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Role of cerebral digital subtraction angiography in the evaluation of pulse synchronous tinnitus

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Journal of Otology 2021年第4期16卷 225-230页

作者： Gregory P.Lekovic zachary R.Barnard Adam Master b Gautam U.Mehta M.Marcel Maya Eric P.Wilkinson Department of Neurosurgery Cedars-Sinai Medical Center127 S San Vicente BlvdLos AngelesCA90048United States Division of Neurosurgery House Institute2100 West 3rd StreetLos AngelesCA90057United States Division of Neurotology House Institute2100 West 3rd StreetLos AngelesCA90057United States Department of Imaging Cedars-Sinai Medical Center127 S San Vicente BlvdLos AngelesCA90048United States

Objectives: The aim of this study was to evaluate the value of digital subtraction angiography (DsA) in thediagnostic evaluation of a highly selected patient population presenting with pulse-synchronous tinnitus(PsT).Methods: We retrospectively reviewed the charts of all patients referred for evaluation of possiblevascular etiology of pulsatile tinnitus. Patients were evaluated with regards to presenting signs,comorbidities, non-invasive imaging results, angiographic findings and ***: Fifteen patients underwent cerebral DsA. Dural arteriovenous fistula (dAVF) was identified in sixpatients, and five patients had other significant vascular pathology identified on DsA. seven patientswith ‘negative’ non-invasive imaging were found to have significant pathology on ***: Catheter angiography may have a significant yield in appropriately selected patients presenting with pulse synchronous tinnitus.

关键词： Pulse-synchronous tinnitus Transverse-sigmoid arteriovenous fistula Vascular tinnitus Cerebral angiography

synergistic effect of picosecond optical and nanosecond electrical pulses on dielectric breakdown in aqueous solutions

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Photonics Research 2021年第3期9卷 416-423页

作者： zachary N.Coker Xiao-Xuan Liang Allen s.Kiester Gary D.Noojin Joel N.Bixler Bennett L.Ibey Alfred Vogel Vladislav V.Yakovlev Department of Physics and Astronomy Texas A&M UniversityCollege StationTexas 77843USA sAIC Ft Sam HoustonTexas 78234USA Institut fur Biomedizinische Optik Universitat zu Lubeck23562 LubeckGermany Air Force Research Laboratory JBSA Fort Sam HoustonTexas 78234USA Department of Biomedical Engineering Texas A&M UniversityCollege StationTexas 77843USA

The combined effect of short(picosecond) optical and(nanosecond) electrical pulses on dielectric breakdown is investigated both theoretically and experimentally. It was demonstrated that nanosecond electrical pulses(nsEPs),being applied simultaneously with picosecond optical pulses, reduce the threshold for optical *** results are discussed with respect to an extended model for opto-electrical-induced *** newly unveiled effect is expected to play a significant role in spatially confined electroporation and further advances in laser-ablation-based processes while also allowing for measurements of ambipolar diffusion constants.

关键词： breakdown optical picosecond

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北京市老年人健康预期寿命及其变化

中华流行病学杂志 2005年第12期26卷 939-942页

作者：汤哲项曼君 zachary Zimmer 方向华 Toshiko Kaneda 北京首都医科大学宣武医院流行病学和社会医学部 100053 Population Council U. s. A.

目的了解北京地区老年人的健康预期寿命和变化。方法采用纵向研究方法对北京城区(宣武区)、郊区(大兴区)和山区(怀柔县)一个有代表性老年人群(3257人)进行了12年追踪，调查其健康和存活状况。用WHO的基本生活能力评估量表(ADL)，评估... 详细信息

