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World Journal of Cardiology 2020年第7期12卷 303-333页

作者： Richard James Lightbody Janice Marie Walsh Taylor yvonne dempsie Annette Graham Department of Biological and Biomedical Sciences School of Health and Life SciencesGlasgow Caledonian UniversityGlasgow G40BAUnited Kingdom

Accumulation of macrophage"foam"cells,laden with cholesterol and cholesteryl ester,within the intima of large arteries,is a hallmark of early"fatty streak"lesions which can progress to complex,multicellular atheromatous plaques,involving lipoproteins from the bloodstream and cells of the innate and adaptive immune *** accumulation triggers induction of genes encoding proteins mediating the atheroprotective cholesterol efflux *** the arterial intima,however,this mechanism is overwhelmed,leading to distinct changes in macrophage phenotype and inflammatory *** the last decade marked gains have been made in understanding of the epigenetic landscape which influence macrophage function,and in particular the importance of small non-coding micro-RNA(miRNA)sequences in this *** review identifies some of the miRNA sequences which play a key role in regulating"foam"cell formation and atherogenesis,highlighting sequences involved in cholesterol accumulation,those influencing inflammation in sterol-loaded cells,and novel sequences and pathways which may offer new strategies to influence macrophage function within atherosclerotic lesions.

关键词： Coronary heart disease Atherosclerosis Macrophage“foam”cell Cholesterol Inflammation MicroRNA

Targeting stroma and tumor,silencing galectin 1 treats orthotopic mouse hepatocellular carcinoma

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Acta Pharmaceutica Sinica B 2024年第1期14卷 292-303页

作者： Tahereh Setayesh Ying Hu Farzam Vaziri Xin Chen Jinping Lai Dongguang Wei Yu-Jui yvonne Wan Department of Medical Pathology and Laboratory Medicine University of CaliforniaDavisSacramentoCA 95817USA Cancer Biology Program the University of Hawaii Cancer CenterHonoluluHI 96813USA Department of Pathology and Laboratory Medicine Kaiser Permanente Sacramento Medical CenterSacramentoCA 95825USA

This study examines inhibiting galectin 1(Gal1)as a treatment option for hepatocellular carcinoma(HCC).Gal1 has immunosuppressive and cancer-promoting *** data showed that Gal1 was highly expressed in human and mouse *** levels of Gal1 positively correlated with the stages of human HCC and negatively with *** roles of Gal1 in HCC were studied using overexpression(OE)or silencing using Igals1 siRNA delivered by *** to HCC initiation induced by RAS and AKT mutations,lgals1-OE and silencing had opposite impacts on tumor *** treatment effect of lgals1 siRNAwas further demonstrated by intersecting HCC at different time points when the tumor load had already reached 9%or even 42%of the body *** spatial transcriptomic profiles of Gal1 silenced and OE HCC,inhibiting matrix formation and recognition of foreign antigen in CD45t cell-enriched areas located at tumor-margin likely contributed to the anti-HCC effects of Gal1 *** the tumors,silencing Gal1 inhibited translational initiation,elongation,and ***,Gal1 silencing increased immune cells as well as expanded cytotoxic T cells within the tumor,and the anti-HCC effect of lgals1 siRNAwas ***,Gal1 silencing has a promising potential for HCC treatment.

关键词： Liver Hepatocellular carcinoma Carbohydrate-binding lectin Galectin 1 Extracellular matrix Translation Spatial transcriptomics Tumor-margin

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天才的童年独步曲

新世纪智能 2024年第ZF期 33-35页

作者： yvonne

在德州的宁静小镇上，生活着一个与众不同的天才少年——谢尔顿·库珀（Sheldon Cooper）。他拥有过人的智商和独特的思维，在社交场合中却显得笨拙可爱。《小谢尔顿》（Young Sheldon）这部情景喜剧，生动展现了谢尔顿充满智慧与情感...

