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Contactin-associated protein-like 2(CNTNAP2)mutations impair the essentialα-secretase cleavages,leading to autism-like phenotypes

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1625-1636页

作者： Qing zhang Mengen xing zhengkai Bao Lu Xu Yang Bai Wanqi Chen Wenhao Pan Fang Cai Qunxian Wang Shipeng Guo Jing zhang zhe Wang Yili Wu Yun zhang Jia-Da Li Weihong Song Oujiang Laboratory(zhejiang Lab for Regenerative Medicine Vision and Brain Health)Zhejiang Key Laboratory of Alzheimer's DiseaseZhejiang Provincial Clinical Research Center for Mental DisordersSchool of Mental Health and Wenzhou Kangning HospitalThe Second Affiliated Hospital and Yuying Children's HospitalInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang 325035China Townsend Family Laboratories Department of PsychiatryBrain Research CenterThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders Ministry of Education Key Laboratory of Child Development and DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Center for Medical Genetics Hunan Key Laboratory of Animal Models for Human DiseasesHunan Key Laboratory of Medical GeneticsHunan International Scientific and Technological Cooperation Base of Animal Models for Human DiseasesSchool of Life SciencesCentral South UniversityChangsha 410078 HunanChina The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijing 100053Chin

Mutations in the Contactin-associated protein-like 2(CNTNAP2)gene are associated with autism spectrum disorder(ASD),and ectodomain shedding of the CNTNAP2 protein plays a role in its ***,key enzymes involved in the C-terminal cleavage of CNTNAP2 remain largely unknown,and the effect of ASD-associated mutations on this process and its role in ASD pathogenesis remain *** this report we showed that CNTNAP2 undergoes sequential cleavages by furin,ADAM10/17-dependent a-secretase and presenilindependent *** identified that the cleavage sites of ADAM10 and ADAM17 in CNTNAP2 locate at its C-terminal residue I79 and L96,and the main a-cleavage product C79 by ADAM10 is required for the subsequent y-secretase cleavage to generate CNTNAP2 intracellular domain(CICD).ASD-associated CNTNAP2 mutations impair the a-cleavage to generate C79,and the inhibition leads to ASDIlike repetitive and social behavior abnormalties in the Cntnap2l1254T knock-in ***,exogenous expression of 79 improves autism-ike phenotypes in the Cntnap2^(11254T) knock-in and Cntnap2^(-/-)knockout *** data demonstrates that the a-secretase is essential for CNTNAP2 processing and its *** study indicates that inhibition of the cleavage by pathogenic mutations underlies ASD pathogenesis,and upregulation of its C-terminal fragments could have therapeutical potentials for ASD treatment.

关键词： NAP2 cleavage subsequent

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Searching for the light leptophilic gauge boson zx via four-lepton final states at the CEPC

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Chinese Physics C 2024年第4期48卷 59-67页

作者：岳崇兴李妍钰王美舒羽张欣蒙 Department of Physics Liaoning Normal UniversityDalian 116029China Center for Theoretical and Experimental High Energy Physics Liaoning Normal UniversityDalian 116029China

We investigate the possibility of detecting the leptophilic gauge boson z_(x) predicted by the U(1)Le−Lμmodel via the processes e+e−→ℓ^(+)ℓ^(−)z_(x)(z_(x)→ℓ^(+)ℓ^(−))and e+e−→ℓ^(+)ℓ^(−)z_(x)(z_(x)→νℓ¯νℓ)at the Circular Electron Positron Collider(CEPC)with a center of mass energy√s=240 GeV and luminosity L=5.6ab^(−1).We provide the expected sensitivities of the CEPC to the parameter space at the 1σ,2σ,3σ,and 5σlevels.

关键词： light gauge boson z_(x) U(1)L_(e)-L_(μ)model Circular Electron Positron Collider

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垄作栽培提升黄花菜产量及改善根际土壤环境

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山西农业大学学报（自然科学版） 2024年第4期44卷 71-81页

作者：阚以琴刘玉兰李名莉邢国明马涛孙胜山西农业大学园艺学院山西晋中030801 山西农业大学高寒区作物研究所山西大同037006

[目的]本研究旨在提高黄花菜的产量,探索适宜大同地区黄花菜的有效栽培模式。[方法]于2022-2023年,以‘大同黄花’为试验材料,采用垄作、平作和沟栽3种栽培方式,通过测定分析黄花菜根际土壤理化属性、根系活力与生物量等指标,探究栽培... 详细信息

