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Multi-omics analysis of adamantinomatous craniopharyngiomas reveals distinct molecular subgroups with prognostic and treatment response significance

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Chinese Medical journal 2024年第7期137卷 859-870页

作者： Xianlong Wang Chuan zhao jincheng Lin Hongxing Liu Qiuhong zeng Huadong Chen ye Wang Dapeng Xu Wen Chen Moping Xu En zhang Da Lin zhixiong Lin Department of Bioinformatics School of Medical Technology and EngineeringKey Laboratory of Medical BioinformaticsKey Laboratory of Ministry of Education for Gastrointestinal CancerFujian Medical UniversityFuzhouFujian 350122China Department of Neurosurgery Sanbo Brain HospitalCapital Medical UniversityBeijing 100093China

Background:Adamantinomatous craniopharyngioma(ACP)is the commonest pediatric sellar *** effective drug is available and interpatient heterogeneity is *** study aimed to identify distinct molecular subgroups of ACP based on the multi-omics profiles,imaging findings,and histological features,in order to predict the response to anti-inflammatory treatment and ***:Totally 142 Chinese cases diagnosed with craniopharyngiomas were profiled,including 119 ACPs and 23 papillary ***-exome sequencing(151 tumors,including recurrent ones),RNA sequencing(84 tumors),and DNA methylome profiling(95 tumors)were *** clustering and non-negative matrix factorization were used for subgrouping,and Cox regression were utilized for prognostic evaluation,***:Three distinct molecular subgroups were identified:WNT,ImA,and *** WNT subgroup showed higher Wnt/β-catenin pathway activity,with a greater number of epithelial cells and more predominantly solid *** ImA and ImB subgroups had activated inflammatory and interferon response pathways,with enhanced immune cell infiltration and more predominantly cystic ***-activated protein kinases(MEK/MAPK)signaling was activated only in ImA samples,while IL-6 and epithelial-mesenchymal transition biomarkers were highly expressed in the ImB group,mostly consisting of *** degree of astrogliosis was significantly elevated in the ImA group,with severe finger-like protrusions at the invasive front of the *** molecular subgrouping was an independent prognostic factor,with the WNT group having longer event-free survival than ImB(Cox,P=0.04).ImA/ImB cases were more likely to respond to immune checkpoint blockade(ICB)therapy than the WNT group(P<0.01).In the preliminary screening of subtyping markers,CD38 was significantly downregulated in WNT compared with ImA and ImB(P=0.01).Conclusions:ACP comprises three molecular subtypes with distinct

关键词： Craniopharyngioma Central nervous system tumor Precision medicine beta Catenin Proto-Oncogene Proteins B-raf

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Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

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Nano Research 2024年第7期17卷 6411-6419页

作者： Hao Chen Xianzhe Tang Yueye Huang Chen Chen Yuheng Yang Chaojie Hao Wenqi Xie Tingjing Huang Xiaofeng Cheng Qingnan Xu Shicong Huang zhi ye Xucong Lin zhaowei Chen zhitong Chen MOE Key Laboratory for Analytical Science of Food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced Therapeutic Center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of Chemistry University College LondonLondon WC1H 0AJUK Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and Food Safety in Fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Biomedical Imaging Science and System Chinese Academy of SciencesShenzhen 518055China

Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

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Surface deformation-dependent mechanical properties of bending nanowires:an ab initio core-shell model

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Applied Mathematics and Mechanics(English Edition) 2022年第2期43卷 219-232页

作者： ye XIAO j.SHANG L.z.KOU Chun LI School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710072China MIIT Key Laboratory of Dynamics and Control of Complex Systems Northwestern Polytechnical UniversityXi’an710072China School of Mechanical Medical and Process EngineeringQueensland University of TechnologyBrisbaneQLD4000Australia

An ab initio core-shell model is proposed to evaluate the surface effect in bending nanowires,in which the elastic modulus depends on the surface relaxation and deformation induced by external *** using first-principles calculations based on the density functional theory(DFT),the surface and bulk properties are calculated for Ag,Pb,and Si *** obtained theoretical predictions of the effective Young’s modulus of nanowires agree well with the experimental data,which shows that the fixed-fixed nanowire is stiffened and the cantilevered nanowire is softened as the characteristic size of the cross section ***,the contrastive analysis on the two kinds of nanowires demonstrates that increasing the nanowire aspect ratio would enhance the surface *** present results could be helpful for understanding the size effect in nanowires and designing nanobeam-based devices in nanoelectromechanical systems(NEMSs).