在德州的宁静小镇上，生活着一个与众不同的天才少年——谢尔顿·库珀（Sheldon Cooper）。他拥有过人的智商和独特的思维，在社交场合中却显得笨拙可爱。《小谢尔顿》（Young Sheldon）这部情景喜剧，生动展现了谢尔顿充满智慧与情感的童年生活。在这部剧中，谢尔顿的聪明才智和对科学的热爱成为了他最闪耀的标签。他独自思考着宇宙的奥秘，享受着孤独带来的思维空间。

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Genetic diversity of the S-type small subunit ribosomal RNA gene of Plasmodium knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 84-90页

作者： Eric Tzyy Jiann Chong Joveen Wan Fen Neoh Tiek Ying Lau Kek Heng Chua yvonne Ai-Lian Lim Ping-Chin Lee Biotechnology Research Institute Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia Department of Biomedical Science Faculty of Medicine BuildingUniversity of Malaya50603 Kuala LumpurMalaysia Centre of Excellence for Research in AIDS(CERiA) University of Malaya50603 Kuala LumpurMalaysia Faculty of Science and Natural Resources Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia

Objective:To determine the genetic diversity of Plasmodium(P.)knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia,targeting the S-type SSU rRNA gene and including aspects of natural selection and ***:Thirty-nine blood samples infected with *** were collected in Sabah,Malaysian Borneo and Peninsular *** S-type SSU rRNA gene was amplified using polymerase chain reaction,cloned into a vector,and *** natural selection and haplotype of the S-type SSU rRNA gene sequences were determined using DnaSP v6 and illustrated using NETWORK *** study's 39 S-type SSU rRNA sequences and eight sequences from the Genbank database were subjected to phylogenetic analysis using MEGA ***:Overall,the phylogenetic analysis showed no evidence of a geographical cluster of *** isolates from different areas in Malaysia based on the S-type SSU rRNA gene *** S-type SSU rRNA gene sequences were relatively conserved and with a purifying *** sharing of the S-type SSU rRNA gene was observed between the *** isolates in Sabah,Malaysian Borneo,but not between Sabah,Malaysian Borneo and Peninsular ***:This study suggests that the S-type SSU rRNA gene of *** isolates in Sabah,Malaysian Borneo,and Peninsular Malaysia has fewer polymorphic sites,representing the conservation of the *** features make the S-type SSU rRNA gene suitable for comparative studies,such as determining the evolutionary relationships and common ancestry among *** species.

关键词： Plasmodium knowlesi S-type small subunit ribosomal RNA Genetic diversity Natural selection Haplotype

冬日魔法：《纳尼亚传奇》修辞之舞及动作妙用

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新世纪智能 2024年第39期 16-24页

作者： yvonne

作者介绍克莱夫·斯特普尔斯·刘易斯(Clive Staples Lewis),英国作家、学者和散文家,以其在奇幻文学领域富有想象力的作品而闻名,其中最为人熟知的是《纳尼亚传奇》系列(The Chronicles of Narnia series)。刘易斯的叙事引人入胜,世界...

作者介绍克莱夫·斯特普尔斯·刘易斯(Clive Staples Lewis),英国作家、学者和散文家,以其在奇幻文学领域富有想象力的作品而闻名,其中最为人熟知的是《纳尼亚传奇》系列(The Chronicles of Narnia series)。刘易斯的叙事引人入胜,世界构建丰富多彩,深刻的哲学主题贯穿其文字之间。他将幻想与道德寓言娓娓道来,这种独特的文学才华在各个年龄层的读者中留下了深远的印记。

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《小妇人》中的人物刻画:无灵主语与修辞的魅力

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新世纪智能 2024年第31期 17-24页

作者： yvonne

作者介绍路易莎·梅·奥尔科特（Louisa May Alcott, 1832—1888），美国女作家，出生于宾夕法尼亚州的日耳曼敦，但她的一生却是在靠近马萨诸塞州的康科特城度过的。受当作家和教师的父亲的影响，她很早就对写作产生了兴趣。因家贫，...

作者介绍路易莎·梅·奥尔科特（Louisa May Alcott, 1832—1888），美国女作家，出生于宾夕法尼亚州的日耳曼敦，但她的一生却是在靠近马萨诸塞州的康科特城度过的。受当作家和教师的父亲的影响，她很早就对写作产生了兴趣。因家贫，路易莎在成为专业作家之前不得不靠做护士、

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GIS-Based Multi-Criteria Decision Analysis (MCDA) and Analytical Hierarchy Process (AHP) Techniques to Derive Flood Risks Management on Rice Productivity in Gishari Marshland

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Journal of Geoscience and Environment Protection 2024年第3期12卷 222-249页