[目的]本研究旨在提高黄花菜的产量,探索适宜大同地区黄花菜的有效栽培模式。[方法]于2022-2023年,以‘大同黄花’为试验材料,采用垄作、平作和沟栽3种栽培方式,通过测定分析黄花菜根际土壤理化属性、根系活力与生物量等指标,探究栽培方式对黄花菜产量的影响。[结果](1)垄作能显著降低0~20 cm土层土壤容重和土壤含水量,提高0~20 cm土层土壤孔隙度。垄作下0~10、10~20 cm土层土壤容重较平作分别降低4.88%和3.37%,土壤含水量分别显著降低17.03%和19.04%,土壤孔隙度分别提高8.28%和7.33%,而沟栽下0~10 cm土层土壤含水量较平作显著提高11.46%;(2)垄作提高0~20 cm土层土壤温度,尤其是表层0~5 cm温度变化幅度最大。(3)垄作提高0~30 cm土层土壤蔗糖酶和脲酶活性,其中0~10 cm土层酶活性最高。(4)在黄花菜展叶期、初花期和盛花期,垄作下的土壤碱解氮含量分别显著提高81.12%、111.42%、40.64%。(5)垄作提高根系活力,在黄花菜抽薹期较平作显著提高21.36%,随着生育进程的推进,根系干物质逐渐增加,在盛花期垄作较平作提高27.63%。(6)在产量方面,垄作较平作显著提高28.89%。[结论]垄作可提高土壤温度、孔隙度、土壤酶活性及土壤养分含量,为黄花菜创造良好的生态环境,利于根系生长,实现黄花菜高产,因此垄作是适合大同地区黄花菜的高效栽培模式。

关键词：黄花菜栽培方式产量根际环境根系发育

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Polymer solar cells with an inverted device configuration using polyhedral oligomeric silsesquioxane-[60]fullerene dyad as a novel electron acceptor

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Science China Chemistry 2012年第5期55卷 749-754页

作者： zHANG Wen-Bin TU YingFeng SUN Hao-Jan YUE kan Gong Xiong CHENG Stephen z. D. College of Polymer Science and Polymer Engineering The University of Akron Akron OH 44325 USA College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 China

A polyhedral oligomeric silsesquioxane-[60]fullerene (POSS-C60) dyad was designed and used as a novel electron acceptor for bulk heterojunction (BHJ) polymer solar cells (PSCs) with an inverted device configuration. The studies of time-resolved photoinduced absorption of the pristine thin film of poly[(4,4'-bis(2-ethylhexyl)dithieno[3,2-b:2',3'-d]silole)-2,6-diyl-alt-(4,7-bis (2-thienyl)-2,1,3-benzothiadiazole)-5,5'-diyl] (SiPCPDTBT) and the composite thin film of SiPCPDTBT:POSS-C60 indicated efficient electron transfer from SiPCPDTBT to POSS-C60 with inhibited back-transfer. BHJ PSCs made by SiPCPDTBT mixed with POSS-C60 yielded the power conversion efficiencies (PCEs) of 1.50%. Under the same operational conditions, PCEs observed from BHJ PSCs made by SiPCPDTBT mixed with [6,6]-phenyl-C61-butyric acid methyl ester were 0.92%. These results demonstrated that POSS-C60 is a potentially good electron acceptor for inverted BHJ PSCs.

关键词： electron acceptor polyhedral oligomeric silsesquioxane fullerene polymer solar cells inverted device structure

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Preparation of polypyrrole/Co_(x)Mo_(y)O_(z)composite and its microwave a bsorption performance

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分子科学学报 2024年第2期40卷 131-137页

作者： WANG Bo Cong Jiyuan xing Shuangxi GUAN hongtao Faculty of Chemistry Northeast Normal UniversityChangchun 130024China School of Materials and Energy Yunnan UniversityKunming 650091China

The present work combines polypyrrole with cobalt molybdenum oxide using an in situ surface growth method to adjust impedance matching and explore the microwave absorption performance of the composite *** complex dielectric constant and magnetic permeability of the samples are measured in the frequency range of 2 to 18 GHz using a vector network analyzer,and their reflection loss(RL)value is *** results show that the obtained PPy/Co_(x)Mo_(y)O_(z)composite exhibits excellent absorption performance at 17.68 GHz under a matching thickness of 2.0 mm,with an RL_(min)of-46.02 dB and an effective absorption bandwidth of 4.08 *** excellent absorption performance can be attributed to the combined effect of multion loss mechanisms,including conduction loss,interface polarization,dipole polarization and eddy current loss.

关键词： microwave absorption polypyrrole cobalt-molybdenum oxide

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Contact-free and pose-invariant hand-biometric-based personal identification system using RGB and depth data

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Journal of zhejiang University-Science C(Computers and Electronics) 2014年第7期15卷 525-536页

作者： Can WANG hong LIU xing LIU Engineering Laboratory on Intelligent Perception for Internet of Things (ELIP) and MOE Key Laboratory of Machine Perception Shenzhen Graduate School Peking University

Hand-biometric-based personal identification is considered to be an effective method for automatic recognition. However, existing systems require strict constraints during data acquisition, such as costly devices,specified postures, simple background, and stable illumination. In this paper, a contactless personal identification system is proposed based on matching hand geometry features and color features. An inexpensive Kinect sensor is used to acquire depth and color images of the hand. During image acquisition, no pegs or surfaces are used to constrain hand position or posture. We segment the hand from the background through depth images through a process which is insensitive to illumination and background. Then finger orientations and landmark points, like finger tips or finger valleys, are obtained by geodesic hand contour analysis. Geometric features are extracted from depth images and palmprint features from intensity images. In previous systems, hand features like finger length and width are normalized, which results in the loss of the original geometric features. In our system, we transform 2D image points into real world coordinates, so that the geometric features remain invariant to distance and perspective effects. Extensive experiments demonstrate that the proposed hand-biometric-based personal identification system is effective and robust in various practical situations.

