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Serum 25-hydroxyvitamin D,genetic susceptibility,and the risk of incident type 2 diabetes:A prospective cohort in East China

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Chinese Medical Journal 2024年第8期137卷 972-979页

作者： Ying Sun Haojie Zhang Bin wang yuying wang Chi Chen Yi Chen Yingli Lu Ningjian wang Institute and Department of Endocrinology and Metabolism Shanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai 200011China Department of Endocrinology and Metabolism and Department of Guideline and Rapid Recommendation Cochrane China CenterMAGIC China CenterChinese Evidence-Based Medicine CenterWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Endocrinology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

Background:The serum vitamin D level varies widely by population,and studies have linked vitamin D levels with the risk of type 2 diabetes mellitus(T2DM).However,the relationship is inconsistent and the impact of vitamin D on T2DM among East Chinese adults is *** study aimed to investigate the association between serum 25-hydroxyvitamin D(25[OH]D)levels and the risk of T2DM and evaluated whether the association is modified by genetic ***:In the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors(SPECT-China)cohort,1862 participants free of T2DM at baseline were included.A weighted genetic risk score was calculated with 28 variants associated with *** logistic models were used to examine the association of serum 25(OH)D and genetic risk with ***:After a 5-year follow-up,132 cases of T2DM were *** observed no significant association between quartiles of serum 25(OH)D and T2DM risk after multivariable adjustment(χ^(2)=0.571,P_(for trend)=0.426).Compared to those in the lowest quartile of 25(OH)D,the odds ratios(ORs)(95%confidence interval[CI])for participants with increased quartiles were 1.29(0.74-2.25),1.35(0.77-2.36),and 1.27(0.72-2.24),*** observed a positive association of glycated hemoglobin(HbA1c)with 25(OH)D at baseline(β=1.752,P=0.001)and after follow-up(β=1.385,P=0.003),and a negative association of ln conversion homeostasis model assessment(HOMA)-βwith 25(OH)D at baseline(β=-0.982,P=0.021).There was no significant interaction between 25(OH)D and diabetes genetic predisposition on the risk of T2DM(χ^(2)=2.710,P_(for interaction)=0.100).The lowest OR(95%CI)of T2DM was among participants with low genetic risk and the highest quartile of 25(OH)D(0.17[0.05-0.62]).Conclusion:Serum 25(OH)D may be irrelevant to the risk of incident T2DM among East Chinese adults regardless of genetic predisposition.

关键词： Vitamin D Diabetes mellitus,Type 2 Genetic predisposition to disease Prospective cohort Glycated hemoglobin SPECT-China

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Life’s Essential 8 and risk of non-communicable chronic diseases:Outcome-wide analyses

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Chinese Medical Journal 2024年第13期137卷 1553-1562页

作者： Yuetian Yu Ying Sun Yuefeng Yu yuying wang Chi Chen Xiao Tan Yingli Lu Ningjian wang Institute and Department of Endocrinology and Metabolism Shanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai 200011China School of Public Health Zhejiang UniversityHangzhou 310058ZhejiangChina Department of Medical Sciences Uppsala UniversityUppsala 75185Sweden

Background:Life’s Simple 7,the former construct of cardiovascular health(CVH)has been used to evaluate adverse non-communicable chronic diseases(NCDs).However,some flaws have been recognized in recent years and Life’s Essential 8 has been *** this study,we aimed to analyze the association between CVH defined by Life’s Essential 8 and risk of 44 common NCDs and further estimate the population attributable fractions(PAFs)of low-moderate CVH scores in the 44 ***:In the UK Biobank,170,726 participants free of 44 common NCDs at baseline were *** Life’s Essential 8 composite measure consists of four health behaviours(diet,physical activity,nicotine exposure,and sleep)and four health factors(body mass index,non-high density lipoprotein cholesterol,blood glucose,and blood pressure),and the maximum CVH score was 100 *** score was categorized into low,moderate,and high *** were followed up for 44 NCDs diagnosis across 10 human system disorders according to the International Classification of Diseases 10th edition(ICD-10)code using linkage to national health records until *** proportional hazard models were used in this *** hazard ratios(HRs)and PAFs of 44 NCDs associated with CVH score were ***:During the median follow-up of 10.85 years,58,889 incident NCD cases were *** linear dose-response associations were found between higher CVH score and lower risk of 25(56.8%)of 44 ***-moderate CVH(<80 points)score accounted for the largest proportion of incident cases in diabetes(PAF:80.3%),followed by gout(59.6%),sleep disorder(55.6%),chronic liver disease(45.9%),chronic kidney disease(40.9%),ischemic heart disease(40.8%),chronic obstructive pulmonary disease(40.0%),endometrium cancer(35.8%),lung cancer(34.0%),and heart failure(34.0%)as the top *** the eight modifiable factors,overweight/obesity explained the largest number of cases of incident NCDs in endocrine,nutritional,and me

