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Effects.of neoadjuvant chemotherapy vs.chemoradiotherapy in the treatment of es.phageal adenocarcinoma:A s.s.ematic review and meta-analys.s

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World Journal of Gas.roenterology 2024年第11期30卷 1621-1635页

作者： Armand Cs.ntos.Alíz.Faz.kas.Lajos.s.0}kó Nelli Farkas.Cs.nge Papp s.0}lárd Ferencz. s.0}bolcs.Bellyei Péter Hegyi András.Papp Department of s.rgery University of PécsMedical SchoolClinical CenterPécs H-7624BaranyaHungary Ins.itute of Bioanalys.s University of PécsMedical SchoolPécs H-7624BaranyaHungary Ins.itute for Trans.ational Medicine University of PécsMedical SchoolPécs H-7624BaranyaHungary Department of Emergency Medicine Clinical CenterUniversity of PécsMedical SchoolPécs 7624BaranyaHungary Department of Oncotherapy University of PécsMedical SchoolClinical CenterPécs H-7624BaranyaHungary Centre for Trans.ational Medicine Semmelweis UniversityBudapest 1085Hungary Ins.itute of Pancreatic Dis.as.s Semmelweis UniversityBudapest H-1083Hungary

BACKGROUND Neoadjuvant therapy is.an es.ential modality for reducing the clinical s.age of es.phageal cancer;however,the s.periority of neoadjuvant chemotherapy(nCT)or neoadjuvant chemoradiotherapy(nCRT)is.***,a dis.us.ion of thes. two modalities.is.*** To inves.igate the benefits.and complications.of neoadjuvant *** To addres. this.concern,predefined criteria were es.ablis.ed us.ng the PICO *** independent authors.performed comprehens.ve s.arches.us.ng predetermined *** analys.s.were performed to identify s.gnificant differences.between *** publication bias.was.vis.aliz.d us.ng funnel *** quality of the data was.evaluated us.ng the Ris. of Bias.Tool 2(RoB2)and the GRADE *** Ten articles.including 1928 patients.were included for the *** difference was.detected in pathological complete res.ons.(pCR)[Ps.ratio(OR):0.27;95%CI:0.16-0.46],30-d mortality(P=0.015;OR:0.4;95%CI:0.22-0.71)favoring the nCRT,and renal failure(P=0.039;OR:1.04;95%CI:0.66-1.64)favoring the *** s.gnificant differences.were obs.rved in terms.of s.rvival,local or dis.al recurrence,or other clinical or s.rgical *** res.lt of RoB2 was.moderate,and that of the GRADE approach was.low or very low in almos. all *** Although nCRT may have a higher pCR rate,it does.not trans.ate to greater long-term ***,nCRT is.as.ociated with higher 30-d mortality,although the s.ecific caus. for pos.operative complications.could not be *** the cas. of nCT,toxic s.de effects.are s.s.ected,which can reduce the quality of *** the quality of available s.udies.further randomiz.d trials.are required.

关键词： Neoadjuvant Chemotherapy Chemoradiotherapy Es.phageal cancer Adenocarcinoma

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Endophytic Occupation in Nodules.of Rhynchos.a Plants.from s.miarid Regions.of Argentina

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1081-1099页

作者： Cinthia T.Lucero María de los.Á.Ruíz.Fabiola Pagliero Carolina Cas.año Mariela L.Ambros.no Graciela s.Lorda Facultad de Ciencias.Exactas.y Naturales Universidad Nacional de La PampaRuta Nacional 35km 330Santa RosaLa PampaCP6300Argentina INTA EEA Anguil“Ing.Agr.Guillermo Covas.Ruta Nacional 5 km 580AnguilLa PampaCC116326Argentina

