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Efficacy and Safety of Bufei Jiedu Granules in Treating Multidrug-Resistant Pulmonary Tuberculosis:A Multi-center,Double-Blinded and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第7期30卷 579-587页

作者： zhang Shao-yan QIU Lei zhang Shun-xian XIAO He-ping CHU Nai-hui zhang Xia zhang hui-qiang ZHENG Pei-yong zhang hui-yong LU Zhen-hui Institute of Respiratory Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China Clinical Research Center Shanghai University of Traditional Chinese MedicineShanghai200032China Department of Tuberculosis Shanghai Pulmonary HospitalTongji UniversityShanghai200433China Department of Tuberculosis Beijing Chest HospitalCapital Medical UniversityBeijing101100China Department of Tuberculosis the Second Hospital of NanjingNanjing210003China Department of Tuberculosis the First Hospital Affiliated to Xinxiang Medical CollegeXinxiangHenan Province453100China

Objective: To assess the efficacy and safety of Bufei Jiedu(BFJD) Granules as adjuvant therapy for patients with multidrug-resistant pulmonary tuberculosis(MDR-PTB). Methods: A large-scale, multi-center, double-blinded, and randomized controlled trial was conducted in 18 sentinel hospitals in China from December 2012 to December 2016. A total of 312 MDR-PTB patients were randomly assigned to BFJD Granules or placebo groups(1:1) using a stratified randomization method, which both received the long-course chemotherapy regimen for 18 months(6 Am-Lfx-P-Z-Pto, 12 Lfx-P-Z-Pto). Meanwhile, patients in both groups also received BFJD Granules or placebo twice a day for a total of 18 months, respectively. The primary outcome was cure rate. The secondary outcomes included time to sputum-culture conversion, changes in lung cavities and quality of life(QoL) of patients. Adverse reactions were monitored during and after the trial. Results: A total of 216 cases completed the trial, 111 in the BFJD Granules group and 105 in the placebo group. BFJD Granules, as adjuvant treatment, increased the cure rate by 13.6% at the end of treatment, compared with the placebo(58.4% vs. 44.8%, P=0.02), and accelerated the median time to sputum-culture conversion(5 months vs. 11 months). The cavity closure rate of the BFJD Granules group(50.6%, 43/85) was higher than that of the placebo group(32.1%, 26/81;P=0.02) in patients who completed the treatment. At the end of the intensive treatment, according to the 36-item Short Form, the BFJD Granules significantly improved physical functioning, general health, and vitality of patients relative to the placebo group(all P<0.01). Overall, the death rates in the two groups were not significantly different;5.1%(8/156) in the BFJD Granules group and 2.6%(4/156) in the placebo group. Conclusions: Supplementing BFJD Granules with the long-course chemotherapy regimen significantly increased the cure rate and cavity closure rate, and rapidly improved QoL of pati

关键词： alternative medicine Chinese herbal formula Bufei Jiedu Granules multidrug-resistant tuberculosis long-course chemotherapy regimen randomized controlled trial

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基于BN与NSGA-Ⅱ的装配式建筑施工风险控制研究

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价值工程 2024年第1期43卷 64-67页

作者：张永辉安徽工业大学管理科学与工程学院马鞍山243002

为有效评估装配式建筑施工风险并采取针对性的控制措施保障施工安全,通过借助模糊贝叶斯网络的反向诊断,确定关键风险因素;构建考虑风险相关性的多目标优化模型,并采用非支配排序遗传算法求解模型。以济南市某装配式建筑项目案例验证方... 详细信息

为有效评估装配式建筑施工风险并采取针对性的控制措施保障施工安全,通过借助模糊贝叶斯网络的反向诊断,确定关键风险因素;构建考虑风险相关性的多目标优化模型,并采用非支配排序遗传算法求解模型。以济南市某装配式建筑项目案例验证方法的合理性,结果表明,项目决策者可以在考虑风险相关性的前提下,根据相应的优化结果给出符合要求的控制措施,为装配式建筑施工风险管理提供了参考与借鉴。

关键词：装配式建筑模糊贝叶斯网络风险相关性 NSGA-Ⅱ算法风险控制

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CalliSpheres载药微球经肝动脉化疗栓塞治疗结直肠癌肝转移的效果观察及护理体会

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山东医学高等专科学校学报 2024年第3期46卷 11-14页

作者：张永会郑桂梅刘松临沂市肿瘤医院山东临沂276034

目的探讨不可手术切除结直肠癌肝转移患者的治疗及护理方法。方法将60例不可手术切除结直肠癌肝转移患者随机分为两组,各30例。两组均行CalliSpheres载药微球经肝动脉化疗栓塞治疗,对照组采用常规护理,观察组采用叙事护理。比较两组肿... 详细信息

