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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju zheng Yixin Li Ting zhang Yanlin fu Peiyan Long Xiao Gao zhengwei Wang zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Self-induced birefringence of white-light continuum generated by interaction of focused femtosecond laser pulses with fused silica

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High Power Laser Science and Engineering 2020年第2期8卷 71-76页

作者： J.Qian G.D.Wang K.Y.Lou D.Y.Shen Q.fu Q.z.zhao State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

White-light continuum can be induced by the interaction of intense femtosecond laser pulses with condensed *** using two orthogonal polarizers,a self-induced birefringence of continuum is observed when focusing femtosecond laser pulses into bulk fused *** is,the generated white-light continuum is synchronously modulated anisotropically while propagating in fused ***-resolved detection confirms that self-induced birefringence of continuum shows a growth and saturation feature with time *** adjusting laser energy,the transmitted intensity of continuum modulated by self-induced birefringence also varies *** analysis with time evolution indicates that it is the focused femtosecond laser pulses that induce anisotropic microstructures in bulk fused silica,and the anisotropic structures at the same time modulate the generated continuum.

关键词： femtosecond laser pulses fused silica self-induced birefringence white-light continuum

根据业务对象组织数据体的结构化数据归档路径探析——基于勘探开发结构化数据归档实践的思考

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档案学通讯 2024年第4期 22-29页

作者：王强符京生中国石油天然气集团有限公司档案馆北京102206 中国石油长庆油田公司档案馆西安710018

在数字转型和数据要素背景下,结构化数据归档对于档案资源体系建设至关重要。结构化数据归档面数据价值鉴定、归档数据组织、归档方式选择的困境,提出根据业务对象组织数据体的归档路径,即确定业务对象——鉴定数据价值——组织归档数... 详细信息

在数字转型和数据要素背景下,结构化数据归档对于档案资源体系建设至关重要。结构化数据归档面数据价值鉴定、归档数据组织、归档方式选择的困境,提出根据业务对象组织数据体的归档路径,即确定业务对象——鉴定数据价值——组织归档数据体——选择归档方式——开展长期保存。以勘探开发结构化数据归档为例进行实证研究,为结构化数据归档提供一种可行方法。

关键词：结构化数据数据归档数据体归档鉴定

断盖配置组合下、中、上部油气运聚空间纵向分布刻画方法及其应用

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地质论评 2024年第5期70卷 2015-2023页

作者：付广丁云浩东北石油大学黑龙江大庆163318

为了搞清含油气盆地断裂与盖层配置(简称断盖配置)组合下、中、上部油气纵向分布规律,在断盖配置组合封闭特征及其下油气运聚空间纵向分布研究的基础上,通过油源断裂输导油气部位和油源断裂与上中下区域性泥岩盖层配置封闭和不封闭部位... 详细信息

为了搞清含油气盆地断裂与盖层配置(简称断盖配置)组合下、中、上部油气纵向分布规律,在断盖配置组合封闭特征及其下油气运聚空间纵向分布研究的基础上,通过油源断裂输导油气部位和油源断裂与上中下区域性泥岩盖层配置封闭和不封闭部位叠合,建立了一套断盖配置组合下、中、上部油气运聚空间纵向分布的刻画方法,并利用其刻画了渤海湾盆地歧口凹陷港东断裂与沙河街组一段中亚段(简称沙一中亚段)、东营组二段(简称东二段)和明化镇组区域性泥岩盖层配置组合油气运聚空间纵向分布,结果表明:港东断裂与沙一中亚段、东二段和明化镇组区域性泥岩盖层配置组合沙一下亚段油气运聚空间纵向分布主要在其东部和西部,港东断裂与沙一中亚段、东二段和明化镇组区域性泥岩盖层配置组合东三段和馆陶组油气运聚空间纵向分布主要在其中部。港东断裂与沙一中亚段、东二段和明化镇组配置组合沙一下亚段油气运聚空间纵向分布相对发育,有利于油气运聚成藏,港东断裂与沙一中亚段、东二段和明化镇组配置组合东三段和馆陶组油气运聚空间纵向分布相对不发育,不利于油气运聚成藏,与目前港东断裂处沙一下亚段、东三段和馆陶组内已发现油气分布相吻合,表明该方法用于刻画断盖配置组合下、中、上部油气运聚空间纵向分布是可行的。

关键词：断盖配置组合下、中、上部油气运聚纵向分布刻画方法

Toward developing Ti alloys with high fatigue crack growth resistance by additive manufacturing

