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基于z′参数的高强铝合金稳态蠕变速率可靠性研究

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原子能科学技术 2020年第4期54卷 709-714页

作者：李昂高蔚吴福张毅核工业理化工程研究院天津300180 国防科技工业核材料技术创新中心天津300180

建立了基于速率温度参数模型的新型高强铝合金z′参数表达式及稳态蠕变速率-可靠度预测方法,z′参数表征稳态蠕变速率数据偏离速率温度参数模型主曲线的程度。结合实测数据,研究了z′参数的统计分布规律。基于z′参数,分别得出新型高强... 详细信息

建立了基于速率温度参数模型的新型高强铝合金z′参数表达式及稳态蠕变速率-可靠度预测方法,z′参数表征稳态蠕变速率数据偏离速率温度参数模型主曲线的程度。结合实测数据,研究了z′参数的统计分布规律。基于z′参数,分别得出新型高强铝合金实验应力-速率温度参数-可靠度曲线和温度-许用应力-可靠度曲线。结果显示,新型高强铝合金z′参数满足正态分布规律。稳态蠕变速率预测上限随可靠度的增加而升高。外推至稳态蠕变速率上限10-7 h-1时,新型高强铝合金在50、80℃下的许用应力(可靠度99.7%)分别为470.0、294.5 MPa。与传统安全系数法相比,基于z′参数的预测结果更合理。

关键词：高强铝合金速率温度参数 z′参数可靠度稳态蠕变速率预测

钠米材料Fe＿2O＿3微结构的正电子寿命谱学研究

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物理学报 1994年第7期43卷 1208-1216页

作者：彭郁卿王涛周诗瑶卜为张立德中国科学院上海原子核研究所中国科学院核分析技术开放研究实验室中国科学院固体物理研究所上海师范大学

用Ｘ射线衍射确定了纳米材料Ｆｅ＿２Ｏ＿３的平均粒径。测量了正电子的寿命。给出了平均粒径随退火温度的变化和短寿命成分τ＿１、中等寿命成分τ＿２以及它们的强度比Ｉ＿２／Ｉ＿１随平均粒径的变化。讨论了纳米材料Ｆｅ＿２Ｏ＿３... 详细信息

用Ｘ射线衍射确定了纳米材料Ｆｅ＿２Ｏ＿３的平均粒径。测量了正电子的寿命。给出了平均粒径随退火温度的变化和短寿命成分τ＿１、中等寿命成分τ＿２以及它们的强度比Ｉ＿２／Ｉ＿１随平均粒径的变化。讨论了纳米材料Ｆｅ＿２Ｏ＿３的界面结构、平均正电子寿命τ与多普勒展宽谱Ｓ参效间的对应关系。

关键词：纳米材料氧化铁正电子湮灭缺陷

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基于卷积神经网络的木材缺陷识别

长春工业大学学报 2019年第4期40卷 332-338页

作者：崔明光张秀梅韩维娜长春工业大学电气与电子工程学院

跨层卷积神经网络模型由输入层、两个交替的卷积层、池化层、全连接层和输出层组成。池化层输出到全连接层,将网络的高层次特征和低层次特征相结合构造分类器。在网络中加入Dropout技术,以防止过拟合的发生。

关键词：卷积神经网络缺陷识别跨层连接 Dropout技术

维生素D联合前列地尔对熊去氧胆酸应答不佳的原发性胆汁性肝硬化疗效观察

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中国中西医结合消化杂志 2017年第9期25卷 651-655页

作者：袁剑峰张翠芳鄂东医疗集团黄石市中心医院(湖北理工学院附属医院)感染科湖北黄石435000

[目的]探讨维生素D联合前列地尔对熊去氧胆酸应答不佳的原发性胆汁性肝硬变患者的临床疗效。[方法]选取2010年1月-2015年9月在黄石市中心医院感染科治疗的157例的原发性胆汁性肝硬化患者,采用随机数字表法分为2组,分别为常规剂量组(77例... 详细信息