关键词： Hand biometric Contact free Pose invariant Identification system Multiple features

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一类上临界状态的两性分支过程的Berry-Esseen界

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南开大学学报（自然科学版） 2024年第1期57卷 106-109,115页

作者：邢永胜山东工商学院数学学院山东烟台264005

考虑了一类一夫多妻制配对模式下两性分支过程,分析了其标准化过程的收敛速度,得到了它的Berry-Esseen界.

关键词：两性Galton-Watson分支过程一夫多妻制 Berry-Esseen界

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一种基于COMSOL的四极场离子运动仿真模型

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质谱学报 2024年第4期45卷 472-481,I0002页

作者：杨丽娜熊行创方向中国计量科学研究院北京100029 国家市场监管重点实验室(计量数字化与数字计量) 北京100029

四极场质谱仪是目前应用最广泛的小型质谱仪器之一。研究四极场中离子运动轨迹,对于深入理解和认识四极场中离子的行为非常重要,不仅有助于提出新的质谱技术问题,也对质谱仪器研制具有指导意义。离子运动的数值模拟和仿真是研究四极杆... 详细信息

四极场质谱仪是目前应用最广泛的小型质谱仪器之一。研究四极场中离子运动轨迹,对于深入理解和认识四极场中离子的行为非常重要,不仅有助于提出新的质谱技术问题,也对质谱仪器研制具有指导意义。离子运动的数值模拟和仿真是研究四极杆中离子运动行为的高效数字化手段。本文基于COMSOL Multiphysics建立了四极场的数字仿真模型Sim-Quaq-COM-V1.0,应用该模型得到的仿真数据结果与理论计算结果一致,可作为研究四极场中离子行为的精确数字化模型。在此基础上,对比研究了双曲四极杆与圆柱四极杆中离子的运动行为,相同条件下,m/z 69离子在双曲四极场中通过的数量约为圆柱四极场的4倍。该仿真计算模型能够快速配置全局参数,节省几何设计和建模的时间,降低计算难度;模型支持并行计算技术,在计算速度和计算量方面均有大幅提升,能够同时处理大量离子,缩短研究周期,助力质谱仪器设计和研发技术的数字化发展。

关键词：四极场数值模拟质谱仪仿真建模 COMSOL

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin J.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.J.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen z.J.Chen z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio J.J.Cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng J.H.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.hong G.Y.Hou X.T.Hou Y.R.Hou z.L.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia z.K.Jia D.Jiang H.B.Jiang P.C.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.kang X.S.kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction

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Structure,ferroelectric,and enhanced fatigue properties of sol–gel-processed new Bi-based perovskite thin films of Bi(Cu_(1/2)Ti_(1/2))O_(3)–PbTiO_(3)

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Chinese Physics B 2024年第5期33卷 608-615页

作者：宋伟宾席国强潘昭刘锦叶旭斌刘哲宏王潇单鹏飞张林兴鲁年鹏樊龙龙秦晓梅龙有文 Department of Physics Shanghai Normal UniversityShanghai 200234China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Institute for Advanced Materials Technology University of Science and Technology BeijingBeijing 100083China Songshan Lake Materials Laboratory Dongguan 523808China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Bi-based perovskite ferroelectric thin films have wide applications in electronic devices due to their excellent ferroelectric *** Bi-based perovskite thin films Bi(Cu_(1/2)Ti_(1/2))O_(3)–PbTiO_(3)(BCT–PT) are deposited on Pt(111)/Ti/SiO_(2)/Si substrates in the present study by the traditional sol–gel *** structures and related ferroelectric and fatigue characteristics are studied *** BCT–PT thin films exhibit good crystallization within the phase-pure perovskite structure,besides,they have a predominant(100) orientation together with a dense and homogeneous *** remnant polarization(2P_(r)) values at 30 μC/cm^(2) and 16 μC/cm^(2) are observed in 0.1BCT–0.9PT and 0.2BCT–0.8PT thin films,*** intriguingly,although the polarization values are not so high,0.2BCT–0.8PT thin films show outstanding polarization fatigue properties,with a high switchable polarization of 93.6% of the starting values after 10^(8) cycles,indicating promising applications in ferroelectric memories.

关键词： ferroelectric thin films perovskite PbTiO_(3)-BiMeO_(3)

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