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TiS2-based saturable absorber for ultrafast fiber lasers

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Photonics Research 2018年第10期6卷 I0046-I0050页

作者： X. zHU S. CHEN M. zHANG L. CHEN Q. Wu J. zHAO Q．JIANG z.zheng H．zHANG School of Electronic and Information Engineering Beihang University Beijing 100191 China Department of Optoelectronics Engineering Shenzhen University Shenzhen 518060 China College of Health Science and Environmental Engineering Shenzhen Technology University Shenzhen 518118 China College of Materials Science and Engineering Shenzhen University Shenzhen 518060 China

We fabricate titanium disulfide(TiS2) using a liquid exfoliation method and subsequently a TiS2-based device by optically depositing the TiS2 material onto the microfiber. This device exhibits a strong nonlinear saturable absorption property with an optical modulation depth of 8.3% at 1560 nm. With the implementation of this all-fiber TiS2-based saturable absorber, we demonstrate that both mode-locking and Q-switching operation can be obtained in a turn-key all-fiber erbium-doped laser cavity. Our findings constitute the first example, to the best of our knowledge, of a TiS2-based saturable absorber for ultrashort pulse generation and highlight the great potential of such devices in two-dimensional nanomaterials-related photonics.

关键词：液体剥离方法激光器通讯技术发展现状

赢率-医学研究中一个直观而易于解释的综合结果（英文）

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上海精神医学 2017年第1期29卷 55-60页

作者： hongyue wang jing peng juila z.zheng bokai wang xiang lu chongshu chen xin m.tu changyong feng Department of Biostatistics and Computational Biology University of Rochester Rochester NY USA Department of Anesthesiology University of Rochester Rochester NY USA Department of Microbiology and Immunology McGill University Montreal QC Canada Department of Family Medicine and Public Health UC San Diego School of Medicine La Jolla CA USA

对于医学研究中的多个结果,研究人员总是需要选择是否使用一个综合性结果(综合多个结果后所得的)作为主要结果。在本文中,我们回顾了治疗效果的一个新测量方式-赢率,它可以很容易地用于具有多个优先级结果的研究中。并且,我们在这块领... 详细信息

对于医学研究中的多个结果,研究人员总是需要选择是否使用一个综合性结果(综合多个结果后所得的)作为主要结果。在本文中,我们回顾了治疗效果的一个新测量方式-赢率,它可以很容易地用于具有多个优先级结果的研究中。并且,我们在这块领域也提出了一些研究课题。

关键词：时间-事件数据生存函数比例风险模型

The differences and similarities between two-sample t-test and paired t-test

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上海精神医学 2017年第3期29卷 184-188页

作者：徐曼菲 Drew FRALICK Julia z.zheng Bokai Wang Xin M.TU Changyong FENG Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Department of Immunology and Microbiology McG ill University Departments of Biostatistics & Computational Biology University of Rochester Department of Family Medicine and Public Health University of California San Diego School of Medicine Departments of Anesthesiology University of Rochester

临床研究中经常遇到比较实验组和对照组之间的结果。双样本t检验(又称为独立样本t检验)和配对t检验可能是运用于比较两个样本之间均值的最广泛的统计方法。然而,这两种方法的运用会产生混淆,从而导致使用不当。本文中,我们讨论了这两种... 详细信息

临床研究中经常遇到比较实验组和对照组之间的结果。双样本t检验(又称为独立样本t检验)和配对t检验可能是运用于比较两个样本之间均值的最广泛的统计方法。然而,这两种方法的运用会产生混淆,从而导致使用不当。本文中,我们讨论了这两种t检验之间的异同性,并运用三个范例来阐述双样本t检验和配对t检验的计算过程。

关键词：样本均值 t检验配对异同独立样本测试方法使用不当计算过程

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比较两组连续性结果的样本计算

上海精神医学 2017年第4期29卷 250-256页

作者： Julia z. zheng Yangyi LI Tuo LIN Angelica ESTRADA Xiang LU Changyong FENG Department of Immunology and Microbiology McGill University Montreal Canada Department of Mathematics State University of New York in Stony Brook Stony Brook NY USA Department of Mathematics University of California in San Diego San Diego CA USA Department of Physics University of California in San Diego San Diego CA USA Department of Biostatistics and Computational Biology University of Rochester Rochester NY USA

概述:所有的临床研究都需要对样本量进行辨证。然而,对于众多生物医学和临床研究人员来说,把握度和样本量看起来就像一个统计学家的魔术。在本文中,我们讨论了把握度和样本量的计算,并说明生物医学和临床研究人员在该分析的可行性和意... 详细信息

概述:所有的临床研究都需要对样本量进行辨证。然而,对于众多生物医学和临床研究人员来说,把握度和样本量看起来就像一个统计学家的魔术。在本文中,我们讨论了把握度和样本量的计算,并说明生物医学和临床研究人员在该分析的可行性和意义中具有重要作用。因此,把握度分析的确是一个互动的过程,并且科学研究人员和统计人员在研究团队中是平等合作的伙伴。

关键词：样本量连续性结果临床研究把握度

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单因素与多因素逻辑回归的不一致性（英文）

上海精神医学 2017年第2期29卷 124-128页

作者： Hongyue WANG Jing PENG Bokai WANG Xiang LU Julia z.zheng Kejia WANG Xin M.TU Changyong FENG Department of Biostatistics and Computational Biology University of Rochester Rochester NY USA Department of Anesthesiology University of Rochester Rochester NY USA Department of Microbiology and Immunology McGill University Montreal QC Canada Department of Family Medicine and Public Health University of California San Diego La Jolla CA USA

逻辑回归是研究协变量对二元结果影响的一种常用的统计方法。它已被广泛应用于临床试验和观察性研究。然而,单因素回归得到的结果和多元逻辑回归得到的结果往往是相互矛盾的。在多元回归中可能对结果会显示出非常强烈的影响的一个协变... 详细信息

逻辑回归是研究协变量对二元结果影响的一种常用的统计方法。它已被广泛应用于临床试验和观察性研究。然而,单因素回归得到的结果和多元逻辑回归得到的结果往往是相互矛盾的。在多元回归中可能对结果会显示出非常强烈的影响的一个协变量在单因素回归中可能不会,反之亦然。这些事实在生物医学研究中并没有引起足够的重视。误用逻辑回归在医学出版物中非常普遍。在本文中,我们研究了单因素和多因素逻辑回归分析的不一致性,并在多元逻辑回归分析的模型部分中给出建议。

关键词：条件期望模型选择逻辑回归

高分辨力MRI化学位移效应预测直肠癌淋巴结转移:结结匹配的病理验证

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国际医学放射学杂志 2017年第6期 736-737页

作者： H.zhang C.zhang z.zheng F.Ye Y.Liu S.zou C.zhou 崔艳芬 Department of Diagnostic Radiology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

摘要目的评估化学位移效应(CSE)和其他标准预测淋巴结转移与否的价值。材料与方法纳入29例行直肠癌根治术的直肠癌病人,行术前和术后标本MRI检查。从横向包埋

关键词：淋巴结预测因子 CSE 化学位移 MRI 直肠癌

Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.Li Nagendran Ramalingam Shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

Influence of introducing zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo Yu zhenyu Sun Weichen zheng Liangwei zhang Yanling Xue Wenning Liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： zhenzhong zheng Jialin Chen Jinghong Xu Bin Jiang Lei Li Yawei Li Yuliang Dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury