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国际医学放射学杂志 2021年第5期 614-615页

作者： Q.Gou L.Wu W.Cui z.mo D.zeng L.Gan 陈小倩

摘要目的评价支架置入联合腔内射频消融(intra-RFA)和肝动脉灌注化疗(HAIC)治疗晚期胆管癌(Ad-BTC)合并胆道梗阻(BO)的疗效和安全性。方法回顾性分析2013

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Protective effects of oleic acid and polyphenols in extra virgin olive oil on cardiovascular diseases

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Food Science and Human Wellness 2024年第2期13卷 529-540页

作者： Yan Lu Jun zhao Qiqi Xin Rong Yuan Yu Miao Manli Yang Hui mo Keji Chen Weihong Cong Laboratory of Cardiovascular Diseases Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China National Clinical Research Center for Chinese Medicine Cardiology Beijing 100091China Traditional Chinese Medicine Department The Aff iliated Hospital of Qingdao UniversityQingdao 266000China Nanjing University of Chinese Medicine Nanjing 210023China Health Bureau of the Government of the Macao Special Administrative Region Macao 999078China

The Mediterranean diet has long been recognized as one of the most effective ways to prevent and improve cardiovascular *** virgin olive oil(EVOO)is the typical sources of fat in the Mediterranean diet which have been shown to have noteworthy nutritional value and positive impact on human *** is worth noting that EVOO owes its superior nutritional value to its bioactive *** main component of EVOO is monounsaturated fatty acids(MUFAs)in the form of oleic *** acid accounts for up to 70%-80%of ***,EVOO contains approximately more than 30 phenolic compounds,of which HT is essential for the protection against cardiovascular *** this review,we focused on the potential mechanisms of oleic acid and polyphenols combat cardiovascular diseases risk in terms of oxidative stress,inflammation,blood pressure,endothelial function and *** review might provide a reference for the studies on cardiovascular protective effects of EVOO.

关键词： Cardiovascular diseases Extra virgin olive oil Oleic acid Polyphenols

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Introducing cerium into TiO_(2)@MnO_(x) hollow-sphere structure for highly active photothermocatalysis degradation of ethyl acetate and NO under H_(2)O at low temperature

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Journal of Rare Earths 2024年第5期42卷 889-898,I0003页

作者： Yinming Fan Yanhong Wang morui Li Yinian zhu zongqiang zhu Shengpeng mo Lihao zhang Shen Tang Xiaobin zhou Yanping zhang Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area Guilin University of TechnologyGuilin541004China The Guangxi Key Laboratory of Theory and Technology for Environmental Pollution Control.Guilin University of Technology.Guilin 541004China Technical Innovation Center of Mine Geological Environmental Restoration Engineering in Southern Karst Area Nanning530022China

The CeO_(2)-TiO_(2)@MnO_(x) catalyst was prepared by the co-precipitation method and applied to the photothermocatalysis system of ethyl acetate and NO simultaneous degradation under H_(2)O at low temperature,which introduced Ce into TiO_(2)@MnO_(x) hollow sptrera *** optimum TiO_(2)/MnO_(x) ratio and Ce introducing amount were obtained in the *** of them,the NO and ethyl acetate conversion percentage of TiO_(2)@MnO_(x)(n_(Mn):n_(Ti)=40:40)is 74%and 62%at 240℃,***_(2)-TiO_(2)@MnO_(x)(n_(Mn):n_(Ce)=1:1)exhibits the best catalytic performance,its efficiency for NO conversion is 83%and the conversion of ethyl acetate reaches 72%at 240℃.In addition,it is confirmed that the Cedoped nanocomposites have more uniform dispersion through various characterization and analysis ***,these catalysts have a large specific surface area as well as a large number of surface-active oxygen and oxygen *** can further improve the catalytic performance based on the adjusted ratio of active ***,this work investigated the relationship between multi-metal interactions and catalytic performance in the presence of H_(2)***,the possible reaction pathways for the simultaneous removal of NO and ethyl acetate were explored in our system.

