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Decoding bone-inspired and cell-instructive cues of scaffolds for bone tissue engineering

Engineered Regeneration 2024年第1期5卷 21-44页

作者： zahid hussain Shah Mehmood Xingzhu Liu Yuanshan Liu Guocheng Wang Renjun Pei School of Nano-Tech and Nano-Bionics University of Science and Technology of China(USTC)Hefei 230026PR China CAS Key Laboratory for Nano-Bio Interface Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123PR China Research Center for Human Tissues and Organs Degeneration Shenzhen Institute of Advanced Technology(SIAT)Chinese Academy of ScienceShenzhen 518055PR China

Bone fractures are common occurrence in clinical settings,creating a high demand for effective repair ***,limited graft availability,donor site morbidities,unpredictable clinical outcomes,immunologic reactions,infection risks,and geometrical mismatching concerns hampered tissue graft use and underscored the need for scaffolds for more effective bone reconstructions due to their tunable *** progress has been carried out in past decade in the fields of nanoceramics synthesis,bioconjugate chemistry,and composite material *** review outlines hierarchical structures and biology of bone tissue,materialistic compo-nents of scaffolds(bioceramics,polymers,bioactive drugs),featured scaffolding strategies(nanofibers,hydrogels,aerogels,bioprinting,and fiber-reinforced composite),and emphasis that hierarchical and physiochemical char-acteristics of bone should be used as an inspiration for scaffold *** review discussed how differences in materiobiological aspects of scaffolds,such as polymer/bioceramic nanocomposite,mineralized nanocomposite,matrix-rich nanocomposite,3D microenvironmental cues,pore space cues,mechanical cues,usage of physical stimulation(magnetic,electroactive,and photoactivated cues),surface cues(wettability,roughness,textured,and surface charge),and biointerface cues(cell-biomaterial interactions,cell-selective homing,and cell regula-tory strategies)modulate cellular and biological response for bone tissue *** study further outlines the challenges and benefits of integrating materiobiological cues of scaffolds for bone tissue engineering.

关键词： Bone substitute Scaffolds Mineralization Materiobiology Bone tissue engineering

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Enhancing alkyne semi-hydrogenation through engineering metal-support interactions of Pd on oxides

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Nano Research 2024年第5期17卷 3707-3713页

作者： Yuefeng Wu Xiaotong Lu Pengfei Cui Wenyu Jia Jun Zhou Yuan Wang hussain zahid Yuxin Wu Muhammad Umer Rafique Xiong Yin Baoshan Li Leyu Wang Guolei Xiang State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China College of Chemical Engineering Beijing University of Chemical TechnologyBeijing 100029China

Supported Pd catalysts show superior activities for olefin productions from alkynes through semi-hydrogenation reactions,but over-hydrogenation into alkanes highly decreases olefin *** phenylacetylene semi-hydrogenation as a model reaction,here we explore the optimization approaches toward better Pd catalysts for alkyne semi-hydrogenation through investigating support effect and metal-support *** results show that the states of Pd with supports can be tuned by varying oxide reducibility,loading ratios,and *** our system,0.06 wt.%Pd on rutile-TiO_(2) nanorods shows the highest activity owing to the synergistic effects of single-atoms and *** reducibility can change the filling degrees of Pd 4d orbitals through varying interfacial bonding strengths,which further affect catalytic activity and selectivity.

关键词： alkyne semi-hydrogenation support effect metal-support interaction Pd catalyst single-atom catalyst

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Establishing simulation model for optimizing efficiency of CNC machine using reliability-centered maintenance approach

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International Journal of Modeling, Simulation, and Scientific Computing 2019年第6期10卷 1-14页

作者： zahid hussain Hamid Jan Sarhad University of Science and Information Technology Peshawar 25000Pakistan

The objective of this work was to enhance the product’s quality by concentrating on the machine’s optimized *** order to increase the machine’s reliability,the basis of reliability-centered maintenance approach was *** purpose was to establish a planned preventive maintenance strategy to identify the machine’s critical components having a noteworthy effect on the product’s *** critical components were prioritized using failure mode and effect analysis(FMEA).The goal of the study was to decrease the ppm time interval for a CNC machine by simulating the projected preventive maintenance time *** this purpose,the simulation software ProModel 7.5 was implemented for the current preventive maintenance procedure to choose the best ppm time interval which contributed better *** dissimilar optimization approaches were applied,however,the first approach yielded the prominent total system cost and the shorter ppm *** results of the study revealed that there was an increase of USD 1878 as a result of an increase in total system cost from USD 78,365 to USD 80,*** maintenance costs were reduced from USD 4196 to USD 2248(46%).The costs associated with good parts increased from USD 8259 to USD 8294(0.4%)and the costs associated with defective parts reduced from USD 171 to USD 3(98.25%),respectively.

