检索结果-南通市图书馆

Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders

Neural Regeneration Research 2024年第6期19卷 1256-1261页

作者： Helen M.Knight Merve DemirbugenÖz Adriana PerezGrovas-Saltijeral Division of Cells Organisms and Molecular GeneticsSchool of Life SciencesUniversity of NottinghamNottinghamUK Department of Pharmaceutical Toxicology Faculty of PharmacyAnkara UniversityAnkaraTurkey

The study of modified RNA known as epitranscriptomics has become increasingly relevant in our understanding of disease-modifying *** of N6 adenosine(m^(6)A)and C5 cytosine(m^(5)C)bases occur on mRNAs,tRNA,mt-tRNA,and rRNA species as well as non-coding *** emerging knowledge of RNA binding proteins that act as writer,reader,and eraser effector proteins,comes a new understanding of physiological processes controlled by these *** processes when spatiotemporally disrupted within cellular nanodomains in highly specialized tissues such as the brain,give rise to different forms of *** this review,we discuss accumulating evidence that changes in the m^(6)A and m^(5)C methylation systems contribute to neurocognitive *** studies first identified mutations within FMR1 to cause intellectual disability Fragile X syndromes several years before FMR1 was identified as an m^(6)A RNA reader ***,familial mutations within the m^(6)A writer gene METTL5,m^(5)C writer genes NSUN2,NSUN3,NSUN5,and NSUN6,as well as THOC2 and THOC6 that form a protein complex with the m^(5)C reader protein ALYREF,were recognized to cause intellectual development ***,differences in expression of the m^(5)C writer and reader effector proteins,NSUN6,NSUN7,and ALYREF in brain tissue are indicated in individuals with Alzheimer's disease,individuals with a high neuropathological load or have suffered traumatic brain ***,an abundance of m^(6)A reader and anti-reader proteins are reported to change across brain regions in Lewy bodies diseases,Alzheimer's disease,and individuals with high cognitive reserve.m^(6)A-modified RNAs are also reported significantly more abundant in dementia with Lewy bodies brain tissue but significantly reduced in Parkinson's disease tissue,whilst modified RNAs are misplaced within diseased cells,particularly where synapses are *** parahippocampal brain tissue,m^(6)A modification is enri

关键词： 5-methylcytosine methylation Alzheimer's disease cognitive diseases epitranscriptomics intellectual disability Lewy body diseases N6 adenosine RNA modification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unlocking the potential of amorphous calcium carbonate: A star ascending in the realm of biomedical application

引用

Acta Pharmaceutica Sinica B 2024年第2期14卷 602-622页

作者： Han liu zhiyang wen zihan liu Yanfang Yang Hongliang wang Xuejun Xia Jun Ye Yuling liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Calcium-based biomaterials have been intensively studied in the field of drug delivery owing to their excellent biocompatibility and ***-based materials can also deliver contrast agents,which can enhance real-time imaging and exert a Ca^(2+)-interfering therapeutic *** on these characteristics,amorphous calcium carbonate(ACC),as a brunch of calcium-based biomaterials,has the potential to become a widely used *** functional ACC can be either discovered in natural organisms or obtained by chemical synthesis However,the standalone presence of ACC is unstable in *** are required to be used as stabilizers or core-shell structures formed by permeable layers or lipids with modified molecules constructed to maintain the stability of ACC until the ACC carrier reaches its *** has high chemical instability and can produce biocompatible products when exposed to an acidic condition in vivo,such as Ca^(2+) with an immune-regulating ability and CO_(2) with an imaging-enhancing *** to these characteristics,ACC has been studied for selfsacrificing templates of carrier construction,targeted delivery of oncology drugs,immunomodulation,tumor imaging,tissue engineering,and calcium *** in this paper has been placed on the origin,structural features,and multiple applications of ***,ACC faces many challenges in clinical translation,and long-term basic research is required to overcome these *** hope that this study will contribute to future innovative research on ACC.

关键词： Amorphous calcium carbonate Drugdelivery system Nanoparticle Acid sensitivity water instability,Tumortherapy Tissue engineering Calcium supplement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

GwAS unravels acid phosphatase ACP2 as a photosynthesis regulator under phosphate starvation conditions through modulating serine metabolism in rice

引用

Plant Communications 2024年第7期5卷 106-119页

作者： Sushuang liu zhan Xu Jemaa Essemine Yanmin liu Chundong liu Feixue zhang zubair Iqbal Mingnan Qu Jiangsu Key Laboratory of Crop Genetics and Physiology/Jiangsu Key Laboratory of Crop Cultivation and Physiology Agricultural College of Yangzhou UniversityYangzhou 225009China Department of Life Sciences and Health Huzhou CollegeHuzhou 313000China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Institute of Crop Huzhou Academy of Agricultural SciencesHuzhou 313000China These authors contributed equally to this article

