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Effect of NCPB and VSPL on pain and quality of life in chronic pancreatitis patients

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World Journal of Gastroenterology 2005年第32期11卷 5010-5014页

作者： Andrzej Basinski Tomasz Stefaniak Ad Vingerhoets Wojciech Makarewicz Lukasz Kaska Aleksander Stanek Andrzej J.Lachinski zbigniew sledzinski Department of Emergency MedicineMedical University of Gdansk Poland Department of GeneralEndocrine and Transplant Surgery Medical University of GdanskPoland Department of Psychology and Healthand Research Institute for Psychology and Health Tilburg Universitythe Netherlands

AIM: To compare the effects of neurolytic celiac plexus block (NCPB) and videothoracoscopic splanchnicectomy (VSPL) on pain and quality of life of chronic pancreatitis (CP) ***: Forty-eight small duct CP patients were treated invasively with NCPB (n = 30) or VSPL (n = 18) in two non-randomized, prospective, case-controlled protocols due to chronic pain syndrome, and compared to a control group who were treated conservatively (n = 32). Visual analog scales were used to assess pain and opioid consumption rate was evaluated. In addition, the quality of life was measured using QLQ C-30 for NCPB and FACIT for *** both questionnaires covered similar problems,they could not be compared directly one with ***, the studies were compared by meta-analysis ***: Both procedures resulted in a significant positive effect on pain of CP patients. Opioids were withdrawn totally in 47.0% of NCPB and 36.4% of VSPL patients,and reduced in 53.0% and 45.4% of the respective patient groups. No reduction in opioid usage was observed in the control group. In addition, fatigue and emotional well-being showed improvements. Finally, NCPB demonstrated stronger positive effects on social support, which might possibly be attributed to earlier presentation of patients treated with ***: Both invasive pain treatment methods are effective in CP patients with chronic pain.

关键词： Chronic pancreatitis Pain Neurolytic celiac plexus block Videothoracoscopic splanchnicectomy Quality of life

Pancreatic Anastomosis Healing

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Open Journal of Pathology 2012年第3期2卷 96-101页

作者： Stanislaw Hac Rafal Peksa Marek Dobosz Tomasz Wysocki Pawel Lampe Katarzyna Kusnierz Pawel Mroczkowski zbigniew sledzinski Department of Digestive Tract Surgery University Hospital of the Medical University of Silesia Katowice Poland Department of General Surgery Gdansk Municipal Hospital of Gdansk Division of Surgical Nursing Medical University of Gdansk Gdansk Poland Department of General Endocrine & Transplant Surgery Medical University of Gdansk Gdansk Poland Department of Pathology Medical University of Gdansk Gdansk Poland Department of Vascular and Visceral Surgery Otto-von-Guericke University Magdeburg Germany

Background: Pancreatoduodenectomy (PD) is a complex procedure with a relatively high risk of complications. There is an increasing trend showing that the success of pancreato-enteral anastomosis depends on surgical skill and the material used. Methods: We present four cases of pancreato-enteral anastomosis resected 37 - 114 days after primary surgery and the analysis of the healing process, i.e., morphology of the pancreatic parenchyma, pancreatic duct, and digestive tract mucosa, as well as the pancreatic reaction to the sewing material by microscopic morphometry. Results: Evidence of regeneration in the columnar-lined mucosa of main pancreatic ducts in all cases of pancreato-enterostomy was observed. The inflammatory foreign-body reaction around monofilament stitch was present without an evident infection. There were no microscopic signs of pancreatic duct damage. Total foreign body reaction varied between 138.1 μm and 207.3 μm. Conclusions: This observation supports the beneficial use of thin monofilament threads for pancreato-enteral anastomosis. There was no evidence of harmful action from gastric or intestinal juices on pancreatic remnant or the Wirsung duct.

关键词： Pancreatoduodenectomy Pancreaticojejunostomy Pancreatogastrostomy Surgical Anastomosis Suture Material

COP 28: Challenge of coping with climate crisis

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The Innovation 2024年第1期5卷 21-22页

作者： Tong Jiang Xiaojia He Buda Su Peni Hausia Havea Ke Wei zbigniew W.Kundzewicz Dong Liu Research Institute of Climatic and Environmental Governance/Institute for Disaster Risk Management School of Geographical ScienceNanjing University of Information Science&TechnologyNanjing 210044China The Administrative Center for China’s Agenda 21 Beijing 100038China Pacific Global Solution Nuku’alofaTongatapu 000676Tonga Centre for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Department of Environmental Engineering and Mechanical Engineering Poznan University of Life Sciences60-637 PoznanPoland The Paper Shanghai United Media GroupShanghai 200040China

The 28th Conference of Parties(COP 28)of the United Nations Framework Convention on Climate Change(UNFCCC)is being held in Dubai,United Arab Emirates,from November 30 to December 12,2023,with the participation of over 160 world leaders(Figure 1).The tone of the COP 28 is set by the observation that,clearly,the nationally determined contributions related to CO_(2) emission reduction are not on track to curb the temperature rise as per the Paris *** order to hold the increase in global mean temperature to well below 2℃ above the pre-industrial level and to pursue efforts to limit the warming to 1.5℃,there is a need for ratcheting up ambition for near-term climate action.