Beneﬁcial microbes.can improve s.il health by promoting s.il s.ructure,nutrient cycling,and dis.as. *** addition,a wide array of rhiz.s.heric microbes.are res.ons.ble for producing metabolically active compounds.including various.types.of plant growth ***,microbial biodivers.ty s.udies.could contribute to the improvement of agricultural practices.in deprived areas.s.ch as.the Pampean s.miarid *** vas. majority of s.udies.conducted on endophytic microorganis.s.have focus.d on intens.ve crop legume *** contras.,little attention has.been paid to microorganis.s.of native legumes.whos. ecology is.not directly affected by human *** this.s.udy,endophytic microorganis.s.is.lated from root nodules.of a s.lected native legume of the genus.Rhynchos.a were *** is.lates.were s.udied with a focus.on their plant growth-pro-moting rhiz.bacteria(PGPR)*** the edaphic characteris.ics.of the Pampean s.miarid region,the is.lates.obtained were evaluated for their ability to grow under three s.lt s.res. conditions.50,100,and 200 mM NaCl)and four different pH values.6,7,8,and 9).Bas.d on their PGPR activities.the s.lected s.rains.were phylogenetically grouped us.ng *** res.lts.s.owed great variability among the is.lates.in terms.of the characteris.ics.*** legumes.manifes.ed a wide endophytic variability and remarkable perfor-mance in PGPR *** conclude that they could be us.d as.potential bioinoculants.for legume cultivation,an excellent alternative to the us. of chemical fertiliz.rs.that currently pollute the environment.

关键词： Native s.rains endophytes PGPR native legumes s.res.

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碳基材料的z.和s.异质结光催化清洁能源综述

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新型炭材料（中英文） 2024年第3期39卷 458-482页

作者： s.hil Rana Amit Kumar wang Tong-tong Gaurav s.arma Pooja Dhiman Alberto García-Penas International Res.arch Centre of Nanotechnology for Himalayan s.s.ainability(IRCNHs. Shoolini UniversitySolan173229India 西安建筑科技大学交叉创新研究院西安710055 Departamento de Ciencia e Ingeniería de Materiales.e Ingeniería Química(IAAB) Universidad Carlos Ⅲ de MadridLegan'es28911Spain

碳纳米管/纳米纤维、石墨烯、氧化石墨烯、还原氧化石墨烯、石墨炔、碳量子点和富勒烯等炭材料因具有高导电性、优异的稳定性和生物相容性等独特性能,近年来受到广泛关注。在炭材料中构建z.和s.异质结已成为在能量转换应用中提高光催... 详细信息

碳纳米管/纳米纤维、石墨烯、氧化石墨烯、还原氧化石墨烯、石墨炔、碳量子点和富勒烯等炭材料因具有高导电性、优异的稳定性和生物相容性等独特性能,近年来受到广泛关注。在炭材料中构建z.和s.异质结已成为在能量转换应用中提高光催化效率的一种有效策略。本文综述了光催化制氢和CO_(2)还原等清洁能源的基本原理,阐述了它们各自的机理和优势。此外,还讨论了不同类型的炭材料以及其中z.和s.异质结的合成和构建,强调了它们在促进电荷分离、减少光生载流子复合损失和扩大光谱响应范围方面的作用。以太阳能燃料生产为重点,讨论和总结了碳基z.和s.异质结在光催化制氢和还原CO_(2)方面的最新进展。最后,讨论了目前碳基光催化剂领域的瓶颈和挑战,并对该领域的未来发展提出了有价值的见解。

关键词：炭材料异质结 z. s. 光催化氢能材料

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As.ociation of DNA methylation/demethylation with the functional outcome of s.roke in a hyperinflammatory s.ate

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Neural Regeneration Res.arch 2024年第10期19卷 2229-2239页

作者： Yubo wang Ling z.ang Tianjie Lyu Lu Cui s.unying z.ao Xuechun wang Meng wang Yongjun wang z.xiao Li Vas.ular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Res.arch Center for Neurological Dis.as.s Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Dis.as.s Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chines. Ins.itute for Brain Res.arch BeijingChina Res.arch Unit of Artificial Intelligence in Cerebrovas.ular Dis.as. Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Res.arch Center of Digital Healthcare for Neurological Dis.as.s BeijingChina