Inorganic phosphorus(Pi)deficiency significantly impacts plant growth,development,and photosynthetic *** study evaluated 206 rice accessions from a MiniCore population under both Pi-sufficient(Pi^(+))and Pi-starvation(Pi^(-))conditions in the field to assess photosynthetic phosphorus use efficiency(PPUE),defined as the ratio of A_(sat)^(Pi^(-))to A_(sat)^(Pi^(+)).A genome-wide association study and differential gene expression analyses identified an acid phosphatase gene(ACP2)that responds strongly to phosphate *** and knockout of ACP2 led to a 67%increase and 32%decrease in PPUE,respectively,compared with wild *** of an elite allele A,by substituting the v5 SNP G with A,resulted in an 18%increase in PPUE in gene-edited ACP2 rice *** phosphate-responsive gene PHR2 was found to transcriptionally activate ACP2 in parallel with PHR2 overexpression,resulting in an 11%increase in *** assays indicated that ACP2 primarily catalyzes the hydrolysis of phosphoethanolamine and *** addition,serine levels increased significantly in the ACP2^(vBG)overexpression line,along with a concomitant decrease in the expression of all nine genes involved in the photorespiratory *** of serine enhanced PPUE and reduced photorespiration rates in ACP2 mutants under Pi-starvation *** deduce that ACP2 plays a crucial role in promoting photosynthesis adaptation to Pi starvation by regulating serine metabolism in rice.

关键词： phosphate starvation GwAS photosynthetic adaption photosynthetic phosphate use efficiency genetic variation SNP rice

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The unitary subgroups of group algebras for a class of finite 2-groups with the derived subgroup of order 2

引用

Science China Mathematics 2024年第9期67卷 1989-2018页

作者： Yulei wang Heguo liu Department of Mathematics Henan University of TechnologyZhengzhou 450001China Department of Mathematics Hainan UniversityHaikou 570228China

Let p be a prime and F be a finite field of characteristic *** that FG is the group algebra of the finite p-group G over the field *** V(FG)denote the group of normalized units in FG and let V_(*)(FG)denote the unitary subgroup of V(FG).If p is odd,then the order of V_(*)(FG)is|F|^((|G-1)/2).However,the case p=2 still is *** this paper,the order of V*(FG)is computed when G is a nonabelian 2-group given by a central extension of the form 1→z_(2^(n))×z_(2^(m))→G→z_(2)×…×z_(2)→1 and G'≌z_(2),n,m≥***,a conjecture is confirmed,i.e.,the order of V_(*)(FG)can be divisible by|F|^(1/2(|G|+|Ω1(G)|)-1),where Ω_(1)(G)={g∈G|g^(2)=1}.

关键词： normalized unit unitary subgroup inner abelian p-group central extension

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In-situ additive manufacturing of high strength yet ductility titanium composites with gradient layered structure using N_(2)

引用

International Journal of Extreme Manufacturing 2024年第3期6卷 387-409页

作者： Yunmian Xiao Changhui Song zibin liu Linqing liu Hanxiang zhou Di wang Yongqiang Yang School of Mechanical and Automotive Engineering South China University of TechnologyGuangzhou 510641People’s Republic of China

It has always been challenging work to reconcile the contradiction between the strength and plasticity of titanium *** powder bed fusion(LPBF) is a convenient method to fabricate innovative composites including those inspired by gradient layered *** this work,we used LPBF to selectively prepare Ti N/Ti gradient layered structure(GLSTi)composites by using different N_(2)–Ar ratios during the LPBF *** systematically investigated the mechanisms of in-situ synthesis Ti N,high strength and ductility of GLSTi composites using microscopic analysis,TEM characterization,and tensile testing with digital image ***,a digital correspondence was established between the N_(2) concentration and the volume fraction of LPBF in-situ synthesized Ti *** results show that the GLSTi composites exhibit superior mechanical properties compared to pure titanium fabricated by LPBF under pure ***,the tensile strength of GLSTi was more than 1.5times higher than that of LPBF-formed pure titanium,reaching up to 1100 MPa,while maintaining a high elongation at fracture of 17%.GLSTi breaks the bottleneck of high strength but low ductility exhibited by conventional nanoceramic particle-strengthened titanium matrix composites,and the hetero-deformation induced strengthening effect formed by the Ti N/Ti layered structure explained its strength-plasticity balanced *** microhardness exhibits a jagged variation of the relatively low hardness of 245 HV0.2 for the pure titanium layer and a high hardness of 408 HV0.2 for the N_(2) in-situ synthesis *** study provides a new concept for the structure-performance digital customization of 3D-printed Ti-based composites.

