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Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens zachary Fitzgerald P.Hande Ozdinler department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and drug discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

巨大良性前列腺增生患者前列腺切除术后血清CK—BB—过性增高

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宁夏医学杂志 1983年第3期 56-56页

作者：膝万钟

血清 CK—BB 同功酶活性罕见异常高度(即可以检出的高度)。前列腺疾病患者中,免疫反应性 CK—BB 或 CK—BB 活性升高,曾被推荐作为前列腺腺癌的一种指征。作者报告一例巨大良性前列腺增生,但无临床或病理学的前列腺腺癌证据的老年男性患... 详细信息

血清 CK—BB 同功酶活性罕见异常高度(即可以检出的高度)。前列腺疾病患者中,免疫反应性 CK—BB 或 CK—BB 活性升高,曾被推荐作为前列腺腺癌的一种指征。作者报告一例巨大良性前列腺增生,但无临床或病理学的前列腺腺癌证据的老年男性患者,用琼脂糖凝胶电泳发现其血清 CK—BB活性是1u/L(正常=0)。为总 CK 活性的10%。前列腺切除术后1小时,血清 CK—BB 进一步增加到16u/L(总 CK 的20%),而术后第二天即变为不可检出。此发现说明:(1)此例血清 CK—BB 活性起源于增大的前列腺,(2)前列腺疾病男性患者血清 CK—BB 活性异常增高,并不一定指示前列腺腺癌的存在,(3)如果使用那些并非一贯都能使“心脏特异性”的 CK—MB 与 CK—BB 分离的方法检测 CK 同功酶,那末,

关键词：前列腺切除术后良性前列腺增生血清 CK BB 患者

Utilizing multiphoton imaging and integrative clearing to reveal sex differences in neuroimmune interactions after nerve injury

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Neural Regeneration Research 2022年第11期17卷 2429-2430页

作者： zachary W.Castillo Michael d.Burton Neuroimmunology and Behavior Laboratory Department of NeuroscienceSchool of Behavioral and Brain SciencesCenter for Advanced Pain StudiesUniversity of Texas at Dallas

With the constant development of multiphoton microscopy,our ability to observe complex and dynamic biological processes deeper within living tissue,is steadily *** use multiphoton microscopy,because experiments can be conducted with little to no invasiveness or tissue damage over a long period of time with no photodamage(Mancuso et al.,2009).This allows for the introduction of tissue into the context of a three-dimensional 3d environment in which visualization of cellular activation and interaction is *** circumventing a distorted reconstruction with limited z-stacks,multiphoton imaging provides enhanced spatiotemporal resolution.

关键词： resolution. multiphoton distorted

Additively manufactured Ti–Ta–Cu alloys for the next-generation load-bearing implants

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International Journal of Extreme Manufacturing 2024年第1期6卷 353-374页

作者： Amit Bandyopadhyay Indranath Mitra Sushant Ciliveri Jose d Avila William dernell Stuart B goodman Susmita Bose W.M.Keck Biomedical Materials Research Laboratory School of Mechanical and Materials EngineeringWashington State UniversityPullmanWA 99164United States of America Veterinary Clinical Sciences College of Veterinary MedicineWashington State UniversityPullmanWA 99164United States of America department of Orthopedic Surgery Stanford University Medical CenterRedwood CityCA 94063United States of America

Bacterial colonization of orthopedic implants is one of the leading causes of failure and clinical complexities for load-bearing metallic implants. Topical or systemic administration of antibiotics may not offer the most efficient defense against colonization, especially in the case of secondary infection, leading to surgical removal of implants and in some cases even limbs. In this study, laser powder bed fusion was implemented to fabricate Ti3Al2V alloy by a 1:1 weight mixture of CpTi and Ti6Al4V powders. Ti-Tantalum(Ta)–Copper(Cu) alloys were further analyzed by the addition of Ta and Cu into the Ti3Al2V custom alloy. The biological,mechanical, and tribo-biocorrosion properties of Ti3Al2V alloy were evaluated. A 10 wt.% Ta(10Ta) and 3 wt.% Cu(3Cu) were added to the Ti3Al2V alloy to enhance biocompatibility and impart inherent bacterial resistance. Additively manufactured implants were investigated for resistance against Pseudomonas aeruginosa and Staphylococcus aureus strains of bacteria for up to 48 h. A 3 wt.% Cu addition to Ti3Al2V displayed improved antibacterial efficacy, i.e.78%–86% with respect to CpTi. Mechanical properties for Ti3Al2V–10Ta–3Cu alloy were evaluated, demonstrating excellent fatigue resistance, exceptional shear strength, and improved tribological and tribo-biocorrosion characteristics when compared to Ti6Al4V. In vivo studies using a rat distal femur model revealed improved early-stage osseointegration for alloys with10 wt.% Ta addition compared to CpTi and Ti6Al4V. The 3 wt.% Cu-added compositions displayed biocompatibility and no adverse infammatory response in vivo. Our results establish the Ti3Al2V–10Ta–3Cu alloy’s synergistic effect on improving both in vivo biocompatibility and microbial resistance for the next generation of load-bearing metallic implants.

