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电子技术（上海） 2024年第6期53卷 118-119页

作者：崔茜山西水利职业技术学院山西044000

阐述地理信息系统技术在城市交通网络优化中的应用,包括数据采集和处理、交通模型和仿真、路网分析和路径规划、交通拥堵管理和交通流优化,从而为城市交通规划提供全面、精准的数据支持。

关键词：城市交通网络优化 GIS 数据采集交通模型

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3D立体格栅–砂界面剪切性状试验研究

建筑技术 2024年第4期55卷 468-470页

作者：崔倩潍坊市潍城区符山水库运营维护中心山东潍坊261055

为探究土工格栅–砂界面的剪切律、强度律和体变律,基于3 D打印技术制作的土工格栅,通过改进的应变控制式直剪仪进行了不同横肋数量的土工格栅与不同干湿类型的标准砂间的界面剪切试验。结果表明:法向应力越大,剪切应力弱化现象越明显,... 详细信息

为探究土工格栅–砂界面的剪切律、强度律和体变律,基于3 D打印技术制作的土工格栅,通过改进的应变控制式直剪仪进行了不同横肋数量的土工格栅与不同干湿类型的标准砂间的界面剪切试验。结果表明:法向应力越大,剪切应力弱化现象越明显,界面抗剪强度及其指标与横肋数量成正比例关系;3 D立体格栅–湿砂界面粘聚力随着横肋数量的增多而减小。3 D立体格栅–干砂界面抗剪强度及其指标比3 D立体格栅–湿砂界面大,剪胀特性更明显。干砂和湿砂均表现出剪胀的体变行为,且横肋数量越多,剪胀特性越明显。研究成果可为探究3 D土工格栅在实际工程中的应用提供参考。

关键词： 3D打印土工格栅标准砂强度律体变律

A high-performance lithium anode based on N-doped composite graphene

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Rare Metals 2024年第3期43卷 1030-1036页

作者： Can Jiao Hao-Bo Sun Li zhang Shang-qian zhao Guo-Yao Pang Chun-Rong zhao Shi-Gang Lu General Research Institute for Nonferrous Metals Beijing100088China China Automotive Battery Research Institute Co.Ltd Beijing101407China

Lithium(Li)metal is the most promising electrode for next-gene ration rechargeable *** order to push the commercialization of the lithium metal batteries,a kind of nitrogen(N)-doped composite graphene(NCG)adopted as the Li plating host was prepared to regulate Li metal nucleation and suppress dendrite ***,a new kind of sandwich-type composite lithium metal(STCL)electrode was developed to improve its *** STCL electrode can be used as convenient as a piece of Li foil but no dendrite *** a symmetric battery,the STCL electrode cycled for more than 4500 h with the overpotential of less than 40 *** due to the creative design,the STCL promises the Li-S battery with a prolonged cycling lifespan.

关键词： Lithium metal anode Lithiophilic N-doped composite graphene Sandwich-type composite lithium metal electrode

A pan-TE map highlights transposable elements underlying domestication and agronomic traits in Asian rice

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National Science Review 2024年第06期 105-118页

作者： Xiaoxia Li Xiaofan Dai Huiying He Yang Lv Longbo Yang Wenchuang He Congcong Liu Hua Wei Xiangpei Liu Qiaoling Yuan Xianmeng Wang Tianyi Wang Bintao zhang Hong zhang Wu Chen Yue Leng Xiaoman Yu Hongge qian Bin zhang Mingliang Guo zhipeng zhang Chuanlin Shi qianqian zhang Yan cui qiang Xu Xinglan Cao Dandan Chen Yongfeng zhou qian qian Lianguang Shang Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural Sciences Rice Research Institute Shenyang Agricultural University Yazhouwan National Laboratory State Key Laboratory of Rice Biology China National Rice Research Institute National Key Laboratory of Tropical Crop Breeding Tropical Crops Genetic Resources InstituteChinese Academy of Tropical Agricultural Sciences

Transposable elements(TEs) are ubiquitous genomic components and hard to study due to being highly repetitive. Here we assembled 232 chromosome-level genomes based on long-read sequencing *** the 232 genomes with 15 existing assemblies, we developed a pan-TE map comprising both cultivated and wild Asian rice. We detected 177 084 high-quality TE variations and inferred their derived state using outgroups. We found TEs were one source of phenotypic variation during rice domestication and differentiation. We identified 1246 genes whose expression variation was associated with TEs but not single-nucleotide polymorphisms(SNPs), such as Os Rboh B, and validated Os Rboh B's relative expression activity using a dual-Luciferase(LUC) reporter assays system. Our pan-TE map allowed us to detect multiple novel loci associated with agronomic traits. Collectively, our findings highlight the contributions of TEs to domestication, differentiation and agronomic traits in rice, and there is massive potential for gene cloning and molecular breeding by the high-quality Asian pan-TE map we generated.

