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Antigen-specific mRNA lipid nanoparticle platforms for the prevention and treatment of allergy and autoimmune diseases

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BMEMat(BioMedical Engineering Materials) 2024年第2期2卷 61-68页

作者： Emma Y.yim Amanda c.Zhou yvonne c.yim Xiang Wang Tian Xia Department of Molecular Cell and Developmental BiologyUniversity of CaliforniaLos AngelesUSA Department of Bioengineering University of CaliforniaLos AngelesUSA Department of chemistry and Biochemistry University of CaliforniaLos AngelesUSA Division of NanoMedicine Department of MedicineCenter for Environmental Implications of Nanotechnology(UC CEIN)California NanoSystems InstituteUniversity of CaliforniaLos AngelesUSA

While most nanomedicines primarily aim to stimulate the immune system against infections or tumors,there is a growing demand for inducing immune tolerance under certain conditions,such as allergic and autoimmune *** have explored nanotechnology-based strategies to induce immune tolerance in a targeted and specific *** approach involves the use of nanoparticles(NPs)to encapsulate immunosuppressive drugs and/or antigens to educate naïve T cells and promote the generation of antigen-specific regulatory T cells that inhibit immune ***,this approach has certain *** hydrophobicity of proteins or peptides restricts the degree to which they can be encapsulated in NPs,which in turn,affects their loading efficiency and treatment *** the emergence of mRNA lipid nanoparticle(LNP)platforms,there is the possibility of overcoming the limitations of protein and peptide *** date,mRNA LNP systems have been shown to provide organ,cellular,and subcellular targeting for the induction of immune *** method of drug delivery is flexible and scalable that can be customized for a specific patient,resulting in an effective means of administering relevant proteins or epitopes to induce antigen-specific immune *** continued research and development,this technology could offer a safer and more effective alternative to current therapies,ultimately improving the quality of life of patients worldwide.

关键词： allergy autoimmune diseases immune tolerance mRNA lipid nanoparticle nanomedicine

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不同材质共享缆绳对浮式风电场系泊响应的影响

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中国舰船研究 2024年第4期19卷 59-70页

作者：仲凡连宇顺郑金海陈文兴马刚 yim Solomon c.S. 河海大学海岸灾害及防护教育部重点实验室江苏南京210098 河海大学港口海岸与近海工程学院江苏南京210098 浙江理工大学纺织纤维材料与加工技术国家地方联合工程实验室浙江杭州310018 哈尔滨工程大学烟台研究院山东烟台264006 俄勒冈州立大学美国俄勒冈州科瓦利斯97331

[目的]旨在合理设计浮式风电场的共享系泊系统,探究不同材质共享缆绳对浮式风电场动力响应的影响。[方法]首先,对浮式风电场设计共享系泊和传统(无共享缆绳)系泊方案,比较两种系泊方案的动力响应和经济成本,验证设计方案的可行性。其次... 详细信息

[目的]旨在合理设计浮式风电场的共享系泊系统,探究不同材质共享缆绳对浮式风电场动力响应的影响。[方法]首先,对浮式风电场设计共享系泊和传统(无共享缆绳)系泊方案,比较两种系泊方案的动力响应和经济成本,验证设计方案的可行性。其次,探究两类共享系泊系统对浮式风电场系泊响应的影响。最后,分析环境载荷的施加方向和缆绳材质对共享缆绳平均张力的影响。[结果]采用不同材质共享系泊系统的浮式风电场,其叶片张力近乎相同;两类共享系泊系统对风机位移和系缆平均张力的影响存在差别。此外,环境载荷施加角度和系缆材质也对风机位移和共享缆绳受力产生影响。[结论]该研究可为系泊系统中共享缆绳选型提供参考。

关键词：共享系泊系统共享缆绳锚链高强聚乙烯缆绳海上浮式风电场

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Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu cheung Ho ching chan Inseo choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law chi Seng Leung chun Yin Tong Kai Kap Wong Wing Lam yim Nikolay S.Karnaukhov Richard Y.c.Kong Maria V.Babak Yudai Matsuda Department of chemistry City University of Hong KongHong Kong SARChina iGEM Team“Variecure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow clinical Research center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATcc *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

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calcium-and sulfate-functionalized artificial cathode–electrolyte interphases of Ni-rich cathode materials

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Rare Metals 2021年第10期40卷 2793-2801页

