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Engineering biomimetic nanosystem targeting multiple tumor radioresistance hallmarks for enhanced radiotherapy

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Science China(Life Sciences) 2024年第7期67卷 1398-1412页

作者： Shuxiang Wang Hongmei Cao cui-cui zhao qian Wang Dianyu Wang Jinjian Liu Lijun Yang Jianfeng Liu State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear MedicineKey Laboratory of Radiopharmacokinetics for Innovative DrugsTianjin Institutes of Health ScienceInstitute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and Therapy(Tianjin)Key Laboratory of Breast Cancer Prevention and TherapyTianjin Medical UniversityMinistry of EducationTianjin 300060China

Tumor cells establish a robust self-defense system characterized by hypoxia,antioxidant overexpression,DNA damage repair,and so forth to resist *** one of these features is insufficient to overcome radioresistance due to the feedback mechanisms initiated by tumor cells under ***,we herein developed an engineering biomimetic nanosystem(M@HHPt)masked with tumor cell membranes and loaded with a hybridized protein-based nanoparticle carrying oxygens(O_(2))and cisplatin prodrugs(Pt(Ⅳ))to target multiple tumor radioresistance hallmarks for enhanced *** administration,M@HHPt actively targeted and smoothly accumulated in tumor cells by virtue of its innate homing abilities to realize efficient co-delivery of O_(2)and Pt(Ⅳ).O_(2)introduction induced hypoxia alleviation cooperated with Pt(Ⅳ)reduction caused glutathione consumption greatly amplified radiotherapy-ignited cellular oxidative ***,the released cisplatin effectively hindered DNA damage repair by crosslinking with radiotherapy-produced DNA ***,M@HHPt-sensitized radiotherapy significantly suppressed the proliferation of lung cancer H1975 cells with an extremely high sensitizer enhancement ratio of 1.91 and the progression of H1975 tumor models with an excellent tumor inhibition rate of 94.7%.Overall,this work provided a feasible strategy for tumor radiosensitization by overcoming multiple radioresistance mechanisms.

关键词： biomimetic nanosystem hypoxia alleviation glutathione consumption oxidative stress amplification DNA damage fixation radiosensitization

Passive daytime radiative cooling coatings with renewable self-cleaning functions

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Chinese Chemical Letters 2024年第2期35卷 257-262页

作者： qian Wu Yubo cui Guifeng Xia Jinlong Yang Shuming Du Xinhong Xiong Li Yang Dong Xu Xu Deng Jiaxi cui Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China Beijing Key Laboratory of Power Generation System Functional Material CHN Energy New Energy Technology Research Institute Ltd.Beijing 102209China Institute for Advanced Study Chengdu UniversityChengdu 610106China

Passive daytime radiative cooling(PDRC)technology is emerging as one of the most promising solutions to the global problem of spacing cooling,but its practical application is limited due to reduced cooling effectiveness caused by daily wear and tear,as well as dirt *** tackle this problem,we report a novel strategy by introducing a renewable armor structure for prolonging the anti-fouling and cooling effectiveness properties of the PDRC *** armor structure is designed by decorating fluorinated hollow glass microspheres(HGM)inside rigid resin composite *** HGM serve triple purposes,including providing isolated cavities for enhanced solar reflectance,reinforcing the matrices to form robust armored structures,and increasing thermal *** the coatings are worn,the HGM on the surface expose their concave cavities with numerous hydrophobic fragments,generating a highly rough surface that guarantee the superhydrophobic *** coatings show a high sunlight reflectance(0.93)and thermal emittance(0.94)in the long-wave infrared window,leading to a cooling of 5℃ below ambient temperature under high solar flux(∼900 W/m^(2)).When anti-fouling functions are reduced,they can be regenerated more than 100 cycles without compromising the PDRC function by simple wearing ***,these coatings can be easily prepared using a one-pot spray method with low-cost materials,exhibit strong adhesion to a variety of substrates,and demonstrate exceptional environmental ***,we anticipate their immediate application opportunities for spacing cooling.