作者： Jean Nepo Nsengiyumva Emmanuel Nshimiyimana Jean Marie Ntakirutimana Phocas Musabyimana yvonne Akimana Fred Shema Set Niyitanga Séverin Hishamunda Callixte Musinga Mpamabara Eliezel Habineza Department of Agricultural Engineering Rwanda Polytechnic IPRC Gishari Rwamagana Rwanda Department of Environmental Information System University of Lay Adventist of Kigali Kigali Campus Kigali Rwanda School of Environmental Science and Engineering Department of Environmental Engineering Suzhou University of Science and Technology Suzhou China Department of Agricultural and Resources Economics School of Agriculture and Environmental Sciences Jomo Kenyatta University of Agriculture and Technology Kigali Campus Kigali Rwanda Department of Smart Agriculture System Hankyong National University Anseong Kyonggi South Korea

Floods are phenomenon with significant socio-economic implications mainly for human loss, agriculture, livestock, soil loss and land degradation, for which many researchers try to identify the most appropriate methodologies by analyzing their temporal and spatial development. This study therefore attempts to employ the GIS-based multi-criteria decision analysis and analytical hierarchy process techniques to derive the flood risks management on rice productivity in the Gishari Agricultural Marshland in Rwamagana district, Rwanda. Here, six influencing potential factors to flooding, including river slope, soil texture, Land Use Land Cover through Land Sat 8, rainfall, river distance and Digital Elevation Model are considered for the delineation of flood risk zones. Data acquisition like Landsat 8 images, DEM, land use land cover, slope, and soil class in the study area were considered. Results showed that if the DEM is outdated or inaccurate due to changes in the terrain, such as construction, excavation, or erosion, the predicted flood patterns might not reflect the actual water flow. This could result unexpected flood extents and depths, potentially inundating rice fields that were not previously at risk and this, expectedly explained that the increase 1 m in elevation would reduce the rice productivity by 0.17% due to unplanned flood risks in marshland. It was found that the change in rainfall distribution in Gishari agricultural marshland would also decrease the rice productivity by 0.0018%, which is a sign that rainfall is a major factor of flooding in rice scheme. Rainfall distribution plays a crucial role in flooding analysis and can directly impact rice productivity. Oppositely, another causal factor was Land Use Land Cover (LULC), where the Multivariate Logistic Regression Model Analysis findings showed that the increase of one unit in Land Use Land Cover would increase rice productivity by 0.17% of the total rice productivity from the Gishari Agricultural Ma

关键词： Multi Criteria Decision Analysis (MCDA) Analytical Hierarchy Analysis (AHA) GIS RS and DEM

Genetic and Agronomic Parameter Estimates of Growth, Yield and Related Traits of Maize (Zea mays L.) under Different Rates of Nitrogen Fertilization

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American Journal of Plant Sciences 2024年第4期15卷 274-291页

作者： Prince Emmanuel Norman Lansana Kamara Aloysius Beah Kelvin Sahr Gborie Francess Sia Saquee Sheku Alfred Kanu Fayia Augustine Kassoh yvonne Sylvia Gloria Ethel Norman Abdul Salaam Kargbo Sierra Leone Agricultural Research Institute (SLARI) Freetown Sierra Leone School of Agriculture Njala University Njala Campus Njala Sierra Leone School of Natural Resources Management Njala University Njala Campus Njala Sierra Leone Department of Agro Biotechnology Institute of Agriculture RUDN University Moscow Russia Faculty of Development Agriculture & Natural Resources Management Eastern Technical University of Sierra Leone Kenema Sierra Leone

This study evaluated the genetic and agronomic parameter estimates of maize under different nitrogen rates. The trial was established at the Njala Agricultural Research Centre experimental site during 2021 and 2022 in a split block design with three maize varieties (IWCD2, 2009EVDT, and DMR-ESR-Yellow) and seven nitrogen (0, 30, 60, 90, 120, 150 and 180 kg∙N∙ha−1) rates. Findings showed that cob diameter and anthesis silking time (ASI) had intermediate heritability, ASI had high genetic advance, ASI and grain yield had high genotypic coefficient of variation (GCV), while traits with high phenotypic coefficient of variation (PCV) were plant height, ASI, grain yield, number of kernel per cob, number of kernel rows, ear length, and ear height. The PCV values were higher than GCV, indicating the influence of the environment in the studied traits. Nitrogen rates and variety significantly (p −1 plots exhibiting the lowest and highest grain yields of 1238 kg∙ha−1 and 2098 kg∙ha−1, respectively. Variety and nitrogen effects on partial factor productivity (PFPN), agronomic efficiency (AEN), net returns (NR), value cost ratio (VCR) and marginal return (MR) indicated that these parameters were significantly affected (p N (41.3 kg grain kg−1∙N) and AEN (29.4 kg grain kg−1∙N) were obtained in the 30 kg∙N∙ha−1 plots, while the highest VCR (2.8) and MR (SLL 1.8 SLL−1 spent on N) were obtained in the 180 kg∙N∙ha−1. The significant influence of variety and nitrogen on traits suggests that increasing yields and maximizing profits require use of appropriate nitrogen fe