作者： Kwangeun Jung Taeeun yim Department of chemistry Incheon National UniversityIncheon 22012Republic of Korea

Ni-rich lithium nickel–cobalt-manganese oxides(NcM) are considered the most promising cathode materials for lithium-ion batteries(LIBs);however, relatively poor cycling performance is a bottleneck preventing their widespread use in energy systems. In this work, we propose the use of a dually functionalized surface modifier, calcium sulfate(caSO_(4), cSO), in an efficient one step method to increase the cycling performance of Ni-rich NcM cathode materials. Thermal treatment of LiNi_(0.8)co_(0.1)Mn_(0.1)O_(2)(NcM811) cathode materials with a cSO precursor allows the formation of an artificial ca-and SO_(x)-functionalized cathode–electrolyte interphase(cEI) layer on the surface of Ni-rich NcM cathode materials. The cEI layer then inhibits electrolyte decomposition at the interface between the Ni-rich NcM cathode and the electrolyte. Successful formation of the cSO-modified cEI layer is confirmed by scanning electron microscopy(SEM) and Fourier transform infrared(FTIR) spectroscopy analyses, and the process does not affect the bulk structure of the Ni-rich NcM cathode material. During cycling, the cSO-modified cEI layer remarkably decreases electrolyte decomposition upon cycling at both room temperature and 45 ℃, leading to a substantial increase in cycling retention of the cells. A cell cycled with a 0.1 cSO-modified(modified with 0.1% cSO)NcM811 cathode exhibits a specific capacity retention of90.0%, while the cell cycled with non-modified NcM811 cathode suffers from continuous fading of cycling retention(74.0%) after 100 cycles. SEM, electrochemical impedance spectroscopy(EIS), X-ray photoelectron spectroscopy(XPS), and inductively coupled plasma mass spectrometry(IcP-MS) results of the recovered electrodes demonstrate that undesired surface reactions such as electrolyte decomposition and metal dissolution are well controlled in the cell because of the artificial cSO-modified cEI layer present on the surface of Ni-rich NcM811 cathodes.

关键词： Lithium-ion battery cathode cathode–electrolyte interphase calcium sulfate Electrochemical performance

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Antibiotic Resistance Profile of Enterococcus faecalis and Enterococcus faecium Isolates from Urine and Pleural Fluid in Two Hospitals of cameroon

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Open Journal of Medical Microbiology 2024年第1期14卷 39-49页

作者： cécile Ingrid Djuikoue Farid Wega Grace Yemina Kombeu cedric Seugnou Nana christiane Possi Kiyang Lussabella Pohoko Medzam Erica Megane Noubissi Makougoum Nellie Mbianga Nkuigoua Herman Koyouo Tagne Mérimé Joël Tchinda Talokou yvonne Valérie Yolande Mavoungou Ashu Michel Agbor Microbiology Department of the Faculty of Health Sciences of the Université des Montagnes Bangangté Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Microbiology Department of the Faculty of Health Sciences of Institut Universitaire du Golf de Guinée Douala Cameroon centre Hospitalier Dominicain St Martin de Porres Yaoundé Cameroun Faculté des Sciences de la Santé Université Marien Ngouabi Brazzaville République du Congo

Enterococcus faecalis and Enterococcus faecium rank among the leading causes of nosocomial bacteremia and urinary tract infections. They often persist on hospital surfaces due to their ability to withstand adverse environmental conditions (low or high temperatures, high pH, and high salinity). The global Enterococcus faecalis-Enterococcus faecium ratio is currently shifting towards Enterococcus faecium. Enterococci present variable levels of resistance to certain families of antibiotics. This is the case for aminoglycosides, beta-lactams and cephalosporins. In 2017, WHO ranked Enterococci among priority pathogens for research and development of new antibiotics. The objective of our study was to determine the antibiotic resistance profile of Enterococcus faecalis and Enterococcus faecium isolates from urine and pleural fluid in two hospitals in cameroon. This cross-sectional and analytic study was carried out between June to August 2023 on hospitalized and day patients in which a cytobacteriological test of urine and pleural fluid was done. The samples were inoculated on cLED Agar for urine and on chocolate + polyvitex and blood agar (prepared from columbia agar) for pleural fluid samples and incubated at 37℃ for 18 to 24 hours. Identification of isolates was carried out using the API 20 STREP micro gallery (Biomerieux, France) and tested for antimicrobial susceptibility. The data on socio-demographical and potential risk factors were recorded using self-administered questionnaires and data from laboratory analyses of the specimen were collected in a data capture sheet. Potential risk factors associated with the presence of Enterococci, were evaluated using the logistic regression in univariate and multivariate analysis. P value considered as significant. A total of 511 patients were recruited who were predominantly females. Enterococcus spp were isolated in 27.79% of our samples with Enterococcus faecalis mostly encountered. Enterococcus spp showed a high