关键词： Simulation model CNC machine reliability-centered maintenance(RCM) failure mode and effect analysis(FMEA) planned preventive maintenance

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Microwaves spark emission spectroscopy for the analysis of cations:A simple form of atomic emission spectroscopy

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Chinese Chemical Letters 2011年第9期22卷 1084-1086页

作者： zahid hussain Khalid Mohammed Khan Khadim hussain Sadam hussain Shahnaz Perveen Department of Chemistry Abdul Wali Khan UniversityMardanPakistan H.E.J.Research Institute of Chemistry International Center for Chemical and Biological SciencesUniversity of KarachiKarachi 75270Pakistan Department of Chemistry Hazara UniversityMansehraPakistan Department of Electronics Quaid-I-Azam UniversityIslamabadPakistan PCSIR Laboratories Complex Shahrah-e-Dr.Salimuzzaman SiddiquiKarachi 75280Pakistan

A novel method for the cation analysis was investigated. The analysis is based on the sparking of the salts of metals in a microwave oven after placing in a graphite cell. The graphite cell absorbs microwaves and produces high temperature which converts the salt into light emitting species. The colour of light was found to dependent on the nature of cation, however, the intensity of the emitted light was found to be depending upon the form and shape of the graphite assembly in addition to the concentration of the salt. This communication presents explanation for all these observations and for the systematic and quantitative analysis using microwave spark emission technique.

关键词： Microwave spark Cation analysis Spark colour Graphite cell Atomic emission

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Synergistic effects of combined therapy of curcumin and Fructus Ligustri Lucidi for treatment of osteoporosis: cellular and molecular evidence of enhanced bone formation

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Journal of Integrative Medicine 2019年第1期17卷 38-45页

作者： Syed Nasir Abbas Bukhari Fahad hussain Hnin Ei Thu zahid hussain Department of Pharmaceutical Chemistry College of Pharmacy Aljouf University Institute of Molecular Biology and Biotechnology (IMBB) The University of Lahore Department of Pharmacology and Dental Therapeutics Faculty of Dentistry Lincoln University CollegePetaling Jaya 47301 Selangor Malaysia Department of Pharmaceutics Faculty of Pharmacy Universiti Teknologi MARA (UiTM)

Objective: The present study explored the effects of the combined herbal therapy consisting of curcumin(CUR) and Fructus Ligustri Lucidi(FLL) on aspects of bone ***: Prior to analyzing the ability of this novel combined herbal therapy to promote aspects of bone regeneration, its cytotoxicity was determined using MC3 T3-E1 cells(pre-osteoblast model). Cell proliferation was evaluated using phase-contrast microscopy and cell differentiation was estimated using alkaline phosphatase activity. The effect of the combined herbal therapy(CUR + FLL) was also assessed in terms of mineralization in the extracellular matrix(ECM) of cultured cells. Further, to explore the molecular mechanisms of bone formation, time-dependent expression of bone-regulating protein biomarkers was also ***: Combined herbal therapy(CUR + FLL) significantly upregulated the viability, proliferation and differentiation of MC3 T3-E1 cells compared to the monotherapy of CUR or FLL. The magnitude of ECM mineralization(calcium deposition) was also higher in MC3 T3-E1 cells treated with combined *** time-dependent expression of bone-forming protein biomarkers revealed that the tendency of expression of these bone-regulating proteins was remarkably higher in cells treated with combined ***: The co-administration of CUR and FLL had superior promotion of elements of bone regeneration in cultured cells, thus could be a promising alternative herbal therapy for the management of bone erosive disorders such as osteoporosis.

关键词： Osteoporosis Curcumin Fructus Ligustri Lucidi Combined herbal therapy Cell proliferation Cell differentiation Bone formation

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Phytopharmacological potential of different species of Morus alba and their bioactive phytochemicals:A review

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 950-956页

作者： Fahad hussain Zohaib Rana Hassan Shafique Arif Malik zahid hussain Institute of Molecular Biology and Biotechnology(IMBB) The University of LahoreRaiwind Road55150LahorePakistan Department of Pharmaceutics Faculty of PharmacyUniversiti Teknologi MARAPuncak Alam CampusBandar Puncak Alam42300SelangorMalaysia