目的了解北京地区老年人的健康预期寿命和变化。方法采用纵向研究方法对北京城区(宣武区)、郊区(大兴区)和山区(怀柔县)一个有代表性老年人群(3257人)进行了12年追踪，调查其健康和存活状况。用WHO的基本生活能力评估量表(ADL)，评估老年人躯体功能健康状况及变化，采用IMaCH多状态法分析多次调查结果及不同健康状况的转变，计算老年人的健康预期寿命及不同时段的变化。结果纵向结果显示一些基本特征在不同时段维持不变：老年人的平均预期寿命(LE)、健康预期寿命(ALE)和健康预期寿命比值(ALE／LE)在城区显著高于农村；女性平均预期寿命高于男性，但ALE／LE低于男性。纵向观察的变化表现为：老年人的平均预期寿命有所提高，增加的幅度在农村大于城区，男性大于女性；城区高龄女性老年人的健康预期寿命近年有明显下降；所有老年人的ALE／LE近年呈下降趋势，尤其是城区老年人和高龄老年人更突出。结论北京地区老年人的健康预期寿命未与预期寿命同步增长，加强心脑血管疾病等慢性病防治，预防残疾和加强功能康复，是提高老年人健康预期寿命和生活质量的基础。

关键词：老年人健康预期寿命纵向观察

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卒中对老年人预期寿命的影响及变化趋势

中华流行病学杂志 2009年第2期30卷 105-109页

作者：方向华汤哲 zachary Zimmer 项曼君 Toshiko Kaneda 首都医科大学宣武医院流行病学和社会医学部北京100053 Population Council USA

目的评价卒中对北京地区老年人预期寿命（LE）、健康预期寿命（ALE）和不健康预期寿命（IALE）的影响，以及上述各项预期寿命指标从1992-1997年到2000-2004年的变化趋势。方法采用纵向研究方法对北京市城区（宣武）、近郊区（大兴）和... 详细信息

目的评价卒中对北京地区老年人预期寿命（LE）、健康预期寿命（ALE）和不健康预期寿命（IALE）的影响，以及上述各项预期寿命指标从1992-1997年到2000-2004年的变化趋势。方法采用纵向研究方法对北京市城区（宣武）、近郊区（大兴）和远郊区（怀柔）有代表性老年人群（3257例）进行12年追踪，调查其健康和存活状况。采用WHO的基本生活能力评估量表（ADL），评估老年人躯体功能健康状况及变化，采用sAs分析比较1992-1997年和2000-2004年2个时间段的LE、ALE和IALE变化。结果各年龄卒中组老年人的LE和ALE均低于非卒中组老年人，IALE则高于非卒中组。基线健康状态是ALE的重要决定因素—基线状态为健康的卒中组老年人，其ALE低于非卒中老年人，但是ALE长于IALE，且卒中组与非卒中组的1ALE无差异；而基线不健康的卒中老年人ALE大幅度减少，IALE超出ALE。城市卒中组老年人的LE和ALE均高于农村，而IALE低于农村。到2000-2004年间，无论城乡，是否患卒中，基线调查时是否处于健康状态，LE均有所增加，其中AEL的增加幅度高于IALE，基线不健康的卒中组老年人的ALE增加幅度最大。结论卒中减低老年人生命数量与质量，对于农村老年卒中患者更为明显。从1992-1997年到2000-2004年期间，北京地区无论是城市还是农村，卒中老年人的LE和ALE都有所延长，提示其生命数量和质量得到改善。

关键词：卒中健康预期寿命生活能力评估量表老年人

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自豪面对残疾

科学新闻 2018年第5期 92-93页

作者： zachary s.Wiersma 倪伟波伊利诺伊大学香槟分校美国科学促进会

噼里啪啦,咯咯作响!会议大厅里响起了嘈杂声。有几个人转过身来看我,想知道这些声音究竟是怎么回事。当我沿着走廊来到研究生院的实验室伙伴身边时,我猛地把头转向左边,然后用手指在右耳上拍得啪啪响,不断地将注意力引向了自己。但当演... 详细信息

噼里啪啦,咯咯作响!会议大厅里响起了嘈杂声。有几个人转过身来看我,想知道这些声音究竟是怎么回事。当我沿着走廊来到研究生院的实验室伙伴身边时,我猛地把头转向左边,然后用手指在右耳上拍得啪啪响,不断地将注意力引向了自己。但当演讲开始时,我已经忘记了别人是怎么看我的。我的注意力完全集中在

