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Associations between PRF1 Ala91 Val polymorphism and risk of hemophagocytic lymphohistiocytosis: a meta-analysis based on 1366 subjects

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World Journal of Pediatrics 2020年第6期16卷 598-606页

作者： Guang-Hua zhu Li-Ping z.ang zhi-Gang Li ang Wei Ying Yang yu Tian Hong-Hao Ma Dong Wang Xiao-Xi zhao yun-ze zhao Na Li Wei Liu Tian-You Wang Rui z.ang Beijing Children's Hospital.Nanlishi Road No.56 Xicheng DistrictBeijingChina

Background Perforin(PRF1)gene mutation can cause the onset of hemophagocytic lymphohistiocytosis(HLH).It has reported that PRFl Ala91 Val polymorphism was related with HLH *** the meta-analysis,we aim to evaluate the association between PRF1 Ala91 Val polymorphism and HLH *** We accomplished a meta-analysis of six published case-control studies including 391 patients with HLH and 975 *** evaluated the quality of each study through Newcastle-Ottawa Scale(NOS).Data analysis was performed with Stata *** In general,all studies were of high quality(NOS score higher than 7).There were statistically significant between the PRFl Ala91 Val polymorphism and HLH risk though the pooled analysis[for Ala/Val ***/Ala:pooled odds ratio(OR)=3.22,95%confidence interval(Cl)1.08-9.56,P=0.035,random model;for Ala/Val+Val/Val ***/Ala:pooled OR=2.96,95%Cl 1.14-7.69,P=0.025,random model].Furthermore,sensitivity analysis also revealed a relationship between PRFl Ala91Val polymorphism and HLH risk(for Ala/Val ***/Ala:pooled OR=5.236,95%Cl 2.72-10.08,P<0.000,/2=12.1%,^heterogeneity=0-332;for Ala/Val+Val/Val ***/Ala,pooled OR=4.856,95%Cl 2.66-8.85,P<0.000,/2=5.9%,Pheterogeneity=0.373).Funnel plot and Egger’s test did not indicate obvious published bias(P=0.841 for Ala/Val ***/Ala;?=0.284 for Ala/Val+Val/Val ***/Ala).Conclusion This meta-analysis indicated that PRFl Ala91 Val polymorphism affects the factor for developing HLH and future studies of PRFl Ala91 Val on the onset of HLH will be guaranteed.

关键词： Ala91Val polymorphism Hemophagocytic lymphohistiocytosis PRFl

Depth determination of the Moho interface beneath the Tibetan plateau and other areas of China

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Earthquake Science 2012年第5期25卷 415-431页

作者： Youshun Sun Diming yu M Nafi Toksz F Dale Morgan Xiyu Wang Jinrong Su Jun Liu State Key Laboratory of Geodesy and Earth's Dynamics Institute of Geodesy and GeophysicsChinese Academy of Sciences Department of Earth Atmospheric and Planetary SciencesMassachusetts Institute of Technology Earthquake Administration of Sichuan Province School of Civil Engineering and Architecture Wuhan University of Technology

We apply the adaptive moving window method of Sun et al. to the most recent catalog data and the data recorded by portable stations to construct the velocity structure of the crust and upper mantle, and to determine the depth of the Moho interface beneath the Tibetan plateau and other areas of China. We first select 2 600 locations in the study region with 1° intervals, then at each location invert for a five-layer 1-D P-wave velocity model from the surface down to the uppermost mantle by performing a Monte Carlo random search. The Moho depth at each location is then determined, and the Moho interface beneath the study region is obtained through proper interpolation with certain smoothing. Compared to depths obtained by previous studies, our results show more accurate Moho depths in the Tibetan plateau, Tianshan region and other areas of the study region.

