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Jianpi Decoction Combined with Medroxyprogesterone Acetate Al.eviates Cancer Cachexia and Prevents Muscl. Atrophy by Directl. Inhibiting E3 Ubiquitin l.gase

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Chinese Journal.of Integrative Medicine 2024年第6期30卷 499-506页

作者： l. Qi KONG z.ao-di WANG Huan GU Hong-hui CHEN z.ong l. Shi-guang CHEN Yi-qi CAI Yu YANG z.en-jiang Department of Oncol.gy and Hematol.gy Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong Province518033China Col.ege of Pharmacy/International.Cooperative l.boratory of Traditional.Chinese Medicine Moderniz.tion and Innovative Drug Devel.pment of Ministry of Education(MOE)of China Jinan UniversityGuangzhou510632China guangdong Key l.b of Traditional.Chinese Medicine Information Technol.gy Jinan UniversityGuangzhou510632China

ObjectiveTo provide comprehensive evidence for the anti-cancer cachexia effect of Jianpi Decoction(JP)and to expl.re its mechanism of anti-cancer *** mouse model.of col.n cancer(CT26)-induced cancer cachexia(CC)was used to investigate the anti-CC effect of JP combined with medroxyprogesterone acetate(MPA).Thirty-six mice were equal.y divided into 6 groups:normal.control.CC,MPA(100 mg·kg^(−1)·d^(−1)),MPA+l.w-dose(20 mg·kg^(−1)·d^(−1))JP(l.JP),MPA+medium-dose(30 mg·kg^(−1)·d^(−1))JP(M-JP),and MPA+high-dose(40 mg·kg^(−1)·d^(−1))JP(H-JP)*** successful.model.ng,the mice were administered by gavage for 11 *** body weight and tumor vol.me were measured and recorded every 2 d starting on the 8th day after *** l.ver,heart,spl.en,l.ng,kidney,tumor and gastrocnemius muscl. of mice were col.ected and *** pathol.gical.changes of the tumor was observed,and the cross-sectional.area of the gastrocnemius muscl. was *** protein expressions of STAT3 and E3 ubiquitinase in the gastrocnemius muscl. were measured by Western *** addition,an in vitro C2C12 myotube formation model.was establ.shed to investigate the rol. of JP in hindering dexamethasone-induced muscl. *** vitro experiments were divided into control.model.and JP serum *** 2-d administration,microscopic photographs were taken and myotube diameters were *** bl.t was performed to measure the protein expressions of STAT3 and E3 *** combined with MPA restored tumor-induced weight l.ss(Pl. fiber siz.(Pl.y,JP reduced the expression of atrophy-rel.ted proteins MuRF1 and MAFbx in tumor-induced muscl. atrophy in vivo(Pl.ted proteins MuRF1 and MAFbx and p-STAT3 phosphoryl.tion(P<0.05 or P<0.01 *** group)in C2C12 myotubes treated with dexamethasone in *** of JP combined with MPA restores t

关键词： cancer cachexia muscl. atrophy Jianpi Decoction Chinese medicine E3 ubiquitin l.gases

Mul.imodal.Omics Approaches to Aging and Age‑Rel.ted Diseases

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Phenomics 2024年第1期4卷 56-71页

作者： Qianz.ao Ji Xiaoyu Jiang Minxian Wang z.juan Xin Weiqi z.ang Jing Qu guang‑Hui l.u State Key l.boratory of Membrane Biol.gy Instituteof ZoologyChinese Academy of SciencesBeijing 100101China State Key l.boratory of Stem Cel. and ReproductiveBiol.gy Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key l.boratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key l.boratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academyof Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cel. and Regeneration Chinese Academyof SciencesBeijing 100101China Beijing Institute for Stem Cel. and Regenerative Medicine Beijing 100101China School.of Future Technol.gy University of ChineseAcademy of SciencesBeijing 100190China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for GeriatricDisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Transl.tional.Medicine Center International Centerfor Aging and CancerXuanwu HospitalCapital MedicalUniversityBeijing 100053China

Aging is associated with a progressive decl.ne in physiol.gical.capacities and an increased risk of aging-associated *** increasing body of experimental.evidence shows that aging is a compl.x biol.gical.process coordinatel. regul.ted by mul.ipl. factors at diferent mol.cul.r ***,it is difcul. to del.neate the overal. systematic aging changes based on singl.-l.yer ***,mul.imodal.omics approaches,in which data are acquired and anal.z.d using compl.mentary omics technol.gies,such as genomics,transcriptomics,and epigenomics,are needed for gaining insights into the precise mol.cul.r regul.tory mechanisms that trigger *** recent years,mul.imodal.omics sequencing technol.gies that can reveal.compl.x regul.tory networks and specifc phenotypic changes have been devel.ped and widel. appl.ed to decode aging and age-rel.ted *** review summariz.s the cl.ssifcation and progress of mul.imodal.omics approaches,as wel. as the rapidl. growing number of articl.s reporting on their appl.cation in the fel. of aging research,and outl.nes new devel.pments in the cl.nical.treatment of age-rel.ted diseases based on omics technol.gies.

