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Journal of Science in Sport and Exercise 2020年第4期2卷 336-348页

作者： zachary m.Gillen marni E.Shoemaker Brianna D.mcKay Nicholas A.Bohannon Sydney m.Gibson Joel T.Cramer Department of Nutrition and Health Sciences University of Nebraska-Lincoln211 Ruth Leverton HallLincolnNE 68583USA

Purpose The purpose of this study was to examine the relationships among leg extension strength,explosive strength,muscle activation,and measurements of growth to predictions of vertical jump performance in youth *** Height,body mass,skinfolds,and quadriceps femoris muscle cross-sectional area were measured in 39 sports active children(20 females,19 males,age=12.52±0.62 years old).Peak torque(PT),rate of torque development(RTD),rate of velocity development(RVD),and rate of electromyographic amplitude rise(RER)were measured during isometric and isokinetic leg ***,RTD,and RVD were expressed in absolute terms and normalized to body *** jump height(JH)and peak power(PP)were assessed during static(SJ),counter-movement(CmJ),and drop(DJ)*** JH exhibited greater correlations with PT normalized to body mass(r=0.387-0.758)than absolute PT(r=0.338-0.417),whereas PP exhibited greater correlations with absolute PT(r=0.368-0.837).Only negligible to moderate relation-ships existed between JH and PP across all jumps(r=0.053-0.605).Over 50%of the variability in PP was predicted in 24 of 30 regression models with absolute muscle strength,muscle activation,and measurements of growth,while only 6 of 30 models predicted more than 50%of the variability in *** Overall,absolute static and dynamic muscle strength,muscle activation,and growth better explained PP meas-ured during vertical jumps than estimated JH.

关键词： Children Adolescent Torque Jump height Power

Role of cerebral digital subtraction angiography in the evaluation of pulse synchronous tinnitus

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Journal of Otology 2021年第4期16卷 225-230页

作者： Gregory P.Lekovic zachary R.Barnard Adam master b Gautam U.mehta m.marcel maya Eric P.Wilkinson Department of Neurosurgery Cedars-Sinai Medical Center127 S San Vicente BlvdLos AngelesCA90048United States Division of Neurosurgery House Institute2100 West 3rd StreetLos AngelesCA90057United States Division of Neurotology House Institute2100 West 3rd StreetLos AngelesCA90057United States Department of Imaging Cedars-Sinai Medical Center127 S San Vicente BlvdLos AngelesCA90048United States

Objectives: The aim of this study was to evaluate the value of digital subtraction angiography (DSA) in thediagnostic evaluation of a highly selected patient population presenting with pulse-synchronous tinnitus(PST).methods: We retrospectively reviewed the charts of all patients referred for evaluation of possiblevascular etiology of pulsatile tinnitus. Patients were evaluated with regards to presenting signs,comorbidities, non-invasive imaging results, angiographic findings and ***: Fifteen patients underwent cerebral DSA. Dural arteriovenous fistula (dAVF) was identified in sixpatients, and five patients had other significant vascular pathology identified on DSA. Seven patientswith ‘negative’ non-invasive imaging were found to have significant pathology on ***: Catheter angiography may have a significant yield in appropriately selected patients presenting with pulse synchronous tinnitus.

关键词： Pulse-synchronous tinnitus Transverse-sigmoid arteriovenous fistula Vascular tinnitus Cerebral angiography

FeH_(x)的稳定性以及氢在地球核-幔边界的传输

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Science Bulletin 2023年第14期68卷 1567-1573,M0004页

作者：何宇 Duck Young Kim Viktor V.Struzhkin zachary m.Geballe Vitali Prakapenka 毛河光 Key Laboratory of High-Temperature and High-Pressure Study of the Earth’s Interior Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China Division of Advanced Nuclear Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Geophysical Laboratory Carnegie InstitutionWashington DC 20015USA Center for Advanced Radiation Sources University of ChicagoChicago IL 60637USA

地球内部水和铁的反应可以生成铁-氢合金.研究铁-氢合金可以增进对地球内部氢传输的认知.我们通过高压实验和第一性原理计算的方法,对高温高压下具有面心立方结构(fcc)FeH_(x)(x≤1)的相稳定性、密度、氢的输运性质和熔点进行了系统研究... 详细信息