关键词： surface effect density functional theory(DFT) surface relaxation surface stress nanowire

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Exploring dielectric phenomena in sulflower-like nanostructures via Monte Carlo technique

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Communications in Theoretical Physics 2024年第4期76卷 188-198页

作者： N Saber z Fadil Hussein Sabbah A Mhirech B Kabouchi L Bahmad Chaitany jayprakash Raorane Siva Sankar Sana Hassan Fouad Mohamed Hashem Laboratory of Condensed Matter and Interdisciplinary Sciences(LaMCScI) Research Unit Labelled CNRSTURL-CNRST-17.Faculty of SciencesPO Box 1014Mohammed Ⅴ University in RabatMorocco College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait School of Chemical Engineering Yeungnam UniversityGyeongsan38541Republic of Korea Applied Medical Science Department Community CollegeKing Saud UniversityPO Box 11433Riyadh Saudi Arabia Department of Dental Health College of Applied Medical SciencesKing Saud UniversityPO Box 12372RiyadhSaudi Arabia

This research focuses on the electric behavior of a mixed ferrielectric sulflower-like *** structure includes a core with spin S_(i)^(z)-1 atoms and a shell with spin σ_(j)^(z)-5/2 *** Blume–Capel model and the Monte Carlo technique(MCt)with the Metropolis algorithm are *** are established for absolute zero,investigating stable spin configurations correlated with various physical *** MCt method explores phase transition behavior and electric hysteresis cycles under different physical parameters.

关键词： sulfower-like nanostructure dielectric characteristics Monte Carlo technique phase transition phase diagrams electric hysteresis

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Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles

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Bone Research 2024年第1期12卷 137-152页

作者： Weicheng Lu jianfei Yan Chenyu Wang Wenpin Qin Xiaoxiao Han zixuan Qin Yu Wei Haoqing Xu jialu Gao Changhe Gao Tao ye Franklin R.Tay Lina Niu Kai jiao Department of Stomatology Tangdu Hospital&State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration&National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxiChina The Dental College of Georgia Augusta UniversityAugustaGAUSA

Brain-derived extracellular vesicles participate in interorgan communication after traumatic brain injury by transporting pathogens to initiate secondary ***-related proteins encapsulated in brain-derived extracellular vesicles can cross the blood‒brain barrier to reach distal *** proteins initiate inflammatory dysfunction,such as neurogenic heterotopic *** recurrent condition is highly debilitating to patients because of its relatively unknown pathogenesis and the lack of effective prophylactic intervention ***,a rat model of neurogenic heterotopic ossification induced by combined traumatic brain injury and achillotenotomy was developed to address these two *** examination of the injured tendon revealed the coexistence of ectopic calcification and fibroblast *** relationships among brain-derived extracellular vesicles,fibroblast pyroptosis and ectopic calcification were further investigated in vitro and in *** injection of the pyroptosis inhibitor Ac-YVAD-cmk reversed the development of neurogenic heterotopic ossification in *** present work highlights the role of brain-derived extracellular vesicles in the pathogenesis of neurogenic heterotopic ossification and offers a potential strategy for preventing neurogenic heterotopic ossification after traumatic brain injury.

关键词： neurogenic ossification pathogenesis

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Carrier transport barrier in AlGaN-based deep ultraviolet LEDs on offcut sapphire substrates

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Chinese Optics Letters 2024年第2期22卷 148-158页

作者：陈秋爽陈荔陈聪高歌郭炜叶继春 Ningbo Institute of Materials Technology and Engineering Ningbo 315201China University of Chinese Academy of Sciences Beijing 100049China

AlGaN-based light-emitting diodes(LEDs)on offcut substrates enhance radiative emission via forming carrier localization centers in multiple quantum wells(MQWs).This study introduces the carrier transport barrier concept,accessing its impact on the quantum efficiency of LEDs grown on different offcut sapphire substrates.A significantly enhanced internal quantum efficiency(IQE)of 83.1%is obtained from MQWs on the 1°offcut sapphire,almost twice that of the controlled 0.2°offcut ***,1°offcut LEDs have higher turn-on voltage and weaker electroluminescence than 0.2°*** calculations demonstrate the existence of a potential barrier on the current path around the step-induced Ga-rich ***-rich stripes reduce the turn-on voltage but restrict sufficient driving current,impacting LED performance.