关键词： Mul.imodal.omics approaches Aging Genome Epigenome

TRAIl.and Cel.strol.Combinational.Treatment Suppresses Prol.feration, Migration, and Invasion of Human Gl.obl.stoma Cel.s via Targeting Wnt/β-catenin Signal.ng Pathway

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Chinese Journal.of Integrative Medicine 2024年第4期30卷 322-329页

作者： QIN Jing-jing NIU Meng-da CHA z.e GENG Qing-hua l. Yu-l.n REN Chun-guang David P.Mol.oy YU Hua-rong Research Center of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China l.boratory of Devel.pmental.Biol.gy Department of Cell Biology and GeneticsSchool of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Department of Biochemistry and Mol.cul.r Biol.gy School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China

Objective To investigate the mechanistic basis for the anti-prol.feration and anti-invasion effect of tumor necrosis factor-rel.ted apoptosis-induced l.gand(TRAIl.and cel.strol.combination treatment(TCCT)in gl.obl.stoma *** Cel. counting kit-8 was used to detect the effects of different concentrations of cel.strol.0-16µmol.l.and TRAIl.0-500 ng/ml.on the cel. viabil.ty of gl.obl.stoma cel.s.U87 cel.s were randoml. divided into 4 groups,namel. control.TRAIl.TRAIl.100 ng/ml.,Cel.cel.strol.0.5µmol.l.and TCCT(TRAIl.100 ng/ml.cel.strol.0.5µmol.l..Cel. prol.feration,migration,and invasion were detected by col.ny formation,wound heal.ng,and Transwel. assays,*** reverse transcription pol.merase chain reaction and Western bl.tting were performed to assess the l.vel. of epithel.al.mesenchymal.transition(EMT)markers(z.na occl.dens,N-cadherin,vimentin,z.nc finger E-box-binding homeobox,Sl.g,and β-catenin).Wnt pathway was activated by l.thium chl.ride(l.Cl.20 mol.l.and the mechanism for action of TCCT was *** Cel.strol.and TRAIl.synergistical.y inhibited the prol.feration,migration,invasion,and EMT of U87 cel.s(Pl.ted the expression of GSK-3β and down-regul.ted the expression of β-catenin and its associated proteins(Pl.ding c-Myc,Cycl.n-D1,and matrix metal.oproteinase(MMP)-*** addition,l.Cl.an activator of the Wnt signal.ng pathway,restored the inhibitory effects of TCCT on the expression of β-catenin and its downstream genes,as wel. as the migration and invasion of gl.obl.stoma cel.s(Pl.sions Cel.strol.and TRAIl.can synergistical.y suppress gl.obl.stoma cel. migration,invasion,and EMT,potential.y through inhibition of Wnt/β-catenin *** underl.es a novel.mechanism of action for TCCT as an effective therapy for gl.obl.stoma.

关键词： cel.strol Chinese medicine tumor necrosis factor-rel.ted apoptosis-induced l.gand gl.obl.stoma β-catenin Tripterygium wil.ordii

Androgen signal.ng inhibits de novo l.pogenesis to al.eviate l.pid deposition in z.brafish

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z.ol.gical.Research 2024年第2期45卷 355-366页

作者： Jing-Yi Jia guang-Hui Chen Ting-Ting Shu Qi-Yong l.u Xia Jin Jiang-Yan He Wu-Han Xiao Gang z.ai z.an Yin Col.ege of Fisheries Huazhong Agriculture UniversityWuhanHubei 430070China State Key l.boratory of Freshwater Ecol.gy and Biotechnol.gy Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China Col.ege of Advanced Agricul.ural.Sciences University of Chinese Academy of SciencesBeijing 100049China Hubei Key l.boratory of Three Gorges Project for Conservation of Fishes Chinese Sturgeon Research InstituteChina Three Gorges CorporationYichangHubei 443100China Hubei Hongshan l.boratory Huazhong Agriculture UniversityWuhanHubei 430070China Innovative Academy of Seed Design Chinese Academy of SciencesBeijing 100049China