Medicinal plants of Moraceae family have been well-recognized traditionally due to their versatile applications in various fields including agriculture, cosmetic and food as well as in pharmaceutical industries. Their biomedical and medicinal importance is reflected from their broad range of pharmacological activities for treatment of various inflammatory conditions, cancer, infectious diseases, and gastrointestinal disorders. The present review was aimed to summarize and critically discuss the biomedical implications of Morus species, their bioactive compounds, and phytochemicals. Bioactivity guided fractionation of these medicinal plants revealed that different types of bioactive phytochemicals and secondary metabolites such as steroids, saponins, alkaloids, glycosides and phenolic compounds including terpenoids, flavonoids, anthocyanins and tannins were present. The critical analysis of the literature revealed that the aqueous, methanolic, and ethanolic extracts of Morus species and their bioactive compounds exhibit remarkable anti-oxidative,anti-diabetic, anti-stress, nephroprotective, antimicrobial, anti-mutagenic, anticancer,anxiolytic, hepatoprotective, anthelmintic, antimicrobial, immune-modulatory and cholesterol lowering effects. Based on the literature review and bioactivity guided investigation of Morus species and their phytomedicinal effects, we anticipate that these herbal products hold excellent potential for future research.

关键词： Moraceae Phytochemicals Pharmacological activities Anti-inflammatory Immunomodulatory Anticancer

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Bimetallic Fe-Mo sulfide/carbon nanocomposites derived from phosphomolybdic acid encapsulated MOF for efficient hydrogen generation

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Journal of Materials Science & Technology 2021年第25期84卷 76-85页

作者： Zheng Huang Zhuxian Yang Mian zahid hussain Quanli Jia Yanqiu Zhu Yongde Xia College of Engineering Mathematics and Physical SciencesUniversity of ExeterExeter EX44QFUK Hennan Key Laboratory of High Temperature Functional Ceramics Zhengzhou UniversityZhengzhou450052China

To tackle the energy crisis and achieve more sustainable development,hydrogen as a clean and renewable energy resource has attracted great *** for cheap but efficient catalysts for hydrogen production from water splitting is urgently *** this report,bimetallic Fe-Mo sulfide/carbon nanocomposites that derived from a polyoxometalate phosphomolybdic acid encapsulated metal-organic framework MIL-100(PMA@MIL-100)have been generated and their applications in electrocatalytic hydrogen generation were *** PMA@MIL-100 precursor is formed via a simple one-pot hydrothermal synthesis method and the bimetallic Fe-Mo sulfide/carbon nanocomposites were obtained by chemical vapor sulfurization of PMA@MIL-100 at high *** nanocomposite samples were fully characterized by a series of techniques including X-ray diffraction,Fourier-transform infrared analysis,thermogravimetric analysis,N2 gas sorption,scanning electron microscopy,transmission electron microscopy,X-ray photoelectron spectroscopy,and were further investigated as electrocatalysts for hydrogen production from water *** hydrogen production activity of the best performed bimetallic Fe-Mo sulfide/carbon nanocomposite exhibits an overpotential of-0.321 V at 10 m A cm^(-2)and a Tafel slope of 62 m V dec^(-1)with a 53%reduction in overpotential compared to Mo-free counterpart *** dramatic improvement in catalytic performance of the Fe-Mo sulfide/carbon composite is attributed to the homogeneous distribution of the nanosized iron sulfide,MoS_(2)particles,and the formation of Fe-Mo-S phases in the S-doped porous carbon *** work has demonstrated a potential approach to fabricate complex heterogeneous catalytic materials for different applications.

关键词： MOF Nanocomposite Encapsulation Metal sulfide Hydrogen generation

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Efficient hepatoprotective activity of cranberry extract against CCl_4-induced hepatotoxicity in Wistar albino rat model: Down-regulation of liver enzymes and strong antioxidant activity

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1054-1058页

作者： Fahad hussain Arif Malik Ujala Ayyaz Hassan Shafique Zohaib Rana zahid hussain Institute of Molecular Biology and Biotechnology (IMBB) The University of Lahore Department of Biochemistry University of AgricultureFaisalabad Department of Pharmaceutics Faculty of Pharmacy Universiti Teknologi MARA Puncak Alam Campus

ObjectiveTo investigate the hepatoprotective efficacy of cranberry extract (CBE) against carbon tetrachloride (CCl4)-induced hepatic injury using in-vivo animal *** hepatoprotective efficacy of CBE (200 and 400 mg/kg) was investigated against CCl4 (4 mL/kg)-induced hepatotoxicity, elevated liver enzymes [ALT (alanine aminotransferase), AST (aspartate aminotransferase), and alkaline phosphatase (ALP)], and total protein (TP) contents in the serum. Moreover, CBE-aided antioxidant defense against hepatotoxic insult of CCl4 was measured by evaluating a number of anti-oxidative biomarkers including reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) in the serum by using spectrophotometric *** showed that the exposure of experimental animals to CCl4 did induce significant hepatotoxicity compared to the non-induced (untreated) group. The oral administration of CBE demonstrated a significant dose-dependent alleviation in the liver enzymes (AST, ALT, and ALP), increased antioxidant defense (GSH, SOD, and CAT), and reduced MDA levels in the serum of treated animals compared to the animals without treatment. The resulting data showed that the administration of CBE decreased the serum levels of ALT, AST, and ALP compared to the CCl4-induced *** resulting data evidenced that CBE exhibits promising hepatoprotective potential against the chemical induced hepatotoxicity, maintains homeostasis in liver enzymes, and can provide significant antioxidant defense against free radicals-induced oxidative stress.

