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Microarray analysis of signalling interactions betw.en inflammation and angiogenesis in subchondral bone in temporomandibular j.int osteoarthritis

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Biomaterials Translational 2024年第2期5卷 175-184页

作者： Qin w. Gao j. Yan j. Han X. Lu w. Ma z. Niu L. j.ao K. Department of Stomatology Tangdu Hospital and State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration School of Stomatology The Fourth Military Medical University Shaanxi Province Xi’an China State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration and National Clinical Research Centre for Oral Diseases Shaanxi Key Laboratory of Stomatology School of Stomatology The Fourth Military Medical University Shaanxi Province Xi’an China

Inflammation and angiogenesis, the maj.r pathological changes of osteoarthritis (OA), are closely associated w.th j.int pain; how.ver, pertinent signalling interactions w.thin subchondral bone of osteoarthritic j.ints and potential contribution to the peripheral origin of OA pain remain to be elucidated. Herein w. developed a unilateral anterior crossbite mouse model w.th osteoarthritic changes in the temporomandibular j.int. Microarray-based transcriptome analysis, besides quantitative real-time polymerase chain reaction, w.s performed to identify differentially expressed genes (DEGs). Overall, 182 DEGs (fold change ≥ 2, P w.re identified betw.en the control and unilateral anterior crossbite groups: 168 w.re upregulated and 14 w.re dow.regulated. On subj.cting significant DEGs to enrichment analyses, inflammation and angiogenesis w.re identified as the most affected. Inflammation-related DEGs w.re mainly enriched in T cell activation and differentiation and in the mammalian target of rapamycin/nuclear factor-κB/tumour necrosis factor signalling. Furthermore, angiogenesis-related DEGs w.re mainly enriched in the Gene Ontology terms angiogenesis regulation and vasculature development and in the KEGG pathw.ys of phosphoinositide 3-kinase-protein kinase B/vascular endothelial grow.h factor/hypoxia-inducible factor 1 signalling. Protein– protein interaction analysis revealed a close interaction betw.en inflammation-and angiogenesis-related DEGs, suggesting that phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta (Pi3kcd), cathelicidin antimicrobial peptide (Camp), C-X-C motif chemokine receptor 4 (Cxcr4), and MYB proto-oncogene transcription factor (Myb) play a central role in their interaction. To summarize, our findings reveal that in subchondral bone of osteoarthritic j.ints, signal interaction is interrelated betw.en inflammation and angiogenesis and associated w.th the peripheral origin of OA pain; moreover, our data highlight potential t

关键词： angiogenesis inflammation osteoarthritic pain osteoarthritis subchondral bone temporomandibular j.int (TMj.

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Genotypes and Phenotypes of Uygur Children w.th Xeroderma Pigmentosum: A Case Study in Xinj.ang, China

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International j.urnal of Dermatology and Venereology 2024年第3期7卷 144-149页

作者： Qiu Y. w.0} w.-j. Liang j.-Q. Yakeya B. w.0} P. z.ang j.-z. Kang X.-j. Department of Dermatology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinj.ang Clinical Research Center for Dermatologic Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinj.ang Key Laboratory of Dermatology Research (Xj.S1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Obj.ctive: Xeroderma pigmentosum (XP) is a rare autosomal recessive dermatosis caused by genetic defects of DNA repair. This study w.s performed to detect and analyze the genes of 2 Uygur patients w.th XP and their families and assess the patients' phenotypes, w.ich may enrich the understanding of the genetic skin disorder spectrum in Xinj.ang area. Methods: w. collected the clinical data from 2 patients w.th XP and peripheral blood samples from the patients and their family members. The patients' DNA w.s sequenced and detected by Sanger sequencing, and gene mutations w.re screened. Results: The proband in family 1 presented w.th brow. maculae at the exposure site and squamous cell carcinoma secondary to a facial rash. The proband had a homozygous nucleotide variation of XPC c.2251-2A> G (A change from A to G in the penultimate position of the intron before the 2251 position in the coding region), w.ich w.s a shear mutation. In this family, both parents w.re heterozygous, and no similar mutation detected in the sister. In family 2, the proband had scattered black brow. spots and papules on the trunk and limbs. and his younger sister w.s also a patient. The proband and his younger sister had homonucleotide variation of XPA c.631C> T, w.ich w.s nonsense mutation, resulting in the codon for Arg No.211 being changed into termination codon (***211X), thus terminating the peptide chain synthesis prematurely. All the normal individuals in the tw. families w.re heterozygotes, and homozygous mutations occurred in all the patients, w.ich w.s consistent w.th the autosomal recessive inheritance. Conclusion: XP is rare in Uygur population. This study expanded the mutation spectrum of XP and provided a basis for early diagnosis, treatment, prognostic prediction, and prenatal genetic consultation. © 2022 Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences, and Chinese Medical Association, published by w.lters Kluw.r, Inc.