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基于潜在迪利克雷分布(LDA)模型的旗舰物种范式研究进展与启示

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生物多样性 2024年第4期32卷 135-149页

作者：刘荆州钱易鑫张燕雪丹崔凤上海海洋大学海洋生物资源与管理学院上海201306 上海海洋大学经济管理学院上海201306

旗舰物种范式是借助代表性物种的公共影响力实现生物多样性保护的一种策略。尽管这一策略在国际上已成为提升公众环保意识和筹措保护资金的重要手段,但国内学界关注度不够,限制了其发展。因此,有必要对国际研究进行梳理,启发国内采取相... 详细信息

旗舰物种范式是借助代表性物种的公共影响力实现生物多样性保护的一种策略。尽管这一策略在国际上已成为提升公众环保意识和筹措保护资金的重要手段,但国内学界关注度不够,限制了其发展。因此,有必要对国际研究进行梳理,启发国内采取相关策略。本文利用潜在迪利克雷分布(latent Dirichlet allocation, LDA)的主题模型,选取英文学术期刊上发表的旗舰物种范式相关文献,聚合为旗舰物种范式的理论研究、旗舰物种项目的案例研究、问卷访谈揭示的公众态度及其影响因素、旗舰物种范式的场景落地问题、旗舰物种范式的负面效应和旗舰物种范式的优化策略等6个主题并进行综述。综述发现:(1)旗舰物种范式存在动物福利问题、天花板效应、“诺亚方舟”问题与未经本土化的保护主义4个负面效应;(2)对应上述问题存在本土化、降干扰、去偏见与跨界传播4个发展方向;(3)旗舰物种范式存在围绕旗舰物种定义与本质属性的冲突。本文进一步讨论了旗舰物种的定义、遴选及其局限性的争论3个重大问题,提出了明确范式的实现形式、多主体协同参与、优化旗舰物种遴选与项目安排、加强本土创新与国际合作等建议。

关键词：生物多样性保护旗舰物种范式 LDA模型研究进展

A stepwise-responsive editor integrated with three copper ions for the treatment of oral squamous cell carcinoma

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Nano Research 2024年第6期17卷 5424-5434页

作者： Jinna Ren Jingying Hu Fan Dong Yan Xu Yang Peng Yuping qian Guanmeng zhang Min Wang Yuguang Wang Department of Prosthodontics Hospital of StomatologyJilin UniversityChangchun 130021China Department of General Dentistry II Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Center of Digital Dentistry Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Nursing Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China The VIP Department School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyang 110002China

Cuprotosis,a new type of cell death,provides great opportunities for the treatment of oral squamous cell carcinoma,as nanocarriers of copper ions can induce cuprotosis and immunogenic ***,we studied an editor that enables production of a nanoparticle“storm”in oral squamous cell carcinoma,maximizing the toxic effect of these particles and reprogramming the tumor microenvironment;as a result,T cells and natural killer(NK)cells can infiltrate the tumor microenvironment to activate an antitumor immune *** this basis,the editor can be combined with optical therapy to improve patient *** this study,the metal ratio was regulated in response to the nanocarrier of acid response ***,in the presence of a specific copper ion content,the nanocarrier could change the permeability of the tumor cell *** on these results,the nanoparticles were cracked in an acidic environment and then released copper ***,the nanoparticles contributed to cuprotosis and immunogenic *** addition,the editor could inhibit murine oral cancer 1(MOC1)tumors in C57BL/6 without *** rate of tumor growth inhibition was as high as approximately 80%.This strategy provides a new idea for ***,it can improve the interaction between immunotherapy and the copper-induced death of oral squamous cell *** all,this study will provide a new opportunity for the effective treatment of oral squamous cell carcinoma.

关键词： cuprotosis immunogenic death photothermal therapy tumor microenvironment immunotherapy

MAVS Antagonizes Human Stem Cell Senescence as a Mitochondrial Stabilizer

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Research 2024年第2期2023卷 239-257页

作者： cui Wang Kuan Yang Xiaoqian Liu Si Wang Moshi Song Juan Carlos Izpisua Belimonte Jing Qu Guang-Hui Liu Weiqi zhang CAS Key Laboratory of Genomic and Precision Medicine Beijng Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of Sciences Beijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Bejing 100101China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Altos Labs Inc.San DiegoCA 94022USA

Mitochondrial dysfunction is a hallmark feature of cellular senescence and organ ***,we asked whether the mitochondrial antiviral signaling protein(MAVS),which is essential for driving antiviral response,also regulates human stem cell *** answer this question,we used CRISPR/Cas9-mediated gene editing and directed differentiation techniques to generate various MAVS-knockout human stem cell *** found that human mesenchymal stem cells(hMSCs)were sensitive to MAVS deficiency,as manifested by accelerated senescence *** uncovered that the role of MAVS in maintaining mitochondrial structural integrity and functional homeostasis depends on its interaction with the guanosine triphosphatase optic atrophy type 1(OPA1).Depletion of MAVS or OPA1 led to the dysfunction of mitochondria and cellular senescence,whereas replenishment of MAVS or OPA1 in MAVS-knockout hMSCs alleviated mitochondrial defects and premature senescence *** together,our data underscore an uncanonical role of MAVS in safeguarding mitochondrial homeostasis and antagonizing human stem cell senescence.