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Journal of Materials Science & Technology 2023年第1期132卷 166-178页

作者： F.Wang L.M.Lei X.fu L.Shi X.M.Luo z.M.Song G.P.zhang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China AECC Commercial Aircraft Engine Co. Ltd.Shanghai 201306China

Fatigue crack growth behaviors were investigated by three-point bending tests for TA19 alloy fabricated by laser metal deposition and four kinds of heat-treated *** crack growth resistance of the TA19 samples in the near-threshold regime and Paris regime was evaluated through the experimental characterization and theoretical analysis of the interaction between fatigue crack andα/βphase inter-face,columnar prior-βgrain boundary and colony *** results show that in the near-threshold regime,the fatigue crack propagation threshold and resistance increase with the increase of widths of lamellarαp phases and colonies,and the decrease of the number ofαlaths with an angle(ϕ)relative to the applied stress direction ranging from 75°to 90°.In the Paris regime,the fatigue cracking path can be deflected at colony boundaries or columnar prior-βgrain *** larger the deflection angle,the more tortuous the cracking path and the lower the fatigue crack growth *** angle(γ)of the columnar prior-βgrain growth direction relative to the build direction affects not onlyϕof differentαvariants,but also the fatigue cracking path deflection angle(θij)at columnar prior-βgrain *** optimal combination ofγ=0°-15°-0°-15°for several adjacent columnar prior-βgrains is derived from the theoretical analysis,and that can effectively avoidϕbeing in the range from 75°to 90°and makeθij as large as *** findings provide a guide for the selection of scanning strategies and process parameters to additively manufacture Ti alloys with high fatigue damage tolerance.

关键词： Ti alloy Fatigue crack growth Additive manufacturing Phase interface Grain boundary

NUMERICAL SIMULATION OF COLUMNAR TO EQUIAXED TRANSITION FOR DIRECTIONALLY SOLIDIFIED Ti-44Al ALLOY

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Acta Metallurgica Sinica(English Letters) 2008年第2期21卷 146-156页

作者： K.F. Wang J.J. Guo G.F. Mi C. Y. Li H.z. fu School of IVlaterials Science and Engineering Henan Polytechnic University Jiaozuo 454100 China School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China

Solute diffusion controlled solidification model was applied to simulate the columnar to equiaxed transition （CET） during directional solidification of Ti-44Al alloy. The simulation results show that the solutal interactions from growing equiaxed grains play an important role on CET. The effects of the applied thermal gradient and pulling velocity, the equiaxed seed spacing and nucleation undercooling on the CET are investigated in the present simulation. The simulated results indicated that the columnar branch spacing depends not only on the thermal gradient and the pulling velocity, but also on number of the seeds. A spacing adjustment can occur through initiation of seeds that develop into new columnar grains. The dependence of the CET on the thermal gradient and pulling velocity, qualitatively agrees with the analytical CET model of Hunt,

关键词： Ti-44Al alloy Directional solidification columnar to equiaxedtransition (CET) Numerical simulation

孔隙水盐度与黏土类型对海洋沉积物水分特征曲线的影响研究

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地质学报 2024年第9期98卷 2795-2805页

作者：付佳妮于晓曦傅晓敏赵航刘昌岭马云刘乐乐青岛市地下水资源保护与修复重点实验室山东青岛266101 自然资源部滨海城市地下空间地质安全重点实验室山东青岛266101 青岛地质工程勘察院(青岛地质勘查开发局) 山东青岛266101 自然资源部天然气水合物重点实验室中国地质调查局青岛海洋地质研究所山东青岛266237 长江师范学院土木建筑工程学院重庆408100 中国海洋大学海底建设与保护山东省工程研究中心山东青岛266100

海洋沉积物在天然气水合物分解或海水入侵过程中会出现孔隙水盐度及水饱和状态不断变化的现象,其透气和透水能力与沉积物水分特征曲线有关,然而孔隙水盐度变化对沉积物水分特征曲线的影响规律目前仍不够清楚。本文采用南海北部天然气水... 详细信息

海洋沉积物在天然气水合物分解或海水入侵过程中会出现孔隙水盐度及水饱和状态不断变化的现象,其透气和透水能力与沉积物水分特征曲线有关,然而孔隙水盐度变化对沉积物水分特征曲线的影响规律目前仍不够清楚。本文采用南海北部天然气水合物赋存区的海洋沉积物与实验室配置的混合沉积物进行试验,使用相对快速的离心机法,测定了不同基质吸力条件下的孔隙水饱和度,分析了黏土矿物类型和孔隙水盐度等因素对沉积物水分特征曲线的影响,选用被广泛使用的van Genuchten模型,率定了模型的拟合参数。结果表明:含黏土石英砂水分特征曲线基本不受黏土矿物种类的影响;南海北部海洋沉积物的黏土质量含量超过35%,但其水分特征曲线在两倍海水盐度范围内也几乎不受影响;对于南海北部海洋沉积物,van Genuchten模型系数a取值为0.00023 kPa^(-1),系数n和m取值分别为0.51和4.9。