目的探讨不可手术切除结直肠癌肝转移患者的治疗及护理方法。方法将60例不可手术切除结直肠癌肝转移患者随机分为两组,各30例。两组均行CalliSpheres载药微球经肝动脉化疗栓塞治疗,对照组采用常规护理,观察组采用叙事护理。比较两组肿瘤控制情况、护理干预效果。结果观察组疾病控制率为90%,高于对照的66.67%(χ^(2)=4.81,P=0.028);观察组SAS、SDS、CD-RISC评分改善程度、护理满意度均优于对照组(P<0.05)。结论应用叙述护理模式有利于提高DEB-TACE治疗不可切除结直肠癌肝转移患者的临床疗效,改善患者负性情绪,提升患者护理满意度。

关键词：结直肠癌肝转移癌经导管肝动脉化疗栓塞术叙事护理

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A Leguminous Shrub (Caragana microphylla) in Semiarid Sandy Soils of North China

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Pedosphere 2006年第3期16卷 319-325页

作者： zhang Tong-hui SU yong-Zhong CUI Jian-Yuan zhang Zhi-hui CHANG Xue-Xiang Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 （China）

Caragana microphylla Lam., a pioneer leguminous shrub species for vegetation re-establishment, is widely distributed in the semi-fixed and fixed sandy lands of the Horqin region. Some soil chemical and physical properties were measured under the canopy of C. microphylla and in the adjacent open areas to determine the effects of individual shrubs on soil properties. The influence of isolated C. microphylla on chemical and physical properties of the topsoil was significantly different between plots under the shrub canopy and in the shrub interspaces. Beneath the shrub canopy greater amounts of fine particle fractions, a higher water-holding capacity, and a lower bulk density, as well as higher aboveground and belowground litter biomass were found. Soil organic C and total N concentrations were 23%-31.6% and 14%-27.2% higher under the shrub canopies than in the shrub interspaces, respectively, giving rise to 'islands of fertility'. In a desertified sandy grassland ecosystem, C. microphylla was believed to play a major role in organic C sequestration, N accumulation, and the hydrologic cycle. Additionally, it has been found to be of ecological importance for vegetative restoration and reversal of desertification.

关键词： Caragana microphylla Lam. degraded sandy grassland soil chemical properties soil physical properties

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Electronic Effect of Carbon Support on Pt Catalyst Supported on Graphite Intercalation Compound

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Chemical Research in Chinese Universities 2010年第3期26卷 465-471页

作者： WEI Ang WANG Qing-jing ZHAO Xiao-hui zhang Shu-yong Key Lab of Colloid and Interface Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shandong University Jinan 250100 P. R. China

Graphite intercalation compounds（GIC） were tested as an experimental model for studying the electronic effect of carbon support on the catalytic activity and poisoning tolerance of Pt catalyst for direct methanol fuel cells. The GIC samples with different intercalation degrees were prepared by electrolyzing graphite flake in H2SO4 for varying the periods of time. The GIC-supported Pt catalyst was deposited electrochemically. The catalytic activity and poisoning tolerance of the GIC-supported Pt catalysts were evaluated. It was found that GIC with sulfate anion as intercalate was able to catalyze methanol electrooxidation, which could be related to the positive charges generated on the graphite layer upon intercalation. As intercalation degree increased, the catalytic activity of the GIC-supported Pt catalyst decreased while the poisoning tolerance improved. This suggests that electron donation from support to catalyst had great effect on both catalytic activity and poisoning tolerance of Pt catalyst. And intercalation can be adopted as another important way to make modification on carboneous catalyst support.

关键词： Catalyst support Electronic effect Graphite intercalation compound Catalytic activity Poisoning tolerance

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A new hopane triterpenoid from Saxiglossum angustissimum

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Chinese Chemical Letters 2008年第7期19卷 835-836页

作者： hui Fang Pi Zhi Hong Zhong Han Li Ruan Peng zhang yong hui zhang Ji Zhou Wu Faculty of Pharmaceutical Sciences Tongji Medical College of Huazhong University of Science and Technology Wuhan 430030 PR China

A new hopane triterpenoid, hopane 22, 29-diol-29-formate （1）, has been isolated from the whole herbs of Saxiglossum angustissimum （Cries.） Ching and its structure has been successfully determined on the basis of s... 详细信息

关键词： Saxiglossum angustissimum Hopane Hopane-22 29-Diol-29-formate

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电动汽车永磁同步电机匝间短路检测算法仿真

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计算机仿真 2024年第2期41卷 167-171页

作者：王良成汪源张永辉三亚学院理工学院海南三亚572022 海南大学信息与通信工程学院海南海口570228

当电机出现匝间短路故障时,电机内部电阻会大幅度降低,电流突增,造成其余元件功率过大问题。若不能及时监测该故障电机将会导致二次损坏。但是,由于短路故障具有瞬时性,其特征获取难度较大。为此提出电动汽车永磁同步电机匝间短路故障... 详细信息

