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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng yuxing yao Chenlu Li Zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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Magnetocontrollable droplet mobility on liquid crystal-infused porous surfaces

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Nano Research 2023年第4期16卷 5098-5107页

作者： Yang Xu yuxing yao Weichen Deng Jen-Chun Fang Robert LDupont Meng Zhang SimonČopar UrošTkalec Xiaoguang Wang William G.Lowrie Department of Chemical and Biomolecular Engineering The Ohio State UniversityColumbusOH 43210USA Division of Chemistry and Chemical Engineering California Institute of TechnologyPasadenaCA 91125USA Department of Physics Faculty of Mathematics and PhysicsUniversity of Ljubljana1000 LjubljanaSlovenia Institute of Biophysics Faculty of MedicineUniversity of Ljubljana1000 LjubljanaSlovenia Department of Physics Faculty of Natural Sciences and MathematicsUniversity of Maribor2000 MariborSlovenia Department of Condensed Matter Physics Jožef Stefan Institute1000 LjubljanaSlovenia Sustainability Institute The Ohio State UniversityColumbusOH 43210USA

Magnetocontrollable droplet mobility on surfaces of both solids and simple fluids have been widely used in a wide range of ***,little is understood about the effect of the magnetic field on the wettability and mobility of droplets on structured ***,we report the manipulation of the dynamic behaviors of water droplets on a film of thermotropic liquid crystals(LCs).We find that the static wetting behavior and static friction of water droplets on a 4’-octyl-4-biphenylcarbonitrile(8CB)film strongly depend on the LC mesophases,and that a magnetic field caused no measurable change to these ***,we find that the droplet dynamics can be affected by a magnetic field as it slides on a nematic 8CB film,but not on isotropic 8CB,and is dependent on both the direction and strength of the magnetic *** measuring the dynamic friction of a droplet sliding on a nematic 8CB film,we find that a magnetic field alters the internal orientational ordering of the 8CB which in turn affects its *** support this interpretation with a scaling argument using the LC magnetic coherence length that includes(i)the elastic energy from the long-range orientational ordering of 8CB and(ii)the free energy from the interaction between 8CB and a magnetic ***,these results advance our understanding of droplet mobility on LC films and enable new designs for responsive surfaces that can manipulate the mobility of water droplets.

关键词： liquid crystals lubricated surfaces magnetic field wettability droplet mobility

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Mercury emission and adsorption characteristics of fly ash in PC and CFB boilers

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Frontiers in Energy 2021年第1期15卷 112-123页

作者： Li JIA Baoguo FAN Xianrong ZHENG Xiaolei QIAO yuxing yao Rui ZHAO Jinrong GUO Yan JIN College of Electrical and Power Engineering Taiyuan University of TechnologyTaiyuan 030024China

The mercury emission was obtained by measuring the mercury contents in flue gas and solid samples in pulverized coal (PC) and circulating fluidized bed (CFB) utility boilers. The relationship was obtained between the mercury emission and adsorption characteristics of fly ash. The parameters included unburned carbon content, particle size, and pore structure of fly ash. The results showed that the majority of mercury released to the atmosphere with the flue gas in PC boiler, while the mercury was enriched in fly ash and captured by the precipitator in CFB boiler. The coal factor was proposed to characterize the impact of coal property on mercury emissions in this paper. As the coal factor increased, the mercury emission to the atmosphere decreased. It was also found that the mercury content of fly ash in the CFB boiler was ten times higher than that in the PC boiler. As the unburned carbon content increased, the mercury adsorbed increased. The capacity of adsorbing mercury by fly ash was directly related to the particle size. The particle size corresponding to the highest content of mercury, which was about 560 ng/g, appeared in the range from 77.5 to 106 µm. The content of mesoporous (4–6 nm) of the fly ash in the particle size of 77.5–106 µm was the highest, which was beneficial to adsorbing the mercury. The specific surface area played a more significant role than specific pore volume in the mercury adsorption process.

关键词： mercury combustion modes coal property fly ash particle size

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生物焦负载金属离子对燃煤烟气中汞吸附的量子化学研究

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动力工程学报 2019年第9期39卷 747-751,757页

作者：姚禹星贾里乔晓磊郑仙荣樊保国金燕太原理工大学电气与动力工程学院

建立了负载金属离子的生物焦(WB)饱和簇模型,并采用量子化学密度泛函理论对单质汞(Hg0)在改性WB表面的吸附过程进行了研究。结果表明:金属离子可以稳定存在于WB表面;Hg0吸附在改性WB表面时,与WB表面发生化学吸附,且金属离子提升了WB对Hg... 详细信息

建立了负载金属离子的生物焦(WB)饱和簇模型,并采用量子化学密度泛函理论对单质汞(Hg0)在改性WB表面的吸附过程进行了研究。结果表明:金属离子可以稳定存在于WB表面;Hg0吸附在改性WB表面时,与WB表面发生化学吸附,且金属离子提升了WB对Hg0的吸附能力。