关键词： Life’s Essential 8 Cardiovascular risk score Non-communicable chronic disease Population health management Cohort analysis Healthy lifestyle UK Biobank

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Birth weight,ideal cardiovascular health metrics in adulthood,and incident cardiovascular disease

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Chinese Medical Journal 2024年第10期137卷 1160-1168页

作者： Ying Sun Bin wang Yuefeng Yu yuying wang Xiao Tan Jihui Zhang Lu Qi Yingli Lu Ningjian wang Department of Endocrinology and Metabolism Institute of Endocrinology and MetabolismShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China School of Public Health Zhejiang UniversityHangzhouZhejiang 310058China Department of Medical Sciences Uppsala UniversityUppsala 75105Sweden Center for Sleep and Circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510370China Department of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLA 70118USA Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMA 02138USA Channing Division of Network Medicine Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02138USA

Background:Prenatal and postnatal factors may have joint effects on cardiovascular health,and we aimed to assess the joint association of birth weight and ideal cardiovascular health metrics(ICVHMs)prospectively in adulthood with incident cardiovascular disease(CVD).Methods:In the UK Biobank,227,833 participants with data on ICVHM components and birth weight and without CVD at baseline were *** ICVHMs included smoking,body mass index,physical activity,diet information,total cholesterol,blood pressure,and hemoglobin *** Cox proportional hazards model was used to estimate the hazard ratios(HRs)and 95%confidence intervals(CIs)in men and ***:Over a median follow-up period of 13.0 years(2,831,236 person-years),we documented 17,477 patients with incident *** with participants with birth weights of 2.5-4.0 kg,the HRs(95%CIs)of CVD among those with low birth weights was 1.08(1.00-1.16)in men and 1.23(1.16-1.31)in *** association between having a birth weight<2.5 kg and CVD risk in men was more prominent for those aged<50 years than for those of older age(P for interaction=0.026).Lower birth weight and non-ideal cardiovascular health metrics were jointly related to an increased risk of *** with birth weights<2.5 kg and ICVHMs score 0-1 had the highest risk of incident CVD(HR[95%CI]:3.93[3.01-5.13]in men;4.24[3.33-5.40]in women).The joint effect(HR[95%CI]:1.36[1.17-1.58])could be decomposed into 24.7%(95%CI:15.0%-34.4%)for a lower birth weight,64.7%(95%CI:56.7%-72.6%)for a lower ICVHM score,and 10.6%(95%CI:2.7%-18.6%)for their additive interaction in ***:Birth weight and ICVHMs were jointly related to CVD *** a normal birth weight and ideal ICVHMs may reduce the risk of CVD,and a simultaneous improvement of both prenatal and postnatal factors could further prevent additional cases in women.

关键词： Birth weight Health metrics Cardiovascular disease Adult Stroke Coronary heart disease

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Research Advances in Infectious Mononucleosis Caused by Epstein-Barr Virus

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Open Journal of Pediatrics 2024年第1期14卷 108-121页

作者： yuying wang Peng Chen Department of Pediatrics The Second Hospital of Jilin University Changchun China

Infectious mononucleosis (IM), primarily caused by the Epstein-Barr virus (EBV), manifests as the classic triad of fever, pharyngitis, and cervical lymphadenopathy. Severe cases may involve organ damage, most commonly affecting the liver. Diagnosis relies on a combination of clinical presentation and laboratory parameters, with commonly used indicators including EBV-specific antibodies, EBV-DNA load, and the ratio of atypical lymphocytes. Treatment primarily involves symptomatic supportive care, with a cautious approach to the routine use of antiviral medications. In recent years, significant research in traditional Chinese medicine has been conducted in China, showing promising advancements. This article provides a comprehensive review of EBV-induced infectious mononucleosis, offering insights for clinical diagnosis and treatment.