关键词： Superhydrophobic Passive radiative cooling Wearing Regeneration Glass resin armor

Decoupling Algorithms for the Gravitational Wave Spacecraft

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 325-337页

作者： XueWang Weizhou zhu zhao cui Xingguang qian Jinke Yang Jianjun Jia Yikun Wang Key Laboratory of Space Active Opto-Electronics Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai200083China University of Chinese Academy of Sciences Beijing100049China Key Laboratory of GravitationalWave Precision Measurement of zhejiang Province Hangzhou Institute for Advanced StudyHangzhou310024China

The gravitational wave spacecraft is a complex multi-input multi-output dynamic *** gravitational wave detection mission requires the spacecraft to achieve single spacecraft with two laser links and high-precision *** one spacecraftwith two laser links,compared to one spacecraft with a single laser link,requires an upgraded decoupling algorithmfor the link *** decoupling algorithmwe designed reassigns the degrees of freedomand forces in the control loop to ensure sufficient degrees of freedomfor optical axis *** addressing the distinct dynamic characteristics of different degrees of freedom,a transfer function compensation method is used in the decoupling process to further minimize motion *** open-loop frequency response of the systemis obtained through *** upgraded decoupling algorithms effectively reduce the open-loop frequency response by 30 *** transfer function compensation method efficiently suppresses the coupling of low-frequency noise.

关键词： Gravitational waves spacecraft laser acquisition decoupling algorithms dynamical model optical axis control

Aseismic performances of constrained damping lining structures made of rubber-sand-concrete

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1522-1537页

作者： Xiancheng Mei qian Sheng Jian Chen zhen cui Jianhe Li Chuanqi Li Daniel Dias State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Key Laboratory of Water Grid Project and Regulation of Ministry of Water Resources Changjiang Institute of SurveyPlanningDesign and ResearchWuhan430010China Laboratory 3SR CNRS UMR 5521Grenoble Alpes UniversityGrenoble38000France School of Automotive and Transportation Engineering Hefei University of TechnologyHefei23009China

Flexible damping technology considering aseismic materials and aseismic structures seems be a good solution for engineering *** this study,a constrained damping structure for underground tunnel lining,using a rubber-sand-concrete(RSC)as the aseismic material,is *** aseismic performances of constrained damping structure were investigated by a series of hammer impact *** damping layer thickness and shape effects on the aseismic performance such as effective duration and acceleration amplitude of time-domain analysis,composite loss factor and damping ratio of the transfer function analysis,and total vibration level of octave spectrum analysis were *** hammer impact tests revealed that the relationship between the aseismic performance and damping layer thickness was not linear,and that the hollow damping layer had a better aseismic performance than the flat damping layer *** aseismic performances of constrained damping structure under different seismicity magnitudes and geological conditions were *** effects of the peak ground acceleration(PGA)and tunnel overburden depth on the aseismic performances such as the maximum principal stress and equivalent plastic strain(PEEQ)were *** numerical results show the constrained damping structure proposed in this paper has a good aseismic performance,with PGA in the range(0.2-1.2)g and tunnel overburden depth in the range of 0-300 m.

关键词： Constrained damping structure Aseismic performance Hammer impact tests Damping layer Peak ground acceleration Overburden depth

Surface deterioration dependent on the crystal facets of spinel LiNi0.5Mn1.5O4 cathode active material

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Journal of Energy Chemistry 2024年第10期97卷 757-766页

作者： qian Li Yan zhao Jifu zhu Wujiu zhang Yi Liu Yaru cui Chao Shen Keyu Xie School of Metallurgical Engineering Xi'an University of Architecture and Technology Shaanxi Union Research Center of University and Enterprise for Cathode Materials of LIBs State Key Laboratory of Solidification Processing Center for Nano Energy Materials Northwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene (NPU) CRRC zhu zhou Institute Co. Ltd.

The spinel LiNi0.5Mn1.5O4（LNMO） cathode active materials（CAMs） are considered a promising alternative to commercially available cathodes such as layered and polyanion oxide cathodes,primarily due to their notable safety and high energy density,particularly in their single-crystal ***,the industrial application of the LNMO CAMs is severely inhibited due to the interfacial deterioration and corrosion under proton-rich and high-voltage *** study successfully designed and synthesized two typical types of crystal facets-exposed single-crystal LNMO *** tracking the electrochemical deterioration and chemical corrosion evolution,this study elucidates the surface degradation mechanisms and intrinsic instability of the LNMO,contingent upon their crystal ***（111） facet,due to its elevated surface energy,is found to be more susceptible to external attack compared to the（100） and（110）*** study highlights the electrochemical corrosion stability of crystal plane engineering for spinel LNMO CAMs.