关键词： Enterococcus faecalis Enterococcus faecium Healthcare-Associated Infections Antimicrobial Resistance cameroon

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critical role of corrosion inhibitors modified by silyl ether functional groups on electrochemical performances of lithium manganese oxides

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Journal of Energy chemistry 2020年第12期29卷 425-433页

作者： Min Ji Seong Taeeun yim Department of chemistry Incheon National UniversityYeonsu-gu 22012IncheonRepublic of Korea Research Institute of Basic Sciences College of Natural ScienceIncheon National UniversityYeonsu-gu 22012IncheonRepublic of Korea

Lithium manganese oxides(Li Mn2 O4, LMO) have attracted significant attention as important cathode materials for lithium-ion batteries(LIBs), which require fast charging based on their intrinsic electrochemical properties. However, these properties are limited by the rapid fading of cycling retention, particularly at high temperatures, because of the severe Mn corrosion triggered by the chemical reaction with fluoride(F-) species existing in the cell. To alleviate this issue, three types of silyl ether(Si–O)-functionalized task-specific additives are proposed, namely methoxytrimethylsilane, dimethoxydimethylsilane, and trimethoxymethylsilane. Ex-situ NMR analyses demonstrated that the Si-additives selectively scavenged the F-species as Si forms new chemical bonds with F via a nucleophilic substitution reaction due to the high binding affinity of Si with F-, thereby leading to a decrease in the F concentration in the cell. Furthermore, the addition of Si-additives in the electrolyte did not significantly affect the ionic conductivity or electrochemical stability of the electrolyte, indicating that these additives are compatible with conventional electrolytes. In addition, the cells cycled with Si-additives exhibited improved cycling retention at room temperature and 45 °c. Among these candidates, a combination of MTSi and the LMO cathode was found to be the most suitable choice in terms of cycling retention(71.0%), whereas the cell cycled with the standard electrolyte suffered from the fading of cycling retention triggered by Mn dissolution(64.4%). Additional ex-situ analyses of the cycled electrodes using SEM, TEM, EIS, XPS, and IcP-MS demonstrated that the use of Si-additives not only improved the surface stability of the LMO cathode but also that of the graphite anode, as the Si-additives prevent Mn corrosion. This inhibits the formation of cracks on the surface of the LMO cathode, facilitating the formation of a stable solid electrolyte interphase layer on the su

关键词： Lithium-ion batteries Lithium manganese oxide cathode Electrolyte additive corrosion Silyl ether Fluoride scavenger

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Homoclinic and heteroclinic solutions of cubic strongly nonlinear autonomous oscillators by hyperbolic Lindstedt-Poincaré method

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Science china(Technological Sciences) 2010年第3期53卷 692-702页

作者： SZE Kam yim Department of Mechanical Engineering The University of Hong Kong

The hyperbolic Lindstedt-Poincaré method is applied to determine the homoclinic and heteroclinic solutions of cubic strongly nonlinear oscillators of the form x + c1 x + c3 x 3= ε f (μ,x,x).In the method,the hyperbolic functions are employed instead of the periodic functions in the Lindstedt-Poincaré *** value of parameter μ under which there exists homoclinic or heteroclinic orbit can be determined by the perturbation *** applications are studied in *** illustrate the accuracy of the present method,its predictions are compared with those of Runge-Kutta method.