地球内部水和铁的反应可以生成铁-氢合金.研究铁-氢合金可以增进对地球内部氢传输的认知.我们通过高压实验和第一性原理计算的方法,对高温高压下具有面心立方结构(fcc)FeH_(x)(x≤1)的相稳定性、密度、氢的输运性质和熔点进行了系统研究,证实了FeH_(x)在165 GPa时的稳定性.通过高温的分子动力学模拟,发现FeH_(x)在下地幔温压下转变为超离子态.在超离子态FeH_(x)中,氢离子快速扩散表现出类似流体的性质,扩散系数高达3.710^(-4)cm~2s^(-1).与超离子态冰类似,氢离子的快速扩散可以导致体系的熵增,使其的熔化温度增加.FeH_(x)可以将氢从地幔传输到外地核,使得外核成为H的潜在储库,并在核-幔边界上方留下了富氧的块状结构.

关键词：离子态第一性原理计算氢离子相稳定性地球内部熔化温度高压实验分子动力学模拟

Same day yttrium-90 radioembolization with single photon emission computed tomography/computed tomography: An opportunity to improve care during the COVID-19 pandemic and beyond

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World Journal of Gastrointestinal Oncology 2021年第5期13卷 440-452页

作者： mohammad Elsayed mohammad Loya James Galt David m Schuster zachary L Bercu Janice Newsome David Brandon Sonia Benenati Keywan Behbahani Richard Duszak Ila Sethi Nima Kokabi Division of Interventional Radiology and Image-Guided medicine Department of Radiology and Imaging SciencesEmory University School of MedicineAtlantaGA 30322United States Division of Nuclear medicine and molecular Imaging Department of Radiology and Imaging SciencesEmory University School of MedicineAtlantaGA 30322United States

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has made it more challenging for patients to undergo yttrium-90(Y-90)radioembolization(RE).Same day Y-90 RE provides an opportunity to minimize logistical challenges and infection risk associated with COVID-19,thus improving patient *** To describe the use of same day Y-90 RE with routine single photon emission computed tomography/computed tomography(SPECT/CT)in order to optimize *** All patients were selected for Y-90 RE through a multidisciplinary tumor board,and were screened and tested for COVID-19 infection per institutional protocol.A same day procedure was developed,consisting of angiography,imaging,and Y-90 resin particle *** SPECT/CT after technetium-99m macroaggregated albumin(Tc-99m mAA)administration was performed for assessment of arterial supply,personalized dosimetry,and extrahepatic ***-treatment Y-90 bremsstrahlung SPECT/CT was performed for confirmation of particle delivery,by utilization of energy windowing to limit signal from previously administered Tc-99m mAA *** A total of 14 patients underwent same day Y-90 RE between march and June *** lung shunt fraction was 6.13%(range 3.5%-13.1%).Y-90 RE was performed for a single lesion in 7 patients,while the remaining 7 patients had treatment of multifocal *** largest lesion measured 8.3 *** patients tolerated the procedure well and were discharged the same *** Same day Y-90 RE with resin-based microspheres is feasible,and provides an opportunity to mitigate infection risk and logistical challenges associated with the COVID-19 pandemic and *** recommend consideration of SPECT/CT,especially among patients with complex malignancies,for the potential to improve outcomes and eligibility of patients to undergo same day Y-90 RE.

关键词： Yttrium-90 radioembolization Same day Selective internal radiotherapy Transarterial radioembolization Single photon emission computed tomography/computed tomography Dosimetry COVID-19

Long-Term Cropping System, Tillage, and Poultry Litter Application Affect the Chemical Properties of an Alabama Ultisol

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Pedosphere 2019年第2期29卷 180-194页

作者： Zhongqi HE Irenus A.TAZISONG Xinhua YIN Dexter B.WATTS zachary N.SENWO Henry Allen TORBERT United States Department of Agriculture-Agricultural Research Service(USDA-ARS) Southern Regional Research Center Department of Biological and Environmental Sciences Alabama A&M University Department of Plant Sciences University of Tennessee United States Department of Agriculture-Agricultural Research Service(USDA-ARS) National Soil Dynamics Laboratory

