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PHASE STRUCTURE FACTOR AND INTERFACE CONJUNCTION FACTOR OF CAST IRON AND ITS COMPOSITION DESIGN

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Acta Metallurgica Sinica(English letters) 1999年第4期12卷 401-407页

作者： z.l.li,z.l.liu ,F.Y.li,X.P.Yang and z.G.Gu Departmentof Materials Science and Engineering ,liaoning Institute of Technology,Jinzhou 121001 ,China

Theempiricalelectrontheory of solidsand molecules( EET) and theimproved TFDtheory wereapplied tocalculatethe phasestructurefactorsand interfaceconjunction factorsofcom mon alloying elementsincastiron. Akind of Si- Mo- Cu ductileiron with rareearth Mg asnodularizer was designed accordingtothese valenceelectron structure parameters. Actual applicationtestsshow thatthelongevity of thisiron is 1.5 timesof thatof high manganesesteel. This accordance of theoretical results and actual effectsshows the composition design methodcan beused in othercastiron research.

关键词： phasestructure factor interface conjunction factor,ductile iron wear resistance,composition design

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Development present state and perspectives on hydrogen-storage alloy for MH-Ni battery

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Development present state and perspectives on hydrogen-stora...

瘤内和瘤周的表观扩散系数(ADC)在评估直肠癌病理预后因素中的应用

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作者： z.l.liu,Y.W.Chen,C.X.li Sihui City Double-win Industry Co.,ltd.,zhaoqing Guangdong,China

＜正＞Development present state of hydrogen-storage alloy for MH-Ni battery was formulated, and current situations of research and development,manufacture and market were especially *** of hydrogen-storage alloys with high capacity and low cost produced in Double-win Company were introduced,*** of production capacity,increase of

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国际医学放射学杂志 2022年第5期45卷 616-616页

作者： Y.Yuan X.l.Chen z.l.liu G.W.Chen H.liu Y.S.liu 邹丽艳

摘要目的探讨肿瘤内和瘤周区的表观扩散系数（ADC）对直肠癌病理预后因素的诊断性能。方法前瞻性纳入146例术前均接受MRI检查的直肠癌病人。2名放射科医

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利用CT成像影像组学进行肝内胆管细胞癌切除无效的术前预测研究

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国际医学放射学杂志 2021年第3期44卷 371-371页

作者： H.P.Chu z.l.liu W.liang Q.zhou Y.zhang K.lei 曹红举

摘要目的探讨和比较影像组学和临床信息在术前预测肝内胆管细胞癌(ICC)切除无效中的价值。方法收集2个中心的203例ICC病人,按照7∶3的比例随机分为训练组和

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虫生菌物Cordyceps jiangxiensis菌体及多糖的深层培养条件优化(英文)

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虫生菌物Cordyceps jiangxiensis菌体及多糖的深层培养条件优化(...

Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

作者： J. H.Xiao, D. X. Chen, J. W. liu, z.l.liu, W. H.Wan, N. Fang, Y.Xiao, Y.Qi and z.Q.liang Key laboratory of Cell Engineering of Guizhou Province, First Affiliated Hospital of zunyi Medical College, zunyi, and 2laboratory of Fungi Resource, Guizhou University, Guiyang, China

研究背景: Cordyceps jiangxiensis,俗称草木王,是一种有悠久民间药用史的虫生菌物药,在《全国中草药汇编》上有文字记载。2000我们初次采集到,经鉴定发现系虫生菌物中一新种(发表在《菌物系统》杂志)。由于虫生菌物自身的遗传特性所决... 详细信息

研究背景: Cordyceps jiangxiensis,俗称草木王,是一种有悠久民间药用史的虫生菌物药,在《全国中草药汇编》上有文字记载。2000我们初次采集到,经鉴定发现系虫生菌物中一新种(发表在《菌物系统》杂志)。由于虫生菌物自身的遗传特性所决定的寄主专一性和特定的生境要求,成为其开发利用的瓶颈。基于其药用价值以及在产地由于长期以来掠夺性采挖造成资源濒临枯竭的现实,因此,解决其培养对该资源可持续发展利用具有重要的理论价值和现实意义。2002—2003年, 我们初步解决了其深层培养的技术难题,抗肿瘤药理试验的初步筛选结果证实其多糖具有抗肿瘤效应。为此,我们拟对其菌体培养和多糖生产进行多指标同步优化,为其开发利用提供实验依据和技术支撑。

关键词： Cordyceps jiangxiensis exopolysaccharide mycelial growth optimization orthogonal submerged culture

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.li Nagendran Ramalingam Shaomin li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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Interplay between creeping fat and gut microbiota: A brand-new perspective on fecal microbiota transplantation in Crohn's disease

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World Journal of Gastroenterology 2025年第2期31卷 138-143页

作者： Ying Wang Jie liu Department of life Sciences and Medicine South District of Endoscopic CenterThe First Affiliated Hospital of University of Science and Technology of ChinaUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastroenterology The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina

Inflammatory bowel disease,particularly Crohn's disease(CD),has been linked to modifications in mesenteric adipose tissue(MAT)and the phenomenon known as"creeping fat"(CrF).The presence of CrF is believed to serve as a predictor for early clinical recurrence following surgical intervention in patients with ***,the incorporation of the mesentery during ileocolic resection for CD has been correlated with a decrease in surgical recurrence,indicating the significant role of MAT in the pathogenesis of *** numerous studies have indicated that dysbiosis of the gut microbiota is a critical factor in the development of CD,the functional implications of translocated microbiota within the MAT of CD patients remain *** manuscript commentary discusses a recent basic research conducted by Wu et *** their study,intestinal bacteria from individuals were transplanted into CD model mice,revealing that fecal microbiota trans-plantation(FMT)from healthy donors alleviated CD symptoms,whereas FMT from CD patients exacerbated these ***,FMT was found to affect intestinal permeability,barrier function,and the levels of proinflammatory factors and ***,these findings suggest that targeting MAT and CrF may hold therapeutic potential for patients with ***,the study did not evaluate the composition of the intestinal microbiota of the donors or the subsequent alterations in the gut ***,the gut microbiota plays a crucial role in the histopathology of CD,and thus,targeting MAT and CrF may represent a promising avenue for treatment in this patient population.

关键词： Crohn's disease Mesenteric adipose tissue Creeping fat Fecal microbiota transplantation Gut microbiota

Network pharmacology:Changes the treatment mode of"one disease-one target"in cancer treatment

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 268-271页

作者： Shuai liu Yong-Wei Yu Department of Cardiology The First People’s Hospital of JiashanJiaxing 314100Zhejiang ProvinceChina Department of Critical Care Medicine The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

The article concluded that network pharmacology provides new ideas and insights into the molecular mechanism of traditional Chinese medicine(TCM)treatment of *** is a new choice and hot spot in the field of cancer *** have also previously published studies on TCM and network *** this letter,we summarize the new paradigm of network pharmacology in cancer treatment mechanisms.

关键词： Network pharmacology Cancer Multicomponent Multitarget Therapy

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning Chang liu Yu-Chi liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong loo lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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