关键词：天然气水合物渗透率海水入侵盐度黏土矿物基质吸力

A Deep-Learning and Transfer-Learning Hybrid Aerosol Retrieval Algorithm for FY4-AGRI:Development and Verification over Asia

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Engineering 2024年第7期38卷 164-174页

作者： Disong fu Hongrong Shi Christian AGueymard Dazhi Yang Yu zheng Huizheng Che Xuehua Fan Xinlei Han Lin Gao Jianchun Bian Minzheng Duan Xiangao Xia Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 10029China Key Laboratory of Cloud-Precipitation Physics and Severe Storms Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Solar Consulting Services ColebrookNH 03576USA School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150006China State Key Laboratory of Severe Weather&Key Laboratory of Atmospheric Chemistry Institute of Atmospheric Composition and Environmental MeteorologyChinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081China National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing100085China Key Laboratory of Compound and Chained Natural Hazards Dynamics Ministry of Emergency Management of ChinaBeijing 100085China h National Satellite Meteorological Center China Meteorological AdministrationBeijing 100081China University of Chinese Academy of Sciences Beijing 100049China

The Advanced Geosynchronous Radiation Imager(AGRI)is a mission-critical instrument for the Fengyun series of *** acquires full-disk images every 15 min and views East Asia every 5 min through 14 spectral bands,enabling the detection of highly variable aerosol optical depth(AOD).Quantitative retrieval of AOD has hitherto been challenging,especially over *** this study,an AOD retrieval algorithm is proposed that combines deep learning and transfer *** algorithm uses core concepts from both the Dark Target(DT)and Deep Blue(DB)algorithms to select features for the machinelearning(ML)algorithm,allowing for AOD retrieval at 550 nm over both dark and bright *** algorithm consists of two steps:①A baseline deep neural network(DNN)with skip connections is developed using 10 min Advanced Himawari Imager(AHI)AODs as the target variable,and②sunphotometer AODs from 89 ground-based stations are used to fine-tune the DNN ***-of-station validation shows that the retrieved AOD attains high accuracy,characterized by a coefficient of determination(R2)of 0.70,a mean bias error(MBE)of 0.03,and a percentage of data within the expected error(EE)of 70.7%.A sensitivity study reveals that the top-of-atmosphere reflectance at 650 and 470 nm,as well as the surface reflectance at 650 nm,are the two largest sources of uncertainty impacting the *** a case study of monitoring an extreme aerosol event,the AGRI AOD is found to be able to capture the detailed temporal evolution of the *** work demonstrates the superiority of the transfer-learning technique in satellite AOD retrievals and the applicability of the retrieved AGRI AOD in monitoring extreme pollution events.

关键词： Aerosol optical depth Retrieval algorithm Deep learning Transfer learning Advanced Geosynchronous Radiation Imager

Coexistence of Dirac and Weyl points in non-centrosymmetric semimetal NbIrTe_(4)

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Chinese Physics B 2024年第4期33卷 146-151页

作者：刘清馨付阳丁鹏飞马欢郭朋杰雷和畅王善才 Department of Physics Key Laboratory of Quantum State Construction and ManipulationRenmin University of ChinaBeijing 100872China Beijing Key Laboratory of Opto-Electronic functional Materials&Micro-Nano Devices Renmin University of ChinaBeijing 100872China

Using angle-resolved photoemission spectroscopy and density functional theory calculations methods,we investigate the electronic structures and topological properties of ternary tellurides NbIrTe_(4),a candidate for type-II Weyl *** demonstrate the presence of several Fermi arcs connecting their corresponding Weyl points on both termination surfaces of the topological *** analysis reveals the existence of Dirac points,in addition to Weyl points,giving both theoretical and experimental evidences of the coexistence of Dirac and Weyl points in a single *** findings not only confirm NbIrTe_(4) as a unique topological semimetal but also open avenues for exploring novel electronic devices based on its coexisting Dirac and Weyl fermions.

关键词： Fermi arc Weyl point Dirac point angle-resolved photoemission spectroscopy