关键词： Chemical corrosion Crystal facets Electrochemical degradation LiNi0.5Mn1.5O4 Surface energy

Strategies to advance thermoelectric performance of PbSe and PbS materials

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Rare Metals 2024年第9期43卷 4099-4114页

作者： zheng-Hao Hou Xin qian Qiu-Juan cui Shu-Fang Wang Li-Dong zhao Shijiazhuang Key Laboratory of Low Carbon Energy Materials College of Chemical EngineeringShijiazhuang University Hebei Key Lab of Optic-Electronic Information and Materials College of Physics Science and Technology Hebei University School of Materials Science and Engineering Beihang University

Thermoelectric materials possess the unique capability to convert thermal energy into electric energy and vice versa, making them promising for waste heat recovery and efficient cooling systems. Currently, extensively investigated thermoelectric materials such as Bi2Te3,PbTe and GeTe exhibit superior thermoelectric properties at room temperature and medium temperature ***, the broad application of these thermoelectric materials has been impeded by the high cost and restricted accessibility of Te and Ge in the earth's crust. Over the past few years, researchers have shown increasing interest in PbSe-and PbS-based materials, primarily attributed to their abundant elemental supply and relatively low costs. The assessment of research progress and a comprehensive overview of optimization strategies in time can significantly contribute to further improving the thermoelectric performance. These strategies include optimizing carrier concentration(aliovalent doping, dynamic doping and defect state), enhancing density-of-state effective mass(band convergence, band flattening and energy filtering effect), optimizing carrier mobility(band sharpening and band alignment) and reducing lattice thermal conductivity(all-scale hierarchical defect structures designing). This systematic summary and analysis provide novel insights and perspectives for the development of thermoelectric materials.

关键词： Carrier concentration

Antioxidant and anti-inflammatory injectable hydrogel microspheres for in situ treatment of tendinopathy

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Regenerative Biomaterials 2024年第3期3卷 92-104页

作者： Qibin Han Lang Bai Yinhua qian Xiaoyu zhang Juan Wang Jing zhou Wenguo cui Yuefeng Hao Xing Yang Department of Orthopedics The Affliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical University Suzhou215008P.R.China Department of Orthopedics Kunshan Hospital of Traditional Chinese MedicineSuzhou 215300P.R.China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025P.R.China

Tendinopathy is a common disorder that causes local dysfunction and reduces quality of *** research has indicated that alterations in the inflammatory microenvironment play a vital role in the pathogenesis of ***,injectable methacrylate gelatin(GelMA)microspheres(GM)were fabricated and loaded with heparin-dopamine conjugate(HDC)and hepatocyte growth factor(HGF).GM@HDC@HGF were designed to balance the inflammatory microenvironment by inhibiting oxidative stress and inflammation,thereby regulating extracellular matrix(ECM)metabolism and halting tendon *** growth factors with heparin was expected to improve the encaption,the catechol groups on dopamine have adhesion and antioxidant properties,allowing potential attachment at the injured site,and better function synergized with ***@HDC@HGF injected in situ in rat Achilles tendinopathy(AT)models significantly downregulated oxidative stress and inflammation,and ameliorated ECM *** conclusion,the multifunctional platform developed presents a promising alternative for the treatment of tendinopathy.