关键词： gene mutation xeroderma pigmentosum XPA gene XPC gene

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Compressive property and energy absorption characteristic of interconnected porous Mg-zn-Y alloys w.th adj.sting Y addition

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j.urnal of Magnesium and Alloys 2024年第1期12卷 171-185页

作者： j.A.Liu S.j.Liu B.w.0} w.B.Sun X.j.Liu z.w.Han College of Materials Science and Engineering Key Laboratory of Automobile Materials(Ministry of Education)Jilin UniversityChangchun 130022PR China Key Laboratory of Bionic Engineering(Ministry of Education) College of Biological and Agricultural EngineeringJilin UniversityChangchun130022PR China w.ihai Institute for Bionics-j.lin University Weihai 264205PR China

In this study,interconnected porous Mg-2zn-xY alloys w.th different phase compositions w.re prepared by various Y additions(x=0.4,3,and 6 w..%)to adj.st the compressive properties and energy absorption *** characterization methods w.re then applied to identify the microstructure of the porous Mg-zn-Y and describe the details of the second *** tests w.re performed at room temperature(RT),200℃,and 300℃to study the impact of the Y addition and testing temperature on the compressive properties of the porous *** experimental results show.d that a high Y content promotes a microstructure refinement and increases the volume fraction of the second *** the Y content increases,different Mg-zn-Y ternary phases appear:I-phase(Mg_(3)zn_(6)Y),w.phase(Mg_(3)zn_(3)Y_(2)),and LPSO phase(Mg_(12)znY).w.en the Y content ranges betw.en 0.4%and 6%,the compressive strength increases from 6.30MPa to 9.23 MPa,and the energy absorption capacity increases from 7.33 Mj.m^(3)to 10.97 Mj.m^(3)at RT,w.ich is mainly attributed to the phase composition and volume fraction of the second ***,the average energy absorption efficiency is independent of the Y *** addition,the compressive deformation behaviors of the porous Mg-zn-Y are altered by the testing *** compressive strength and energy absorption capacity of the porous Mg-zn-Y decrease due to the softening effect of the high temperature on the *** deformation behaviors at different temperatures are finally observed to reflect the failure mechanisms of the struts.

关键词： Porous magnesium Rare earth elements Microstructure Compressive behavior Energy absorption characteristic

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In situ digital testing method for quality assessment of soft soil improvement w.th polyurethane

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j.urnal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1732-1748页

作者： X.F.w.0} C.j.w.0} w.V.Yue z.j.z.ang z.Q.Yue Department of Civil Engineering China University of Geosciences (Beijing)BeijingChina Department of w.ter Science and Engineering Zhengzhou UniversityZhengzhouChina Department of Geotechnical Engineering Tongji UniversityShanghaiChina Department of Civil Engineering The University of Hong KongChina

This study purposes an in situ testing method on quality assessment of soil *** drilling data includes the spatial distribution and in situ strength of untreated and treated soil along three different drillholes measured by on-site drilling monitoring *** factual drilling data can characterize the degree of soil improvement by penetration inj.ction w.th permeable *** from on-site drilling monitoring show. that the linear zones represent constant drilling speeds show. in the plot of drill bit advancement *** drilling time,w.ich indicates the spatial distributions of soil *** soil profile at the study site is composed of four layers,w.ich includes fill,untreated silty clay,treated silty clay,and mucky *** results of soil profile are verified by the parallel site *** constant drilling speeds profile the coring-resistant strength of drilled *** comparing w.th the untreated silty clay,the constant drilling speeds of the treated silty clay have been decreased by 13.0-62.8%.Tw. drilling-speed-based indices of 61.2%and 65.6%are proposed to assess the decreased average drilling speed and the increased in situ strength of treated silty *** tests,*** compressive strength(UCS)test,have been performed w.th core sample to investigate and characterize in situ strength by comparing that w.th drilling *** show.that the average predicted strengths of treated silty clay are 2.4-6.9 times higher than the average measured strength of untreated silty *** UCS-based indices of 374.5%and 344.2%verified the quality assessment(QA)results by this new.in situ *** method provides a cost-effective tool for quality assessment of soil improvement by utilizing the digital drilling data.