关键词：药学研究

基于Illumina RNA-seq短序列的转录组从头组装软件比较与优化(英文)

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植物分类与资源学报 2012年第5期34卷 487-501页

作者：赵磊 zachary LARsON-RABIN 陈斯云郭振华中国科学院昆明植物研究所中国西南野生生物种质资源库云南昆明650201

利用公共数据库中果蝇F1代和栽培水稻基于高通量Illumina测序平台的RNA-seq短序列数据,比较了8个(AByss,Velvet,sOAPdenovo,Oases,Trinity,Multiple-k,T-IDBA and Trans-AByss)转录组从头组装软件。结果显示,在基于单一k-mer和多重k-mer方法的两类软件中,Trinity和Trans-AByss分别表现出最好的组装性能,而其它软件性能比较接近。我们还发现基于多重k-mer比单一k-mer可以组装获得更多的总碱基数目,但是即使利用最好的多重k-mer组装软件,所获得的数据质量也比研究人员所期望的要低。鉴于此,我们提出了"ETM"优化方法,将多重k-mer方法组合到Trinity中,使其在具有最好的组装性能的基础上兼具了多重k-mer的优势,测试结果显示了该方法具有一定的优越性。我们的研究结果为用户选择合适的软件提供了依据,对推动基于高通量Illumina测序的转录组研究具有重要意义。

关键词：高通量二代测序转录组从头组装优化

Comprehensive study of a versatile polyol synthesis approach for cathode materials for Li-ion batteries

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Nano Research 2019年第9期12卷 2238-2249页

作者： Hyeseung Chung Antonin Grenier Ricky Huang Xuefeng Wang zachary Lebens-Higgins Jean-Marie Doux shawn sallis Chengyu song Peter Ercius Karena Chapman Louis F.J.Piper Hyung-Man Cho Minghao Zhang Ying shirley Meng Department of NanoEngineering University of CaliforniaSan DiegoLa JollaCA 92093USA Chemistry Department Stony Brook UniversityStony BrookNY 11794USA Department of Physics Applied Physics and AstronomyBinghamton UniversityBinghamtonNY 13902USA Advanced Light source Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA National Center for Electron Microscopy Molecular FoundryLawrence Berkeley National LaboratoryBerkeleyCA 94720USA

This work reports a comprehensive study of a novel polyol method that can successfully synthesize layered LiNi0.4Mn0.4Co0.2O2,spinel LiNi0.5Mn1.5O4,and olivine LiCoPO4 cathode *** properly designed,polyol method offers many advantages such as low cost,ease of use,and proven scalability for industrial *** importantly,the unique properties of polyol solvent allow for greater morphology control as shown by all the resulting materials exhibiting monodispersed nanoparticles *** morphology contributes to improved lithium ion transport due to short diffusion ***-synthesized LiNi0.4Mn0.4Co0.2O2 delivers a reversible capacity of 101 and 82 mAh.g-1 using high current rate of 5C and 10C,*** also displays surprisingly high surface structure stability after chargedischarge *** step of the reaction was investigated to understand the underlying polyol synthesis mechanism.A combination of in situ and ex situ studies reveal the structural and chemical transformation of Ni-Co alloy nanocrystals overwrapped by a Mn-and Li-embedded organic matrix to a sedes of intermediate phases,and then eventually to the desired layered oxide phase with a homogeneous distribution of Ni,Co,and *** envisage that this type of analysis will promote the development of optimized synthesis protocols by establishing links between experimental factors and important structural and chemical properties of the desired *** insights can open a new direction of research to synthesize high-performance intercalation compounds by allowing unprecedented control of intermediate phases using experimental parameters.