关键词： CRISPR/Cas9 homeostasis Mitochondrial

“难以被建构的城市”——论城市题材在“十七年小说”中的“困境”

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榆林学院学报 2024年第3期34卷 85-91,118页

作者：崔谦陕西师范大学文学院陕西西安710062

“十七年小说”中,城市题材作品远没有达到如“革命历史小说”、农村题材小说那样代表作家众多、经典之作频出的高度。造成这一文学现象的原因是多方面的,从文学传统上来说,现代文学时期城市题材小说数量有限,而且多表现的是对城市的批... 详细信息

“十七年小说”中,城市题材作品远没有达到如“革命历史小说”、农村题材小说那样代表作家众多、经典之作频出的高度。造成这一文学现象的原因是多方面的,从文学传统上来说,现代文学时期城市题材小说数量有限,而且多表现的是对城市的批判,故没有形成可供“十七年小说”借鉴的资源。从现实层面上来说,随着建国后社会主义制度在城市的确立,对城市的书写逐渐从都市生活转向工业生产,但这却与当代作家的写作经验产生了“错位”。此外,农村题材较城市题材更容易实现当代文学对“革命的现代性”的追求,这无疑让城市题材在“十七年小说”题材选择过程中处于了劣势。

关键词： “十七年小说” 城市题材乡土小说 “工业题材” “革命的现代性”

Association of DNA methylation/demethylation with the functional outcome of stroke in a hyperinflammatory state

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Neural Regeneration Research 2024年第10期19卷 2229-2239页

作者： Yubo Wang Ling zhang Tianjie Lyu Lu cui Shunying zhao Xuechun Wang Meng Wang Yongjun Wang zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina

Inflammation is closely related to stroke prognosis, and high inflammation status leads to poor functional outcome in stroke. DNA methylation is involved in the pathogenesis and prognosis of stroke. However, the effect of DNA methylation on stroke at high levels of inflammation is unclear. In this study, we constructed a hyperinflammatory cerebral ischemia mouse model and investigated the effect of hypomethylation and hypermethylation on the functional outcome. We constructed a mouse model of transient middle cerebral artery occlusion and treated the mice with lipopolysaccharide to induce a hyperinflammatory state. To investigate the effect of DNA methylation on stroke, we used small molecule inhibitors to restrain the function of key DNA methylation and demethylation enzymes. 2,3,5-Triphenyltetrazolium chloride staining, neurological function scores, neurobehavioral tests, enzyme-linked immunosorbent assay, quantitative reverse transcription PCR and western blot assay were used to evaluate the effects after stroke in mice. We assessed changes in the global methylation status by measuring DNA 5-mc and DNA 5-hmc levels in peripheral blood after the use of the inhibitor. In the group treated with the DNA methylation inhibitor, brain tissue 2,3,5-triphenyltetrazolium chloride staining showed an increase in infarct volume, which was accompanied by a decrease in neurological scores and worsening of neurobehavioral performance. The levels of inflammatory factors interleukin 6 and interleukin-1 beta in ischemic brain tissue and plasma were elevated, indicating increased inflammation. Related inflammatory pathway exploration showed significant overactivation of nuclear factor kappa B. These results suggested that inhibiting DNA methylation led to poor functional outcome in mice with high inflammation following stroke. Further, the effects were reversed by inhibition of DNA demethylation. Our findings suggest that DNA methylation regulates the inflammatory response in stroke

关键词： DNA demethylation DNA methylation DNMT3A functional outcome hyperinflammatory state interleukin neuroinflammation stroke TET2

Understanding the combustion behavior of electric bicycle batteries and unveiling its relationship with fire extinguishing

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Journal of Energy Chemistry 2024年第4期91卷 609-618页

作者： zhanglong Yu Xueling Shen Ran Xu zheng Wang zengming Wan Mingyang Chen Yi cui Yanyan Fang Xiaoli Ma China Automotive Battery Research Institute Co. Ltd.Beijing 101407China China Grinm Group Co. Ltd.Beijing 100088China Ministry of Industry and Information Technology Equipment Industry Development CenterBeijing 100846China Hefei Guoxuan High-tech Power energy Co. Ltd.Hefei 230000AnhuiChina

In this study,a detailed analysis of the combustion behaviors of the lithium iron phosphate(LFP)and lithium manganese oxide(LMO)batteries used in electric bicycles was *** research included quantitative measurements of the combustion duration,flame height,combustion temperature,heat release rate,and total heat *** results indicated that LMO batteries exhibited higher combustion temperatures of 600–700°C,flame heights of 70–75 cm,a significantly higher heat release rate of40.1 k W(12 Ah),and a total heat release of 1.04 MJ(12 Ah)compared to LFP batteries with the same *** on these experimental results,a normalized total heat release(NORTHR)parameter was proposed,demonstrating good universality for batteries with different *** this parameter,quantitative calculations and optimization of the extinguishing agent dosage were conducted for fires involving these two types of batteries,and the method was validated by extinguishing fires for these two types of battery packs with water-based extinguishing fluids.

关键词： Combustion behavior Electric bicycle Lithium-ion battery Fire extinguishing Normalized total heat release