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Insect Science 2018年第6期25卷 1102-1107页

作者： Stanislas Talaga Alain Dejean Clémence mouza yves Dumont Céline Leroy lnsUtut Pasteur de la Guyane Unitéd'Entomologie MédicaleCayenne cedexFrance CNRS UMR EcoFoGAgroParisTechCiradINRAUniversitédes AntillesUniversitéde GuyaneKourouFrance CNRS INPTUPSEcolabUniversitéde ToulouseToulouseFrance AmAP CIRADCNRSINRAIRDUniversit6MontpellierMontpellierFrance

Interspecific competition with native species during biological invasions can sometimes limit alien *** aimed to determine the potential ecological effects of Limatus durhamii Theobald 1901,a native Neotropical mosquito (Diptera:Culicidae) species,on the invasive species Aedes (Stegomyia)aegypti (Linnaeus 1762)that breeds in the same artificial water *** time and adult dry mass were measured in 3 rearing conditions:control (a single larva),intraspecific competition (2 conspecific larvae),and interspecific competition (2 heterospecific larvae).Food was provided ad libitum to eliminate exploitative *** ***,development time was not affected by interspecific interference competition (nonsignificant differences with the control)and the adult dry mass was significantly higher,meaning that individual fitness likely ***,because previous studies showed longer development time and lighter adults during competition with other invasive mosquitoes,it is likely that *** can express a different phenotype depending on the competing *** similar pattern found for *** females and the nonsignificant difference with the control for males explain in part why this species can compete with ***.

关键词： Aedes aegypti increased fitness interference competition Limatus durhamii phenotypic plasticity resistance to invasion

Effect of elbow position on radiographic measurements of radio-capitellar alignment

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World Journal of Orthopedics 2016年第2期7卷 117-122页

作者： Emilie Sandman Fanny Canet Yvan Petit G-yves Laflamme George S Athwal Dominique m Rouleau Hopital du Sacré-Cour de montréal the Hand and Upper Limb Centre

AIm:To evaluate the effect of different elbow and forearm positions on radiocapitellar ***:Fifty-one healthy volunteers were recruited and bilateral elbow radiographs were taken to form a radiologic *** elbow radiographs were taken with the elbow in five different positions:maximal extension and forearm in neutral,maximal flexion and forearm in neutral,elbow at 90° and forearm in neutral,elbow at 90° and forearm in supination and elbow at 90° and forearm in pronation.A goniometer was used to verify the accuracy of the elbow's position for the radiographs at a 90° *** radiocapitellar ratio(RCR)measurements were then taken on the collected radiographs using the Slice Omatic *** orthopedic resident performed the radiographic measurements on the 102 elbows,for a total of 510 lateral elbow radiographic *** paired t-tests and Pearson coefficients were used to assess the differences and correlations between the RCR in each ***:mean RCR values were-2% ± 7%(maximal extension),-5% ± 9%(maximal flexion),and for elbow at 90° and forearm in neutral-2% ± 5%,supination 1% ± 6% and pronation 1% ± 5%.ANOVA analyses demonstrated significant differences between the RCRin different elbow and forearm *** t-tests confirmed significant differences between the RCR at maximal flexion and flexion at 90°,and maximal extension and *** Pearson coefficient showed significant correlations between the RCR with the elbow at 90°-maximal flexion;the forearm in neutralsupination;the forearm in ***:Overall,95% of the RCR values are included in the normal range(obtained at 90° of flexion)and a value outside this range,in any position,should raise suspicion for instability.