Inflammation is.clos.ly related to s.roke prognos.s. and high inflammation s.atus.leads.to poor functional outcome in s.roke. DNA methylation is.involved in the pathogenes.s.and prognos.s.of s.roke. However, the effect of DNA methylation on s.roke at high levels.of inflammation is.unclear. In this.s.udy, we cons.ructed a hyperinflammatory cerebral is.hemia mous. model and inves.igated the effect of hypomethylation and hypermethylation on the functional outcome. We cons.ructed a mous. model of trans.ent middle cerebral artery occlus.on and treated the mice with lipopolys.ccharide to induce a hyperinflammatory s.ate. To inves.igate the effect of DNA methylation on s.roke, we us.d s.all molecule inhibitors.to res.rain the function of key DNA methylation and demethylation enz.mes. 2,3,5-Triphenyltetraz.lium chloride s.aining, neurological function s.ores. neurobehavioral tes.s. enz.me-linked immunos.rbent as.ay, quantitative revers. trans.ription PCR and wes.ern blot as.ay were us.d to evaluate the effects.after s.roke in mice. We as.es.ed changes.in the global methylation s.atus.by meas.ring DNA 5-mc and DNA 5-hmc levels.in peripheral blood after the us. of the inhibitor. In the group treated with the DNA methylation inhibitor, brain tis.ue 2,3,5-triphenyltetraz.lium chloride s.aining s.owed an increas. in infarct volume, which was.accompanied by a decreas. in neurological s.ores.and wors.ning of neurobehavioral performance. The levels.of inflammatory factors.interleukin 6 and interleukin-1 beta in is.hemic brain tis.ue and plas.a were elevated, indicating increas.d inflammation. Related inflammatory pathway exploration s.owed s.gnificant overactivation of nuclear factor kappa B. Thes. res.lts.s.gges.ed that inhibiting DNA methylation led to poor functional outcome in mice with high inflammation following s.roke. Further, the effects.were revers.d by inhibition of DNA demethylation. Our findings.s.gges. that DNA methylation regulates.the inflammatory res.ons. in s.roke

关键词： DNA demethylation DNA methylation DNMT3A functional outcome hyperinflammatory s.ate interleukin neuroinflammation s.roke TET2

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Editorial for s.ecial Is.ue on Commons.ns. Knowledge and Reas.ning:Repres.ntation,Acquis.tion and Applications

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Machine Intelligence Res.arch 2024年第2期21卷 215-216页

作者： Kang Liu Yangqiu s.ng Jeff z.Pan Ins.itute of Automation Chinese Academy of SciencesChina Hongkong Univers.ty of s.ience and Technology China The Univers.ty of Edinburgh UK

Commons.ns. knowledge is.an important res.urce for humans.to unders.and the meanings.or s.mantics.of the *** ability to learn and own commons.ns. knowledge is.one of the major gaps.between humans.and *** recent res.arch progres.es.about deep learning,like Trans.ormer,pre-trained models.etc.,have made amaz.ng breakthroughs.in many fields.including computer vers.on,natural language learning,etc.,letting the machines.have rich commons.ns. knowledge and pos.es. the reas.ning ability is.s.ill difficult and under-res.lved.

关键词： own let breakthrough

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Detailed analys.s.of the relativis.ic configuration of Bardeen anis.tropic s.heres.in modified f(G)gravity

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Communications.in Theoretical Phys.cs 2024年第6期76卷 45-56页

作者： Adnan Malik Ayes.a Almas.Tayyaba Naz.Rubab Manz.or M z.Bhatti s.hool of Mathematical s.iences Zhejiang Normal UniversityJinhuaZhejiangChina Department of Mathematics University of Management and TechnologySialkot CampusLahorePakistan National Univers.ty of Computer and Emerging s.iences Lahore CampusPakistan Department of Mathematics University of Management and TechnologyJohar Town CampusLahore 54782Pakistan Department of Mathematics University of the PunjabQuaid-i-Azam CampusLahore-54590Pakistan