关键词： carrier localization step-bunching potential barrier offcut substrate DUV LEDs

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Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation

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World journal of Diabetes 2024年第5期15卷 958-976页

作者： Hong Xu Li-Bo zhang Yi-Yi Luo Ling Wang ye-Pin zhang Pei-Qi Chen Xue-Ying Ba jian Han Heng Luo Department of Ophthalmology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Precision Medicine Center of Chuxiong Yi Autonomous Prefecture The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Endocrinology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina Department of Pathology The People’s Hospital of Chuxiong Yi Autonomous Prefecture&The Fourth Affiliated Hospital of Dali UniversityChuxiong Yi Autonomous Prefecture 675000Yunnan ProvinceChina

BACKGROUND Synaptotagmins(SYTs)are a family of 17 membrane transporters that function as calcium ion sensors during the release of Ca2+-dependent neurotransmitters and ***,few studies have reported whether members of the SYT family play a role in glucose uptake in diabetic retinopathy(DR)through Ca2+/glucose transporter-1(GLUT1)and the possible regulatory mechanism of *** To elucidate the role of the SYT family in the regulation of glucose transport in retinal pigment epithelial cells and explore its potential as a therapeutic target for the clinical management of *** DR was induced by streptozotocin in C57BL/6j mice and by high glucose medium in human retinal pigment epithelial cells(ARPE-19).Bioinformatics analysis,reverse transcriptase-polymerase chain reaction,Western blot,flow cytometry,ELISA,HE staining,and TUNEL staining were used for *** Six differentially expressed proteins(SYT2,SYT3,SYT4,SYT7,SYT11,and SYT13)were found between the DR and control groups,and SYT4 was highly *** induces SYT4 overexpression,manipulates Ca2+influx to induce GLUT1 fusion with the plasma membrane,promotes abnormal expression of the glucose transporter GLUT1 and excessive glucose uptake,induces ARPE-19 cell apoptosis,and promotes DR *** deficiency inhibits the proteasomal degradation of SYT4 in DR,resulting in SYT4 accumulation and enhanced GLUT1 fusion with the plasma membrane,and these effects were blocked by oe-Parkin ***,dysregulation of the myelin transcription factor 1(Myt1)-induced transcription of SYT4 in DR further activated the SYT4-mediated stimulus-secretion coupling process,and this process was inhibited in the oe-MYT1-treated *** Our study reveals the key role of SYT4 in regulating glucose transport in retinal pigment epithelial cells during the pathogenesis of DR and the underlying mechanism and suggests potential therapeutic targets for clinical DR.

关键词： Diabetic retinopathy Glucose transporter-1 Synaptotagmin 4 Parkin Myelin transcription factor 1

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基于管道应变的应力弱磁检测模型

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油气储运 2024年第1期43卷 67-74页

作者：田野国家管网集团西部管道有限责任公司

【目的】金属磁记忆(Metal Magnetic Memory,MMM)应力检测技术支持非接触、在线检测,在以钢制油气管道为代表对象的铁磁性材料应力损伤检测领域具有很好的应用潜力,现有研究缺乏对磁力学关系的全面分析,需要建立一套完整的磁力学关系体... 详细信息

【目的】金属磁记忆(Metal Magnetic Memory,MMM)应力检测技术支持非接触、在线检测,在以钢制油气管道为代表对象的铁磁性材料应力损伤检测领域具有很好的应用潜力,现有研究缺乏对磁力学关系的全面分析,需要建立一套完整的磁力学关系体系,明确MMM检测信号与弹塑性阶段应力集中的对应关系。【方法】基于j-A理论,建立管道磁化强度与应变关系数值模型,计算分析管道变形过程中MMM检测信号特征,研究了应力影响下的无磁滞磁化曲线形状参数、钉扎系数对MMM信号的影响规律,并对应变与磁信号的关系开展全尺寸水压试验验证。【结果】管道在受力过程中,应变逐渐增大,磁化强度曲线在弹性变形阶段发生第1次翻转,翻转位置位于近屈服处,且随无磁滞磁化曲线形状参数的增大而提前;当管体发生塑性变形时,位错引起材料磁学特性改变,磁化强度曲线出现第2次翻转,翻转位置位于屈服点附近,且受钉扎系数影响较大,随着钉扎系数增大,翻转位置延后,翻转处应变呈2次函数减小趋势,第1次翻转与第2次翻转方向相反。【结论】利用该特征,根据磁记忆信号翻转规律与被检管道相同材料标定试验结果的相位对比分析,可判断钢制油气管道应力集中处是否发生塑性应变,实现对管道应力集中区域的快速定性检测。(图8,参30)