关键词： Lindstedt-Poincaré Method nonlinear autonomous oscillator homoclinic orbit heteroclinic orbit

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Dually-functionalized Ni-rich layered oxides for high-capacity lithium-ion batteries

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Journal of Materials Science & Technology 2021年第27期86卷 70-76页

作者： Ji Won Kim Kwangeun Jung Taeeun yim Department of chemistry Incheon National University119 Academy-roYeonsu-guIncheon 22012Republic of Korea

Layered lithium nickel-cobalt-manganese oxides(NcM)have been highlighted as advanced cathode materials for lithium-ion batteries(LIBs);however,their low interfacial stability must be overcome to ensure stable cycling performance of the *** this work,we propose a one-step surface modification method that uses a task-specific precursor,N,N,N,N-tetraethylsulfamide(NTESA),to improve interfacial stability of Ni-rich NcM cathode *** unstable surface properties of Ni-rich NcM cathode material are improved by embedding an artificial cathode-electrolyte interphase(cEI)layer on the cathode surface by heat treatment of the Ni-rich NcM cathode material with an NTESA precursor at low *** material analyses indicate that this approach allows the formation of amine-and sulfone-functionalized cEI layers on the surface of Ni-rich NcM cathode material without changing the layered structure of the cathode ***-functionalized Ni-rich NcM cathode materials exhibit improved cycling retention after 100 cycles:for example,a cell cycled with a 3.0 NTESA-modified NcM811 cathode presents the highest retention ratio of 88.3%,whereas a cell cycled with a non-functionalized NcM811 cathode suffers from rapid fading of the cycling performance(68.4%).Our additional SEM,XPS,and EIS analyses indicate that electrolyte decomposition is suppressed during electrochemical cycling,thereby leading to smaller increases in the internal ***-MS analyses of the cycled anodes also indicate that the NTESA-based artificial cEI layer inhibits the dissolution of transition metal components from the Ni-rich NcM cathode materials,thereby contributing to an improved overall electrochemical performance of the cell.

关键词： Lithium-ion battery cathode cathode-electrolyte interphase N,N,N,N-Tetraethylsulfamide Electrochemical performance

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Protective Role of Salidroside against Aging in A Mouse Model Induced by D-galactose

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Biomedical and Environmental Sciences 2010年第2期23卷 161-166页

作者： YI-YANG yvonne LI Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China

Objective To investigate the protective effects of putative AGEs （advanced glycation endproducts） inhibitor salidroside against aging in an accelerated mouse aging model induced by D-galactose. Methods A group of 5-month-old c57BL/6J mice were treated daily with D-galactose, D-galactose combined with salidroside, salidroside alone, and control buffer for 8 weeks. At the end of the treatment, serum AGEs levels, neurological activities, expression of glial fibrillary acidic protein （GFAP） and neurotrophin-3 （NT-3） in the cerebral cortex, as well as lymphocyte proliferation and IL-2 production were determined. Results D-galactose induced mouse aging model was developed as described before. As expected, salidroside blocked D-galactose induced increase of serum AGEs levels. It also reversed D-galactose induced aging effects in neural and immune system, as evidenced by improving motor activity, increasing memory latency time, and enhancing lymphocyte mitogenesis and interleukin-2 （IL-2） production. Furthermore, elevated expression of GFAP and NT-3 in the aged model mice was also reduced upon salidroside treatment. conclusion Salidroside inhibits AGEs formation in vivo, which at least partially contributes to its anti-aging effect in D-galactose induced aging model.

关键词： Salidroside Aging D-galactose

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Wireless actuation and control of ionic polymer-metal composite actuator using a microwave link

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International Journal of Smart and Nano Materials 2012年第4期3卷 244-262页

作者： J.S.Lee W.yim c.Bae K.J.Kim Department of Mechanical Engineering University of NevadaLas VegasUSA Department of chemistry University of NevadaLas VegasUSA Department of Mechanical Engineering University of NevadaRenoUSA

The ionic polymer–metal composite(IPMc),a type of electroactive polymer(EAP)actuator,has created a unique opportunity to design robots that mimic the motion of biological systems due to its soft structure and operation at a low *** this polymer actuator has strong potential for a next-generation artificial muscle actuator,it has been observed by many researchers that supplying actuation voltages in multiple locations is *** robotic applications,a tethered operation is prohibited and the battery weight can be critical for actual *** this research,the remote unit can provide necessary power and control signals to the target mobile robot units actuated by *** research addresses a novel approach of using a wireless power link between the IPMc and a remote unit using microstrip patch antennas designed on the electrode surface of the IPMc for transmitting the *** modulation of the microwave is proposed to selectively actuate a particular portion of the IPMc where the matching patch antenna pattern is *** approach can be especially useful for long-term operation of small-scale locomotion units and avoids problems caused by complex internal wiring often observed in various types of biologically inspired robots.

关键词： ionic polymer-metal composite actuator microwave link wireless actuation robotic application biomimetic robot

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