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Chinese Physics C 2020年第4期44卷 I0001-I0004,1-102页

作者： M.Ablikim M.N.Achasov P.Adlarson S.Ahmed M.Albrecht M.Alekseev A.Amoroso F.F.An Q.An Y.Bai O.Bakina R.Baldini Ferroli Y.Ban K.Begzsuren j.V.Bennett N.Berger M.Bertani D.Bettoni F.Bianchi j Biernat j.Bloms I.Boyko R.A.Briere L.Calibbi H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin j.Chai j.F.Chang W.L.Chang j.Charles G.Chelkov Chen G.Chen H.S.Chen j.C.Chen M.L.Chen S.j.Chen Y.B.Chen H.Y.Cheng W.Cheng G.Cibinetto F.Cossio X.F.Cui H.L.Dai j.P.Dai X.C.Dai A.Dbeyssi D.Dedovich z.Y.Deng A.Denig Denysenko M.Destefanis S.Descotes-Genon F.De Mori Y.Ding C.Dong j.Dong L.Y.Dong M.Y.Dong z.L.Dou S.X.Du S.I.Eidelman j.z.Fan j.Fang S.S.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng M.Fritsch C.D.Fu Y.Fu Q.Gao X.L.Gao Y.Gao Y.Gao Y.G.Gao z.Gao B.Garillon I.Garzia E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl M.Greco L.M.Gu M.H.Gu Y.T.Gu A.Q.Guo F.K.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov S.Han X.Q.Hao F.A.Harris K.L.He F.H.Heinsius T.Held Y.K.Heng Y.R.Hou z.L.Hou H.M.Hu j.F.Hu T.Hu Y.Hu G.S.Huang j.S.Huang X.T.Huang X.z.Huang z.L.Huang N.Huesken T.Hussain W.Ikegami Andersson W.Imoehl M.Irshad Q.ji Q.P.ji X.B.ji X.L.ji H.L.jiang X.S.jiang X.Y.jiang j.B.jiao z.jiao D.P.jin S.jin Y.jin T.johansson N.Kalantar-Nayestanaki X.S.Kang R.Kappert M.Kavatsyuk B.C.Ke I.K.Keshk T.Khan A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc M.Kurth M.G.Kurth W.Kuhn j.S.Lange P.Larin L.Lavezzi H.Leithoff T.Lenz C.Li Cheng Li D.M.Li F.Li F.Y.Li G.Li H.B.Li H.j.Li j.C.Li j.W.Li Ke Li L.K.Li Lei Li P.L.Li P.R.Li Q.Y.Li W.D.Li W.G.Li X.H.Li X.L.Li X.N.Li X.Q.Li z.B.Li H.Liang H.Liang Y.F.Liang Y.T.Liang G.R.Liao L.z.Liao j.Libby C.X.Lin D.X.Lin Y.j.Lin B.Liu B.j.Liu C.X.Liu D.Liu D.Y.Liu F.H.Liu Fang Liu Feng Liu H.B.Liu H.M.Liu Huanhuan Liu Huihui Liu j.B.Liu j.Y.Liu K.Y.Liu Ke Liu Q.Liu S.B.Liu T.Liu X.Liu X.Y.Liu Y.B.Liu z.A.Liu zhiqing Liu Y.F.Long X.C.Lou H.j.Lu j.D.Lu j.G.Lu Y.Lu Y.P.Lu C.L.Luo M.X.Luo P.W.Luo T.Luo X.L.Luo S.Lusso X.R.Lyu F.C.Ma H.L.Ma L.L.Ma M.M.Ma Q.M.Ma X.N.Ma X.X. Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of Advanced Science and Technology Beijing 100190China COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200443China G.I.Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of Science and Technology Luoyang 471003China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati I-00044FrascatiItaly INFN Sezione di Ferrara I-44122FerraraItaly Institute of Physics and Technology Peace Ave.54BUlaanbaatar 13330Mongolia johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16D-35392 GiessenGermany KVI-CART University of GroningenNL-9747 AA GroningenThe Netherlands Lanzhou University Lanzhou 730000China Liaoning University Shenyang 110036China Nanjing Normal University Nanjing 210023China Nanjing University Nanjing 210093China Nankai University Tianjin 300071China Peking University Beijing 100871China Shandong University Jinan 250100China Shanghai