关键词： Hepatotoxicity Carbon tetrachloride Oxidative stress Liver enzymes Cranberry extract Hepatoprotective

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Exploring dynamic biomedical algorithm of Eurycoma longifolia Jack and its bioactive phytochemicals: A review of pharmacokinetic and pharmacodynamic implications and future prospects

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Asian Pacific Journal of Tropical Medicine 2018年第2期11卷 89-97页

作者： Hnin Ei Thu zahid hussain Isa Naina Mohamed Ahmad Nazrun Shuid Department of Pharmacology Faculty of MedicineUniversity Kebangsaan Malaysia(The National University of Malaysia) Department of Pharmaceutics Faculty of PharmacyUniversiti Teknologi MARAPuncak Alam Campus

Eurycoma longifolia Jack(***) is a well-recognized traditional herbal medicine that offers a wide dynamic range of biomedical applications including anti-osteoporotic, anticancer, anti-proliferative, anti-malarial, antimicrobial, antioxidant, aphrodisiac, antiinflammatory, anxiolytic, anti-diabetic, anti-rheumatism and anti-ulcer *** review aims to overview the pharmacokinetic and a pharmacodynamic algorithm of *** and its bioactive *** of pharmacokinetic profile revealed that *** exhibit higher bioavailability, high volume of distribution, slow elimination rate, and does not show inhibitory effects on cytochrome P450 *** has been used, alone or in combination with other pharmacological agents, in the form of crude extracts, standard extracts, or decoctions of different plant parts(i.e., herbs, shrubs, stem, leaves, and roots) for the treatment of various ailments in animals and *** various bioactive constituents, eurycomanone has been found to be the most remarkable, super-stable, versatile, and most potent phytochemical(isolated or extracted from root extracts) against various types of animals and human *** on its well-established pharmacokinetic and pharmacodynamic profiles, we suggested that *** can be a well-accepted complementary and alternative medicine for the treatment of different types of human ailments.

关键词： Eurycoma longifolia Jack Pharmacokinetic profile Pharmacodynamic algorithm Eurycomanone Quassinoids

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Multi-Modality and Feature Fusion-Based COVID-19 Detection Through Long Short-Term Memory

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Computers, Materials & Continua 2022年第9期72卷 4357-4374页

作者： Noureen Fatima Rashid Jahangir Ghulam Mujtaba Adnan Akhunzada zahid hussain Shaikh Faiza Qureshi Center of Excellence for Robotics Artificial Intelligenceand BlockchainDepartment of Computer ScienceSukkur IBA UniversitySukkurPakistan Department of Computer Science COMSATS University Islamabad–Vehari CampusPakistan Faculty of Computing and Informatics University Malaysia SabahKota Kinabalu88400Malaysia Department of Mathematics Sukkur IBA UniversitySukkurPakistan

The Coronavirus Disease 2019(COVID-19)pandemic poses the worldwide challenges surpassing the boundaries of country,religion,race,and *** current benchmark method for the detection of COVID-19 is the reverse transcription polymerase chain reaction(RT-PCR)***,this testing method is accurate enough for the diagnosis of ***,it is time-consuming,expensive,expert-dependent,and violates social *** this paper,this research proposed an effective multimodality-based and feature fusion-based(MMFF)COVID-19 detection technique through deep neural *** multi-modality,we have utilized the cough samples,breathe samples and sound samples of healthy as well as COVID-19 patients from publicly available COSWARA *** set of experimental analyses were performed to evaluate the performance of our proposed *** useful features were extracted from the aforementioned modalities that were then fed as an input to long short-term memory recurrent neural network algorithms for the classification *** set of experimental analyses were performed to evaluate the performance of our proposed *** experimental results showed that our proposed approach outperformed compared to four baseline approaches published *** believe that our proposed technique will assists potential users to diagnose the COVID-19 without the intervention of any expert in minimum amount of time.

关键词： Covid-19 detection long short-term memory feature fusion deep learning audio classification

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