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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 315-324,I0001,I0002页

作者： Dimitrios Moris Brian I.Shaw Cecilia Ong Ashton Connor Mariya L.Samoylova Samuel j.Kesseli Nader Abraham jared Gloria Robin Schmitz zachary W.Fitch Bryan M.Clary Andrew S.Barbas Department of Surgery Duke University Medical CenterDurhamNCUSA

Background:Selection of the optimal treatment modality for primary liver cancers remains complex,balancing patient condition,liver function,and extent of *** individuals with preserved liver function,liver resection remains the primary approach for treatment with curative intent but may be associated with significant *** purpose of this study was to establish a simple scoring system based on Model for End-stage Liver Disease(MELD)and extent of resection to guide risk assessment for liver ***:The 2005-2015 NSQIP database was queried for patients undergoing liver resection for primary liver *** first developed a model that incorporated the extent of resection(1 point for major hepatectomy)and a MELD-Na score category of low(MELD-Na=6,1 point),medium(MELD-Na=7-10,2 points)or high(MELD-Na>10,3 points)with a score range of 1-4,called the Hepatic Resection Risk Score(HeRS).We tested the predictive value of this model on the dataset using logistic *** next developed an optimal multivariable model using backwards sequential selection of variables under logistic *** performed K-fold cross validation on both *** operating characteristics were plotted and the optimal sensitivity and specificity for each model were calculated to obtain positive and negative predictive ***:A total of 4,510 patients were *** was associated with increased odds of 30-day mortality[HeRS=2:OR=3.23(1.16-8.99),P=0.025;HeRS=3:OR=6.54(2.39-17.90),P<0.001;HeRS=4:OR=13.69(4.90-38.22),P<0.001].The AUC for this model was *** AUC for the optimal multivariable model was higher at *** K-fold cross validation,the positive predictive value(PPV)and negative predictive value(NPV)of these two models were similar at PPV=6.4%and NPV=97.7%for the HeRS only model and PPV=8.4%and NPV=98.1%for the optimal multivariable ***:The HeRS offers a simple heuristic for estimating 30-day mortality after resectio

关键词： Hepatocellular carcinoma(HCC) cholangiocarcinoma liver resection Model for End-stage Liver Disease(MELD) outcomes

2018年《journal of Diabetes》第7期中文导读

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中华内分泌代谢杂志 2018年第7期34卷 610-614页

作者： j Diabetes编辑部 j Diabetes编辑部

在美国大约有9％的人群受糖尿病的影响，但在全部住院患者中却占到了25％。糖尿病患者的90d再住院率要比非糖尿病人群高40％，前者30d再住院率为14．4％～22．7％，90d再住院率〉26％，1年再住院率达到了30％。

关键词：非糖尿病人群再住院率导读中文住院患者

2018年《journal of Diabetes》第10期中文导读

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中华内分泌代谢杂志 2018年第10期34卷 882-886页

作者：《j Diabetes》编辑部 j Diabetes编辑部

胰岛素抵抗。

关键词：导读中文胰岛素抵抗心血管疾病糖尿病

科学程序设计引论用Mathematica和C求解计算问题 5

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Subnanometer-resolved chemical imaging via multivariate analysis of tip-enhanced Raman maps

2001年

作者：（美）joseph L.zachary 裘宗燕等译

本书包括计算科学；人口密度：数字的计算特性；厄拉多塞：有效数字及其区间运算；通向天国之梯：舍入误差的累积等内容。

ISBN: (纸本)7040093987

本书包括计算科学；人口密度：数字的计算特性；厄拉多塞：有效数字及其区间运算；通向天国之梯：舍入误差的累积等内容。

关键词：概论应用程序语言 C语言数值计算

来源：畅想之星图书光盘版（南... 评论

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Light(Science & Applications) 2017年第1期6卷 382-389页

作者： Song jiang Xianbiao Zhang Yao Zhang Chunrui Hu Rui Zhang Yang Zhang Yuan Liao zachary j Smith Zhenchao Dong jG Hou Hefei National Laboratory for Physical Sciences at the Microscale and Synergetic Innovation Center of Quantum Information&Quantum Physics University of Science and Technology of ChinaHefeiAnhui 230026China Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefeiAnhui 230026China

Tip-enhanced Raman spectroscopy(TERS)is a powerful surface analysis technique that can provide subnanometer-resolved images of nanostructures with site-specific chemical ***,due to the limitation of weak Raman signals and the resultant difficulty in achieving TERS imaging with good signal-to-noise ratios(SNRs),the conventional single-peak analysis is unsuitable for distinguishing complex molecular architectures at the subnanometer *** we demonstrate that the combination of subnanometer-resolved TERS imaging and advanced multivariate analysis can provide an unbiased panoramic view of the chemical identity and spatial distribution of different molecules on surfaces,yielding high-quality chemical images despite limited SNRs in individual pixel-level *** methodology allows us to exploit the full power of TERS imaging and unambiguously distinguish between adjacent molecules with a resolution of~0.4 nm,as well as to resolve submolecular features and the differences in molecular adsorption *** results provide a promising methodology that promotes TERS imaging as a routine analytical technique for the analysis of complex nanostructures on surfaces.