There has recently been a dramatic renewal of interest in hadron spectroscopy and charm physics. This renaissance has been driven in part by the discovery of a plethora of charmonium-like XYz states at BESⅢ and B factories, and the observation of an intriguing proton-antiproton threshold enhancement and the possibly related X(1835) meson state at BESⅢ, as well as the threshold measurements of charm mesons and charm baryons. We present a detailed survey of the important topics in tau-charm physics and hadron physics that can be further explored at BESⅢ during the remaining operation period of BEPCⅡ. This survey will help in the optimization of the data-taking plan over the coming years, and provides physics motivation for the possible upgrade of BEPCⅡ to higher luminosity.

关键词： meson hadron optimization

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Evidence for the decays of ∧_c^+→∑^+η and ∑^+η’

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Chinese Physics C 2019年第8期43卷 15-23页

作者： M.Ablikim F.F.An Q.An Y.Bai Y.Ban H.Cai X.Cai G.F.Cao j.F.Chang G.Chen H.S.Chen j.C.Chen M.L.Chen P.L.Chen S.j.Chen Y.B.Chen W.Cheng H.LDai j.P.Dai z.Y.Deng Y.Ding C.Dong j.Dong L.Y.Dong M.Y.Dong z.L.Dou S.X.Du P.F.Duan j.z.Fan j.Fang S.S.Fang Y.Fang C.Q.Feng C.D.Fu Y.Fu Q.Gao X.L.Gao Y.Gao Y.G.Gao z.Gao L.Gong W.X.Gong L.M.Gu M.H.Gu Y.T.Gu A.Q.Guo L.B.Guo R.P.Guo Y.P.Guo S.Han X.Q.Hao K.L.He Y.K.Heng z.L.Hou H.M.Hu j.F.Hu T.Hu Y.Hu G.S.Huang j.S.Huang X.T.Huang X.z.Huang z.L.Huang Q.ji Q.P.ji X.B.ji X.L.ji X.S.jiang X.Y.jiang j.B.jiao z.jiao D.P.jin S.jin Y.jin X.S.Kang B.C.Ke C.Li Cheng Li D.M.Li F.Li F.Y.Li G.Li H.B.Li H.j.Li j.C.Li j.W.Li Ke Li Lei Li P.L.Li P.R.Li Q.Y.Li T.Li W.D.Li W.G.Li X.L.Li X.N. Li X.Q.Li z.B.Li H.Liang Y.F.Liang Y.T.Liang G.R.Liao L.z.Liao C.X.Lin D.X.Lin B.Liu B.j.Liu C.X.Liu D.Liu D.Y.Liu F.H.Liu Fang Liu Feng Liu H.B.Liu H.L.Liu H.M.Liu Huanhuan Liu Huihui Liu j.B.Liu j.Y.Liu K.Liu K.Y.Liu Ke Liu Q.Liu S.B.Liu X.Liu Y.B.Liu z.A.Liu zhiqing Liu Y.F.Long X.C.Lou H.j.Lu j.D.Lu j.G.Lu Y.Lu Y.P.Lu C.L.Luo M.X.Luo T.Luo X.L.Luo X.R.Lyu F.C.Ma H.L.Ma L.L.Ma M.M.Ma Q.M.Ma X.N.Ma X.X.Ma X.Y.Ma Y.M.Ma Y.j.Mao z.P.Mao z.X.Meng j.Min T.j.Min X.H.Mo Y.j.Mo z.Ning S.L.Niu S.L.Olsen Q.Ouyang Y.Pan H.P.Peng j.L.Ping R.G.Ping H.R.Qi M.Qi T.Y.Qi S.Qian C.F.Qiao N.Qin z.H.Qin j.F.Qiu S.Q.Qu G.Rong W.Shan X.Y.Shan M.Shao C.P. Shen P.X.Shen X.Y.Shen H.Y.Sheng X.Shi j.j.Song X.Y.Song G.X.sun j.F.sun L.sun S.S.sun X.H.sun Y.j.sun Y.K.sun Y.z.sun z.j.sun z.T.sun Y.T.Tan C.j.Tang G.Y.Tang