关键词： Moho depth Moho interface Tibetan plateau

Crustal and uppermost mantle structure of Caucasus and surrounding regions

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Earthquake Science 2012年第5期25卷 505-515页

作者： Youshun Sun M Nafi Toksz Randolph J Martin Mary Krasovec Diming yu Qingyun Liu Jun Liu State Key Laboratory of Geodesy and Earth's Dynamics Institute of Geodesy and GeophysicsChinese Academy of Sciences Department of Earth Atmospheric and Planetary SciencesMassachusetts Institute of Technology New England Research Inc.White River Jct. School of Civil Engineering and Architecture Wuhan University of Technology

A 3-D P-wave velocity model is developed for the crust and uppermost mantle of Caucasus and the surrounding area by applying the tomographic method of zhao et al. using 300 000 high-quality P-wave first arrivals from 43 000 events between 1964 and 2005. This tomographic method can accommodate velocity discontinuities such as the Moho in addition to smooth velocity variations. The spatial resolution is 1°× 1° in the horizontal direction and 10 km in depth. The velocity images of the upper crust correspond well with the surface geology. Beneath the southern Caucasus high velocity anomalies are found in the middle crust and low velocity anomalies are found in the uppermost mantle. Relatively low Pn velocities are located under the Lesser Caucasus, eastern Turkey, and northern Iran. Higher Pn velocities occur under the eastern portion of the Black Sea and the southern Caspian Sea, and also extend into the eastern edge of Azerbaijan. Tomographic model significantly reduces the travel-time residuals.

关键词： Caucasus region crustal structure Pn velocity 3-D tomography

Review on the study of metallurgical process engineering

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International Journal of Minerals,Metallurgy and Materials 2021年第8期28卷 1253-1263页

作者： Rui-yu Yin Central Iron and Steel Research Institute Beijing 100081China

After nearly one hundred years of research, metallurgy(metallurgical science and engineering) has gradually become a system with three levels of knowledge:(1) micro metallurgy at the atomic/molecular scale,(2) process metallurgy at the procedure/device, and(3) macrodynamic metallurgy at the full process/process group. Macro-dynamic metallurgy development must eliminate the concept of an "isolated system" and establish concepts of "flow," "process network," and "operating program" to study the "structure–function–efficiency" in the macrodynamic operation of metallurgical manufacturing processes. It means considering "flow" as the ontology and observing dynamic change by"flow" to solve the green and intelligent potential of metallurgical enterprises. Metallurgical process engineering is integrated metallurgy, toplevel designed metallurgy, macro-dynamic operated metallurgy, and engineering science level metallurgy. Metallurgical process engineering is a cross-level, comprehensive, and integrated study of the macro-dynamic operation of manufacturing processes. Metallurgical process engineering studies the physical nature and constitutive characteristics of the dynamic operation of steel manufacturing process, as well as the analysis-optimization of the set of procedure functions, coordination-optimization of the set of procedures' relations, and reconstruction-optimization of the set of procedures in the manufacturing process. The study establishes rules for the macro operation of the manufacturing process, as well as dynamic and precise objectives of engineering design and production operation.

关键词： metallurgical process engineering cross-level comprehensive integration macro-dynamic operation new branch of metallurgy

急性主动脉夹层合并2型糖尿病患者危险因素、预后及快速筛查研究

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中国全科医学 2025年第9期28卷 1100-1105页

作者：黄璐捷张小英俞莎莎浙江省宁波市医疗中心李惠利医院老年医学科

背景急性主动脉夹层（AAD）合并2型糖尿病的发病率呈上升趋势，然而，关于其危险因素和预后的研究较少。因此，积极寻求临床一种简便且有效的诊断工具已成为研究的重点。目的分析AAD合并2型糖尿病患者危险因素、预后及快速筛查方法。方... 详细信息

