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Modeling Drug Concentration in Blood through Caputo-Fabrizio and Caputo Fractional Derivatives

Computer Modeling in Engineering & Sciences 2023年第6期135卷 2767-2785页

作者： Muath Awadalla Kinda Abuasbeh yves yannick yameni noupoue Mohammed S.Abdo Department of Mathematics and Statistics College of ScienceKing Faisal UniversityHafufAl Ahsa31982Saudi Arabia Institute of Statistics Biostatistics and Actuarial ScienceFaculty of ScienceUniversite Catholique de LouvainLouvain-La-Neuve1348Belgium Department of Mathematics Hodeidah UniversityAl-Hudaydah3114Yemen

This study focuses on the dynamics of drug concentration in the *** general,the concentration level of a drug in the blood is evaluated by themean of an ordinary and first-order differential *** precisely,it is solved through an initial value *** proposed a newmodeling technique for studying drug concentration in blood *** technique is based on two fractional derivatives,namely,Caputo and Caputo-Fabrizio *** first provided comprehensive and detailed proof of the existence of at least one solution to the problem;we later proved the uniqueness of the existing *** proof was written using the Caputo-Fabrizio fractional derivative and some fixed-point *** via theUlam-Hyers(UH)technique was also *** application of the proposedmodel on two real data sets revealed that the Caputo derivative wasmore suitable in this ***,for the first data set,the model based on the Caputo derivative yielded a Mean Squared Error(MSE)of 0.03095 with a corresponding best value of fractional order of derivative of ***-Fabrizio-basedderivative appeared to be the second-best method for the problem,with an MSE of 0.04324 for a corresponding best fractional derivative order of *** the second experiment,Caputo derivative-based model still performed the best as it yielded an MSE of 0.04066,whereas the classical and the Caputo-Fabrizio methods were tied with the same MSE of *** interesting finding was that the MSE yielded by the Caputo-Fabrizio fractional derivative coincided with the MSE obtained from the classical approach.

关键词： Pharmacokinetics caputo fractional derivative stability study Caputo-Fabrizio fractional derivative

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Materno-Fetal Outcomes of COVID-19 Infected Pregnant Women Managed at the Douala Gyneco-Obstetric and Pediatric Hospital—Cameroon

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Open Journal of Obstetrics and Gynecology 2020年第9期10卷 1279-1294页

作者： Alphonse Nyong Ngalame Humphry Tatah Neng Rakya Inna Dominique Tamchom Djomo Diane Estelle Modjo Kamdem Bilkissou Moustapha Julie Ngo Batta Diomede Njinkui Noukeu Dominique Enyama Rodrigue Tiokeng yannick Onana yves Moumbe Martial Zanga Jules Fils Ndongo Armand Kamga Robert Tchounzou Ultrich Keumayou Lemone Chingnabo Toudjirob Djiallati Emmanuel Passoret Estella Toyoum Ramadji Jean Blaise Ebimbe Servais Albert F. Bagnaka Eloumou Darolles Wekam Mwadjie Guy Pascal Ngaba Emile Telesphore Mboudou Gynecology and Obstetrics Unit Douala Gyneco-Obstetric and Pediatric Hospital Douala Cameroon Faculty of Medicine and Biomedical Sciences University of Ngaoundere Ngaoundere Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon Faculty of Health Sciences University of Buea Buea Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon

Introduction: The first case of the novel coronavirus (COVID-19) pandemic in Cameroon was confirmed on March 6, 2020. Though widely considered that pregnant women are more susceptible to respiratory tract infections, the available body of literature on the effect of COVID-19 on pregnancy outcomes is shy from being conclusive. In Cameroon, the Douala Gyneco-Obstetric and Pediatric Hospital (DGOPH) was one of the main frontline tertiary health facilities for the management of severe forms of the disease. After four months of managing COVID-19 cases in the general population and especially in pregnant women at the DGOPH, we decided to take a stop, analyze our findings from the patients managed in order to drive future policies and clinical practices via informed decisions. Overall objective: To describe and understand the clinical burden of patients managed for COVID-19 in pregnancy or post-partum at the DGOPH. Methodology: Cross-sectional and descriptive study covering four months—March 24th to July 24th 2020 at DGOPH. Using a pretested questionnaire, we systematically enrolled all patients who fulfilled the inclusion criteria, with analysis done using proportions from an excel spreadsheet. Results: A

关键词： COVID-19 DGOPH Pregnancy Outcome Mortality

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