关键词： polyol cathode synthesis nanoparticle LiNi0.4Mn0.4Co0.2O2(NMC)

Leg Extension strength, Explosive strength, Muscle Activation, and Growth as Predictors of Vertical Jump Performance in Youth Athletes

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Journal of science in sport and Exercise 2020年第4期2卷 336-348页

作者： zachary M.Gillen Marni E.shoemaker Brianna D.McKay Nicholas A.Bohannon sydney M.Gibson Joel T.Cramer Department of Nutrition and Health sciences University of Nebraska-Lincoln211 Ruth Leverton HallLincolnNE 68583USA

Purpose The purpose of this study was to examine the relationships among leg extension strength,explosive strength,muscle activation,and measurements of growth to predictions of vertical jump performance in youth *** Height,body mass,skinfolds,and quadriceps femoris muscle cross-sectional area were measured in 39 sports active children(20 females,19 males,age=12.52±0.62 years old).Peak torque(PT),rate of torque development(RTD),rate of velocity development(RVD),and rate of electromyographic amplitude rise(RER)were measured during isometric and isokinetic leg ***,RTD,and RVD were expressed in absolute terms and normalized to body *** jump height(JH)and peak power(PP)were assessed during static(sJ),counter-movement(CMJ),and drop(DJ)*** JH exhibited greater correlations with PT normalized to body mass(r=0.387-0.758)than absolute PT(r=0.338-0.417),whereas PP exhibited greater correlations with absolute PT(r=0.368-0.837).Only negligible to moderate relation-ships existed between JH and PP across all jumps(r=0.053-0.605).Over 50%of the variability in PP was predicted in 24 of 30 regression models with absolute muscle strength,muscle activation,and measurements of growth,while only 6 of 30 models predicted more than 50%of the variability in *** Overall,absolute static and dynamic muscle strength,muscle activation,and growth better explained PP meas-ured during vertical jumps than estimated JH.

关键词： Children Adolescent Torque Jump height Power

Discovery of Key Molecular Pathways of C1 Metabolism and Formaldehyde Detoxification in Maize through a systematic Bioinformatics Literature Review

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Agricultural sciences 2015年第5期6卷 571-585页

作者： P. Deonikar s. Kothandaram M. Mohan Cori Kollin Phoebe Konecky Rachael Olovyanniko zachary Zamore Brian Carey V. A. s. Ayyadurai International Center for Integrative systems Cambridge MA USA Livingston High school Livingston NJ USA

Computational systems biology approaches provide insights to understand complex molecular phenomena in living systems. such understanding demands the need to systematically interrogate and review existing literature to refine and distil key molecular pathways. This paper explores a methodological process to identify key molecular pathways from systematic bioinformatics literature review. This process is used to identify molecular pathways for a ubiquitous molecular process in all plant biological systems: C1 metabolism and formaldehyde detoxification, specific to maize. The C1 metabolism is essential for all organisms to provide one-carbon units for methylation and other types of modifications, as well as for nucleic acid, amino acid, and other biomolecule syntheses. Formaldehyde is a toxic one-carbon molecule which is produced endogenously and found in the environment, and whose detoxification is an important part of C1 metabolism. This systematic review involves a five-part process: 1) framing of the research question;2) literature collection based on a parallel search strategy;3) relevant study selection based on search refinement;4) molecular pathway identification;and 5) integration of key molecular pathway mechanisms to yield a well-defined set molecular systems associated with a particular biochemical function. Findings from this systematic review produced three main molecular systems: a) methionine biosynthesis;b) the methylation cycle;and c) formaldehyde detoxification. specific insights from the resulting molecular pathways indicate that normal C1 metabolism involves the transfer of a carbon group from serine through a folate-mediated pathway to methionine, and eventually the methylation of a biomolecule. In photosynthetic tissues, C1 metabolism often proceeds in reverse towards serine biosynthesis and formate oxidation. C1 metabolism, in maize, appears to be present in the developing embryo and endosperm indicating that these cells are vulnerable to pertu

关键词： systematic Review Bioinformatics Molecular Pathway C1 Metabolism Formaldehyde Detoxification Maize Methionine Biosynthesis Methylation Cycle Folate-Mediated Pathways