X.Tang B.Wang B.L.Wang C.W.Wang D.Y.Wang Dan Wang K.Wang L.L.Wang L.S.Wang M.Wang Meng Wang P.Wang P.L.Wang W.P.Wang X.F.Wang Y.Wang Y.F.Wang z.Wang z.G.Wang z.Y.Wang zongyuan Wang D.H.Wei S.P.Wen L.H.Wu L.j.Wu z.Wu L.Xia Y.Xia D.Xiao Y.j.Xiao z.j.Xiao Y.G.Xie Y.H.Xie X.A.Xiong Q.L.Xiu G.F.Xu j.j.Xu L.Xu Q.j.Xu Q.N.Xu X.P.Xu F.Yan L.Yan w.B.Yan W.C.Yan Y.H.Yan H.j.Yang H.X.Yang L.Yang S.L.Yang Y.H.Yang Y.X.Yang Yifan Yang z.Q.Yang M.Ye M.H.Ye j.H.Yin z.Y.You B.X.Yu C.X.Yu j.S.Yu C.z.Yuan Y.Yuan Y.zeng B.X.zhang B.Y.zhang Institute of High Energy Physics G.I.Budker Institute of Nuclear Physics SB RAS(BINP) the Novosibirsk State University Helmholtz Institute Mainz Bochum Ruhr-University University of Turin INFN State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Southeast University joint Institute for Nuclear Research INFN Laboratori Nazionali di Frascati Peking University Institute of Physics and Technology Indiana University Bloomington Carnegie Mellon University johannes Gutenberg University of Mainz INFN Sezione di Ferrara Wuhan University Ankara University University of Chinese Academy of Sciences Istanbul Bilgi University the Moscow Institute of Physics and Technology the Functional Electronics Laboratory Tomsk State University University of South China Nanjing University Shanghai jiao Tong University Key Laboratory for Particle Physics Astrophysics and CosmologyMinistry of EducationShanghai Key Laboratory for Particle Physics and CosmologyInstitute of Nuclear and Particle Physics Liaoning University Nankai University zhengzhou University Tsinghua University University of Ferrara University of Eastern Piedmont Central China Normal University University of Minnesota Minneapolis GSI Helmholtzcentre for Heavy Ion Research GmbH Guangxi University Nanjing Normal University KVI-CART University of Groningen Henan Normal University University of Hawaii Honolulu Shandong University University of the Punjab University of Muenster Uppsala University Huangshan College University of jinan justus-Liebig-Universitaet Giessen II.Physikalisches Institut Istanbul Arel University Soochow University Beijing Institute of Petrochemical Technology China Center of Advanced Science and Technology sun Yat-Sen University Sichuan University Guangxi Normal University Indian Institute of Technology Madras Shanxi University Henan University of Science and Technology Lanzhou University zhejiang University Fudan University Key Laboratory of Nuclear Physics and Ion-beam Application(MOE)and Institute of