[目的]探讨维生素D联合前列地尔对熊去氧胆酸应答不佳的原发性胆汁性肝硬变患者的临床疗效。[方法]选取2010年1月-2015年9月在黄石市中心医院感染科治疗的157例的原发性胆汁性肝硬化患者,采用随机数字表法分为2组,分别为常规剂量组(77例)和大剂量组(80例)13-15mg·kg^(-1)·d^(-1)、20-25mg·kg^(-1)·d^(-1)熊去氧胆酸进行治疗,疗程持续6个月。再用随机数字表的方法将熊去氧胆酸应答不佳的81例患者分为维生素D组、前列地尔组和联合组,3组均给予20~25mg·kg^(-1)·d^(-1)熊去氧胆酸治疗,27例维生素D组患者加用维生素D0.02mg/次,1次/d,27例前列地尔组加用前列地尔2ml+10ml生理盐水静脉注射,1次/d,每月治疗7d,联合组加用维生素D+前列地尔,用法用量同前2组。3组均治疗3月,观察治疗前后2组患者肝功能及T淋巴细胞亚群、细胞因子IL-2、TNF-α的变化、并比较治疗有效率和记录不良反应。[结果]常规剂量组(77例)和大剂量组(80例)对于UDCA应答不佳比较[58.4%(45/77)48.2%(39/81)],差异无统计学意义(P>0.05)。治疗后,维生素D组、前列地尔组和联合组总胆红素、谷丙转氨酸、谷草转氨酸、碱性磷酸酶和谷氨酸转移酶均降低,联合组下降程度优于另外2组,维生素D组下降程度优于前列地尔组,差异均具有统计学意义(P<0.05);治疗后,3组CD4^+水平下降,CD8^+水平上升,CD4^+/CD8^+比值下降,同时IL-2及TNF-α水平也较治疗前下降,联合组治疗后CD4^+、CD8^+、CD4^+/CD8^+、IL-2、TNF-α变化差异优于另外2组,维生素D组变化差异优于前列地尔组,差异均具有统计学意义(P<0.05);联合组的总有效率为95.2%(19/21)和维生素D组的71.4%(15/21)要高于前列地尔组47.6%(10/21),差异均具有统计学意义(P<0.05)。[结论]运用维生素D联合前列地尔治疗熊去氧胆酸应答不佳的原发性胆汁性肝硬变患者疗效良好,能够明显改善患者肝功能和免疫功能。

关键词：维生素D 前列地尔熊去氧胆酸原发性胆汁性肝硬化

视交叉周围肿瘤位置与视觉诱发电位受损程度的关系

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眼科研究 2010年第12期28卷 1180-1182页

作者：轩昂史大鹏河南省人民医院放射科郑州450003

目的分析视交叉周围肿瘤的磁共振成像(MRI)表现,探讨其与视觉诱发电位(VEP)异常的关系。方法回顾性病例分析。100例视交叉周围肿瘤同时行鞍区MRI及VEP检查,根据MRI显示肿瘤位置以及压迫方式的不同划分为A、B、C类。依据Silva标准将VEP... 详细信息

目的分析视交叉周围肿瘤的磁共振成像(MRI)表现,探讨其与视觉诱发电位(VEP)异常的关系。方法回顾性病例分析。100例视交叉周围肿瘤同时行鞍区MRI及VEP检查,根据MRI显示肿瘤位置以及压迫方式的不同划分为A、B、C类。依据Silva标准将VEP表现划分为Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ共5级。结果 MRI检查显示,57例肿瘤向上压迫视交叉(A类),18例肿瘤向下压迫视交叉(B类),25例视交叉被肿瘤包埋(C类)。3组视力下降的程度为C类>A类>B类。与A类肿瘤相比,C类VEP的异常率增加,差异有统计学意义(z=-2.632,P=0.008),A类比B类的VEP异常率高,差异有统计学意义(z=-3.964,P=0.000)。VEP的P100波隐含时接近正常(Ⅰ级)者18眼(18/114,15.8%)为A类,16眼(16/114,14.0%)为B类,C类0眼。仅表现为P100波隐含时延长或波幅下降(Ⅱ级)者A类40眼(40/114,35.1%),B类14眼(14/36,38.9%),C类17眼(17/50,34.0%)。P100波隐含时延长并波幅降低(Ⅲ)者A类50眼(50/114,43.9%),B类5眼(5/36,13.9%),C类28眼(28/50,56%)。P100波隐含时延长,波形难以辨认或记录不到(Ⅳ级、Ⅴ级)者A类2眼,B类及C类共3眼。结论视交叉周围肿瘤造成的VEP异常以肿瘤包埋视交叉时最重,视交叉向上受压次之,向下受压时最轻。