关键词： Epstein-Barr Virus Infectious Mononucleosis Children

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Precise mode control of laser-written waveguides for broadband,low-dispersion 3D integrated optics

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Light(Science & Applications) 2024年第6期13卷 1186-1195页

作者： yuying wang Lijing Zhong Kuen Yao Lau Xuhu Han Yi Yang Jiacheng Hu Sergei Firstov Zhi Chen Zhijun Ma Limin Tong Kin Seng Chiang Dezhi Tan Jianrong Qiu College of Optical Science and Engineering Zhejiang University310027HangzhouChina Institute of Light+X Science and Technology College of Information Science and EngineeringNingbo University315211NingboChina School of Optoelectronic Science and Engineering&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow University215006SuzhouChina Prokhorov General Physics Institute of the Russian Academy of Sciences Dianov Fiber Optics Research Center38 Vavilov str.Moscow119333Russia Zhejiang Lab 311121HangzhouChina College of Materials Science and Engineering Key Laboratory of Advanced Materials of Yunnan ProvinceKunming University of Science and Technology650093KunmingYunnanChina Department of Electrical Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARChina School of Materials Science and Engineering Zhejiang University310027HangzhouChina

Three-dimensional(3D)glass chips are promising waveguide platforms for building hybrid 3D photonic circuits due to their 3D topological capabilities,large transparent windows,and low coupling *** present,the key challenge in scaling down a benchtop optical system to a glass chip is the lack of precise methods for controlling the mode field and optical coupling of 3D waveguide ***,we propose an overlap-controlled multi-scan(OCMS)method based on laser-direct lithography that allows customizing the refractive index profile of 3D waveguides with high spatial precision in a variety of *** the basis of this method,we achieve variable mode-field distribution,robust and broadband coupling,and thereby demonstrate dispersionless LP21-mode conversion of supercontinuum pulses with the largest deviation of<0.1 dB in coupling ratios on 210 nm *** approach provides a route to achieve ultra-broadband and low-dispersion coupling in 3D photonic circuits,with overwhelming advantages over conventional planar waveguide-optic platforms for on-chip transmission and manipulation of ultrashort laser pulses and broadband supercontinuum.

关键词： waveguide mode dispersion

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公司减资规则的反思与重构

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环球法律评论 2024年第1期46卷 21-41页

作者：王毓莹中国政法大学

减资规则,既关乎公司资本安全、债权人保护,又关乎股东平等与公司自治。我国《公司法》上的减资规则面临两重困境,一是因法律漏洞引起的同案异判困境;二是《公司法》的修订解除了对公司资本制度的大量管制情况下的体系协调困境。减资规... 详细信息

减资规则,既关乎公司资本安全、债权人保护,又关乎股东平等与公司自治。我国《公司法》上的减资规则面临两重困境,一是因法律漏洞引起的同案异判困境;二是《公司法》的修订解除了对公司资本制度的大量管制情况下的体系协调困境。减资规则系统性的变动,有资本维持路径与偿债能力测试模式两种方案,《公司法》的修订延续此前的法律逻辑选择了前者,并对违法减资法律责任、形式减资、非等比例减资等问题作出明确规定,虽然具有显著进步,但仍是未竟的转型。沿着《公司法》的理念,减资规则在法律适用中应当从严解释实质减资规则,从宽解释形式减资规则和非等比例减资规则。从制度完善的角度而言,减资规则应在继续秉承资本维持原则的基础上,充分吸收偿债能力测试模式之优势,通过赋予董事会在特定减资事项上部分决策权限,以偿债能力声明机制改进减资通知机制等具体举措,实现减资规则的系统性“升级”。

关键词：减资规则资本维持原则偿债能力测试资本信用资产信用

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有限公司股权对外转让中“同意权”规则的反思与重构

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中国法律评论 2024年第2期56卷 84-98页

作者：王毓莹中国政法大学法律硕士学院

《公司法》(2023)删除有限责任公司股权对外转让“同意权”规则,仅保留股东优先购买权模式下的限制规则无法承载“同意权”所承担的制度功能。股权转让具有契约性和组织性双重属性,“同意权”规则能够满足股权转让组织性的要求,也能兼... 详细信息

《公司法》(2023)删除有限责任公司股权对外转让“同意权”规则,仅保留股东优先购买权模式下的限制规则无法承载“同意权”所承担的制度功能。股权转让具有契约性和组织性双重属性,“同意权”规则能够满足股权转让组织性的要求,也能兼顾股权转让的契约自由主张,具有体系性的制度优势,因而应当予以保留。但是《公司法》(2018)的“弱同意权”规则也并没有发挥“同意权”的真正作用,鉴于此,应当在规则上明确“同意权”为股东同意权而非公司同意权;在立法上至少应当将“同意权”保留为缺省性规则,明确公司对股权转让的登记义务和违反“同意权”的法律责任,同时细化公司章程对“同意权”另有规定的内容,充分发挥缺省性规则的优势。