关键词： laser powder bed fusion layered structure composites in-situ synthesis TiN strength-plasticity synergy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Graph Attention Residual Network Based Routing and Fault-Tolerant SchedulingMechanism for Data Flow in Power Communication Network

引用

Computers, Materials and Continua 2024年第1期81卷 1641-1665页

作者： Lin z. zeng z. Yu Y. Ren Y. Qiu X. Chen J. State Key Laboratory ofNetworking and Switching Technology Beijing University of Posts and Telecommunications Beijing 100876 China State Grid Jiangsu Electric Power Co. Ltd Nanjing 210008 China

For permanent faults (PF) in the power communication network (PCN), such as link interruptions, the timesensitive networking (TSN) relied on by PCN, typically employs spatial redundancy fault-tolerance methods to keep service stability and reliability, which often limits TSN scheduling performance in fault-free ideal states. So this paper proposes a graph attention residual network-based routing and fault-tolerant scheduling mechanism (GRFS) for data flow in PCN, which specifically includes a communication system architecture for integrated terminals based on a cyclic queuing and forwarding (CQF) model and fault recovery method, which reduces the impact of faults by simplified scheduling configurations of CQF and fault-tolerance of prioritizing the rerouting of faulty time-sensitive (TS) flows; considering that PF leading to changes in network topology is more appropriately solved by doing routing and time slot injection decisions hop-by-hop, and that reasonable network load can reduce the damage caused by PF and reserve resources for the rerouting of faulty TS flows, an optimization model for joint routing and scheduling is constructed with scheduling success rate as the objective, and with traffic latency and network load as constraints; to catch changes in TSN topology and traffic load, a D3QN algorithm based on a multi-head graph attention residual network (MGAR) is designed to solve the problem model, where the MGAR based encoder reconstructs theTSNstatus into feature embedding vectors, and a dueling network decoder performs decoding tasks on the reconstructed feature embedding vectors. Simulation results show that GRFS outperforms heuristic fault-tolerance algorithms and other benchmark schemes by approximately 10%in routing and scheduling success rate in ideal states and 5% in rerouting and rescheduling success rate in fault states. © 2024 The Authors. Published by Tech Science Press.

关键词： deep reinforcement learning fault tolerance graph attention network Time-sensitive network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The preparation and performance analysis of zirconium-modified aluminum phosphate-based high-temperature(RT-1500℃)resistant adhesive for joining alumina in extreme environment

引用

Journal of Advanced Ceramics 2024年第7期13卷 911-932页

作者： Jingxuan liu Yange wan Bo Xiao Jiancun Li zhanming Hu Ruoyu zhang Xiaoxia Hu Jiachen liu Guoshuai Cai Hongli liu Mingchao wang College of Science Civil Aviation University of ChinaTianjin 300300China Department of Safety Engineering Civil Aviation University of ChinaTianjin 300300China Binzhou Beicheng Construction Engineering Materials Testing Co. Ltd.Binzhou 256602China Department of Aviation Engineering Civil Aviation University of ChinaTianjin 300300China School of Materials and Engineering Key Lab of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin UniversityTianjin 300072China

High-temperature-resistant adhesives are critical materials in the aerospace *** zirconium-modified aluminum phosphate-based adhesives developed in this work had the advantage of adjustable thermal expansibility,achieving a high matching of coefficient of thermal expansion(CTE)with *** introduction of zirconium can significantly improve the thermal stability of the adhesive matrix,and the zr/Al ratio substantially affects the various reaction processes inside the adhesive,especially the types of zirconium-containing *** of the zirconium-containing compounds in the A7z3 adhesive were zrO_(2) only when the mass ratio of zirconium hydroxide to aluminum hydroxide was 3:7,which was the key reason why it had the highest *** room-temperature bonding strength of A7z3 after heat treatment at 1500℃reached 67.2 *** pretreatment at 1500℃,the high-temperature bonding strength of A7z3 was greater than 50 MPa in the range of(room temperature)RT-1000℃.After 40 thermal cycles between RT and 1500℃,the bonding strength still reached 10 *** bonding occurred at temperatures below 1000℃,while chemical bonding dominated above 1000℃based on the generation of Al5BO9 and mullite at the interfaces.