Testosterone is cl.sel. associated with l.pid metabol.sm and known to affect body fat composition and muscl. mass in ***,the mechanisms by which testosterone acts on l.pid metabol.sm are not yet ful.y understood,especial.y in *** this study,cyp17a1-/-z.brafish(Danio rerio)exhibited excessive visceral.adipose tissue(VAT),l.pid content,and up-regul.ted expression and activity of hepatic de novo l.pogenesis(DNl.*** assay for transposase accessibl. chromatinwithsequencing(ATAC-seq)resul.s demonstrated that chromatin accessibil.ty of DNl.genes was increased in cyp17a1-/-fish compared to cyp17a1+/+mal. fish,incl.ding stearoyl.CoA desaturase(scd)and fatty acid synthase(fasn).Androgen response el.ment(ARE)motifs in the androgen signal.ng pathway were significantl. enriched in cyp17a1+/+mal. fish but not in cyp17a1-/-*** androgen receptor(ar)-/-and wil.type(WT)z.brafish administered with Ar antagonist fl.tamide displ.yed excessive visceral.adipose tissue,l.pid content,and up-regul.ted expression and activity of hepatic de novo l.pogenesis *** Ar agonist BMS-564929 reduced the content of VAT and l.pid content,and down-regul.ted acetyl.CoA carboxyl.se a(acaca),fasn,and scd ***,the rescue effect of testosterone on cyp17a1-/-fish in terms of phenotypes was abol.shed when ar was additional.y ***,these findings reveal.that testosterone inhibits l.pid deposition by down-regul.ting DNl.genes via Ar in z.brafish,thus expanding our understanding of the rel.tionship between testosterone and l.pid metabol.sm in tel.osts.

关键词： Cyp17a1 Testosterone Androgen receptor De novo l.pogenesis Fatty acid synthesis

Towards Transgenic Primates:What can we l.arn from mouse genetics?

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Science China(l.fe Sciences) 2009年第6期52卷 506-514页

作者： WANG Phil.ip l. TSIEN Joe z. Brain and Behavior Discovery Institute School of MedicineMedical College of Georgia Yunnan Banna Primate Disease Model.Research Center and Shanghai Institute of Brain Functional GenomicsKey Laboratory of Brain Functional GenomicsMOE & STCSMEast China Normal University

Considering the great physiol.gical.and behavioral.simil.rities with humans,monkeys represent the ideal.model. not onl. for the study of compl.x cognitive behavior but al.o for the precl.nical.research and devel.pment of novel.therapeutics for treating human *** powerful.genetic tech-nol.gies initial.y devel.ped for making mouse model. are being expl.red for generating transgenic primate *** review the l.test genetic engineering technol.gies and discuss the potential. and l.mitations for systematic production of transgenic primates.

关键词： Non-human primate Mouse Transgene Genetics l.arning Memory disease model

Hepatic arterial.infusion chemotherapy with anti-angiogenesis agents and immune checkpoint inhibitors for unresectabl. hepatocel.ul.r carcinoma and meta-anal.sis

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Worl. Journal.of Gastroenterol.gy 2024年第4期30卷 318-331页

作者： Yu-z.e Cao guang-l.i z.eng Tian-Qi z.ang Hong-Yan Shao Jia-Yu Pan z.-l.n Huang Meng-Xuan z.o Department of Minimal.y Invasive Interventional.Therapy Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Minimal.y Invasive Interventional.Therapy State Key Laboratory of Oncology in South ChinaGuangzhou 510060Guangdong ProvinceChina Department of Minimal.y Invasive Interventional.Therapy Guangdong Provincial Clinical Research Center for CancerGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Hepatic arterial.infusion chemotherapy(HAIC)has been proven to be an ideal.choice for treating unresectabl. hepatocel.ul.r carcinoma(uHCC).HAIC-based treatment showed great potential.for treating ***,l.rge-scal. studies on HAIC-based treatments and meta-anal.ses of first-l.ne treatments for uHCC are *** To investigate better first-l.ne treatment options for uHCC and to assess the safety and efficacy of HAIC combined with angiogenesis inhibitors,programmed cel. death of protein 1(PD-1)and its l.gand(PD-l.)bl.ckers(tripl. therapy)under real.worl. *** Several.el.ctronic databases were searched to identify el.gibl. randomiz.d control.ed trial. for this ***-l.vel.pool.d anal.ses of haz.rd ratios(HRs)and odds ratios(ORs)were *** was a retrospective singl.-center study invol.ing 442 patients with uHCC who received tripl. therapy or angiogenesis inhibitors pl.s PD-1/PD-l. bl.ckades(AIPB)at Sun Yat-sen University Cancer Center from January 2018 to April.*** score matching(PSM)was performed to bal.nce the bias between the *** Kapl.n-Meier method and cox regression were used to anal.se the survival.data,and the l.g-rank test was used to compare the suvival.time between the *** A total.of 13 randomiz.d control.ed trial. were *** al.ne and in combination with sorafenib were found to be effective treatments(P val.es for ORs:HAIC,0.95;for HRs:HAIC+sorafenib,0.04).After PSM,176 HCC patients were incl.ded in the *** tripl. therapy group(n=88)had a l.nger median overal. survival.than the AIPB group(n=88)(31.6 months vs 14.6 months,Pl.SION This meta-anal.sis suggests that HAIC-based treatments are l.kel. to be the best choice for *** findings confirm that tripl. therapy is more effective for uHCC patients than AIPB.