关键词： Figure limit COP

Britanin–a beacon of hope against gastrointestinal tumors?

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World Journal of Clinical Oncology 2024年第4期15卷 523-530页

作者： Agnieszka Kajdanek Damian Kołat Lin-Yong Zhao Mateusz Kciuk zbigniew Pasieka Żaneta Kałuzińska-Kołat Department of Biomedicine and Experimental Surgery Medical University of LodzLodz 90-136LodzkiePoland Department of Functional Genomics Medical University of LodzLodz 90-752LodzkiePoland Department of General Surgery&Laboratory of Gastric Cancer State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Gastric Cancer Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Molecular Biotechnology and Genetics University of LodzLodz 90-237LodzkiePoland

Britanin is a bioactive sesquiterpene lactone known for its potent anti-inflammatory and anti-oxidant *** also exhibits significant anti-tumor activity,suppressing tumor growth in vitro and in *** current body of research on Britanin includes thirty papers predominantly related to neoplasms,the majority of which are gastrointestinal tumors that have not been summarized *** drive academic debate,the present paper reviews the available research on Britanin in gastrointestinal *** also outlines novel research directions using data not directly concerned with the digestive system,but which could be adopted in future gastrointestinal *** was found to counteract liver,colorectal,pancreatic,and gastric tumors,by regulating proliferation,apoptosis,autophagy,immune response,migration,and *** confirmed in pancreatic,gastric,and liver cancer,its most commonly noted molecular effects include nuclear factor kappa B and B-cell lymphoma 2 downregulation,as well as Bcl-2-associated X protein ***,it has been found to induce the Akt kinase and Forkhead box O1 axis,activate the AMP-activated protein kinase pathway,elevate interleukin-2 and peroxisome proliferator-activated receptor-γlevels,reduce interleukin-10,as well as downregulate matrix metalloproteinase-9,Twist family bHLH transcription factor 1,and *** also inhibits Myc–HIF1αinteraction and programmed death ligand 1 transcription by interrupting the Ras/RAF/MEK/ERK pathway and mTOR/P70S6K/4EBP1 *** research should aim to unravel the link between Britanin and acetylcholinesterase,mast cells,osteolysis,and ischemia,as compelling data have been provided by studies outside the gastrointestinal *** the cytotoxicity of Britanin on noncancerous cells is significantly lower than that on tumor cells,while still being effective against the latter,further in-depth studies with the use of animal models are *** compound exhi

关键词： Britanin Sesquiterpene lactones Chemotherapeutics Gastrointestinal tumors In vitro In vivo

Thermal Activation of the Combustion Chamber of a Reciprocating Internal Combustion Engine

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Journal of Thermal Science 2018年第5期27卷 449-455页

作者： SROKA zbigniew SADLAK zbigniew Wroclaw University of Science and Technology Wroclaw 50370 Poland Ingenieurbüro Sadlak Munich 80807 Germany

The dominant feature of the work of many specialists on the design of the internal combustion engine is to achieve the possible lowest fuel consumption, which is the most convenient measure of the efficiency of the thermodynamic cycle. From the very beginning of this heat machine, there are many of solutions that are better or worse fit to the global development trend. In this paper, the authors suggest the possibility closer to the optimal solution by introducing structural active zones, where the task is instantaneous(during one cycle) heat transfer to the skin layer on elements of the combustion chamber and to transfer part of the recovered heat to the next cycle, reaching a growth effect of the useful efficiency by 10% to 20%. The solution is different from the ones used by the fact that it is only partially insulating barrier, and the main goal is focused on supporting the next thermal cycle by which it is possible to affect as mentioned above. This paper describes the idea of the functioning of the active combustion chamber and pointed out the technical capabilities of its creation.

关键词： heat transfer active combustion chamber reciprocating engine

Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods

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World Journal of Methodology 2024年第2期14卷 17-37页

作者： Piotr Gromek Zuzanna Senkowska Elzbieta Pluciennik zbigniew Pasieka Lin-Yong Zhao Adrianna Gielecinska Mateusz Kciuk Karol Klosinski Zaneta Kaluzinska-Kolat Damian Kolat Department of Functional Genomics Medical University of LodzLodz 90-752LodzkiePoland Department of Biomedicine and Experimental Surgery Medical University of LodzLodz 90-136LodzkiePoland Department of General Surgery&Laboratory of Gastric Cancer State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Gastric Cancer Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Molecular Biotechnology and Genetics University of LodzLodz 90-237LodzkiePoland Doctoral School of Exact and Natural Sciences University of LodzLodz 90-237LodzkiePoland