背景急性主动脉夹层（AAD）合并2型糖尿病的发病率呈上升趋势，然而，关于其危险因素和预后的研究较少。因此，积极寻求临床一种简便且有效的诊断工具已成为研究的重点。目的分析AAD合并2型糖尿病患者危险因素、预后及快速筛查方法。方法选取2016年1月—2022年10月宁波市医疗中心李惠利医院收治的168例AAD患者为研究对象，使用主动脉夹层检测风险评分（ADD-RS）量表对患者进行初筛分诊。选用主动脉CT血管造影（CTA）检查结果作为AAD确诊的“金标准”，比较主动脉CTA确诊结果与ADD-RS量表的初筛结果。根据是否合并2型糖尿病分为糖尿病组和非糖尿病组，收集两组的一般资料，采用多因素Logistic回归分析探讨AAD患者合并2型糖尿病的危险因素；比较两组的短期预后及疼痛评分。采用多因素Cox回归分析AAD患者短期预后的影响因素，采用受试者工作特征（ROC）曲线分析ADD-RS量表对AAD合并2型糖尿病的筛查价值。结果本研究糖尿病组59例，非糖尿病组109例。多因素Logistic回归分析显示，增龄（OR=1.088,95%CI=1.042～1.136,P0.05）；两组30 d死亡率分别为3.39%和3.67%，差异无统计学意义（P>0.05）。多因素Cox回归分析显示高血压不是影响AAD患者短期预后的独立因素（HR=0.673,95%CI=0.094～4.791,P>0.05）。糖尿病组的ADD-RS为1(1)分，高于非糖尿病组的1(2)分（z=-4.640,Pz=2.309,P=0.021）;ADD-RS量表筛查AAD合并2型糖尿病的ROC曲线下面积为0.706(95%CI=0.634～0.779)。结论 AAD合并2型糖尿病患者的危险因素有年龄增高、BMI≥25 kg/m2、冠心病、高脂血症、LVEF升高，且ADD-RS量表在AAD合并2型糖尿病患者的风险评估中具有较高的临床筛查价值。

关键词：急性主动脉夹层糖尿病,2型主动脉夹层检测风险评分快速诊治

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基于PFV策略的连续型元胞自动机交通流模型

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交通运输系统工程与信息 2019年第3期19卷 75-80页

作者：彭勇沙晓宇刘世洁 DENNIS z. yu 重庆交通大学交通运输学院重庆400074 海口市交通运输和港航管理局海口570135 克拉克森大学商学院波茨坦NY13699美国

科学合理的微观交通流仿真模型是研究交通控制手段有效性的关键.本文结合一种考虑驾驶员视野内前后多车影响的跟驰策略,建立了连续型元胞自动机交通流模型.仿真实验表明,仿真数据与实测数据有较好的拟合性,仿真得到的K-Q、K-V和Q-V图能... 详细信息

科学合理的微观交通流仿真模型是研究交通控制手段有效性的关键.本文结合一种考虑驾驶员视野内前后多车影响的跟驰策略,建立了连续型元胞自动机交通流模型.仿真实验表明,仿真数据与实测数据有较好的拟合性,仿真得到的K-Q、K-V和Q-V图能较好地反映实际道路交通流的失稳现象,所建立的模型具有适应不同场景的兼容性与灵活性,能够作为研究我国实际道路交通流问题的仿真工具.

关键词：综合交通运输跟驰策略元胞自动机交通流交通系统仿真

两种织纹螺对TTX和PSP摄食转移的初步研究

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厦门大学学报（自然科学版） 2007年第A01期46卷 124-126页

作者：张雷郁昂于杰厦门大学近海海洋环境科学国家重点实验室环境科学研究中心福建厦门361005

织纹螺(Nassariusspp.)是沿海地区较常见的螺种之一,对其带毒途径现还存有分歧.本文选择厦门海域常见两种织纹螺,粗肋织纹螺(Nassarius nodiferus)和红带织纹螺(Nassarius succinctus)作为研究对象,以实验室生态环境下培养的塔玛亚历山... 详细信息

织纹螺(Nassariusspp.)是沿海地区较常见的螺种之一,对其带毒途径现还存有分歧.本文选择厦门海域常见两种织纹螺,粗肋织纹螺(Nassarius nodiferus)和红带织纹螺(Nassarius succinctus)作为研究对象,以实验室生态环境下培养的塔玛亚历山大藻和月腹刺鲀内脏投喂织纹螺.采用美国分析化学家协会推荐的小白鼠的生物检测法,对织纹螺进行毒素检测.小白鼠生物检测结果表明,红带织纹螺本身不带毒性,而粗肋织纹螺本身带有毒性,麻痹性贝毒和河豚毒素两种毒素都可以通过摄食转移累积毒性.