关键词：视交叉肿瘤视觉诱发电位磁共振成像

Associations between PRF1 Ala91 Val polymorphism and risk of hemophagocytic lymphohistiocytosis: a meta-analysis based on 1366 subjects

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World Journal of Pediatrics 2020年第6期16卷 598-606页

作者： Guang-Hua zhu Li-Ping z.ang zhi-Gang Li ang Wei Ying Yang Yu Tian Hong-Hao Ma Dong Wang Xiao-Xi zhao Yun-ze zhao Na Li Wei Liu Tian-You Wang Rui z.ang Beijing Children's Hospital.Nanlishi Road No.56 Xicheng DistrictBeijingChina

Background Perforin(PRF1)gene mutation can cause the onset of hemophagocytic lymphohistiocytosis(HLH).It has reported that PRFl Ala91 Val polymorphism was related with HLH *** the meta-analysis,we aim to evaluate the association between PRF1 Ala91 Val polymorphism and HLH *** We accomplished a meta-analysis of six published case-control studies including 391 patients with HLH and 975 *** evaluated the quality of each study through Newcastle-Ottawa Scale(NOS).Data analysis was performed with Stata *** In general,all studies were of high quality(NOS score higher than 7).There were statistically significant between the PRFl Ala91 Val polymorphism and HLH risk though the pooled analysis[for Ala/Val ***/Ala:pooled odds ratio(OR)=3.22,95%confidence interval(Cl)1.08-9.56,P=0.035,random model;for Ala/Val+Val/Val ***/Ala:pooled OR=2.96,95%Cl 1.14-7.69,P=0.025,random model].Furthermore,sensitivity analysis also revealed a relationship between PRFl Ala91Val polymorphism and HLH risk(for Ala/Val ***/Ala:pooled OR=5.236,95%Cl 2.72-10.08,P<0.000,/2=12.1%,^heterogeneity=0-332;for Ala/Val+Val/Val ***/Ala,pooled OR=4.856,95%Cl 2.66-8.85,P<0.000,/2=5.9%,Pheterogeneity=0.373).Funnel plot and Egger’s test did not indicate obvious published bias(P=0.841 for Ala/Val ***/Ala;?=0.284 for Ala/Val+Val/Val ***/Ala).Conclusion This meta-analysis indicated that PRFl Ala91 Val polymorphism affects the factor for developing HLH and future studies of PRFl Ala91 Val on the onset of HLH will be guaranteed.

关键词： Ala91Val polymorphism Hemophagocytic lymphohistiocytosis PRFl

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大数据背景下签到轨迹数据质量评价与实证

统计与决策 2019年第24期35卷 19-23页

作者：潘晓马昂石家庄铁道大学经济管理学院

随着定位技术的蓬勃发展,位置相关数据量呈指数式增长,其中数据劣质的问题日益显著。数据质量是统计工作的核心。轨迹大数据在各行各业应用渗透性不断扩大,确保轨迹大数据的可靠性、准确性和及时性,才能做出合理的决策,大数据的机遇和... 详细信息

随着定位技术的蓬勃发展,位置相关数据量呈指数式增长,其中数据劣质的问题日益显著。数据质量是统计工作的核心。轨迹大数据在各行各业应用渗透性不断扩大,确保轨迹大数据的可靠性、准确性和及时性,才能做出合理的决策,大数据的机遇和优势才能充分得到发挥。基于此,文章构建了大数据背景下签到轨迹数据质量的影响因素指标模型,利用真实的签到数据集,分析了影响签到轨迹数据质量的影响因素,并提出了提高签到轨迹数据质量的对策和方法。

关键词：签到轨迹数据数据质量大数据

Oral microbiome and pancreatic cancer

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World Journal of Gastroenterology 2020年第48期26卷 7679-7692页

作者： Ai-Lin Wei Mao Li Guo-Qing Li Xuan Wang Wei-Ming Hu zhen-Lu Li Jue Yuan Hong-Ying Liu Li-Li zhou Ka Li ang Li Mei Rosemary Fu Department of Pancreatic Surgery West China HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina Key Laboratory of Transplant Engineering and Immunology Regenerative Medicine Research CenterWest China HospitalSichuan UniversityChengdu 610000Sichuan ProvinceChina West China School of Public Health/West China fourth Hospital Sichuan UniversityChengdu 610000Sichuan ProvinceChina West China Hospital/West China School of Nursing Sichuan UniversityChengdu 610000Sichuan ProvinceChina Boston College William F.Connell School of Nursing Boston College William F.Connell SchoolMA02467United States