In accordance with the World Health Organization data,cancer remains at the forefront of fatal *** upward trend in cancer incidence and mortality has been observed globally,emphasizing that efforts in developing detection and treatment methods should *** diagnostic path typically begins with learning the medical history of a patient;this is followed by basic blood tests and imaging tests to indicate where cancer may be located to schedule a needle *** initiation of diagnosis is crucial since delayed cancer detection entails higher costs of treatment and ***,there is a need for novel cancer detection methods such as liquid biopsy,elastography,synthetic biosensors,fluorescence imaging,and reflectance confocal *** therapeutic methods,although still common in clinical practice,pose many limitations and are ***,there is a dynamic advancement of clinical research and the development of more precise and effective methods such as oncolytic virotherapy,exosome-based therapy,nanotechnology,dendritic cells,chimeric antigen receptors,immune checkpoint inhibitors,natural product-based therapy,tumor-treating fields,and photodynamic *** present paper compares available data on conventional and modern methods of cancer detection and therapy to facilitate an understanding of this rapidly advancing field and its future *** evidenced,modern methods are not without drawbacks;there is still a need to develop new detection strategies and therapeutic approaches to improve sensitivity,specificity,safety,and ***,an appropriate route has been taken,as confirmed by the approval of some modern methods by the Food and Drug Administration.

关键词： Cancer detection Liquid biopsy Synthetic biosensors Fluorescence imaging Reflectance confocal microscopy Elastography Cancer therapy Tumor-treating fields Oncolytic virotherapy Nanotechnology

New complexes of heteroaromatic N-oxides with europium,uranyl and zinc ions

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Journal of Rare Earths 2012年第6期30卷 552-558页

作者： zbigniew Hnatejko Faculty of Chemistry Adam Mickiewicz UniversityGrunwaldzka 660-780 PoznańPoland

New solid complexes of europium, uranyl and zinc ions with N-oxides of 4-chloro-2,6-dimethylpyridine, quinoline and 4-meth- oxyquinaldinic acid in presence different anions were obtained and characterized by elemental and TG analyses, IR and luminescence spectra. The compounds are crystalline, hydrated or anhydrous salts with colours typical of metal ions. Thermal studies showed that in hydrated salts lattice or coordination water molecules are present. A role of different anions in the formation of various types of the complexes is presented.

关键词： complexes europium 4-methoxyquinaldinic acid N-oxide 4-chloro-2,6-dimethylpyridine N-oxide quinoline N-oxide uranyl zinc

Comparative analysis of the effects of gunpowder and plasma ignition in closed vessel tests

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Defence Technology（防务技术） 2019年第5期15卷 668-673页

作者： Radoslaw Trebinski zbigniew Leciejewski zbigniew Surma Jakub Michalski Military University of Technology Department of Mechatronics and Aerospace

This paper presents the results of a comparative investigation into the effects of the ignition method on the ballistic properties of a single-base gun propellant,as determined via closed vessel *** gunpowder ignition and plasma jet ignition methods were used,and differences in the ignition time were *** influence of the ignition method on the dynamic vivacity is *** is shown that this influence is significant in the first phase of the combustion process,and with respect to the low values of the loading *** the second phase of the combustion process,and for large values of the loading density,the dynamic vivacity plots for the two ignition methods *** the burning law,close values of the exponent were obtained for the two ignition *** dynamic vivacity plots determined for plasma ignition reveal stronger dependence on the loading density than those determined for gunpowder *** conclusion is that plasma ignition is not a solution to the problems inherent to the process of determining the ballistic properties of propellants,which results in deviation of the burning process from the geometric burning law.

关键词： Closed vessel test Gun propellant Gunpowder ignition Plasma ignition

Twenty years of coal mining-induced subsidence in the Upper Silesia in Poland identified using InSAR

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International Journal of Coal Science & Technology 2022年第6期9卷 64-74页

作者： Maria Przylucka zbigniew Kowalski zbigniew Perski Polish Geological Institute-National Research Institute Geohazards CenterWarsawPoland Polish Geological Institute-National Research Institute Geohazards CenterCrakowPoland

The paper presents the results of terrain subsidence monitoring in Poland's Upper Silesian Coal Basin(USCB)mining area using Differential Interferometry Synthetic Aperture Radar(DInSAR)and Persistent Scatterer Interferometry(PSI).The study area accounts for almost three million inhabitants where mining which started in the 19th century,has produced severe damage to buildings and urban infrastructures in past *** analysis aimed to combine eight different datasets,processed in two techniques,coming from various sensors and covering different *** a result,a map of areas that have been exposed to subsidence within 3045 square kilometers was *** map covers a period of twenty years of intensive mining activities,i.e.1992-2012.A total of 81 interferograms were used in the *** interferograms allowed not only to determine subsidence troughs(basins)formed from 1992 to 2012 but also to observe subsidence development over *** work also included five sets of PSI processing,covering different temporal and spatial ranges,which were used to determine zones of residual *** on InSAR datasets,an area of 521 square kilometers under the influence of mining activities were *** the subsiding zones,an area of 312.5 square kilometers of the rapid increase in subsidence was identified on the *** study of combined different InSAR datasets provided large-area and long-term information on the impact of mining activities in the Upper Silesia Coal Basin.

关键词： Surface subsidence Mining subsidence InSAR Ground subsidence monitoring Upper Silesia Coal Basin