关键词：织纹螺河豚毒素麻痹性贝毒小白鼠生物测定法

Effects of temperature and thermally-induced microstructure change on hydraulic conductivity of Boom Clay

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第3期9卷 1-13页

作者： W.z. Chen Y.S. Ma H.D. yu F.F. Li X.L. Li X. Sillen Research Centre of Geotechnical and Structural Engineering Shandong University Jinan Shandong 250061 China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil Mechanics Chinese Academy of Sciences Wuhan 430071 China University of Chinese Academy of Sciences Beijing 100049 China European Underground Research Infrastructure for Disposal of Nuclear Waste in Clay Environment EIG Euridice Mol 2400 Belgium ONDRAF/NIRAS Brussel 1210 Belgium

Boom Clay is one of the potential host rocks for deep geological disposal of high-level radioactive nuclear waste in Belgium. In order to investigate the mechanism of hydraulic conductivity variation under complex thermo-mechanical coupling conditions and to better understand the thermo-hydromechanical(THM) coupling behaviour of Boom Clay, a series of permeability tests using temperaturecontrolled triaxial cell has been carried out on the Boom Clay samples taken from Belgian underground research laboratory(URL) HADES. Due to its sedimentary nature, Boom Clay presents acrossanisotropy with respect to its sub-horizontal bedding plane. Direct measurements of the vertical(Kv)and horizontal(Kh)hydraulic conductivities show that the hydraulic conductivity at 80℃ is about 2.4 times larger than that at room temperature(23℃), and the hydraulic conductivity variation with temperature is basically reversible during heatingecooling cycle. The anisotropic property of Boom Clay is studied by scanning electron microscope(SEM) tests, which highlight the transversely isotropic characteristics of intact Boom Clay. It is shown that the sub-horizontal bedding feature accounts for the horizontal permeability higher than the vertical one. The measured increment in hydraulic conductivity with temperature is lower than the calculated one when merely considering the changes in water kinematic viscosity and density with temperature. The nuclear magnetic resonance(NMR) tests have also been carried out to investigate the impact of microstructure variation on the THM properties of clay. The results show that heating under unconstrained boundary condition will produce larger size of pores and weaken the microstructure. The discrepancy between the hydraulic conductivity experimentally measured and predicted(considering water viscosity and density changes with temperature) can be attributed to the microstructural weakening effect on the thermal volume change behaviour of Boom Clay. Based on the ex

关键词： Boom Clay Permeability Thermal effect Anisotropy Microstructure

A first order superfluid-Mott insulator transition for a Bose–Hubbard model in an emergent lattice

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Communications in Theoretical Physics 2022年第12期74卷 124-129页

作者： yu Chen Graduate School of China Academy of Engineering Physics Beijing 100193China

The combination of strong correlation and emergent lattice can be achieved when quantum gases are confined in a superradiant Fabry–Perot *** addition to the discoveries of exotic phases,such as density wave ordered Mott insulator and superfluid,a surprising kink structure is found in the slope of the cavity strength as a function of the pumping *** this article,we show that the appearance of such a kink is a manifestation of a liquid–vapour-like transition between two superfluids with different *** slopes in the immediate neighborhood of the kink become divergent at the liquid–vapour critical points and display a critical scaling law with a critical exponent 1 in the quantum critical region.

关键词： Bose-Hubbard model emergent symmetry cavity QED liquid-gas transition