关键词： tendinopathy oxidative stress inflammation microspheres

Heterostructural NiFeW disulfide and hydroxide dual‐trimetallic core‐shell nanosheets for synergistically effective water oxidatio

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Carbon Energy 2024年第8期6卷 192-204页

作者： Peng‐Fei Guo Yang Yang Bing zhu qian‐Nan Yang Yan Jia Wei‐Tao Wang zhao‐Tie Liu Shi‐qiang zhao Xun cui Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi'anChina School of Chemistry and Chemical Engineering Shaanxi Normal UniversityXi'anChina Key Laboratory of Carbon Materials of zhejiang Province Wenzhou Key Lab of Advanced Energy Storage and ConversionZhejiang Province Key Lab of Leather EngineeringCollege of Chemistry and Materials EngineeringWenzhou UniversityWenzhouChina State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhanChina

A stable and highly active core‐shell heterostructure electrocatalyst is essential for catalyzing oxygen evolution reaction(OER).Here,a dual‐trimetallic core‐shell heterostructure OER electrocatalyst that consists of a NiFeWS_(2)inner core and an amorphous NiFeW(OH)_(z)outer shell is designed and synthesized using in situ electrochemical *** electrochemical measurements of different as‐synthesized catalysts with a similar mass loading suggest that the core‐shell Ni_(0.66)Fe_(0.17)W_(0.17)S_(2)@amorphous NiFeW(OH)_(z)nanosheets exhibit the highest overall performance compared with that of other bimetallic reference catalysts for the ***,the nanosheet arrays were in situ grown on hydrophilic‐treated carbon paper to fabricate an integrated three‐dimensional electrode that affords a current density of 10 mA cm^(−2)at a small overpotential of 182 mV and a low Tafel slope of 35 mV decade^(−1)in basic *** Faradaic efficiency of core‐shell Ni_(0.66)Fe_(0.17)W_(0.17)S_(2)@amorphous NiFeW(OH)_(z)is as high as 99.5%for *** scanning electron microscope,transmission electron microscope,and X‐ray photoelectron spectroscopy analyses confirm that this electrode has excellent stability in morphology and elementary composition after long‐term electrochemical ***,density functional theory calculations further indicate that the core‐shell heterojunction increased the conductivity of the catalyst,optimized the adsorption energy of the OER intermediates,and improved the OER *** study provides a universal strategy for designing more active core‐shell structure electrocatalysts based on the rule of coordinated regulation between electronic transport and active sites.

关键词： amorphous NiFeW hydroxide core‐shell heterojunction in situ electrochemical tuning NiFeW disulfide oxygen evolution reaction

Functional dissection of parabrachial substrates in processing nociceptive information

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zoological Research 2024年第3期45卷 633-647页

作者： Jin Ke Wei-Cheng Lu Hai-Yang Jing Shen qian Sun-Wook Moon Guang-Fu cui Wei-Xin qian Xiao-Jing Che qian zhang Shi-Shi Lai Ling zhang Ying-Jie zhu Jing-Dun Xie Tian-Wen Huang Shenzhen Key Laboratory of Drug Addiction Shenzhen-Hong Kong Institute of Brain ScienceBrain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China University of Chinese Academy of Sciences Beijing 100049China Department of Anesthesiology State Key Laboratory of Oncology in South ChinaGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China University of Science and Technology of China HefeiAnhui 230027China Department of Anesthesiology Shenzhen University General Hospital and Shenzhen University Academy of Clinical Medical SciencesShenzhen UniversityShenzhenGuangdong 518055China School of Medicine Yunnan UniversityKunmingYunnan 650091China

Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of *** lateral parabrachial nucleus(lPBN),composed of external-(elPBN),dorsal-(dlPBN),and central/superior-subnuclei(jointly referred to as slPBN),receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity ***,the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain *** this study,we used region-specific neuronal depletion or silencing approaches combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor(NK1R)(lPBNNK1R)are crucial for driving pain-associated self-care behaviors evoked by sustained noxious thermal and mechanical stimuli applied to skin or bone/muscle,while elPBN neurons are dispensable for driving such ***,lPBNNK1R neurons are specifically required for forming sustained somatic pain-induced negative teaching signals and aversive memory but are not necessary for fear-learning or escape behaviors elicited by external ***,both lPBNNK1R and elPBN neurons contribute to chemical irritant-induced nocifensive *** results reveal the functional organization of parabrachial substrates that drive distinct behavioral outcomes in response to sustained pain versus external danger under physiological conditions.

关键词： Lateral parabrachial nucleus Substance P receptor Pain affect Defensive reaction Somatosensory