关键词： Photothermocatalysis Ethyl acetate NO Low temperature H_(2)O Rare earths

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Primordial black hole mass functions as a probe of cosmic origin

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 164-171页

作者： Yi-Fu Cai Chengfeng Tang Geyu mo Sheng-Feng Yan Chao Chen Xiao-Han Ma Bo Wang Wentao Luo Damien A.Easson Antonino Marcianò Deep Space Exploration Laboratory/School of Physical Sciences University of Science and Technology of ChinaHefei 230026China CAS Key Laboratory for Researches in Galaxies and Cosmology/Department of Astronomy School of Astronomy and Space ScienceUniversity of Science and Technology of ChinaHefei 230026China Istituto Nazionale di Fisica Nucleare(INFN) Sezione di MilanoMilano 20146Italy DiSAT Universitàdegli Studi dell'InsubriaComo 22100Italy Jockey Club Institute for Advanced Study The Hong Kong University of Science and TechnologyHong KongChina Department of Physics Arizona State UniversityTempe 85287-1504USA Department of Physics&Center for Field Theory and Particle Physics Fudan UniversityShanghai 200433China Laboratori Nazionali di Frascati INFN Via Enrico Fermi 541 Frascati(Roma)00044Italy INFN sezione Roma Tor Vergata Rome I-00133Italy School of Physics University of Electronic Science and Technology of ChinaChengdu11731China

We discuss a novel window to probe the origin of our universe via the mass functions of primordial black holes(PBHs).The mass functions of PBHs are simply estimated using the conventional Press-Schechter formalism for two paradigms of cosmic origin,including inflationaryΛCDM and bounce *** standard inflationaryΛCDM model cannot generate an appreciable number of massive PBHs;however,non-trivial inflation models with blue-tilted power spectra at small scales and matter bounce cosmology provide formation mechanisms for heavy PBHs,which in turn,may seed the observed supermassive black holes(SMBHs).By fitting the SMBH mass functions at high redshift(z~6)derived from Sloan Digital Sky Survey(SDSS)and Canada-France High-z Quasar Survey(CFHQS)quasars,for two paradigms of cosmic origin,we derive constraints on the PBH density fraction fPBHat z~6 and the characteristic mass M_(★),with the prior assumption that all SMBHs stem from *** demonstrate that this newly proposed procedure,relying on astronomical measurements that utilize deep-field surveys of SMBHs at high redshift,can be used to constrain models of cosmic ***,although not the main focus of this paper,we evolve the mass function from z~6 to z~0 through an assumption of 3×10^(8)-year Eddington’s accretion,and give a rough estimation of fPBHat z~0.

关键词： origin cosmic massive

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Bifunctional noble-metal-free cocatalyst coating enabling better coupling of photocatalytic CO_(2)reduction and H_(2)O oxidation on direct z-scheme heterojunction

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Nano Research 2024年第6期17卷 5022-5030页

作者： Wei zhao Weihao mo Yan zhang Lingxuan Hu Yiyi zheng zhulei Chen Xiangyue Niu Yuling zhao Lichun Liu Shuxian zhong Song Bai Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China College of Biological Chemical Sciences and Engineering and Nanotechnology Research InstituteJiaxing UniversityJiaxing 314001China College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua 321004China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058China School of Biological and Chemical Engineering Panzhihua UniversityPanzhihua 617000China

Selective loading of spatially separated redox cocatalysts on direct z-scheme heterojunctions holds great promise for advancing the efficiency of artificial photosynthesis,which however is limited to the photodeposition of noble metal cocatalysts and the fabrication of hollow double-shelled semiconductor ***,the co-exposure of discrete cocatalyst and semiconductor increases the product diversity when both the exposed sites of which participate in CO_(2)***,we present a facile and versatile protocol to overcome these limitations via surface coating of z-scheme heterojunctions with bifunctional noble-metal-free *** Cu_(2)O/Fe_(2)O_(3)(CF)as a model heterojunction and layered Ni(OH)_(2)as a model cocatalyst,it is found that Ni(OH)_(2)lying on the surfaces of Cu_(2)O and Fe_(2)O_(3)separately co-catalyzes the CO_(2)reduction and H_(2)O *** experimental and theoretical investigation reveals that the Ni(OH)_(2)outer layer:(i)mitigates the charge recombination in CF and balances their transfer and consumption;(ii)reduces the rate-determining barriers for CO_(2)-to-CO and H_(2)O-to-O_(2)conversion,(iii)suppresses the side proton reduction occurring on CF,and(iv)protects the CF from component *** expected,the redox reactions stoichiometrically proceed,and significantly enhanced photocatalytic activity,selectivity,and stability in CO generation are achieved by the stacked Cu_(2)O/Fe_(2)O_(3)@Ni(OH)_(2)in contrast to *** study demonstrates the significance of the synergy between bifunctional cocatalysts and z-scheme heterojunctions for improving the efficacy of overall redox reactions,opening a fresh avenue for the rational design of artificial photosynthetic systems.