关键词： Elbow subluxation Radiocapitellar ratio Elbow Elbow dislocation

VEGF in hepatocellular carcinoma and surrounding cirrhotic liver tissues

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World Journal of Gastroenterology 2006年第5期12卷 830-831页

作者： muriel mathonnet Bernard Descottes Denis Valleix Francois Labrousse yves Denizot Service de Chimrgie DigestiveEndocrinienne et GénéraleCHU DupuytrenLimogesFrance Service de Chirurgie Viscérale et TransplantationCHU DupuytrenLimogesFrance Service d'Anatomo-Pathologie CHU DupuytrenLimogesFrance UmR CNRS 6101Faculté de MédecineLimogesFrance

We read with a great interest the recent work of Deli and colleagues. in the World Journal of Gastroenterology reporting vascular endothelial growth factor （VEGF） expression in hepatocellular carcinoma （HCC） and cirrhotic liver tissues. This well-documented work shows that VEGF was significantly higher in surrounding cirrhotic liver tissues than in HCC. Authors assessed VEGF expression using immunohistochemistry. The immunohistochemical staining is an efficient tool to assess the percentage of cells stained positively for VEGF but is not really efficient to estimate their true VEGF content. Evaluation of the VEGF protein by an enzyme-linked immunosorbent assay 0ELISA） has been reported, by us and others, to be an efficient tool in order to assess tissue VEGF expression. We have, thus, tested whether the ELISA method might be an efficient tool in order to confirm data reporting higher amounts of VEGF in surrounding cirrhotic liver tissues than in HCC. Deli and colleagues. also correctly pointed out that basic fibroblast growth factor （bFGF） has been reported to act cooperatively on VEGF expression. We have, thus, also assessed bFGF tissue levels in order to search for a putative link between VEGF and bFGF levels in cirrhotic tissues.

关键词： Vascular endothelial growth factor Hepatocellular carcinoma, Cirrhotic liver tissues

Nucleation kinetics of paramagnetic and diamagnetic metal melts under a high magnetic field

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Journal of materials Science & Technology 2021年第14期73卷 165-170页

作者： Zhipeng Long Qiuyue Jiang Jiantao Wang Long Hou Xing Yu yves Fautrelle Zhongming Ren Xi Li State Key Laboratory of Advanced Special Steels Shanghai UniversityShanghai200072China SImAP-EPm-madylam/G-INP/CNRS PHELMABP 75.38402St Martin d'Heres Cedex.France

The influence of a high magnetic field(HmF)on the nucleation kinetics of paramagnetic aluminum and diamagnetic zinc melts has been investigated by differential thermal analysis(DTA).It is found that the application of an HmF increases the undercooling of pure aluminum and pure zinc at the same heatingcooling ***,the quantitative analysis of activation energy calculated from the DTA results using the Kissinger method manifests that the HmF reduces the activation energy of pure aluminum and pure *** of magnetism,the nucleation frequency under an HmF is higher than that without an ***,the increase in undercooling under the HmF is mainly attributed to the increase of the contact angle,calculated by the functional relationship between the cooling rate and *** result is consistent with the increase of the calculated nucleation work for pure aluminum and pure ***,the increase in undercooling caused by the HmF is partly ascribed to the magnetic field-induced suppression of thermal convection in the undercooled melt.

关键词： Undercooling Activation energy Nucleation work High magnetic field

Platelet-activating factor in cirrhotic liver and hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第17期12卷 2773-2778页

作者： muriel mathonnet Bernard Descottes Denis Valleix Véronique Truffinet Franois Labrousse yves Denizot Service de Chirurgie Digestive Endocrinienne et Générale CHU Dupuytren2 avenue Luther King87042 LimogesFrance Service de Chirurgie Viscérale et Transplantation CHU Dupuytren 2 avenue Martin Luther King87042 LimogesFrance UmR CNRS 6101 Faculté de médecine 2 rue du Docteur Marcland87025 LimogesFrance Supported by "La Ligue Nationale Fran(?)aise Centre le Cancer" (Comité de la Corrèze) Service d'Anatomo-Pathologie CHU Dupuytren 2 avenue Luther King87042 LimogesFrance UmR CNRS 6101 Faculté de médecine 2 rue du Docteur Marcland87025 LimogesFrance Supported by "La Ligue Nationale Franaise Centre le Cancer" (Comité de la Corrèze)