Sustainable agricultural practices have been steadily increasing in the last couple of decades. These management practices frequently involve cover crops, less or no-tillage, and organic fertilization. In this study, we evaluated the effects of cropping systems,tillage and no-tillage, and the application of poultry litter(PL) on selected soil physicochemical properties and soil test nutrients. Soil samples were collected from the topmost surface(0–5 cm) and subsurface(5–10 cm) layers. The general effect trend was PL application > no-tillage > cover crop > cropping type. There were more statistically significant(P ≤ 0.05) correlations between the 18 soil attributes at the topmost surface than at the subsurface. This could be due to the accumulation of external C inputs and nutrients by crop residues and PL application as well as the retaining effects of no-tillage on less mobile nutrient components. Because of their high mobility and volatile nature, total nitrogen(N), ammonia-N(NH_4^+-N), and nitrate-N(NO_3^--N) levels varied greatly(high standard deviations), showing no consistent patterns among the treatments. Compared to the soybean cropping system, corn, especially with the wheat cover crop, contributed more to the total carbon(C) and sulfur(S) in the topmost surface soils(0–5 cm). Poultry litter application greatly increased pH, cation exchange capacity(CEC), base saturation, magnesium(mg), phosphorus(P), calcium(Ca),sodium(Na), potassium(K), manganese(mn), copper(Cu), and zinc(Zn) in both soil layers. Contrast comparisons revealed that PL application had more of an effect on these soil chemical properties than no-tillage and cropping systems. These results will shed light on developing better nutrient management practices while reducing their runoff potentials.

关键词： conventional tillage cover crop mehlich-3 extraction no-tillage nutrient management practice organic fertilization soil attributes soil test nutrients

Impact of Chromium Propionate Supplementation and Days of Adaptation on Energy Status in Newly Weaned Steer Calves^*

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Open Journal of Animal Sciences 2023年第4期13卷 409-420页

作者： zachary Kidd Foster Smith Department of Animal Science South Dakota State University Brookings USA

The objective of this research was to evaluate the influences that supplemental dietary chromium propionate (CrP;0 or 0.4 mg·kg-1 added to the total diet on a Dm basis) has on plasma indicators of energy status in newly weaned steers upon introduction to the feedlot. For this experiment single source, Angus steers (n = 28;BW = 289 ± 12.0 kg) from a ranch in Western South Dakota were weaned and immediately shipped 579 km to the Ruminant Nutrition Center (RNC) in Brookings, SD. Steers were allotted to one of four 7.6 m × 7.6 m pens (2 pens/diet;7 steers/pen) at 4 d post-arrival to the RNC and test diets were initiated. No anabolic implant was used in this study. Subsequent BW measurements were obtained at 1400 h, to accommodate a post-prandial timing for blood sampling. This was 4 h after initial access to feed, and immediately prior to the afternoon feed delivery. Weights and blood sampling occurred on d 5, 12, 19, and 33. Whole blood samples were collected from all steers via jugular venipuncture and separated as plasma. There were no diet x day interactions (P ≥ 0.51) for plasma glucose, insulin, or urea-N. Plasma glucose, insulin, and urea-n levels were similar between diets (P ≥ 0.35). Plasma glucose and urea-n levels were not different across days (P ≥ 0.59). Insulin levels differed as a result of days of adaptation and were greatest (P = 0.01) on d 12 regardless of diet. There tended (P = 0.12) to be a diet x day interaction for NEFA levels. Plasma NEFA levels tended to be lower (P = 0.13) for calves fed CrP on d 5, and were greater (P = 0.09) on d 12 in calves fed CrP. The shift in NEFA on d 12 coincided with the spike in insulin levels. Both events occurred at the time that NEg intake was approaching the acclimated plateau and neither event impacted glucose status. In non-ruminants, elevated insulin concentrations decrease circulating NEFA levels. We detected minimal differences in regard to plasma indicators of lipid metabolism in this