关键词： Ti6Al4V load-bearing implants additive manufacturing 3d printing antibacterial performance

乙烯基乙酸酯合成钯-金催化剂中金的助催化作用(英文)

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催化学报 2008年第11期29卷 1178-1186页

作者：陈明树 d.W.goodman 厦门大学化学化工学院化学系和固体表面物理化学国家重点实验室福建厦门361005 德克萨斯A&M大学化学系德克萨斯州科利奇站

硅胶负载的钯-金双金属催化剂是乙烯乙酰氧基化制乙烯基乙酸酯(VA)的高选择性催化剂,本文应用平面和负载纳米颗粒模型催化剂体系研究金的助催化作用,应用低能离子散射谱、低能电子衍射、X射线光电子能谱、反射红外吸收光谱及程序升温脱... 详细信息

硅胶负载的钯-金双金属催化剂是乙烯乙酰氧基化制乙烯基乙酸酯(VA)的高选择性催化剂,本文应用平面和负载纳米颗粒模型催化剂体系研究金的助催化作用,应用低能离子散射谱、低能电子衍射、X射线光电子能谱、反射红外吸收光谱及程序升温脱附等技术表征这些模型催化剂.结果表明,金的主要助催化作用是隔离催化剂表面的催化活性钯原子,形成孤立的钯活性中心,从而大大抑制或消除反应物和/或产物在毗邻多原子钯中心上的深度分解,提高VA合成的选择性及活性.同时由于形成了孤立的钯原子活性中心,反应副产物或中间物之一的一氧化碳吸附较弱,避免了催化剂表面的一氧化碳中毒,进而提高催化活性.

关键词：乙烯基乙酸酯双金属钯金合金效应

BUILdING INTERIOR TUBES ANd NONIMAGING REFLECTORS(BITNR)STUdIES

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Journal of Green Building 2020年第2期15卷 213-248页

作者： Joel H.goodman P.O.Box 14 DodgevilleWI 53533

Building Interior Tubes and Nonimaging Reflectors(BITNR)solar thermal concentrators for mid-temperature applications in snow and dust regions,previously titled BIETR now include non-evacuated tube-receivers.A nonpublic walk-in solar collector space has fixed receiver-tubes with matching involute(rounded W)reflectors forming target-rectangles for augmenting large CPC troughs and relaxed tracking E&W‘wing’reflectors with a glass or solid polycarbonate building envelope collector *** is a BITNR reflector‘wings’tracker invention by George Helmholz and proof-of-concept development by university undergraduate engineering *** are:building types,structure,and construction and reflector materials for global *** architectural feasibility studies with air and water-steam systems include:small wood frame structures,two-car garages,house size demonstration,long-span atriums,large concourses,towers,additions,and verification-test *** studies indicate integrated solar thermal mid-temperature technologies with building-size nonimaging CPC reflectors are main organizing factors for building design and site ***/BIETR undergraduate student mechanical and structural engineering semester projects at the University of Wisconsin-Platteville are reported.A BITNR R&d project proposal is outlined which includes:a greenhouse test facility,evaluation of test stands,and development of a computer simulation design aid for architects.

关键词： architectural mid-temperature concentrators building interior big CPCs building interior receiver-tubes Helmholz‘wings’tracker BITNR student engineering projects

SMALL HELIOSTATS CSP SYSTEMS ON LONG-SPAN HANGING ROOFS

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Journal of Green Building 2019年第2期14卷 219-242页