当电机出现匝间短路故障时,电机内部电阻会大幅度降低,电流突增,造成其余元件功率过大问题。若不能及时监测该故障电机将会导致二次损坏。但是,由于短路故障具有瞬时性,其特征获取难度较大。为此提出电动汽车永磁同步电机匝间短路故障检测方法。构建驱动汽车的永磁同步电机模型,依据当永磁同步电机模型处于匝间短路故障状态时,基波电流与正序电流的制约关系失效的原理,提取电机匝间短路故障特征。基于此利用粒子群算法-最小二乘支持向量机(Particle swarm optimization-Least Squares Support Vector Machine,PSO-LSSVM)获取故障检测结果,实现电动汽车永磁同步电机匝间短路故障的检测。实验结果表明,研究方法在任意时刻检测到的负载力矩均与实际值吻合,且输出的电机残余能量具有较高可靠性,说明了上述方法具有较强的可应用性。

关键词：永磁同步电机匝间短路原因故障特征改进粒子群算法支持向量机

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复杂环境新能源汽车永磁电机传感器故障诊断

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计算机仿真 2024年第4期41卷 136-140页

作者：王良成汪源张永辉三亚学院理工学院海南三亚572022 海南大学信息与通信工程学院海南海口570228

新能源汽车电机驱动过程中由于电机系统本身噪声、传感器运行特性和各个部件接触不良等因素影响下,永磁电机传感器易处于异常工作状态和故障状态。电动汽车电机运行环境的复杂性导致故障诊断难度也相对较大。于是提出新能源汽车永磁电... 详细信息

新能源汽车电机驱动过程中由于电机系统本身噪声、传感器运行特性和各个部件接触不良等因素影响下,永磁电机传感器易处于异常工作状态和故障状态。电动汽车电机运行环境的复杂性导致故障诊断难度也相对较大。于是提出新能源汽车永磁电机传感器故障诊断方法。通过分析永磁电机机械运动方式构建新能源汽车永磁电机数学模型,将上述模型与滑模观测器结合,捕捉任意时刻永磁电机传感器故障状态。基于此,提取传感器故障状态下的特征量,并输入支持向量机中,根据支持向量机输出的分类结果实现新能源汽车永磁电机传感器故障诊断。实验结果表明,针对新能源汽车恒速形式和新能源汽车变速形式,研究方法的诊断结构均与实际情况相符。

关键词：新能源汽车永磁电机传感器滑模观测器故障特征量支持向量机

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Controlled Radical Polymerization of Methyl Methacrylate Catalyzed by Hybrid Supported Iron Catalyst

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Chemical Research in Chinese Universities 2005年第6期21卷 737-739页

作者： LI Zhong-hui, zhang yong-ming XUE Min-zhao ZHOU Lei LIU Yan-gang College of Chemistry and Chemical Engineering Shanghai Jiaotong University Shanghai 200240 P. R. China

A supported iron catalyst, which was prepared by anchoring FeCl2/FeCl3 on the cross-linking macroporous polyacrylate ion exchange resin, was evaluated via the controlled radical polymerization. When a small amount of CuCl2/ Me6TREN was added, the controllability of the polymerization over the iron-mediated catalyst was significantly improved（Mw/Mn = 1.23-1.73 ）, affording a polymer with a low residual metal via a simple catalyst separation procedure. After suitable regeneration, the supported iron catalyst could also he recycled. UV-Vis analysis showed that the additional copper catalyst could facilitate the radical deactivation process.

关键词： Controlled radical polymerization Supported catalyst Iron halide Copper halide

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早期持续气道正压通气在小儿重症肺炎合并呼吸衰竭救治中的应用

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四川解剖学杂志 2024年第2期32卷 11-13页

作者：张会永郭长根祁亚平漯河市第二人民医院儿童重症医学科漯河462000

目的:探讨早期持续气道正压通气(CPAP)在小儿重症肺炎合并呼吸衰竭救治中的应用效果.方法:选取2021年1月至2023年1月本院收治的116例重症肺炎合并呼吸衰竭患儿为研究对象.随机将其分为CPAP组(n=58,给予CPAP治疗)和常规组(n=58,给予经鼻... 详细信息

目的:探讨早期持续气道正压通气(CPAP)在小儿重症肺炎合并呼吸衰竭救治中的应用效果.方法:选取2021年1月至2023年1月本院收治的116例重症肺炎合并呼吸衰竭患儿为研究对象.随机将其分为CPAP组(n=58,给予CPAP治疗)和常规组(n=58,给予经鼻导管吸氧治疗).采用统计学方法,对两组患者动脉血气分析指标[动脉血二氧化碳分压(PaCO_(2))、动脉血氧饱和度(SaO_(2))、动脉血氧分压(PaO_(2))],治疗疗效,临床症状缓解时间和并发症总发生率进行比较.结果:治疗后,CPAP组患儿PaCO_(2)低于常规组,SaO_(2)、PaO_(2)高于常规组,差异均有统计学意义(P<0.05).CPAP组治疗总有效率高于常规组,临床症状缓解时间均短于常规组,并发症总发生率低于常规组,差异均有统计学意义(P<0.05).结论:与经鼻导管吸氧治疗相比较,CPAP在小儿重症肺炎合并呼吸衰竭救治中的临床效果更好,适合临床推广应用.

关键词：连续气道正压通气肺炎呼吸功能不全儿童

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