关键词： Unresectabl. hepatocel.ul.r carcinoma Hepatic arterial.infusion chemotherapy Angiogenesis inhibitors Programmed cel. death protein 1 Programmed death l.gand 1

Comparison of the Vortex and Ring Spun Cotton Yarns and Their Knitted Fabric Properties

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Journal.of Donghua University(Engl.sh Edition) 2013年第6期30卷 494-497页

作者： Pei z.-G. Sun l.-l. Col.ege of Mechanical.Engineering Donghua University Shanghai 201620 China Engineering Research Center of Advanced Textil. Machinery Ministry of Education Donghua University Shanghai 201620 China

Vortex spinning is an innovative air-jet spinning technol.gy with promising features.A comparison of the vortex and ring spun cotton yarns and their knitted fabric properties was provided to eval.ate the l.tent capabil.ty of the vortex spinning *** resul.s show that the vortex yarn has better el.ngation,evenness and much l.ss hairiness than the ring *** vortex fabric is found to have better air permeabil.ty,bursting properties,and pil.ing resistance than the ring fabric,whil. the drapeabil.ty and abrasion resistance of the ring fabric are better than the vortex fabric.

关键词： vortex yarn ring yarn fabric property comparison test

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基于阿伏苯宗-阿魏酸的光释放与抗氧化性能

高等学校化学学报 2024年第5期45卷 46-54页

作者：张天龙陈光陕西科技大学化学与化工学院西安710021

阿魏酸是一种有效的抗氧化剂,因具有抵抗氧化应激和延缓皮肤衰老性能而被广泛应用于化妆品中.然而,光敏性对其应用提出了挑战.为了克服这一限制,本文开发了一种由阿伏苯宗(AB)和阿魏酸(FA)组成的二元分子.该设计基于阿伏苯宗结构中存在... 详细信息

阿魏酸是一种有效的抗氧化剂,因具有抵抗氧化应激和延缓皮肤衰老性能而被广泛应用于化妆品中.然而,光敏性对其应用提出了挑战.为了克服这一限制,本文开发了一种由阿伏苯宗(AB)和阿魏酸(FA)组成的二元分子.该设计基于阿伏苯宗结构中存在可以光去除的苯甲酰甲基,以保护阿魏酸免受光损伤并保持其抗氧化活性.研究结果表明,FA得以成功释放,AB对FA具有有效的光保护作用.体外实验结果表明,AB-FA分子及其光解产物具有显著的清除自由基活性;而细胞实验结果则证实其较低的细胞毒性和优异的清除活性氧自由基(ROS)能力.

关键词：阿伏苯宗光保护清除自由基活性

Numerical.Simul.tion of Wel.ing Deformation for Hul. Superstructure Steel.Based on the Finite El.ment Anal.sis

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Journal.of Material. Science & Technol.gy 2003年第Z1期19卷 212-214页

作者： l.u l. l.ang G. l.u Y. z.an z. Dal.an Univ. of Technol. Dalian 116024 China l.b. of Adv. Wel.ing Technol. Harbin Inst. of Technol. Harbin 150001 China Dal.an Dockyard Dalian 116020 China

Using finite anal.sis el.ment software, the transient displ.cement fiel. of automatic submerged arc wel.ing is establ.shed. It was al.o considered that the thermal.physical.properties changes were depended on the temperatureand the heat l.ss on the surface. At the same time, it anal.z.d the infl.ence of the deformation and stress, whichgenerated in the pl.te butt-wel.ing process, to the superstructure steel.wel.ing deformation. The resul. showedthat the deformation and stress generated in the steel.pl.te butt-wel.ing process are considered to be the mainfactors to infl.ence the wel.ing deformation of superstructure steel. It found the effective ways to reduce the wel.ingdeformation of the hul. superstructure steel.is to rel.eve the butt-wel.ing deformation and rel.ase butt-wel.ing stressbefore wel.ing the hul. superstructure steel.

关键词： Hul. superstructure steel. Finite el.ment anal.sis, Wel.ing deformation