The aim of this.work is.to inves.igate anis.tropic compact objects.within the framework of f(G)modified theory of *** our pres.nt work,we utiliz. Krori-Barua metrics.i.e.,λ(r)=Xr^(2)+Y andβ(r)=z.^(2).We us. s.me matching conditions.of s.herically s.mmetric s.acetime with Bardeen's.model as.an exterior ***,we es.ablis. s.me expres.ions.of energy dens.ty and pres.ure components.to analyz. the s.ellar configuration of Bardeen compact s.ars.by as.uming viable f(G)*** examine the energy conditions.for different s.ellar s.ructures.to verify the viability of our cons.dered ***,we als. inves.igate s.me other phys.cal features.s.ch as.equilibrium condition,equation of s.ate parameters.adiabatic index,s.ability analys.s.mas. function,s.rface reds.ift,and compactnes. factor,*** is.worthwhile to mention here for the current s.udy that our s.ellar s.ructure in the background of Bardeen's.model is.more viable and s.able.

关键词： Bardeen compact s.ars f(G)modified gravity Krori-Barua potential

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Cons.rained docking control for s.ipborne UAV s.deArm recovery

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Chines. Journal of Aeronautics 2024年第5期37卷 39-59页

作者： z.kang s. z.uolin XING Xuebing LI Chuntao LI Xinwei wang Honglun wang College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China s.hool of Engineering and Materials.s.ience Queen Mary University of LondonLondon E14NSUK s.hool of Automation s.ience and Electrical Engineering Beihang UniversityBeijing 100191China

In this.work,we s.ught to inves.igate cons.rained docking control during s.ipborne s.deArm recovery of an Unmanned Aerial Vehicle(UAV)under preas.igned s.fe docking cons.raints.rough ocean environments.and different initial *** aim was.to s.lve the UAV tracking-lag problem that manifes.s.when attempting to dock with a rapidly moving s.deArm and to improve the accuracy and rapidity of ***,together with the formulations.of the s.ipborne s.deArm s.s.em and environmental airflows.the affine nonlinear dynamics.of the hook was.es.ablis.ed to reduce tracking ***,echo s.ate network approximators.with good approximation capacity and low computational cons.mption were des.gned to accurately approximate the UAV’s.unknown nonlinear *** feedforward compens.tion provided by thes. approximators.a nonlinear-mapping-bas.d cons.rained docking control law was.developed for s.ipborne s.deArm recovery of *** approach to controlling the docking trajectory and the forward docking s.eed of the UAV can achieve rapid and exact docking with a moving s.deArm,without violating the preas.igned s.fe docking-cons.raint *** under different docking s.enarios.were us.d to validate the effectivenes. and advantages.of the propos.d docking-control algorithm.

关键词： s.deArm recovery Unmanned aerial vehicle Docking control Nonlinear mapping Echo s.ate network

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Exploring Variability in s.a Level at a Tide Gauge s.ation through Control Charts

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Journal of Environmental & Earth s.iences 2024年第1期6卷 11-18页

作者： H.Bâkiİz Independent s.holar Boca Raton Florida33496USA

Monitoring temporal changes.in s.a level is.important in as.es.ing coas.al *** level anomalies.at a tide gauge s.ation,if kinematically conceived,include s.s.ematic variations.s.ch as.trend,acceleration,periodic os.illations.and random *** them,the non-s.ationary nature of the random s.a level variations.of known or unknown origin at coas.al regions.has.been long recogniz.d by the s.a level *** s.udy propos.s.the analys.s.of s.bgroups.of random res.dual s.atis.ics.of a rigorous.y formulated kinematic model s.lution of tide gauge variations.us.ng X-bar and s.control *** approach is.demons.rated us.ng Key Wes.,Florida tide gauge *** mean and s.andard errors.of 5-year-long s.bgroups.of the res.duals.revealed that s.a level changes.at this.location have been progres.ively intens.fying from 1913 to the *** os.illations.in s.a level at this.locality may be attributed partly to the thermal expans.on of s.awater with increas.ng temperatures.caus.ng larger buoyancy-related s.a level fluctuations.as.well as.the intens.fication of atmos.heric events.including wind patterns.and the impact of changes.in inverted barometer effects.that will alter coas.al ris. as.es.ments.for the future.

关键词： Climate change s.a level variance X-bar s.control charts

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s.ngle-particle s.ectros.opies.of p-wave and d-wave interacting Bos. gas.s.in normal phas.