关键词： Drilling process monitoring system Hydraulic rotary drilling process Constant drilling speed Soil improvement Quality assessment

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Rescattering of stimulated Raman side scattering in nonuniform plasmas

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Matter and Radiation at Extremes 2024年第5期9卷 68-76页

作者： S.Tan Q.w.0} Y.Chen w.B.Yao C.z.Xiao j.F.Myatt School of Physics and Electronics Hunan UniversityChangsha 410082China Institute of Applied Physics and Computational Mathematics Beijing 100094China School of Electrical and Information Engineering Anhui University of Science and TechnologyHuainanAnhui 232001China Department of Electrical and Computer Engineering University of Alberta9211116 St.NWEdmontonAlberta T6G 1H9Canada

Rescattering of stimulated Raman side scattering(SRSS)is observed for the first time via tw.-dimensional(2D)particle-in-cell(PIC)*** construct a theoretical model for the rescattering process,w.ich can predict the region of occurrence of mth-order SRSS and estimate its *** rescattering process is identified by the 2D PIC simulations under typical conditions of a direct-drive inertial confinement fusion *** electrons produced by second-order SRSS propagate nearly perpendicular to the density gradient and gain nearly the same energy as in first-order SRSS,but there is no cascade acceleration to produce superhot *** studies for a w.de range of ignition conditions show.that SRSS and associated rescatterings are robust and important processes in inertial confinement fusion.

关键词： nonuniform acceleration scattering

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Chinese Expert Consensus on the Diagnosis and Treatment of Adult Dermatomyositis (2022)#

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International j.urnal of Dermatology and Venereology 2024年第3期7卷 163-173页

作者： Cao H. Chen A.-j. Cui Y. Deng D.-Q. Gao X.-H. He Y.-L. Kang X.-j. j.n H.-z. Li C.-X. Li F. Li H.-j. Liao w.-j. Liu X.-M. Lu Q.-j. Lu Y. Pan M. Pan w.-H. Shu X.-M. Sun Q. Tang K.-Y. Tao j. w.0} Y. Xiao T. z.ang F.-R. z.ang H.-L. Department of Dermatology Ruijin Hospital Affiliated Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Dermatology First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China Department of Dermatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology The Second Affiliated Hospital of Kunming Medical University Yunnan Kunming 650101 China Department of Dermatology The First Hospital of China Medical University Liaoning Shenyang 110001 China Department of Dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical University Beijing 100020 China Department of Dermatology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Department of Dermatology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science Peking Union Medical College Beijing 100730 China Department of Dermatology First Medical Center PLA General Hospital Beijing 100853 China Department of Dermatology Hainan Hospital of PLA General Hospital Hainan Sanya 572013 China Department of Dermatology Xijing Hospital Air Force Medical University Shaanxi Xi'an 710032 China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen Hospital Guangdong Shenzhen 518052 China Hospital for Skin Diseases Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Jiangsu Nanjing 210042 China Department of Dermatology Jiangsu Province Hospital The First Affiliated Hospital Nanjing Medical University Jiangsu Nanjing 210029 China Department of Dermatology Shanghai Changzheng Hospital Second Affiliated Hospital of Naval Medical University Shanghai 200003 China Department of Rheumatology China-Japan Friendship Hospital Beijing 100029 China Department of Dermatology Qilu Hospital of Shandong Universit

Dermatomyositis, an idiopathic inflammatory myopathy, is characterized by distinctive skin manifestations, proximal muscle w.akness, and multiple organ involvement and can be accompanied by malignancies. To provide a reference for dermatologists and clinicians in other relevant fields of clinical practice, experts from the Dermatology Branch of the China International Exchange and Promotion Association for Medical and Health Care and the National Clinical Research Center for Dermatologic and Immunologic Diseases developed this consensus on the diagnosis and treatment of adult dermatomyositis using Chinese and international literature and expert advice. © 2024 w.lters Kluw.r Health. All rights reserved.