关键词：管道应变应力检测磁记忆磁-力学关系

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电动装载机电液复合制动协同控制策略研究

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农业机械学报 2024年第6期55卷 442-450页

作者：叶月影吴瑕林添良集美大学诚毅学院厦门361021 福建省移动机械绿色智能驱动与传动重点实验室厦门361021 华侨大学机电及自动化学院厦门361021

针对电动装载机的电液复合制动系统,为满足多工况制动需求以及保障制动安全性,本文提出了一种基于再生制动自由行程液压制动阀的电动装载机液压制动系统。结合电动装载机的理想前后轮制动力分配曲线以及制动意图识别得到的制动强度,制... 详细信息

针对电动装载机的电液复合制动系统,为满足多工况制动需求以及保障制动安全性,本文提出了一种基于再生制动自由行程液压制动阀的电动装载机液压制动系统。结合电动装载机的理想前后轮制动力分配曲线以及制动意图识别得到的制动强度,制定了制动强度与整车制动力矩需求的分配曲线;为进一步提高再生制动力与液压制动力分配的协调性,同时兼顾制动能量回收效率,提出了一种基于行走再生制动和液压制动的电液复合制动协同控制策略,降低了整车总制动力矩波动,保证了制动模式切换的平顺性。最后,搭建了基于AMESim-Matlab/Simulink联合仿真模型,并搭建试验样机,验证了电动装载机复合制动协同控制策略的可行性,结果表明,该系统能量回收效率可达71.6%,制动回收率可达44.5%,一个工作循环实现节能7.6%,说明本文提出的控制策略具有良好的制动性能和能量回收效率。

关键词：电动装载机复合制动液压制动能量回收协同控制

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Abnormal function of EPHA2/p.R957P mutant in congenital cataract

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International journal of Ophthalmology(English edition) 2024年第6期17卷 1007-1017页

作者： jing-jin zhang zong-Fu Cao Bi-Ting zhou ju-Hua Yang zhong Li Shuang Lin Xiao-Le Chen Nan-Wen zhang Qin ye Xu Ma Yi-Hua zhu Department of Ophthalmology the First Affiliated Hospital of Fujian Medical UniversityFujian Institute of OphthalmologyFujian Provincial Clinical Medical Research Center of Eye Diseases and OptometryFuzhou 350005Fujian ProvinceChina Department of Ophthalmology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100000China National Human Genetic Resources Center National Research Institute for Family PlanningBeijing 100081China Department of Bioengineering and Biopharmaceutics School of PharmacyFujian Medical UniversityFuzhou 350004Fujian ProvinceChina

AIM:To identify genetic defects in a Chinese family with congenital posterior polar cataracts and assess the ***:A four-generation Chinese family affected with autosomal dominant congenital cataract was *** individuals took part in this study including 5 affected and 14 unaffected *** sequencing targeted hot-spot regions of 27 congenital cataract-causing genes for variant *** pathogenicity of the variant was evaluated by the guidelines of American College of Medical Genetics and InterVar *** microscopy was applied to detect the subcellular localization of fluorescence-labeled ephrin type-A receptor 2(EPHA2).Co-immunoprecipitation assay was implemented to estimate the interaction between EphA2 and other lens membrane *** mRNA and protein expression were analyzed by reverse transcription-polymerase chain reaction(qRT-PCR)and Western blotting assay,*** cell migration was analyzed by wound healing *** model was generated by ectopic expression of human EPHA2/p.R957P mutant to demonstrate whether the mutant could cause lens opacity in ***:A novel missense and pathogenic variant c.2870G>C was identified in the sterile alpha motif(SAM)domain of *** studies demonstrated the variant’s impact:reduced EPHA2 protein expression,altered subcellular localization,and disrupted interactions with other lens membrane *** mutant notably enhanced human lens epithelial cell migration,and induced a central cloudy region and roughness in zebrafish lenses with ectopic expression of human EPHA2/p.R957P mutant under differential interference contrast(DIC)***:Novel pathogenic c.2870G>C variant of EPHA2 in a Chinese congenital cataract family contributes to disease pathogenesis.

关键词： congenital cataract EPHA2 missense variant function analysis

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