophage immunoregulation

Recent development in electrode design for wide-temperature supercapacitors

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Science China Chemistry 2025年第1期68卷 96-117页

作者： Jianhong Liu qiang Zhou Yuxiao Lin Xinsheng zhao Guangmin Zhou Xiaoxiao Li School of Physics and Electronic Engineering Jiangsu Normal UniversityXuzhou 221116China Tsinghua-Berkeley Shenzhen Institute&Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China

An ever-increasing market demand has stimulated the soaring enthusiasm of researchers to develop wide-temperature supercapacitors(SCs).The active electrode is one of the most important parts of SC,which is directly related to the energy density,power transmission and long-term cyclability of the device in the wide-temperature *** with the SC electrodes aimed for room-temperature application,the SC electrodes for operating at wide-temperature scene often face greater *** this review,the main challenges of SC electrodes under various temperature conditions,including low,high and cross-fade temperatures,are *** relevant performance decay and failure mechanisms of wide-temperature SC electrodes are *** addition,this review deals with the recent studies and developments in robust wide-temperature SC electrodes with respect to the rational design of electrode structures and the exploitation of advanced active ***,the future directions for exploring reliable wide-temperature SCs are also proposed.

关键词： supercapacitor wide-temperature electrode design active materials

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Bowel preparation before colonoscopy: Consequences, mechanisms, and treatment of intestinal dysbiosis

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World Journal of Gastroenterology 2025年第2期31卷 13-26页

作者： ze-Long Zheng Qing-Fan Zheng Li-qiang Wang Yi Liu Department of Gastroenterology(Endoscopy Center) China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

The term“gut microbiota”primarily refers to the ecological community of various microorganisms in the gut,which constitutes the largest microbial community in the human *** adequate bowel preparation can improve the results of colonoscopy,it may interfere with the gut *** preparation for colonoscopy can lead to transient changes in the gut microbiota,potentially affecting an individual’s health,especially in vulnerable populations,such as patients with inflammatory bowel ***,measures such as oral pro-biotics may ameliorate these adverse *** focused on the bowel prepa-ration-induced changes in the gut microbiota and host health status,hypothesized the factors influencing these changes,and attempted to identify measures that may reduce dysbiosis,thereby providing more information for individualized bowel preparation for colonoscopy in the future.

关键词： Bowel preparation Colonoscopy Microbiota Inflammatory bowel disease Probiotics

MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self‑Powered Motion Sensing

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Nano-Micro Letters 2025年第3期17卷 265-279页

作者： Yu‑ze Wang Yu‑Chang Wang Ting‑Ting Liu Quan‑Liang zhao Chen‑Sha Li Mao‑Sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Peking UniversityBeijing 100871People’s Republic of China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

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Optimizing cooling approach of spiral coil for an electromagnetic steel teeming system of ladle in continuous casting production

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JOURNAL OF IRON AND STEEL RESEARCH INTERNATIONAL 2025年第1期32卷 85-94页

作者： He, Ming Wang, Qing-wei zhao, Li-jia Mu, Wang-zhong Liu, Xing-an Wang, qiang Shenyang Agr Univ Coll Hort Shenyang 110866 Liaoning Peoples R China Northeastern Univ Key Lab Electromagnet Proc Mat Minist Educ Shenyang 110819 Liaoning Peoples R China Shenyang Agr Univ Minist Educ Key Lab Protected Hort Shenyang 110866 Liaoning Peoples R China KTH Royal Inst Technol Dept Mat Sci & Engn S-10044 Stockholm Sweden

To address the current issues with the conventional slide gate system utilized in the steel teeming process, a unique electromagnetic induction controlled automated steel teeming (EICAST) technology has been developed. Cooling means of spiral coil in this technology is directly related to its service life. Firstly, heat transfer processes of air cooling and spray cooling were compared and analyzed. Secondly, the impacts of water temperature, water flow rate and air flow rate were examined in order to maximize the spray cooling effect. To maintain coil temperature at a low value consistently throughout the entire thermal cycle process of the ladle, a combined cooling mode was finally employed. Numerical simulation was applied to examine the coil temperature variation with different cooling systems and characteristics. Before coil operation, spray cooling is said to be more effective. By controlling the water flow rate and air flow rate, the spray cooling effect is enhanced. However, water temperature has little or no impact when using spray cooling. Air cooling during the secondary refining process and spray cooling prior to coil operation are combined to further lower coil temperature. When the direction of the spray cooling is from bottom to top, the coil temperature is lowered below 165 degrees C. A practical induction coil cooling plan was provided for the EICAST technology's production process.