作者： Joel H.goodman P.O Box 14 DodgevilleWisconsin 53533USA

Building Integrated Concentrating Solar Power (BI-CSP) schematic studies with small scale exterior two-axis tracking heliostats anchored on and semi-shading long span hanging roofs with elevated receiver(s) are presented for populated urban and rural locations. Hanging roofs (inverted shallow dome shape) with two-way structural cables and mostly square infill prefabricated slabs/panels supported from a perimeter horizontal circular donut shape rim-girder-platform without a center tension ring studies are for comparing to radial cable structural configurations with a center tension ring. Cable gap grouting between slabs/panels form a pre-tensioned inverted shell structure after temporary weights are removed. Securing vertical heliostat posts studies include: three vertical bolts cast in grout gap two-way cables intersections for three point adjustment of horizontal post base plates;and one-axis adjustable manufactured post brackets bolted to sloped roof surfaces at holes cast in the gaps/slabs. A main case study schematic is around a 30m/100ft diameter hanging roof with a 0.07 sag/diameter ratio with around 271 1m2 heliostats for 230kWt solar thermal steam or air to around 300degC/572degF building integrated thermal energy storage (molten salt, firebricks, etc.) and applications (water purification, cooling, industrial process heat, etc.). A BI-CSP hanging roofs R&d project proposal is outlined: with a circular roof study diameter range of around 25m/82ft-200m/656ft diameter for comparing two-way and radial cable structural configurations for distributed steam stations and a wide range of application temperatures.

关键词： Building-integrated CSP long-span hanging roof small heliostats solar urban design

Impact of hydrolysis on surface area and energy storage applications of activated carbons produced from corn fiber and soy hulls

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Carbon Resources Conversion 2020年第1期3卷 19-28页

作者： zachary d.Herde Ruchira dharmasena Gamini Sumanasekera Jaya Shankar Tumuluru Jagannadh Satyavolu Conn Center for Renewable Energy Research University of LouisvilleLouisvilleKYUSA Energy Systems Laboratory Idaho National LaboratoryIdaho FallsIDUSA School of Chemical and Biomolecular Eng Georgia Institute of TechnologyUnited States

Complete utilization of lignocellulosic biomass through the creation of value-added coproducts is one of the key strategies of the Bioenergy Technologies Office(BETO)for the cost-effective production of biofuels and biochemicals.A green approach to producing lightweight and high specific surface area(SSA)activated carbons(ACs)from sustainable biomass sources is of great interest to producers and users of energy devices such as batteries and *** direct conversion from biomass has been studied extensively,AC with relatively high surface areas can be produced more cost-effectively when leveraged as a co-product from a *** this paper,we discuss the production of high specific surface area activated carbons from residual fiber(fiber remaining after extraction of C5-sugars)generated as part of a C5 *** surface,morphological characteristics using SEM and TEM,and energy storage behavior of ACs produced using the C5 extracted residual fiber were evaluated in the present *** ACs produced from the residual fiber delivered an order of magnitude higher surface area than the one directly from corn pericarp fiber and soy *** surface area of the ACs produced from pre-hydrolysis ddG was only 10 m^(2)/g compared to 689 m^(2)/g for soy hulls whereas after hydrolysis these values increased significantly(ddG:1700 m^(2)/g and soy hulls:1300 m^(2)/g).TEM images indicated high exfoliation,explaining the change in surface area *** the same current density(500 mA/g)the cycling performance of the ACs increased as the surface area increased significantly.

关键词： Agricultural residues Hydrolysis Activated carbon Surface area characterization Surface morphology

Facile synthesis of intra-nanogap enhanced Raman tags with different shapes

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Nano Research 2024年第9期17卷 8415-8423页

作者： Sanjun Fan Brian T.Scarpitti Zhewen Luo Abigail E.Smith Jian Ye zachary d.Schultz department of Chemistry and Biochemistry The Ohio State UniversityColumbusOhio 43210USA School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China

Hot spot engineering in plasmonic nanostructures plays a significant role in surface-enhanced Raman scattering(SERS)for bioanalysis and cell ***,creating stable,reproducible,and strong SERS signals remains challenging due to the potential interference from surrounding chemicals and locating SERS-active analytes into hot-spot ***,we developed a straightforward approach to synthesize intra-gap nanoparticles encapsulating 4-nitrobenzenethiol(4-NBT)as a reporter molecule within these gaps to avoid outside *** made three kinds of intra-gap nanoparticles using nanorods,bipyramids,and nanospheres as cores,in which the nanorods based intra-gap nanoparticles exhibit the highest SERS *** advantage of our method is the ease of preparation of high-yield and stable intra-gap nanoparticles characterized by a short incubation time(10 min)with 4-NBT and quick synthesis without requiring an additional step to centrifuge for the purification of core *** intense localized field in the synthesized hot spots of these plasmonic gap nanostructures holds great promise as a SERS substrate for a broad range of quantitative optical applications.

关键词： hot spot engineering surface enhanced Raman scattering intra-gap nanoparticles 4-nitrobenzenethiol