关键词： Nitrogen Rates Genetic and Agronomic Estimates Introduced Genotypes Grain Yield Zea mays

Antibiotic Resistance Profile of Enterococcus faecalis and Enterococcus faecium Isolates from Urine and Pleural Fluid in Two Hospitals of Cameroon

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Open Journal of Medical Microbiology 2024年第1期14卷 39-49页

作者： Cécile Ingrid Djuikoue Farid Wega Grace Yemina Kombeu Cedric Seugnou Nana Christiane Possi Kiyang Lussabella Pohoko Medzam Erica Megane Noubissi Makougoum Nellie Mbianga Nkuigoua Herman Koyouo Tagne Mérimé Joël Tchinda Talokou yvonne Valérie Yolande Mavoungou Ashu Michel Agbor Microbiology Department of the Faculty of Health Sciences of the Université des Montagnes Bangangté Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Microbiology Department of the Faculty of Health Sciences of Institut Universitaire du Golf de Guinée Douala Cameroon Centre Hospitalier Dominicain St Martin de Porres Yaoundé Cameroun Faculté des Sciences de la Santé Université Marien Ngouabi Brazzaville République du Congo

Enterococcus faecalis and Enterococcus faecium rank among the leading causes of nosocomial bacteremia and urinary tract infections. They often persist on hospital surfaces due to their ability to withstand adverse environmental conditions (low or high temperatures, high pH, and high salinity). The global Enterococcus faecalis-Enterococcus faecium ratio is currently shifting towards Enterococcus faecium. Enterococci present variable levels of resistance to certain families of antibiotics. This is the case for aminoglycosides, beta-lactams and cephalosporins. In 2017, WHO ranked Enterococci among priority pathogens for research and development of new antibiotics. The objective of our study was to determine the antibiotic resistance profile of Enterococcus faecalis and Enterococcus faecium isolates from urine and pleural fluid in two hospitals in Cameroon. This cross-sectional and analytic study was carried out between June to August 2023 on hospitalized and day patients in which a cytobacteriological test of urine and pleural fluid was done. The samples were inoculated on CLED Agar for urine and on Chocolate + polyvitex and blood agar (prepared from Columbia agar) for pleural fluid samples and incubated at 37℃ for 18 to 24 hours. Identification of isolates was carried out using the API 20 STREP micro gallery (Biomerieux, France) and tested for antimicrobial susceptibility. The data on socio-demographical and potential risk factors were recorded using self-administered questionnaires and data from laboratory analyses of the specimen were collected in a data capture sheet. Potential risk factors associated with the presence of Enterococci, were evaluated using the logistic regression in univariate and multivariate analysis. P value < 0.05 was considered as significant. A total of 511 patients were recruited who were predominantly females. Enterococcus spp were isolated in 27.79% of our samples with Enterococcus faecalis mostly encountered. Enterococcus spp showed a high

关键词： Enterococcus faecalis Enterococcus faecium Healthcare-Associated Infections Antimicrobial Resistance Cameroon

Additively manufactured fiber-reinforced composites:A review of mechanical behavior and opportunities

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Journal of Materials Science & Technology 2022年第24期119卷 219-244页

作者： Jiahui Li yvonne Durandet Xiaodong Huang Guangyong Sun Dong Ruan Department of Mechanical Engineering and Product Design Engineering School of EngineeringSwinburne University of TechnologyHawthornVIC 3122Australia State Key Laboratory of Advanced Design and Manufacture for Vehicle Body Hunan UniversityChangsha 410082China

Recent developments in additive manufacturing techniques have facilitated the fabrication of fiberreinforced composite *** this paper,the mechanical properties and deformation mechanisms of discontinuous and continuous fiber-reinforced composites fabricated by various additive manufacturing techniques are comprehensively *** effects of fiber type,orientation and weight/volume fraction,printing path,and stacking sequence on the mechanical properties of additively manufactured composites are *** addition,the applications of additively manufactured composites,the main challenges of the current additive manufacturing techniques,and recommendations for future work are also presented.

关键词： Additive manufacturing Discontinuous and continuous fiber-reinforced composites Mechanical properties Deformation mechanism Applications

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