AIm： Platelet-activating factor （PAF） is a pro-inflammatory and angiogenic lipid mediator. Here we aimed to investigate levels of PAF, lyso-PAF （the PAF precursor）, phospholipase A2 （PLA2, the enzymatic activity generating lyso-PAF）, acetylhydrolase activity （AHA, the PAF degrading enzyme） and PAF receptor （PAF-R） transcripts in cirrhotic liver and hepatocellular carcinoma （HCC）. mETHODS： Twenty-nine patients with HCC were enrolled in this study. Cirrhosis was present in fourteen patients and seven had no liver disease. Tissue PAF levels were investigated by a platelet-aggregation assay. lyso- PAF was assessed after its chemical acetylation into PAR AHA was determined by degradation of [^3H]-PAE PLA2 levels were assessed by EIA. PAF-R transcripts were investigated using RT-PCR. RESULTS： Elevated amounts of PAF and PAF-R transcripts 1 （leukocyte-type） were found in cirrhotic tissues as compared with non-cirrhotic ones. Higher amounts of PAF and PAF-R transcripts 1 and 2 （tissue-type） were found in HCC tissues as compared with non-tumor tissues. PLA2, lyso-PAF and AHA levels were not changed in cirrhotic tissues and HCC. CONCLUSION： While the role of PAF is currently unknown in liver physiology, this study suggests its potential involvement in the inflammatory network found in the cirrhotic liver and in the angiogenic response during HCC.

关键词： Hepatocellular carcinoma Cirrhosis Platelet- activating factor PAF receptors

Deletion of the immunoglobulin heavy chain 3′ regulatory region super-enhancer affects somatic hypermutation in B1 B cells

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Cellular & molecular Immunology 2019年第2期16卷 195-197页

作者： Issaoui Hussein Ghazzaui Nour Boyer François Denizot yves Saintamand Alexis Centre National de la Recherche Scientifique Unitémixte de Recherche 7276 Institut National de la Santéet de la Recherche Médicale U1262CBRSrue du Pr.Descottes87025 LimogesFrance INSERm U1236 UniversitéRennes 1RennesFrance

mouse B1 B cells originate in the embryonic liver and are the major B-cell population in the peritoneal and pleural cavities.1–5 By contrast,mouse B2 B cells originate in the bone marrow and are the major B-cell population in the bone marrow,spleen,and blood.B1 and B2 B cells differ not only in their origin and locations,but also in their antigen specificity,cell surface markers,capacities for class-switch recombination(CSR)and somatic hypermutation(SHm).IgH cis-regulatory regions and,particularly,transcriptional super-enhancers are major locus regulators under both normal and pathological conditions.6,7 Important differences have been found regarding the ability of the IgH 3′regulatory region(3′RR)super-enhancer to control the B1 and B2 B-cell fate.

关键词： spleen specificity peritoneal

IgD class switch recombination is not controlled through the immunoglobulin heavy chain 3′ regulatory region super-enhancer

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Cellular & molecular Immunology 2017年第10期14卷 871-874页

作者： Hussein Issaoui Nour Ghazzaui Alexis Saintamand yves Denizot François Boyer UmR CNRS 7276 University of LimogesCBRS87025 LimogesFrance Present address:INSERm U1236 UniversitéRennes 1RennesFrance

In secondary lymphoid organs,mature B cells express membrane immunoglobulin(Ig)of m and D isotypes(Igm and IgD,respectively)of the same specificity through alternative splicing of a pre-mRNA encompassing the VDJ variable region and Cμand Cδheavy chain constant exons.1 After encountering antigen,B cells undergo class switch recombination(CSR)by which the Cμgene is substituted with Cγ,Cεor Cα,thereby generating IgG,IgE and IgA antibodies of the same antigenic specificity but with new effector *** requires the DNA-editing enzyme activation-induced deaminase(AID).

关键词： functions. substituted thereby