关键词： Beef Steers Chromium Feedlot Adaptation Insulin Newly Weaned

Tire-derived carbon for catalytic preparation of biofuels from feedstocks containing free fatty acids

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Carbon Resources Conversion 2018年第2期1卷 165-173页

作者： zachary D.Hood Shiba P.Adhikari Samuel F.Evans Hui Wang Yunchao Li Amit K.Naskar miaofang Chi Abdou Lachgar m.Parans Paranthaman School of Chemistry and Biochemistry Georgia Institute of TechnologyAtlantaGA 30332USA Center for Nanophase materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Chemistry Wake Forest UniversityWinston-SalemNC 27109USA Center for Energy Environmentand Sustainability(CEES)Wake Forest UniversityWinston-SalemNC 27109USA Chemical Sciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA The Bredesen Center for Interdisciplinary Research and Graduate Education The University of TennesseeKnoxvilleTN 37996USA mechanical Engineering and Conn Center for Renewable Energy Research University of LouisvilleLouisvilleKY 40292USA materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTN 37831USA materials Science and Technology Division(mSTD) Oak Ridge National LaboratoryOak RidgeTN 37831USA

The utilization of waste feedstocks rich in free fatty acids(FFAs)improves biofuel production on the basis of economics and ***,converting these feedstocks to usable biofuel poses inherent problems in terms of the FFA to biofuel conversion yield and the catalyst ***,we report novel ferric sulfate impregnated carbon derived from waste tires as highly active catalysts for FFA to biofuel *** approach takes advantage of facile synthesis methods involving sonication and dehydration processes to create materials that are useful for the efficient catalytic conversion of FFAs to advanced *** of FFAs to fatty acid methyl esters was achieved at 65C and atmospheric pressure with>98%yield even in the presence of *** catalysts maintained similar activity after four successive uses,which indicates that the active catalytic sites are effectively supported by the three-dimensional meso/microporous architecture of the tire-derived carbon.

关键词： Biofuels Solid acidcatalyst Recycled tires Free fattyacids Esterification

mortality in patients with heart failure and suicidal ideation discharged to skilled nursing facilities

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Journal of Geriatric Cardiology 2022年第3期19卷 198-208页

作者： melanie L Bozzay Lan Jiang Andrew R Zullo melissa R Riester Jacob A Lafo zachary J Kunicki James L Rudolph Caroline madrigal Rachel Clements Sebhat Erqou Wen-Chih Wu Stephen Correia Jennifer m Primack Department of Psychiatry&Human Behavior Alpert Medical School of Brown UniversityBox G-BHProvidenceRhode IslandUnited States VA RR&D Center for Neurorestoration and Neurotechnology Providence VA Medical Center830 Chalkstone BoulevardProvidenceRhode IslandUnited States VA Center of Innovation in Long Term Services Providence VA Medical Center830 Chalkstone BoulevardProvidenceRhode IslandUnited States Department of Health Services Policyand PracticeBrown University School of Public HealthBox G-S121-8ProvidenceRhode IslandUnited States Department of medicine Alpert Medical School of Brown UniversityBox G-BHProvidenceRhode IslandUnited States

Heart failure(HF)is a leading cause of morbidity and mortality in the United States.[1]A chronically,disabling and debilitating condition,HF often results in hospital admission and subsequent readmission.[2]After hos-pitalization,nearly 25%of older adults with HF are discharged to skilled nursing facilities(SNFs)for re-habilitation due to difficulties with functioning in-dependently.[3]Critically,patients with HF dis-charged to SNFs also show significantly higher rates of mortality.[2]Identifying factors that predict mortality among this important patient population,especially factors that could be addressed in the hospital setting,is an important step toward im-proving survivability among these patients.

关键词： patients mortality nursing

Inhibition of the cystic fibrosis transmembrane conductance regulator in cardiomyocytes causes alterations in PKA activity and intracellular Ca2+

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Inhibition of the cystic fibrosis transmembrane conductance ...