We study the hadronic decays of ∧c+ to the final states ∑+η and ∑+η’,using an e+e-annihilation data sample of 567 pb-1 taken at a center-of-mass energy of 4.6 GeV with the BESIII detector at the BEPCⅡ *** find evidence for the decays ∧c+→∑+η and ∑+η’ with statistical significance of 2.5σ and 3.2σ,*** to the reference decays ∧c+→∑+π0 and ∑+ω,we obtain the ratios of the branching fractions■and ■to be 0.35±0.16±0.02 and 0.86±0.34±0.04,*** upper limits at the 90% confidence level are set to be■and■.Using BESIII measurements of the branching fractions of the reference decays,we determine B（∧c+→∑+η）=（0.41±0.19±0.05）%（<0.68%）and B（∧c+→∑+η’）=（1.34±0.53 ±0.19）%（<1.9%）.Here,the first uncertainties are statistical and the second *** obtained branching fraction of ∧c+→∑+η is consistent with the previous measurement,and the branching fraction of ∧c+→∑+η’ is measured for the first time.

关键词： charmed baryon ∧c^+ decays branching fractions

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Observation of e^+e^-→D_s^+■^((*)0)K^- and study of the P-wave D_s mesons

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Chinese Physics C 2019年第3期43卷 5-16页

作者： M.Ablikim M.N.Achasov S.Ahmed M.Albrecht M.Alekseev A.Amoroso F.F.An Q.An Y.Bai O.Bakina R.Baldini Ferroli Y.Ban K.Begzsuren D.W.Bennett j.V.Bennett N.Berger M.Bertani D.Bettoni F.Bianchi I.Boyko R.A.Briere H.Cai X.Cai A.Calcaterra G.F.Cao S.A.Cetin j.Chai j.F.Chang W.L.Chang G.Chelkov G.Chen H.S.Chen j.C.Chen M.L.Chen S.j.Chen Y.B.Chen W.S.Cheng G.Cibinetto F.Cossio H.L.Dai j.P.Dai A.Dbeyssi D.Dedovich z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori Y.Ding C.Dong j.Dong L.Y.Dong M.Y.Dong z.L.Dou S.X.Du j.z.Fan j.Fang S.S.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng M.Fritsch C.D.Fu Y.Fu Q.Gao X.L.Gao Y.N.Gao Y.G.Gao z.Gao B.Garillon I.Garzia A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl M.Greco L.M.Gu M.H.Gu S.Gu Y.T.Gu A.Q.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov z.Haddadi S.Han X.Q.Hao F.A.Harris K.L.He F.H.Heinsius T.Held Y.K.Heng z.L.Hou H.M.Hu j.F.Hu T.Hu Y.Hu G.S.Huang j.S.Huang X.T.Huang X.z.Huang z.L.Huang N.Huesken T.Hussain W.Ikegami Andersson W.Imoehl M.Irshad Q.ji Q.P.ji X.B.ji X.L.ji H.L.jiang X.S.jiang X.Y.jiang j.B.jiao z.jiao D.P.jin S.jin Y.jin T.johansson N.Kalantar-Nayestanaki X.S.Kang M.Kavatsyuk B.C.Ke I.K.Keshk T.Khan A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc M.Kurth W.Kühn j.S.Lange P.Larin L.Lavezzi H.Leithoff C.Li Cheng Li D.M.Li F.Li F.Y.Li G.Li H.B.Li H.j.Li j.C.Li j.W.Li Ke Li L.K.Li Lei Li P.L.Li P.R.Li Q.Y.Li W.D.Li W.G.Li X.L.Li X.N.Li X.Q.Li z.B.Li H.Liang Y.F.Liang Y.T.Liang G.R.Liao L.z.Liao j.Libby C.X.Lin D.X.Lin B.Liu B.j.Liu C.X.Liu D.Liu D.Y.Liu F.H.Liu Fang Liu Feng Liu H.B.Liu H.L Liu H.M.Liu Huanhuan Liu Huihui Liu j.B.Liu j.Y.Liu K.Y.Liu Kai Liu Ke Liu Q.Liu S.B.Liu X.Liu Y.B.Liu z.A.Liu zhiqing Liu Y.F.Long X.C.Lou H.j.Lu j.D.Lu j.G.Lu Y.Lu Y.P.Lu C.L.Luo M.X.Luo P.W.Luo T.Luo X.L.Luo S.Lusso X.R.Lyu F.C.Ma H.L.Ma L.L.Ma M.M.Ma Q.M.Ma X.N.Ma X.X.Ma X.Y.Ma Y.M.Ma F.E.Maas M.Maggiora S.Maldaner Q.A.Malik A.Mangoni Y.j.Mao z.P.Mao S.Marcello z.X.Meng j.G.Messchendorp G.Mezzadri j.Min T.j.Min R.E.Mitchell X.H.Mo Y Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of Advanced Science and Technology Beijing 100190China COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200443China G.I.Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of Science and Technology Luoyang 471003China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati I-00044FrascatiItaly INFN Sezione di Ferrara I-44122FerraraItaly Institute of Physics and Technology Peace Ave.54BUlaanbaatar 13330Mongolia johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16D-35392 GiessenGermany KVI-CART University of GroningenNL-9747 AA GroningenThe Netherlands Lanzhou University Lanzhou 730000China Liaoning University Shenyang 110036China Nanjing Normal University Nanjing 210023China Nanjing University Nanjing 210093China Nankai University Tianjin 300071China Peking University Beijing 100871China Shandong University Jinan 250100China Shanghai

