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Shear band evolution and mechanical behavior of cold-rolled zr-based amorphous alloy sheets:An in-situ study

Journal of Materials Science & Technology 2024年第14期181卷 115-127页

作者： C.Y.zhang z.W.zhu S.T.li Y.Y.Wang z.k.li H.li G.Yuan H.F.zhang School of Metallurgy Northeastern UniversityShenyang 110819China Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China The State key Laboratory of Rolling and Automation(RAL) Northeastern UniversityShenyang 110819China

Cold rolling process can regulate the microstructure and mechanical properties of amorphous alloys,but it is still a challenging task to reveal their microscopic ***,we designed an in-situ SEM observation device for the cold rolling process of amorphous alloy,and visually observed the formation and evolution of shear bands during single-pass and multi-pass rolling process of the zr_(55)Cu_(30)Al_(10)Ni_(5)amorphous alloy *** is found that the evolution process of shear bands in the rolling process of amorphous alloy shows heritability,which is mainly reflected in two aspects:one is that the shear band formation pattern in the single-pass rolling process is more inclined to inherit the previous shear band formation pattern;the other is that the shear deformation is more likely to occur in the pre-existing shear bands in the multi-pass rolling *** rule can be used to guide the controlled genera-tion of shear bands in amorphous ***,we emphasized the importance of pre-existing shear band orientations and systematically investigated the mechanical behavior of the amorphous alloys with pre-existing shear bands by in-situ SEM *** is found that the mechanical properties of the as-rolled amorphous alloys are determined by the competition between the work-softening of the pre-existing shear band itself and the work-hardening caused by the blocking effect of the pre-existing shear bands on the shear *** on this,we enhance the tensile fracture strength and the tensile ductility of the amorphous alloy by adjusting the orientation of the pre-existing shear bands parallel to the tensile stress axis so that the pre-existing shear bands prevent the linear propagation and destruction of the new shear bands.

关键词： Amorphous alloy Cold rolling Shear band Mechanical behavior In-situ study Plasticity

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EFFECT OF Si ON THE MICROSTRUCTURE AND MECHANICAL PROPERTIES OF THE Al-4.5%Cu ALLOYS

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Acta Metallurgica Sinica(English Letters) 2006年第6期19卷 405-410页

作者： N.Han X.F.Bian z.k.li T.Mao C.D.Wang key Laboratory of liquid Structure and Heredity of Materials Ministry of EducationShandong UniversityJinan 250061 China

The effect of Si on the microstructure and mechanical properties of binary Al-4.5%Cu alloy has been investigated. The results show that the addition of Si does not have any effect on alloy strength; however, it decreases the ductility of the as-cast Al-4.5%Cu alloy. It is obvious that after T4 heat treatment, the microstructure and mechanical properties of Al-4.5%Cu-Si alloys are improved, especially for the alloy with an Si addition of 2%.

关键词： Al-Cu alloy Si heat treatment mechanical property

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Distribution of Be in a Ti-Based Bulk Metallic Glass Composite Containing B-Ti

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Journal of Materials Science & Technology 2017年第7期33卷 708-711页

作者： L.zhang W.Q.li z.W.zhu H.M.Fu H.li z.k.li H.W.zhang A.M.Wang H.F.zhang Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences 110016 Shenyang China

In order to obtain a glassy matrix during quenching, Be is often selected as a constituent of the compositions of Ti/zr-based bulk metallic glass composites（BMGCs）. The in situ formed β phase in Be-bearing BMGCs was reported to be Be-free. However, a thorough investigation of the distribution of Be in BMGCs is still missing to date. In this work, the distribution of Be in a Ti_（47.5）zr_（33）Cu_（5.8）Co_3Be_（12.5）（at.%） BMGC was studied by the secondary ion mass spectrometry（SIMS） and the electron energy loss spectroscopy（EELS）.It is found that Be almost totally dissolves in the glassy matrix, but a very weak intensity of Be in β phase is still detectable by SIMS, and the content of Be in β-Ti is estimated to be about 0.3 at.%. Based on the recently established two-phase quasi-equilibrium of BMGCs, the distinct solubility of Be in the glassy matrix and in β-Ti has been explained.