关键词：股权转让 “同意权” 人合性优先购买权

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算法裁判风险的形成归因与化解

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法律适用 2024年第5期 60-73页

作者：王毓莹中国政法大学法律硕士学院

随着智慧法院建设的持续推进,算法在司法审判中逐渐进入深度应用阶段,相关风险也随之激增,审判的公开透明原则、司法为民宗旨以及司法公正理念都受到了算法技术的冲击。分析可知,法律与技术衔接转换困难、权力分配格局失衡、传统司法向... 详细信息

随着智慧法院建设的持续推进,算法在司法审判中逐渐进入深度应用阶段,相关风险也随之激增,审判的公开透明原则、司法为民宗旨以及司法公正理念都受到了算法技术的冲击。分析可知,法律与技术衔接转换困难、权力分配格局失衡、传统司法向智能司法转型陷入困境是风险形成的深层原因。对此,在思路设计维度应当坚持司法质效和算法裁判安全并重;尊重司法规律,防止技术依赖;衡平算法裁判的权力格局。在路径厘定层面需要分类分级确定算法技术在审判中的适用尺度,吸收法院案件纠错机制,从技术的法律观视野强化算法裁判的透明度。

关键词：算法裁判智慧司法智慧法院算法风险

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情报视角下科技论文数据泄露风险的研判、规避与阻断

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编辑学报 2024年第2期36卷 129-134页

作者：王育英王群燕《情报杂志》编辑部 710054 中共陕西省委党校(陕西行政学院) 西安710061

大国竞争使科研成果成为国外智库或情报机构收集情报的重要信息源之一,以科技论文为载体的科技交流数据泄露风险进一步增加。开展科技论文数据泄露风险研究,可为出版工作提供警示与参考。通过实例和定量分析阐释科技论文数据泄露风险防... 详细信息

大国竞争使科研成果成为国外智库或情报机构收集情报的重要信息源之一,以科技论文为载体的科技交流数据泄露风险进一步增加。开展科技论文数据泄露风险研究,可为出版工作提供警示与参考。通过实例和定量分析阐释科技论文数据泄露风险防范的必要性,结合大数据特点分析数据泄露风险发生原因,指出数据泄露风险识别难点,运用知己知彼的情报学方略,从对内对外2个方面研判数据泄露风险,反向推理风险规避关键点,探寻出一条数据泄露风险溯源性阻断路径,即科技期刊出版单位应切实履行对作者的告知义务,创新告知形式方法,提高实效,同时细化对科技论文数据泄露风险的审查。

关键词：情报科技论文科技期刊数据风险数据泄露

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中长波红外探测技术发展与空间应用进展（英文）

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Frontiers of Information Technology & Electronic Engineering 2024年第8期25卷 1031-1057页

作者：王玉莹李劲东孙鹤枝李享中国空间技术研究院北京空间飞行器总体设计部中国空间技术研究院遥感卫星总体部

中波、长波红外探测大气穿透力强、识别伪装目标能力优越，是制约未来天基对地观测、天文探测能力的关键技术，其对低温、遥远、弱目标和低对比度目标的探测性能决定空间红外遥感系统能否探得清、看得远。由于天基红外探测系统探测目标... 详细信息

中波、长波红外探测大气穿透力强、识别伪装目标能力优越，是制约未来天基对地观测、天文探测能力的关键技术，其对低温、遥远、弱目标和低对比度目标的探测性能决定空间红外遥感系统能否探得清、看得远。由于天基红外探测系统探测目标的多样化，不同任务目标对探测器的需求也十分不同。本文梳理天基红外探测技术的发展脉络和研究进展，对中长波红外探测器技术及其空间应用进行综述，基于对天基遥感应用中地面像元分辨率(GSD)、探测距离和噪声等效温差(NETD)等关键性能指标的综合分析，厘清其与红外探测器相关参数的关联，进而具体分析像元间距、探测器NETD、探测率及工作温度等对天基红外遥感性能的影响。最后根据未来高分辨率、体系效能型天基遥感的发展趋势，提出了中长波红外探测技术面临的挑战和发展方向。

关键词：红外探测空间应用中长波红外探测天基对地观测遥感

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