关键词： z-scheme heterojunction bifunctional cocatalyst CO_(2)reduction H_(2)O oxidation stoichiometric redox reaction

CT引导下125I近距离放疗治疗一线化疗失败的转移性软组织肉瘤的可行性和临床价值

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国际医学放射学杂志 2018年第3期 364-364页

作者： z.mo T.zhang Y.zhang z.Xiang H.Yan z.zhong 于清扬 State Key Laboratory of Oncology in South China Collaborative Innovation Centre for Cancer Medicine Sun Yat-Sen University Cancer Centre

摘要目的探讨CT引导下的125I近距离放射治疗对一线化疗失败的转移性软组织肉瘤(STS)治疗的可行性和有效性。方法从2010年1月—2015年7月,共招募93例转移

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带有非一致约束和通讯时延的异构网络约束一致性

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控制理论与应用 2024年第8期41卷 1427-1437页

作者：莫立坡张豪哲北京工商大学电商与物流学院北京100048 北京工商大学数学与统计学院北京100048

本文主要致力于研究一类具有非一致的凸位置约束、非凸速度约束和非一致的通信时延的异构多智能体网络的约束一致性问题,其中异构多智能体网络由一阶和二阶智能体构成.首先,为每个智能体设计了一个分布式控制算法,同时,引入了两类坐标变... 详细信息

本文主要致力于研究一类具有非一致的凸位置约束、非凸速度约束和非一致的通信时延的异构多智能体网络的约束一致性问题,其中异构多智能体网络由一阶和二阶智能体构成.首先,为每个智能体设计了一个分布式控制算法,同时,引入了两类坐标变换,将带有时延的异构系统转化为带有异构非线性误差和无时延的线性时变系统.为了处理异构非线性误差,本文采用了一种几何学技巧,使组合变量的非线性动态可以被线性动态所控制.然后,通过投影算子和非负矩阵的性质,在一些弱的假设下,证明了随着时间的演进,非线性误差能收敛为零,从而达成系统的受限一致性.最后,本文给出两个数值算例验证了结果的正确性.

关键词：异构网络非凸速度约束位置约束通讯时延一致性

TOPK Inhibition Enhances the Sensitivity of Colorectal Cancer Cells to Radiotherapy by Reducing the DNA Damage Response

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Current Medical Science 2024年第3期44卷 545-553页

作者： Shi-gui PANG Xin zHANG zhao-xin LI Li-fei HE Feng CHEN Ming-long LIU Ying-ze HUANG Jian-mei mo Kong-lan LUO Juan-juan XIAO Feng zHU Department of Oncology The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Cancer Research Institute The Affiliated Hospital of Guilin Medical UniversityGuilin541001China Translational Medical Center Huaihe HospitalHenan UniversityKaifeng475000China Guangxi Key Laboratory of molecular Medicine in Liver Injury and Repair The Affiliated Hospital of Guilin Medical UniversityGuilin541001China

Objective Abnormal expression of T-lymphokine-activated killer cell-originated protein kinase(TOPK)was reported to be closely related to the resistance of prostate cancer to radiotherapy and to targeted drug resistance in lung ***,the role of TOPK inhibition in enhancing radiosensitivity of colorectal cancer(CRC)cells is *** study aimed to evaluate the radiosensitization of TOPK knockdown in CRC *** The expression of TOPK was detected in CRC tissues by immunohistochemistry,and the effect of TOPK knockdown was detected in CRC cells by Western ***-8 and clonogenic assays were used to detect the growth and clonogenic ability of CRC cells after TOPK knockdown combined with radiotherapy in CRC ***,proteomic analysis showed that the phosphorylation of TOPK downstream proteins changed after *** damage was detected by the comet *** in the DNA damage response signaling pathway were analyzed by Western blotting,and apoptosis was detected by flow *** The expression of TOPK was significantly greater in CRC tissues at grades 2–4 than in those at grade *** irradiation,CRC cells with genetically silenced TOPK had shorter comet tails and reduced expression levels of DNA damage response-associated proteins,including phospho-cyclin-dependent kinase 1(p-CDK1),phospho-ataxia telangiectasia-mutated(p-ATM),poly ADP-ribose polymerase(PARP),and meiotic recombination 11 homolog 1(MRE11).Conclusions TOPK was overexpressed in patients with moderately to poorly differentiated ***,TOPK knockdown significantly enhanced the radiosensitivity of CRC cells by reducing the DNA damage response.