Studies of e^+e~→D_s^+■^((*)0)K^-and the P-wave charmed-strange mesons are performed based on an e^+e^-collision data sample corresponding to an integrated luminosity of 567 pb^(-1) collected with the BESIII detector at s^(1/2)=4.600 GeV. The processes of e^+e^-→D_s^+■^(*0)K^- and D_s^+■~0K^- are observed for the first time and are found to be dominated by the modes D_s^+D_(s1)(2536)^-and D_s^+D_(s2)~*(2573)^-, respectively. The Born cross sections are measured to be σ~B(e^+e^-→D_s^+■^(*0)K^-) =(10.1±2.3±0.8) pb and σ~B(e^+e^-→D_s^+■~0K^-) =(19.4±2.3± 1.6) pb, and the products of Born cross section and the decay branching fraction are measured to be σ~B(e^+e^-→D_s^+D_(s1)(2536)^-+c.c.)·B(D_(s1)(2536)^-→■^(*0)K^-)=(7.5±1.8±0.7) pb and σ~B(e^+e^-→D_s^+D_(s2)~*(2573)^-+ c.c.)·B(D_(s2)~*(2573)^-→■~0 K^-)=(19.7 ± 2.9 ±2.0) pb. For the D_(s1)(2536)^-and D_(s2)~*(2573)^-mesons, the masses and widths are measured to be M(D_(s1)(2536)^-)=(2537.7±0.5 ±3.1) MeV/c2, Γ(D_(s1)(2536)^-) =(1.7 ±1.2 ±0.6)MeV, and M(D_(s2)~*(2573)^-)=(2570.7±2.0 ±1.7) MeV/c^2, Γ(D_(s2)~*(2573)^-)=(17.2 ±3.6 ±1.1) MeV. The spin-parity of the D_(s2)~*(2573)^-meson is determined to be j^p= 2^+. In addition, the processes e^+e^-→D_s^+■^((*)0)K^-are searched for using the data samples taken at four(two) center-of-mass energies between 4.416(4.527) and 4.575 GeV, and upper limits at the 90% confidence level on the cross sections are determined.