关键词： Bulk metallic glass(BMG) Metallic glass composite Beryllium Quasi-equilibrium

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Achieving high hetero-deformation induced(HDI)strengthening and hardening in brass by dual heterostructures

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Journal of Materials Science & Technology 2022年第3期98卷 244-247页

作者： X.T.Fang z.k.li Y.F.Wang M.Ruiz X.L.Ma H.Y.Wang Y.zhu R.Schoell C.zheng D.kaoumi Y.T.zhu Department of Materials Science and Engineering North Carolina State UniversityRaleighNC 27695USA key Laboratory for Anisotropy and Texture of Materials of Ministry of Education Northeastern UniversityShenyang 110819China School of Aeronautics and Astronautics Sichuan UniversityChengdu 610065China Department of Materials Science and Engineering Texas A and M UniversityCollege StationTX 77840USA Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleighNC 27695USA Department of Nuclear Engineering North Carolina State UniversityRaleighNC 27695USA Science and Technology on Thermostructural Composite Materials Laboratory Northwestern Polytechnical UniversityXi’an 710072China

Heterostructured materials,defined as materials that contain multiple zones with dramatically different flow stresses,have the potential to push the envelope of the strength-ductility of metals and alloys beyond what can be obtained conventionally[1–3].A prominent example is the heterogeneous lamella Ti that is as strong as its ultrafine-grained Ti,while as ductile as the coarsegrained Ti[4].

关键词： grain strengthening deformation

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RFLP mapping and race specificity of bacterial blight resistance genes (QTLs) in rice

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Science China(life Sciences) 1998年第5期41卷 542-547页

作者：罗利军梅捍卫赵新华钟代彬王一平余新桥应存山 z.k.li A.H.Paterson D.L.Wang R.E.Tabien L.zhu J.W.Stansel 1. China National Rice Research Institute 310006 Hangzhou China 2. Texas A & M University 77843 College Station TX USA

By using a set of 315 recombinant inbred lines (RILs) from the cross Lemont (japonica)×Teqing (indica) and a complete linkage map with 186 well distributed RFLP markers and 3 morphological markers, a major gene (Xa4) and 10 QTLs and 9 pairs of epistasis loci conferring horizontal resistance to three strains of \%Xanthomonas oryza\% pv \%oryza (Xoo)\% were mapped. The Teqing allele at Xa4 on chromosome 11 acts as a dominant resistant gene against pathogen race CR4 and CX08, but as an additive QTL with a significantly (47%) reduced effect \{against the\} virulent strain, CR6. The major gene Xa4 exhibited stronger degree of race specificity. Most QTLs showed consistent levels of resistance against all three \%Xoo\% strains. The results suggest that a high level durable resistance to \%Xoo\% may be achieved by cumulative effects of multiple QTL.

关键词： bacterial blight RFLP QTL race specificity.

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Subspecies specific RAPD markers in rice

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Chinese Rice Research Newsletter 2002年第1期10卷 2-2页

作者： D.S.Brar z.k.li Plant Breeding Geneticsand Biochemistry DivisionIRRIDAPO Box 7777Metro ManilaPhilippines

The cultivated rice(Oryza sativa L.)is known to contain two major subspecies,indica(O. stativa L. ssp. indica)and japonica(O. sativa L. ***). The indica and japonica differentiation

关键词： Subspecies specific RAPD markers in rice gene

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Subspecies specific° PAPD markers in rice

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Chinese Rice Research Newsletter 2002年第1期 2-2页

作者： D.S.Brar z.k.li Philippines and Biochemistry Division Metro Manila Genetics DAPO Box 7777 Plant Breeding IRRI

The culivated rice (Oryza sativa L. )is known to contain two major scb-species, indica (O. sativa L. ***) and japonica (O. sativa *** )ssp. japonica). The indica andjaponica differentiation resulted insignifficance of hybrid sterility andhybrid breakdown, which are barriersof gene flow between the two majorsubgene pools within O. sativa.

关键词： St PAPD markers in rice Subspecies specific

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Study of seepage generation technology in excavation process based on 3D geo-mechanical model

Study of seepage generation technology in excavation process...

引用

The 2nd ISRM International Young Scholars’Symposium on Rock Mechanics

作者： k.z.Wang College of Civil Engineering and Architecture,zhejiang University of Technology,Hangzhou,zhejiang,China State key Laboratory of Hydroscience and Engineering,Tsinghua University,Beijing,China z.k.li,L.J.Cheng & z.z.zhang State key Laboratory of Hydroscience and Engineering,Tsinghua University,Beijing,China F.lin & Q.Y.Cheng College of Civil Engineering and Architecture,zhejiang University of Technology,Hangzhou,zhejiang,China

Seepage is one of the key factors which affect the stress and deformation of surrounding rock in excavation *** combining 3D geo-mechanical model test for the diversion tunnel of JinpingⅡHydropower Station,two hydraulic servo-controlled water supply schemes are *** discrete holey tube seepage generation system is optimized and selected for solving the percolating water question among the test bench retaining plate system,the mini-type multi-point extensometer transfer rod and the support *** on discrete multi-principal stress plane,a new loading technology which has waterproof function is brought forward to make sure to generate the initial stress field while no seepage in assembly airbag steel sleeve and the wire hole of data collection *** high simulation of seepage field is realized.

关键词： Study of seepage generation technology in excavation process based on 3D geo-mechanical model

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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.li Nagendran Ramalingam Shaomin li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang Fei Yang zixiao li Qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

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