关键词： T-lymphokine-activated killer cell-originated protein kinase colorectal cancer DNA damage response radiosensitivity

股骨近端内翻去旋转截骨联合改良骨盆三联截骨术治疗脑瘫髋脱位

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中华骨科杂志 2024年第3期44卷 152-160页

作者：莫国枢李旭广州华新骨科医院儿童骨科

目的评估股骨近端内翻去旋转截骨联合改良骨盆三联截骨术治疗脑瘫髋脱位的临床疗效。方法回顾性分析2018年11月至2022年9月接受股骨近端内翻去旋转截骨联合改良骨盆三联截骨术治疗23例(28髋)脑瘫髋脱位患者的病历资料, 男17例、女6例, ... 详细信息

目的评估股骨近端内翻去旋转截骨联合改良骨盆三联截骨术治疗脑瘫髋脱位的临床疗效。方法回顾性分析2018年11月至2022年9月接受股骨近端内翻去旋转截骨联合改良骨盆三联截骨术治疗23例(28髋)脑瘫髋脱位患者的病历资料, 男17例、女6例, 左侧11髋、右侧17髋, 手术年龄为7.7(6.9, 8.9)岁。术前8髋存在疼痛症状。对患者施行股骨转子下三维截骨矫形并应用儿童髋关节钢板内固定, 经Smith-Petersen入路及会阴入路行改良骨盆三联截骨。手术前后完善临床评估, 包括髋关节疼痛程度及关节活动度;影像学评估指标包括位移指数(migration percentage, MP)、髋臼指数(acetabular index, AI)、髋臼偏移(acetabular offset, AO)、颈干角(neck shaft angle, NSA)和股骨前倾角(femoral neck anteversion, FNA)。结果所有被纳入的病例均得到随访, 随访时间为15(12, 20)个月。手术时间为6.1(5.5, 6.9)h, 术中失血量为(400±153)ml(范围200～800 ml)。未观察到坐骨神经损伤、切口或深部感染的病例。术后1周MP为0%(0%, 0%), 与术前50.5%(38.2%, 75.8%)的差异有统计学意义(z=4.624, Pz=4.623, Pz=4.099, Pz=4.541, Pz=4.407, Pz=0.561, P=0.575)。结论改良骨盆三联截骨术可有效矫正脑瘫髋脱位的髋臼畸形, 联合股骨近端内翻去旋转截骨能有效矫正脑瘫髋脱位、缓解疼痛并保留髋关节活动度。

关键词：脑性瘫痪髋脱位关节成形术骨盆截骨术

Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study

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World Journal of Stem Cells 2024年第1期16卷 19-32页

作者： ErdinçCivelek Serdar Kabatas Eyüp Can Savrunlu Furkan Diren Necati Kaplan Demet Ofluoğlu Erdal Karaöz Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalÇorlu 59860TekirdağTurkey Department of Physical Medicine and Rehabilitation Ofluoğlu KlinikGöztepe 34728IstanbulTurkey Liv Hospital Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell)Beşiktaş34340IstanbulTurkey Department of Histology and Embryology Istinye UniversityFaculty of MedicineZeytinburnu 34010IstanbulTurkey Istinye University Center for Stem Cell and Tissue Engineering Research and PracticeBeşiktaş34340IstanbulTurkey

BACKGROUND Peripheral nerve injury can result in significant clinical complications that have uncertain ***,there is a lack of effective pharmacological interventions for nerve damage,despite the existence of several small compounds,Despite the objective of achieving full functional restoration by surgical intervention,the persistent challenge of inadequate functional recovery remains a significant concern in the context of peripheral nerve *** To examine the impact of exosomes on the process of functional recovery following a complete radial nerve *** A male individual,aged 24,who is right-hand dominant and an immigrant,arrived with an injury caused by a knife *** cut is located on the left arm,specifically below the *** neurological examination and electrodiagnostic testing reveal evidence of left radial nerve *** sural autograft was utilized for repair,followed by the application of 1 mL of mesenchymal stem cell-derived exosome,comprising 5 billion *** exosome was split into four equal volumes of 0.25 mL each and delivered microsurgically to both the proximal and distal stumps using the subepineural *** patient was subjected to a period of 180 d during which they had neurological examination and electrodiagnostic *** The duration of the patient’s follow-up period was 180 *** increasing Tinel’s sign and sensory-motor recovery were detected even at the 10th wk following nerve *** the conclusion of the 6-mo post-treatment period,an evaluation was conducted to measure the extent of improvement in motor and sensory functions of the *** assessment was based on the British Medical Research Council scale and the Mackinnon-Dellon *** results indicated that the level of improvement in motor function was classified as M5,denoting an excellent ***,the level of improvement in sensory function was classified as S3+,indicating a good *** is

关键词： Mesenchymal stem cell Exosomes Radial nerve Sural nerve