关键词：生物焦 Hg0 金属离子密度泛函理论吸附

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生物焦微观特性及分子结构研究

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环境化学 2019年第4期38卷 876-886页

作者：贾里姚禹星韩飞樊保国郑仙荣乔晓磊金燕太原理工大学电气与动力工程学院太原030024

本文利用多种表征手段,研究了汞吸附剂核桃壳生物焦的热解特性、孔隙结构与官能团等微观特性,并基于所获得的化学结构利用ChemBioOffice构建了生物焦的分子结构单体模型.结果表明,生物质的热解过程分为三个阶段,所形成的生物焦孔隙发达... 详细信息

本文利用多种表征手段,研究了汞吸附剂核桃壳生物焦的热解特性、孔隙结构与官能团等微观特性,并基于所获得的化学结构利用ChemBioOffice构建了生物焦的分子结构单体模型.结果表明,生物质的热解过程分为三个阶段,所形成的生物焦孔隙发达,并含有丰富的表面官能团.生物焦的大分子结构中芳香碳是主要组成部分,而脂肪碳则起到联结芳香结构单元的作用.而且生物焦是一种短程有序的非晶态物质,结构中存在一定数量的石墨微晶结构.基于表征结果,所构建的分子模型以芳香结构为主,并含有1个甲基、4个羟基以及8个羰基,分子式为C_(55)H_(37)NO_(14),M_r=935.同时对模型进行了验证.另外,基于分子力学,在UFF、Dreiding和MM2,3种力场下对三维模型进行了结构优化,其中UFF力场优化后的三维结构的总势能最大,而MM2力场势能最小.利用量子化学半经验PM6方法对3种优化后构象的生成热进行了研究,其中Dreiding力场下优化的结构更稳定.

关键词：生物焦微观特性分子结构能量优化汞

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不同吸附条件下生物炭的汞吸附特性研究

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环境污染与防治 2019年第3期41卷 300-306页

作者：李犇贾里姚禹星霍锐鹏乔晓磊樊保国太原理工大学电气与动力工程学院山西太原030024

为了获得汞初始浓度、吸附温度以及气氛(O_2、CO_2、SO_2浓度)等不同吸附条件下生物炭的汞吸附特性,对等温和非等温条件下制备的核桃壳生物炭(分别记为WS_(iso)和WS_(var))进行了研究,并利用比表面积和孔隙度分析仪、傅立叶变换红外光... 详细信息

为了获得汞初始浓度、吸附温度以及气氛(O_2、CO_2、SO_2浓度)等不同吸附条件下生物炭的汞吸附特性,对等温和非等温条件下制备的核桃壳生物炭(分别记为WS_(iso)和WS_(var))进行了研究,并利用比表面积和孔隙度分析仪、傅立叶变换红外光谱仪表征生物炭的孔隙结构和表面官能团等微观特性,探究其影响机理。结果表明:WS_(iso)和WS_(var)孔隙结构及表面化学性质不同,其中WS_(iso)的累积孔体积较大,为0.130 8cm^3/g,WS_(var)的含氧表面官能团数量和种类较多;在相同吸附条件下,WS_(iso)的汞吸附效果整体上优于WS_(var);汞初始浓度、CO_2和O_2浓度的升高会对生物炭汞吸附性能起到促进作用;随着吸附温度和SO_2浓度的升高,生物炭的吸附性能有所下降。

关键词：生物炭汞孔隙结构表面官能团吸附条件

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Hydrate formation in oil–water systems: Investigations of the influences of water cut and anti-agglomerant

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Chinese Journal of Chemical Engineering 2020年第2期28卷 369-377页

作者： Guangchun Song yuxing Li Wuchang Wang Kai Jiang Zhengzhuo Shi Shupeng yao Shandong Province Key Laboratory of Oil-Gas Storage and Transportation Safety China University of PetroleumQingdao 266580China

To investigate the characteristics of hydrate formation in oil–water systems, a high-pressure cell equipped with visual windows was used where a series of hydrate formation experiments were performed from natural gas + diesel oil + water systems at different water cuts and anti-agglomerant concentrations. According to the temperature and pressure profiles in test experiments, the processes of hydrate formation under two kinds of experimental procedures were analyzed first. Then, based on the experimental phenomena observed through the visual windows, the influences of water cut and anti-agglomerant on the places of hydrate formation and distribution, hydrate morphologies and hydrate morphological evolvements were investigated. Hydrate agglomeration, hydrate deposition and hydrate film growth on the wall were observed in experiments. Furthermore, three different mechanisms for hydrate film growth on the wall were identified. In addition, the influences of water cut and anti-agglomerant on the induction time of hydrate formation were also studied.