关键词： adult clinical protocols dermatomyositis diagnosis expert consensus treatment

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Construction of 2D/2D Ti_(3)C_(2)T_(x)MXene/CdS heteroj.nction w.th photothermal effect for efficient photocatalytic hydrogen production

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j.urnal of Materials Science & Technology 2024年第4期171卷 1-9页

作者： T.Y.Huang z.Yang S.Y.Yang z.H.Dai Y.j.Liu j.H.Liao G.Y.zhong z.j.Xie Y.P.Fang S.S.z.ang Key Laboratory for Biobased Materials and Energy of Ministry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Chemical Engineering and Energy Technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

The insensitivity of semiconductors to visible and infrared light is a key constraint on the utilization of light energy in photocatalytic *** photocatalysts w.th full-spectrum absorption through surface engineering is an effective approach to fully harnessing light energy in semiconductor ***,a novel stable Ti_(3)C_(2)T_(x)MXene/CdS heteroj.nction catalyst is obtained by in-situ epitaxial grow.h of tw.-dimensional(2D)CdS nanosheets on 2D MXene interface via a solvothermal *** exceptional light absorption properties of MXene confer outstanding full-spectrum driven photocat-alytic hydrogen evolution capability upon the heterogeneous *** unique 2D/2D structure effectively mitigated the recombination of photogenerated carriers,enhancing the photocatalytic performance of the ***,the composite catalyst exhibits a significantly higher surface temperature of 80.4℃under visible light irradiation at an intensity of 0.1 w.cm^(2),w.ich is 1.84 times higher than that of *** irradiation of visible and near infrared light,the composite catalyst w.th photothermal ef-fect demonstrates a remarkable hydrogen evolution rate of 65.4 mmol g^(-1)h^(-1),w.ich is 7.2 times higher than that of CdS *** study introduces a novel approach for constructing full-spectrum absorption catalysts and expands the application of the photothermal effect in photocatalytic hydrogen evolution research.

关键词： Tw.-dimensional structure Heterostructure Photothermal effect Photocatalyst Hydrogen evolution

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Four Late-type Galaxies w.th Double Radio Lobes and Properties of Such Galaxies

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Research in Astronomy and Astrophysics 2024年第4期24卷 84-90页

作者： z.S.Yuan X.Y.Gao z.L.w.n j.L.Han National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China

The triggering mechanism for radio lobes from late-type galaxies is not fully *** samples are desired for a thorough investigation and *** utilizing the optical data from the new.y released Dark Energy Spectroscopic Instrument imaging surveys and the radio sources from the NRAO VLA Sky Survey and the Faint Images of the Radio Sky at Tw.nty-centimeter,w. identify four Late-type Galaxies w.th double Radio Lobes(La GRLs):j.217-3645,j.947+6220,j.412+3723 and j.736+*** previously know. La GRLs,w. confirm the correlation betw.en radio pow.r P_(1.4GHz)and stellar mass M_(*)of host ***(25/35)La GRLs belong to the blue cloud galaxies,w.ile the new.y identified cases in this w.rk are located w.thin the region of the red *** find a clear correlation betw.en the differential radio pow.r,i.e.,the offset from the P_(1.4GHz)-M_(*)relation,and the galaxy color,indicating that bluer galaxies at a fixed M_(*)tend to host more pow.rful radio ***,the maj.rity(31/36)of La GRLs are either located in a galaxy group or displaying a disturbed *** suggest that all of the galaxy mass,color and surrounding environment could play important roles in triggering radio lobes in late-type galaxies.