关键词： cross section P-wave D_s mesons resonance parameters spin-parity BESIII

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying sun Haoyan Li Dongqing sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing jun Wu Minmin Xiao Fangqing zhao jing-Dong j.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi sun Shiqian Shen Robert j.Thomas M.Brandon Westover Can zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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Impact of ocean data assimilation on the seasonal forecast of the 2014/15 marine heatwave in the Northeast Pacific Ocean

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 24-31页

作者： Tiantian Tang jiaying He Huihang sun jingjia Luo Institute for Climate and Application Research(ICAR)/Key Laboratory of Meteorological Disaster Nanjing University of Information Science and TechnologyNanjingChina

A remarkable marine heatwave,known as the“Blob”,occurred in the Northeast Pacific Ocean from late 2013 to early 2016,which displayed strong warm anomalies extending from the surface to a depth of 300 *** study employed two assimilation schemes based on the global Climate Forecast System of Nanjing University of Information Science(NUIST-CFS 1.0)to investigate the impact of ocean data assimilation on the seasonal prediction of this extreme marine *** sea surface temperature(SST)nudging scheme assimilates SST only,while the deterministic ensemble Kalman filter(EnKF)scheme assimilates observations from the surface to the deep *** latter notably improves the forecasting skill for subsurface temperature anomalies,especially at the depth of 100-300 m(the lower layer),outperforming the SST nudging *** excels in predicting both horizontal and vertical heat transport in the lower layer,contributing to improved forecasts of the lower-layer warming during the *** improvements stem from the assimilation of subsurface observational data,which are important in predicting the upper-ocean *** results suggest that assimilating ocean data with the EnKF scheme significantly enhances the accuracy in predicting subsurface temperature anomalies during the Blob and offers better understanding of its underlying mechanisms.

关键词： Seasonal forecast Ocean data assimilation Marine heatwave Subsurface temperature

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Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

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journal of Energy Chemistry 2025年第1期100卷 760-769页

作者： Lin Peng Yu Bai Hang Li Meixiu Qu zhenhua Wang Kening sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

Lithium-sulfur （Li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （LiPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes Li2S dissolution and nucleation ***,the Li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 mA h cm-2under E/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： Lithium sulfur batteries

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Fluorinated poly(p-triphenylene isatin) anion exchange membranes based on hydrophilic hydroxyl side chain modulation for fuel cells

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journal of Energy Chemistry 2025年第1期100卷 702-709页

作者： Yiman Gu Yanchao zhang zhanyu Li Yijia Lei Baozeng sun Xiaoyu Yu zhe Wang College of Chemistry and Life Science Changchun University of Technology College of Chemical Engineering Changchun University of Technology School of Materials Science and Engineering Changchun University of Technology Key Laboratory of Advanced Functional Polymer Membrane Materials of jilin Province

The development of alkaline fuel cells is moving forward at an accelerated pace,and the application of ether-free bonded polymers to anion exchange membranes （AEMs） has been widely ***,the question of the“trade-off”between AEM ionic conductivity and dimensional stability remains *** strategy of inducing microphase separation to improve the performance of AEM has attracted much attention recently,but the design of optimal molecular structures is still being ***,this work introduced different ratios of 3-bromo-1,1,1-trifluoroacetone （x=40,50,and 60） into the main chain of poly（p-terphenylene isatin）.Because fluorinated groups have excellent hydrophobicity,hydrophilic hydroxyl-containing side chains are introduced to jointly adjust the formation of phase separation *** results show that PTI-PTF50-NOH AEM with the appropriate fluorinated group ratio has the best ionic conductivity and alkali stability under the combined effect of *** has an ionic conductivity of 133.83 mS cm-1at 80°*** addition,the OH-conductivity remains at 89%of the initial value at 80°C and 3 M KOH for 1056 h of *** cell polarization curve based on PTI-PTF50-NOH shows a power density of 734.76 mW cm-2at a current density of 1807.7 mA cm-2.

关键词： Anion exchange membranes Poly(p-terphenylene isatin) Hydrophilic-hydrophobic phase separation Fluorinated group

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Influence of introducing zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： junjie Li Wenbo Yu zhenyu sun Weichen zheng Liangwei zhang Yanling Xue Wenning Liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

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Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui sun Sanlong Wang Pengyang Wang Yali Liu Shanshan Qi Biao Shi Ying zhao Xiaodan zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

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