关键词： chemical imaging hyperspectral imaging multivariate analysis nanoimaging tip-enhanced Raman spectroscopy

NKR-P1B expression in gut-associated innate lymphoid cells is required for the control of gastrointestinal tract infections

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Cellular & Molecular Immunology 2019年第11期16卷 868-877页

作者： Elias Abou-Samra zachary Hickey Oscar A.Aguilar Michal Scur Ahmad Bakur Mahmoud Sergey Pyatibrat Megan M.Tu jeffrey Francispillai Arthur Mortha james R.Carlyle Mir Munir A.Rahim Andrew P.Makrigiannis Department of Biochemistry Microbiology and ImmunologyUniversity of Ottawa451 Smyth RoadOttawaON K1H 8M5Canada Department of Immunology University of Toronto1 King’s College CircleTorontoON M5S 1A8Canada Sunnybrook Research Institute 2075 Bayview AvenueTorontoON M4N 3M5Canada Department of Microbiology and Immunology Dalhousie University5850 College StreetHalifaxNS B3H 4R2Canada College of Applied Medical Sciences Taibah UniversityMadinah MunawwarahSaudi Arabia Division of Anatomical Pathology Department of Pathology and Laboratory MedicineThe Ottawa HospitalUniversity of Ottawa501 Smyth RoadOttawaON K1H 8L6Canada

Helper-type innate lymphoid cells(ILC)play an important role in intestinal *** of the NKR-P1 gene family are expressed in various innate immune cells,including natural killer(NK)cells,and their cognate Clr ligand family members are expressed in various specialized tissues,including the intestinal epithelium,where they may play an important role in mucosalassociated innate immune *** this study,we show that the inhibitory NKR-P1B receptor,but not the Ly49 receptor,is expressed in gut-resident NK cells,ILC,and a subset ofγδT cells in a tissue-specific ***3 cells constitute the predominant cell subset expressing NKR-P1B in the gut lamina *** known NKR-P1B ligand Clr-b is broadly expressed in gut-associated cells of hematopoietic *** genetic deletion of NKR-P1B results in a higher frequency and number of ILC3 andγδT cells in the gut lamina ***,the function of gut-resident ILC3,NK,andγδT cells in NKR-P1B-deficient mice is impaired during gastrointestinal tract infection by Citrobacter rodentium or Salmonella typhimurium,resulting in increased systemic bacterial dissemination in NKR-P1B-deficient *** findings highlight the role of the NKR-P1B:Clr-b recognition system in the modulation of intestinal innate immune cell functions.

关键词： Innate lymphoid cells Natural killer cells Gut-associated immune cells NKR-P1B receptor Innate immunity

The best thing a foreign citizen can do is to stay indoors as much as possible

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国际人才交流 2020年第2期 65-65页

作者： zachary j Smith University of Science and Technology of China

The majority of my foreign friends are staying in China,however,a few have left to their home ***,in my personal opinion,traveling exposes you to more danger than staying at ***,because some infected people may have few symptoms,if you travel home,you may bring the virus with you to your home *** these factors together,I believe it is safer and more considerate to others to stay in place for the time being.

关键词： travel traveling however

Conjugate Addition of Indoles to <i>α,β</i>-Unsaturated Ketones Using Bismuth (III) Bromide

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Green and Sustainable Chemistry 2019年第3期9卷 79-84页

作者： Tyler j. Rauwolf Zhijia Geng zachary P. Kinney jared L. Renfroe jack H. Roireau Lauren T. Yep Ram S. Mohan Laboratory for Environmentally Friendly Organic Synthesis Department of Chemistry Illinois Wesleyan University Bloomington IL USA

An efficient method for the conjugate addition of indoles to a variety of chalcones using BiBr3 in ethanol (190 proof) is reported. Products are isolated by a simple procedure that avoids an aqueous work up and extensive chromatography, thus minimizing waste. Bismuth (III) compounds are especially attractive from a green chemistry perspective because they are remarkably nontoxic, non-corrosive and relatively inexpensive.

关键词： Bismuth Bismuth Bromide Conjugate Addition Green Chemistry Indoles

Chronic Physical Stress Does Not Interact with Epstein-Barr Virus (EBV)-Encoded Dutpase to Alter the Sickness Response

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journal of Behavioral and Brain Science 2015年第11期5卷 513-523页

作者： Taryn G. Aubrecht zachary M. Weil Bachir Abi Salloum Maria Eugenia Ariza Marshall Williams Brenda Reader Ronald Glaser john Sheridan Randy j. Nelson Departments of Neuroscience The Ohio State University Columbus OH USA Molecular Virology Immunology & Medical Genetics The Ohio State University Columbus OH USA Institute of Behavioral Medicine Research Wexner Medical Center Comprehensive Cancer Center The Ohio State University Columbus OH USA Division of Biosciences College of Dentistry The Ohio State University Columbus OH USA

Most adult humans have been infected with Epstein-Barr virus (EBV), which is thought to contribute to the development of chronic fatigue syndrome. Stress is known to influence the immune system and can exacerbate the sickness response. Although a role for psychological stress in the sickness response, particularly in combination with EBV-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase) has been established, and the role of physical stressors in these interactions remains unspecified. In this study, we seek to determine the interaction of chronic physical (swim) stress and EBV-encoded dUTPase injection. We hypothesize that a chronic physical stressor will exacerbate the sickness response following EBV-encoded dUTPase injection. To test this hypothesis mice receive daily injections of EBV-encoded dUTPase or vehicle and are subjected to 15 min of swim stress each day for 14 days or left unmanipulated. On the final evening of injections mice undergo behavioral testing. EBV-encoded dUTPase injection alone produces some sickness behaviors. The physical swimming stress does not alter the sickness response.

关键词： Epstein-Barr Virus Swim Stress Sickness Response