Is tumor cell specificity distinct from tumor selectivity in vivo?A quantitative NIR molecular imaging analysis of nanoliposome targeting

2008北京国际生理科学学术大会

作者： SELLERS zachary m XIANG Kevin BEST Philip m Department of molecular and Integrative Physiology College of medicine University of Illinois at Urbana-ChampaignUrbanaIL

Background and Aims:The existence of the cystic fibrosis transmembrane conductance regulator (CFTR) in the heart is well established;however,its physiological role has yet to be ***,we found that inhibition of CFTR in spontaneously beating cardiomyocytes led to significant,but recoverable,decreases in contraction *** beating cardiomyocytes are sensitive to alterations in PKA and Ca mobilization, therefore,we investigated if inhibition of CFTR leads to alterations in PKA activity or intracellular Ca(Ca) and the effect this may have on changes in contraction ***:Separately,we used fluorescent resonance energy transfer and Fura-2,to monitor changes in quiescent cardiomyocyte PKA activity or Ca,respectively. Additionally,we examined the role of calcium-activated Cl channels(CaCC) in contraction rate using niflumic acid (100μmol/L) or autocamtide-2-related inhibitory peptide(AIP;1μmol/L).Inhibition of CFTR was achieved by use of CFTR-172(20μmol/L),a specific pharmacological inhibitor of CFTR,or CFTR KO ***:CFTR-172 caused a significant decrease in PKA activity that resolved within 20 min,mimicking the effect of CFTR-172 on contraction *** contrast,CFIR-172 caused a significant increase in Ca that peaked within 2.6±0.5 min and returned to levels below baseline within 20 *** spontaneously beating cardiomyocytes,niflumic acid caused a significant,but transient decrease in contraction rate;that was similar to CFTR *** contrast,AIP caused a small,but reproducible decrease in contraction ***,combinations of CFTR inhibition(by CPTR-172 or CFTR KO mice) with niflumic acid or AIP resulted in significant and sustained decreases in contraction rate. Specifically,in cardiomyocytes exposed to CFTR-172,niflumic acid or AIP significantly attenuated the recovery phase following the initial inhibition of contraction rate by ***:We conclude that the decrease in cardiomyocyte contraction rate by inhi

关键词： CFTR cardiomyocyte calcium

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Nano Research 2021年第5期14卷 1344-1354页

作者： Girgis Obaid Kimberley Samkoe Kenneth Tichauer Shazia Bano Yeonjae Park zachary Silber Sassan Hodge Susan Callaghan mina Guirguis Srivalleesha mallidi Brian Pogue Tayyaba Hasan Wellman Center for Photomedicine Massachusetts General Hospital and Harvard Medical SchoolBostonMA02114USA Department of Bioengineering University of Texas at DallasRichardsonTX75080USA Thayer School of Engineering Dartmouth CollegeHanoverNH037551USA Armour College of Engineering Illinois Institute of TechnologyChicagoIL60616USA Division of Health Sciences and Technology Harvard University and Massachusetts Institute of TechnologyCambridgeMA02139USA

The significance and ability for receptor targeted nanoliposomes(tNLs)to bind to their molecular targets in solid tumors in vivo has been questioned,particularly as the efficiency of their tumor accumulation and selectivity is not always predictive of their efficacy or molecular *** study presents,for the first time,in situ near-infrared(NIR)molecular imaging-based quantitation of the in vivo specificity of tNLs for their target receptors,as opposed to tumor selectivity,which includes influences of enhanced tumor permeability and *** show that neither tumor delivery nor selectivity(tumor-to-normal ratio)of cetuximab and IRDye conjugated tNLs correlate with epidermal growth factor receptor(EGFR)expression in U251,U87,and 9L tumors,and in fact underrepresent their imaging-derived molecular specificity by up to 94.2%.Conversely,their in vivo specificity,which we quantify as the concentration of tNL-reported tumor EGFR provided by NIR molecular imaging,correlates positively with EGFR expression levels in vitro and ex vivo(Pearson’s r=0.92 and 0.96,respectively).This study provides a unique opportunity to address the problematic disconnect between tNL synthesis and in vivo *** findings encourage their continued adoption as platforms for precision medicine,and facilitates intelligent synthesis and patient customization in order to improve safety profiles and therapeutic outcomes.

关键词： molecular recognition receptors nanoparticles specificity cancer