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对人工智能配电网络进行谐波分析的新方法

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智能建筑电气技术 2014年第3期8卷 114-116页

作者： zahir j.paracha Akhtar Kalam Rubbiya Ali 于娟

1绪论在电力系统中，持续供电已经变成对电力部门的一个挑战。用户对转换开关和现代化电子电路使用量的增加，为配电网络注入了不可预测的谐波，扰乱了供电质量。

关键词：谐波分析配电网络人工智能供电质量电力系统电力部门电子电路转换开关

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Impact of Distributed Generation on Smart Grid Transient Stability

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Smart Grid and Renewable Energy 2011年第2期2卷 99-109页

作者： Nur Asyik Hidayatullah zahir j. paracha Akhtar Kalam School of Engineering and Science Victoria University

In the 21st century Smart Grid and Renewable Energy technologies are an important issue with regards to global climate change problem and energy security. The evolution of current conventional or centralized generation in form of distributed generation and Smart Power Grid (SPG) has great opportunity and potentially can eradicate several issues associated with energy efficiency, energy security and the drawback of aging power system infrastructures. In order to meet the rising electrical power demand and increasing service quality as well as reducing pollution, the existing power grid infrastructure should be developed into Smart Grid (SG) that is flexible for interconnectivity with the distributed generation. However, integrating distributed generation to power system causes several technical issues especially system stability. To make the power grid become “smarter”, particularly in terms of stability, Flexible AC Transmission System (FACTS) device especially Static VAR Compensator (SVC) is used. This paper explores Smart Grid technologies and distributed generation systems. Furthermore, it discusses the impact of distributed generation on Smart Grid, particularly its system stability after installing distributed generation in the Smart Grid. This was done by examining the system stability during interconnection and faults on the system and validated with Dig-SILENT Power Factory Software V 13.2.

关键词： Smart Grid Future Grid Distributed Generation Flexible AC Transmission System (FACTS) Static VAR System (SVS)

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Hepatopancreatoduodenectomy for metastatic duodenal gastrointestinal stromal tumor

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Hepatobiliary & Pancreatic Diseases International 2006年第1期5卷 147-150页

作者： Charalabos Stratopoulos zahir Soonawalla juan Piris Peter j Friend Nuffield Department of Surgery and the Department of Cellular Pathology

BACKGROUND: Duodenal gastrointestinal stromal tumors, which are rare, comprise 3%-5% of all gastrointestinal stromai tumors. We present a case of a metastatic duodenal gastrointestinal stromal tumor that was successfully treated by simultaneous tight hemihepatectomy and pancreaticoduodenectomy. METHODS: A 50-year-old woman was admitted to our department for the treatment of a possible metastatic duodenal gastrointestinal stromal tumor (GIST). At laparotomy a large duodenal tumor was found displacing the head of the pancreas. A 3 cm in diameter lesion in the posterior aspect of segment Ⅷ of the liver was also noted. Simultaneous right hepatectomy and pancreaticoduodenectomy were performed. RESULTS: Histological examination revealed a high grade metastatic duodenal GIST strongly positive for c-kit, CD34, and vimentin. The patient had no additional therapy. A follow-up of 21 months showed that the patient is very well and there is no evidence of recurrent diseases. CONCLUSIONS: Malignant stromai tumors of the duodenum are rarely encountered. They are usually slow growing, and may be amenable to curative surgery, even after occurrence of metastases. Resection of localized liver metastasis is still advocated when feasible, since imatinib does not provide a complete or long-term response. Combined surgical resection is an efficacious treatment for patients with metastatic duodenal gastrointestinal stromal tumor.

关键词： duodenal neoplasms hepatectomy pancreaticoduodenectomy liver metastasis gastrointestinal stromal tumor

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The PARP-1 Inhibitor Olaparib Causes Retention of γ-H2AX Foci in <i>BRCA</i>1 Heterozygote Cells Following Exposure to Gamma Radiation

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journal of Cancer Therapy 2013年第11期4卷 44-52页

作者： Emma C. Bourton Piers N. Plowman Amanda j. Harvey Sheba Adam zahir Christopher N. Parris Brunel Institute of Cancer Genetics and Pharmacogenomics Division of Biosciences School of Health Sciences and Social Care Brunel University Uxbridge UK Department of Radiotherapy St Bartholomew’s Hospital West Smithfield London UK

A novel treatment for cancer patients with homozygous deletions of BRCA1 and BRCA2 is to use drugs that inhibit the enzyme poly(ADP-ribose) polymerase (PARP). Specific inhibition of PARP-1 can induce synthetic lethality in irradiated cancer cells while theoretically leaving normal tissue unaffected. We recently demonstrated in a cell survival assay that lymphoblastoid cells with mono-allelic mutations of BRCA1 were hypersensitive to gamma radiation in the presence of the PARP-1 inhibitor Olaparib compared to normal cells and mono-allelic BRCA2 cells. To determine if the enhanced radiation sensitivity was due to a persistence of DNA strand breaks, we performed γ-H2AX foci analysis in cells derived from two normal individuals, three heterozygous BRCA1 and three heterozygous BRCA2 cell lines. Cells were exposed to 2 Gy gamma radiation in the presence or absence of 5 μM Olaparib. Using immunofluorescence and imaging flow cytometry, foci were measured in untreated cells and at 0.5, 3, 5 and 24 hours post-irradiation. In all lymphoblastoid cells treated with 2 Gy gamma radiation, there was a predictable induction of DNA strand breaks, with a modest but significant retention of foci over 24 hours in irradiated cells treated with Olaparib (ANOVA P < 0.05). However, in mono-allelic BRCA1 cells, there was a failure to fully repair DNA double-strand breaks (DSB) in the presence of Olaparib, evidenced by a significant retention of foci at 24 hours’ post irradiation (t-Test P These data show that the cellular hypersensitivity of mono-allelic BRCA1 lymphoblastoid cells to gamma radiation in the presence of the Olaparib is due to the retention of DNA DSB. These data may indicate that patients with inherited mutations in the BRCA1 gene treated with radiotherapy and PARP-1 inhibitors may experience elevated radiation-associated normal tissue toxicity.

关键词： BRCA1 BRCA2 Heterozygote Radiosensitivity PARP Inhibitor Gamma-H2AX Imaging Flow Cytometry

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The PARP-1 Inhibitor Olaparib Causes Retention of γ-H2AX Foci in BRCA1 Heterozygote Cells Following Exposure to Gamma Radiation

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journal of Cancer Therapy（癌症治疗） 2013年第11期

作者： Emma C. Bourton Piers N. Plowman Amanda j. Harvey Sheba Adam zahir Christopher N. Parris

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