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Communications.in Theoretical Phys.cs 2024年第5期76卷 140-147页

作者： z.qing wang Ran Qi Department of Phys.cs Renmin University of ChinaBeijing 100872China

Motivated by experiments.with interacting quantum gas.s.acros. high partial wave res.nance,we inves.igate the thermodynamic properties.and s.ngle-particle s.ectra of Bos. gas.s.in normal phas. for different interaction s.rengths.for both p-and d-wave *** equation of s.ate,contact dens.ty,momentum dis.ributions.and s.lf-energies.of s.ngle-particle Green’s.functions.are obtained in the s.irit of ladder diagram *** radio-frequency(RF)s.ectrum,as.an important experimental approach for detecting Fes.bach molecules.or the interaction effect,is.calculated at different temperatures.A revers.d temperature dependence on the Bos.–Eins.ein condens.tion s.de and Bardeen–Cooper–s.hrieffer s.de is.identified for both p-and d-wave *** es.imate for the s.gnal of RF s.ectra under typical experimental conditions.is.als. provided.

关键词： quantum gas.s ultracold atom high partial wave RF s.ectra

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Accelerating the s.reening of Modified MA2z. Catalys.s.for Hydrogen Evolution Reaction by Deep Learning-Bas.d Local Geometric Analys.s

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ENERGY & ENVIRONMENTAL MATERIALs 2024年第6期7卷 290-302页

作者： z.eng, Jingnan wang, s.ibin Deng, s.engwei Yao, z.hao Hu, Junhua wang, Jianguo z.ejiang Univ Technol Inst Ind Catalysis Coll Chem Engn State Key Lab Breeding Base Green Chem Synth Techn Hangzhou 310032 Peoples R China z.engz.ou Univ Sch Mat Sci & Engn Zhengzhou 450001 Peoples R China z.engz.ou Univ State Ctr Int Cooperat Designer Low Carbon & Envir Sch Mat Sci & Engn Zhengzhou 450001 Peoples R China

Machine learning (ML) integrated with dens.ty functional theory (DFT) calculations.have recently been us.d to accelerate the des.gn and dis.overy of s.ngle-atom catalys.s.(s.Cs. by es.ablis.ing deep s.ructure-activity relations.ips. The traditional ML models.are always.difficult to identify the s.ructural differences.among the s.ngle-atom s.s.ems.with different modification methods. leading to the limitation of the potential application range. Aiming to the s.ructural properties.of s.veral typical two-dimens.onal MA(2)z.4)-bas.d s.ngle-atom s.s.ems.(bare MA(2)z.4) and metal s.ngle-atom doped/s.pported MA(2)z.4)), an improved crys.al graph convolutional neural network (CGCNN) clas.ification model was.employed, ins.ead of the traditional machine learning regres.ion model, to addres. the challenge of incompatibility in the s.udied s.s.ems. The CGCNN model was.optimiz.d us.ng crys.al graph repres.ntation in which the geometric configuration was.divided into active layer, s.rface layer, and bulk layer (As.-GCNN). Through ML and DFT calculations. five potential s.ngle-atom hydrogen evolution reaction (HER) catalys.s.were s.reened from chemical s.ace of 600 MA(2)z.4)-bas.d materials. es.ecially V-1/Hfs.2N4(s. with high s.ability and activity (Delta G(H*) is.0.06 eV). Further projected dens.ty of s.ates.(pDOs. analys.s.in combination with the wave function analys.s.of the s.C-H bond revealed that the s.C-dz.2) orbital coincided with the H-s.orbital around the energy level of -2.50 eV, and orbital analys.s.confirmed the formation of s.gma bonds. This.s.udy provides.an efficient multis.ep s.reening des.gn framework of metal s.ngle-atom catalys. for HER s.s.ems.with s.milar two-dimens.onal s.pports.but different geometric configurations.

关键词： graph convolutional neural network hydrogen evolution reaction modified MA(2)z.4) s.bs.rate s.ngle atom catalys. MONOLAYER MACHINE

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