关键词： high-temperature-resistant adhesive thermal expansion property zirconium-modified aluminum phosphate bonding performance thermal cycling bonding mechanism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Critical role of carbon support in metal nanoaggregate facilitating Fe-N-C catalyst for PEM fuel cell application

引用

Journal of Energy Chemistry 2024年第10期97卷 669-676,I0014页

作者： Liming Guo Xin wan Qingtao liu Xiaofang liu Jiaxiang Shang Ronghai Yu Jianglan Shui School of Materials Science and Engineering Beihang UniversityBeijing 100191China Tianmushan Laboratory Hangzhou 310023ZhejiangChina

Metal nanoaggregates can simultaneously enhance the activity and stability of Fe-N-C catalysts in proton-exchange-membrane fuel cells(PEMFC).Previous studies on the relevant mechanism have focused on the direct interaction between FeN_(4)active sites and metal ***,the role of carbon support that hosts metal nanoaggregates and active sites has been ***,a Fe-N-C catalyst encapsulating inactive gold nanoparticles is prepared as a model catalyst to investigate the electronic tuning of Au nanoparticles(NPs)towards the carbon *** NPs donate electrons to carbon support,making it rich inπelectrons,which reduces the work function and regulates the electronic configuration of the FeN_(4)sites for an enhanced ORR ***,the electron-rich carbon support can mitigate the electron depletion of FeN_(4)sites caused by carbon support oxidation,thereby preserving its high *** yield and accumulation of H_(2)O_(2)are thus alleviated,which delays the oxidation of the catalyst and benefits the *** to the electron-rich carbon support,the composite catalyst achieves a top-level peak power density of 0.74 w/cm^(2) in a 1.5 bar H_(2)-air PEMFC,as well as the improved *** work elucidates the key role of carbon support in the performance enhancement of the FeN-C/metal nanoaggregate composite catalysts for fuel cell application.

关键词： Fuel cells Oxygen reduction reaction Fe-N-C Hetero-structure catalyst Carbon support

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Boosting the Oxygen Reduction Performance of Fe-N-C Catalyst Using zeolite as an Oxygen Reservoir

引用

Transactions of Tianjin University 2024年第5期30卷 428-435页

作者： weihao liu Qingtao liu Xin wan Jianglan Shui School of Materials Science and Engineering Beihang UniversityBeijing 100191China School of Space and Environment Beihang UniversityBeijing 102206China Tianmushan Laboratory Hangzhou 311115China

Non-precious metal electrocatalysts(such as Fe-N-C materials) for the oxygen(O_(2)) reduction reaction demand a high catalyst loading in fuel cell devices to achieve workable performance. However, the extremely low solubility of O_(2) in water creates severe mass transport resistance in the thick catalyst layer of Fe-N-C catalysts. Here, we introduce silicalite-1 nanocrystals with hydrophobic cavities as sustainable O_(2) reservoirs to overcome the mass transport issue of Fe-N-C catalysts. The extra O_(2) supply to the adjacent catalysts significantly alleviated the negative effects of the severe mass transport resistance. The hybrid catalyst(Fe-N-C@silicalite-1) achieved a higher limiting current density than Fe-N-C in the half-cell test. In the H_(2)-O_(2) and H_2-air proton exchange membrane fuel cells, Fe-N-C@silicalite-1 exhibited a 16.3% and 20.2% increase in peak power density compared with Fe-N-C, respectively. The O_(2)-concentrating additive provides an effective approach for improving the mass transport imposed by the low solubility of O_(2) in water.

关键词： Oxygen reduction reaction Fuel cell Fe-N-C catalyst Oxygen reservoir Mass transport

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Construction of z-scheme Cu-CeO_(2)/BiOBr heterojunction for enhanced photocatalytic degradation of sulfathiazole

引用

Chinese Chemical Letters 2024年第7期35卷 167-172页

作者： Xingmin Chen Yunyun wu Yao Tang Peishen Li Shuai Gao Qiang wang wen liu Sihui zhan College of Environmental Sciences and Engineering Nankai UniversityTianjin 300350China Laboratory for Micro-Sized Functional Materials&College of Elementary Education and Department of Chemistry Capital Normal UniversityBeijing 100048China College of Environmental Sciences and Engineering The Key Laboratory of Water and Sediment Sciences(MOE)Peking UniversityBeijing 100871China

The utilization of an efficient photocatalyst is crucial for the photocatalytic degradation of antibiotics in water through visible light,which is an imperative requirement for the remediation of water *** this study,a novel Cu-CeO_(2)/BiOBr z-type heterojunction was synthesized by calcination and hydrothermal methods,and the degradation rate of sulfathiazole(STz)antibiotic solution was studied using simulated illumination(300 w xenon lamp).The results indicated that 3%Cu-CeO_(2)/BiOBr achieved a degradation rate of 92.3%within 90 min when treating 20 mg/L STz solution,demonstrating its potential for practical water treatment *** using various chemical instruments revealed that 3%Cu-CeO_(2)/Bi OBr exhibited the lowest electron-hole recombination rate and electron transfer ***,the utilization of ESR data and quenching experiments has substantiated the involvement of hydroxyl radicals(·OH)and superoxide radicals(·O_(2)^(-))as the primary active ***,a plausible degradation mechanism has been *** findings offer a prospective approach for the development of heterojunction materials with appropriate band matching.

关键词： Cu-CeO_(2)/BiOBr nanoheterojunction Photocatalytic degradation Sulfathiazole z-scheme

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：