关键词： Hydrates Formation Oil–water system Water cut Anti-agglomerant

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Hydrate agglomeration modeling and pipeline hydrate slurry flow behavior simulation

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Chinese Journal of Chemical Engineering 2019年第1期27卷 32-43页

作者： Guangchun Song yuxing Li Wuchang Wang Kai Jiang Zhengzhuo Shi Shupeng yao Shandong Key Laboratory of Oil-Gas Storage and Transportation Safety College of Pipeline and Civil EngineeringChina University of Petroleum

Dynamic modeling and numerical simulation of hydrate slurry flow behavior are of great importance to offshore hydrate *** this purpose, a dynamic model of hydrate agglomeration was proposed in this *** on population balance equation, the frame of the dynamic model was established first, which took both hydrate agglomeration and hydrate breakage into ***, the calculating methods of four key parameters involved in the dynamic model were given according to hydrate agglomeration *** four key parameters are collision frequency, agglomeration efficiency, breakage frequency and the size distribution of sub particles resulting from particle *** the whole dynamic model was built, it was combined with several traditional solid–liquid flow models and then together solved by the CFD software FLUENT ***, using this method, the influences of flow rate and hydrate volume fraction on hydrate particle size distribution, hydrate volume concentration distribution and pipeline pressure drop were simulated and analyzed.

关键词： Hydrate Agglomeration Flow behavior Dynamic model Numerical simulation Population balance

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电解液改善锂离子电池低温析锂研究进展

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储能科学与技术 2024年第7期13卷 2192-2205页

作者：李泽珩徐磊姚雨星闫崇翟喜民郝雪纯陈爱兵黄佳琦别晓非孙焕丽范丽珍张强清华大学化学工程系绿电化工研究中心绿色反应工程与工艺北京市重点实验室北京100084 浙江大学化学工程与生物工程学院浙江杭州310058 北京理工大学前沿交叉科学研究院北京100081 中国第一汽车股份有限公司吉林长春130013 河北科技大学化学与制药工程学院河北石家庄050018 北京科技大学新材料技术研究院北京100083 清华大学碳中和研究院北京100084 清华大学山西清洁能源研究院山西太原030032

锂离子电池作为便携式电子产品和电动汽车的“心脏”,在推动人类社会的无化石燃料化中发挥着至关重要的作用。然而,在低温条件下(0℃及以下)充电时,锂离子电池电极极化急剧增大,导致了严重的析锂问题。通过合理设计低温电解液,降低低温... 详细信息

锂离子电池作为便携式电子产品和电动汽车的“心脏”,在推动人类社会的无化石燃料化中发挥着至关重要的作用。然而,在低温条件下(0℃及以下)充电时,锂离子电池电极极化急剧增大,导致了严重的析锂问题。通过合理设计低温电解液,降低低温充电时电极极化,并构建稳定的电解液-电极界面,可以有效遏制析锂及其对锂离子电池带来的不利影响。本文首先阐释了低温下锂离子电池析锂的形成机制,并指出低温电解液的设计是改善锂离子电池低温析锂行为的有效途径。接着,本文进一步介绍了缓解低温析锂问题的几种电解液设计策略,包括降低去溶剂化能垒的弱溶剂化电解液和共嵌入电解液、衍生低阻抗固态电解质界面膜(SEI)的局部高盐电解液以及钝化析锂的羧酸酯基高盐电解液,同时比较了这些策略的优劣势。最后,结合现有研究成果,展望了电解液调控低温析锂行为的未来研究方向,提出了发展实时析锂预警方法、采用实用化条件评估电解液抑制低温析锂能力以及设计兼顾电化学动力学和界面稳定性的高比能硅碳负极用低温电解液,以望实现低温锂离子电池的高容量发挥和长循环寿命。

关键词：析锂低温电解液锂离子电池电极极化

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The greenhouse gas budget for China's terrestrial ecosystems

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National Science Review 2023年第12期10卷 55-57页

作者： Xuhui Wang Yuanyi Gao Kai Wang yuxing Sang Yilong Wang Yuzhong Zhang Songbai Hong yao Zhang Wenping Yuan Institute of Carbon Neutrality Sino-French Institute for Earth System Science College of Urban and Environmental Sciences Peking University State Key Laboratory of Tibetan Plateau Earth System Resources and Environment(TPESRE) Institute of Tibetan Plateau ResearchChinese Academy of Sciences Key Laboratory of Coastal Environment and Resources of Zhejiang Province School of EngineeringWestlake University Institute of Advanced Technology Westlake Institute for Advanced Study School of Atmospheric Sciences Sun Yat-sen University

The increased atmospheric concentrations of greenhouse gases (GHGs,including CO2, CH4 and N2O) are unequivocally the major driving forces of climate warming [1]. These GHGs originate not only from the use of fossil fuels, but also from disturbances to and management of terrestrial *** evidence suggests that terrestrial ecosystems,

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