关键词： Electromagnetic induction controlled automated steel teeming technology Spiral coil Spray cooling Heat transfer Continuous casting

The crosstalk between cellular survival pressures and N6-methyladenosine modification in hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 67-75页

作者： Chu-Li Fu Zheng-Wei zhao qiang-Nu Zhang Department of Hematology and Oncology Guangzhou Women and Children's Medical Center Guangzhou Medical University Biomedicine Research Center Guangdong Provincial Key Laboratory of Major Obstetric Disease Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology the Third Affiliated Hospital of Guangzhou Medical University

Background:Within the tumor microenvironment, survival pressures are prevalent with potent drivers of tumor progression, angiogenesis, and therapeutic resistance. N6-methyladenosine (m6 A) methylation has been recognized as a critical post-transcriptional mechanism regulating various aspects of mRNA metabolism. Understanding the intricate interplay between survival pressures and m6 A modification provides new insights into the molecular mechanisms underlying hepatocellular carcinoma (HCC) progression and highlights the potential for targeting the survival pressures-m6 A axis in HCC diagnosis and *** sources:A literature search was conducted in Pub Med, MEDLINE, and Web of Science for relevant articles published up to April 2024. The keywords used for the search included hepatocellular carcinoma,cellular survival, survival pressure, N6-methyladenosine, tumor microenvironment, stress response, and ***:This review delves into the multifaceted roles of survival pressures and m6 A RNA methylation in HCC, highlighting how survival pressures modulate the m6 A landscape, the impact of m6 A modification on survival pressure-responsive gene expression, and the consequent effects on HCC cell survival,proliferation, metastasis, and resistance to treatment. Furthermore, we explored the therapeutic potential of targeting this crosstalk, proposing strategies that leverage the understanding of survival pressures and m6 A RNA methylation mechanisms to develop novel, and more effective treatments for ***:The interplay between survival pressures and m6 A RNA methylation emerges as a complex regulatory network that influences HCC pathogenesis and progression.

关键词： Hepatocellular carcinoma N6-methyladenosine methylation Hypoxia Target therapy Survival pressure

Research progress of ischemia-free liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 18-22页

作者： Ming-Xi Zhang qiang zhao Xiao-Shun He Organ Transplant Center First Affiliated Hospital of Sun Yat-sen University Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology

Ischemia-reperfusion injury (IRI) is an inherent issue in organ transplantation. Because of the allograft shortage, more and more extended criteria donor (ECD) organs are used, unfortunately these grafts are more susceptible to IRI. Although machine perfusion technology has brought hope to alleviate IRI, this technology is still unable to eradicate IRI-related organ damage. Ischemia-free liver transplantation (IFLT)can completely avoid IRI, thereby improve graft function and recipient outcome, and allow to expand organ pool. This review summarized the latest progresses in IFLT, and speculated the future development of this concept.

关键词： Ischemia-free liver transplantation Normothermic machine perfusion Ischemia-reperfusion injury

Electronic modulation towards MOFs as template derived CoP via engineered heteroatom defect for a highly effcient overall water splitting

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Journal of Energy Chemistry 2025年第02期101卷 598-607页

作者： Meijie Ding Zhiqiang Wei Dexue Liu Wenhua zhao qiang Lu Zhiming Li Qingsong Yu Chenggong Lu Hua Yang State Key Laboratory of Advanced Processing and Recycling of Non-ferrous Metals Lanzhou University of Technology School of Science Lanzhou University of Technology

The reasonable design of material morphology and eco-friendly electrocatalysts are essential to highly efficient water *** is proposed that a promising strategy effectively regulates the electronic structure of the d-orbitals of CoP using cerium doping in this paper,thus significantly improving the intrinsic property and conductivity of CoP for water *** a result,the as-synthesize porous Ce-doped CoP micro-polyhedron composite derived from Ce-ZIF-67 as bifunctional electrocatalytic materials exhibits excellent electrocatalytic performance in both the oxygen evolution reaction（OER） and the hydrogen evolution reaction（HER）,overpotentials of about 152 mV for HER at 10 mA cm-2and about 352 mV for OER at 50 mA cm-2,and especially it shows outstanding long-term ***,an alkaline electrolyzer,using Ce0.04Co0.96P electrocatalyst as both the anode and cathode,delivers a cell voltage value of1.55 V at the current density of 10 mA *** calculation results of the density functional theory（DFT）demonstrate that the introduction of an appropriate amount of Ce into CoP can enhance the conductivity,and can induce the electronic modulation to regulate the selective adsorption of reaction intermediates on catalytic surface and the formation of O*intermediates（CoOOH）,which exhibits an excellent electrocatalytic *** study provides novel insights into the design of an extraordinary performance water-splitting of the multicomponent electrocatalysts.

关键词： Cerium Hydrogen evolution Oxygen evolution Phosphides Water splitting