BACKGROUND Microbiota profiles differ between patients with pancreatic cancer and healthy people,and understanding these differences may help in early detection of pancreatic *** sampling is an easy and cost-effective way to determine microbiota profiles compared to fecal and tissue sample *** To investigate the saliva microbiome distribution in patients with pancreatic adenocarcinoma(PDAC)and the role of oral microbiota profiles in detection and risk prediction of pancreatic *** We conducted a prospective study of patients with pancreatic cancer(n=41)and healthy individuals(n=69).Bacterial taxa were identified by 16S ribosomal ribonucleic acid gene sequencing,and a linear discriminant analysis effect size algorithm was used to identify differences in *** taxonomic unit values of all selected taxa were converted into a normalized z-score,and logistic regressions were used to calculate risk prediction of pancreatic *** Compared with the healthy control group,carriage of Streptococcus and Leptotrichina(z-score)was associated with a higher risk of PDAC[odds ratio(OR)=5.344,95%confidence interval(CI):1.282-22.282,P=0.021 and OR=6.886,95%CI:1.423-33.337,P=0.016,respectively].Veillonella and Neisseria(z-score)were considered a protective microbe that decreased the risk of PDAC(OR=0.187,95%CI:0.055-0.631,P=0.007 and OR=0.309,95%CI:0.100-0.952,P=0.041,respectively).Among the patients with PDAC,patients reporting bloating have a higher abundance of Porphyromonas(P=0.039),Fusobacterium(P=0.024),and Alloprevotella(P=0.041);while patients reporting jaundice had a higher amount of Prevotella(P=0.008);patients reporting dark brown urine had a higher amount of Veillonella(P=0.035).Patients reporting diarrhea had a lower amount of Neisseria and Campylobacter(P=0.024 and P=0.034),and patients reporting vomiting had decreased Alloprevotella(P=0.036).CONCLUSION Saliva microbiome was able to distinguish patients with pancreatic ca

关键词： Oral microbiota Dysbiosis Pancreatic cancer Cancer detection 16s rRNA High-throughput sequencing

SURGERY AND MULTI MODAL THERAPYIN COLON-angIN RECTAL CANCER

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实用临床医药杂志 2005年第9期9卷 9-27页

作者： K.H.Link T.A.Sagban z.L.Ji Surgical Center and Asklepios Tumortreatment Center Rhein-Main(ATC) Asklepios Paulinen Klinik(APK)Wiesbaden Germany Dept.General and Visceral Surgery Puji HospitalYangzhou UniversityChina

1 SummaryThe 5-year-survival rates of surgically treated patients are varying and depend on UICC stages/substages with remarkable variations in between published reports, surgical hospital units, individual surgeons, and continents. These variations may be due to surgical techniques, training status, hospital and individual case volume, but also on referral patterns, and statistical evaluation methods. Survival time and cure rates are significantly improved by modern adjuvant chemotherapy in colon cancers UICC Ⅲ and in substages of UICC Ⅱ (e.g. UICC Ⅱ B) by 5%-16%, and adjuvant radiochemotherapy in rectal cancer by 10%-14% when compared to surgical controls. In three modern colon cancer trials standard adjuvant chemotherapy was further improved by increasing the survival rates, e.g. from 59% to 71% in stage Ⅲ and IIB patients. In rectal cancer neoadjuvant radio(chemo)therapy decreases local relapse rates vs. postoperative adjuvant radio(chemo)therapy. Since surgery in rectal cancer has also been significantly improved by total mesorectal excision (TME) and better surgical training, the indications and methods for multimodal therapy have changed from UICC Ⅱ+Ⅲ to more individual criteria. Molecular and genetic factors, such as thymidylate synthase (TS), microsatellite instability (MSI) or loss of chromosome 18q/DCC might have an independent impact on prognosis in the spontaneous course, but could also help to individually select colon and rectal cancer patients and treatment protocols for multimodal therapy. Thus, surgery and multimodal therapy has become very complex, needs regularly be updated in competent reviews, and should be conducted in specialized centers of multi-and interdisciplinary excellence.

关键词：结肠癌直肠癌手术治疗综合治疗