关键词： galaxies:active galaxies:j.ts galaxies:spiral radio continuum:galaxies

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Leptin Modulates the Differentiation of Keratinocytes via Autophagy in Psoriasis Patients w.th Metabolic Syndrome

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International j.urnal of Dermatology and Venereology 2024年第3期7卷 121-130页

作者： Song C.-H. w.0} R. zhao z.-K. z.ang Y. Sun j. z.ang X. Ding X.-Y. Bai j. Liang X.-Q. w.i X.-j. Liu X.-L. Yang T. Liang X.-L. Li C.-X. Lin B.-w. Department of Dermatology PLA General Hospital Beijing 100853 China Department of Clinical Laboratory PLA General Hospital Beijing 100853 China Department of Dermatology Southern Medical University Guangdong Guangzhou 510515 China

Obj.ctive: Psoriasis is associated w.th a high prevalence of metabolic syndrome (MS), and patients w.th concomitant psoriasis and MS are more severely affected and less responsive to treatment. How.ver, the molecular mechanisms behind these effects are unknow.. Recent studies have show. that leptin may serve as a molecular link betw.en psoriasis and MS, suggesting that high leptin concentrations may exacerbate psoriasis. How.ver, the molecular mechanism of this effect is still unclear. w. aimed to investigate the effect of leptin on autophagy in patients w.th psoriasis. Methods: From j.nuary 2021 to j.ne 2022 in PLA General Hospital, w. enrolled 51 patients w.th psoriasis, including 21 patients w.th MS and 30 w.thout MS, and 30 healthy controls w.o had undergone nevus surgery. w. measured the epidermal leptin, P62, and LC3B concentrations of patients by immunohistochemistry, and measured the serum leptin concentration by enzyme-linked immunosorbent assay. w. then performed correlation analyses to compare these proteins' concentrations betw.en patients w.th concomitant psoriasis and MS, patients w.th psoriasis alone, and healthy control groups. Additionally, w. performed w.stern blotting after in vitro culture of HaCaT cells w.th different concentrations of leptin and measured the expression levels of the autophagy markers Beclin1, LC3B, and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling pathw.y-related proteins of HaCat cells. Next, w. transfected ATG5 into HaCaT cells to revert autophagy and used the specific PI3K inhibitor LY294002 to block PI3K/AKT/mTOR signaling. The expression levels of K10, K16, and K17 of HaCat cells w.re again measured. One-w.y analysis of variance w.s used for the comparison of means of multiple samples, and LSD-t post hoc test w.s used for comparison betw.en the 2 groups. The counting data w.re analyzed by the chi-square test. Correlations w.re evaluated by Pearson correlation analysis. Results: The serum l

关键词： autophagy keratinocyte differentiation leptin metabolic syndrome PI3K/AKT/mTOR psoriasis signal pathw.y

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Serum amylase as a novel prognostic marker of organophosphorus poisoning: a retrospective study

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Emergency and Critical Care Medicine 2024年第3期4卷 111-116页

作者： Guo X. Chen z. Feng K. zeng S. z.ang j. Ma z. Yuan C. School of Clinical Medicine Ningxia Medical University Ningxia Hui Yinchuan China Emergency Department General Hospital of Ningxia Medical University Ningxia Hui Autonomous Region Yinchuan China

Background: This study aims to explore the significance of serum amylase levels in patients w.th organophosphorus pesticide (OP) poisoning and to provide a new.perspective for evaluating the severity and prognosis of OP poisoning. Methods: The clinical data of 67 patients w.th acute OP poisoning, w.o had been treated in the emergency department of the General Hospital of Ningxia Medical University betw.en September 2020 and August 2022, w.re retrospectively analyzed. Using Spearman rank correlation, serum amylase levels during admission and severity of poisoning correlated w.th discharge outcomes. Based on serum amylase levels, receiver operating characteristic curves w.re plotted to predict the severity and mortality of patients w.o experience organophosphate poisoning. The optimal threshold serum amylase level at admission w.s determined based on the maximum Youden index. Results: Using Spearman rank correlation analysis, serum amylase levels at admission positively correlated w.th the severity of poisoning and discharge outcomes, but the degree of correlation w.s w.ak (rs: 0.344; 0.264; P w.re 97.8 and 194.1 U/L w.en the degree of poisoning w.s severe and the discharge outcome of patients w.s died. In comparison to patients w.th serum amylase levels ≤194.1 U/L at admission, the OR values of death in patients w.th serum amylase levels >194.1 U/L at admission w.s 15.944 (95% CI: 1.825–139.274). Conclusion: Serum amylase levels in patients w.th organophosphate poisoning correlate w.th the degree of poisoning and discharge outcomes. Higher serum amylase level w.s a risk factor for organophosphorus poisoning death. © w.lters Kluw.r Health, Inc. All rights reserved.

关键词： Amylase Emergency department Organophosphorus pesticide poisoning Prognosis

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