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J-comb: An image fusion algorithm to combine observations covering different spatial frequency ranges

Science China(Physics,Mechanics & Astronomy) 2022年第9期65卷 138-156页

作者： Sihan Jiao yuxin lin Xiangyu Shui Jingwen Wu Zhiyuan Ren Di Li National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Centre for Astrochemical Studies Max-Planck-Institut f¨ur Extraterrestrische PhysikGarching 85748Germany Astrophysics Department Munich UniversityMunich 81679Germany NAOC-UKZN Computational Astrophysics Centre University of KwaZulu-NatalDurban 4000South Africa

Ground-based, high-resolution bolometric(sub)millimeter continuum mapping observations on spatially extended target sources are often subject to significant missing fluxes. This hampers accurate quantitative analyses. Missing flux can be recovered by fusing high-resolution images with observations that preserve extended structures. However, the commonly adopted image fusion approaches do not maintain the simplicity of the beam response function and do not try to elaborate the details of the yielded beam response functions. These make the comparison of the observations at multiple wavelengths not straightforward. We present a new algorithm, J-comb, which combines the high and low-resolution images linearly. By applying a taper function to the low-pass filtered image and combining it with a high-pass filtered image using proper weights, the beam response functions of our combined images are guaranteed to have near-Gaussian shapes. This makes it easy to convolve the observations at multiple wavelengths to share the same beam response functions. Moreover, we introduce a strategy to tackle the specific problem that the imaging at 850 μm from the present-date ground-based bolometric instrument and that taken with the Planck satellite do not overlap in the Fourier domain. We benchmarked our method against two other widely-used image combination algorithms, CASA-feather and MIRIAD-immerge, with mock observations of star-forming molecular clouds. We demonstrate that the performance of the J-comb algorithm is superior to those of the other two algorithms. We applied the J-comb algorithm to real observational data of the Orion A star-forming region. We successfully produced dust temperature and column density maps with ~10′′angular resolution, unveiling much greater details than the previous results. A py Thon code release of J-comb and implementation of the algorithm are available at https://***/Sihan Jiao/J-comb.

关键词： star formation molecular clouds image processing

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Can Turbulent, High-density Gas Form Stars in Molecular Clouds: A Case Study in Ophiuchus

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Research in Astronomy and Astrophysics 2022年第7期22卷 235-243页

作者： Sihan Jiao Jingwen Wu Hao Ruan yuxin lin Chao-Wei Tsai linjing Feng National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Centre for Astrochemical Studies Max-Planck-Institut für Extraterrestrische PhysikGießenbachstraße 1D-85748 GarchingGermany

Star formation is governed by the interplay between gravity and turbulence in most of molecular *** theoretical works assume that dense gas,whose column density is above a critical value in the column density probability distribution function(N-PDF),where gravity starts to overcome turbulence,becomes star-forming gas and will collapse to form ***,these high-density gases will include some very turbulent areas in the *** these dense but turbulent gases also form stars?We test this scenario in Ophiuchus molecular cloud using N-PDF analysis and find that at least in some regions,the turbulent,dense gas is not forming *** identified two isolated high-density structures in Ophiuchus,which are gravitationally unbound and show no sign of star *** high densities may come from turbulence.

关键词： ISM:clouds stars:formation ISM:structure

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Aero-optical wavefront measurement technique based on BOS and its applications

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Chinese Science Bulletin 2011年第22期56卷 2320-2326页

作者： TIAN LiFeng YI ShiHe ZHAO yuxin HE lin CHEN Zhi College of Aerospace and Material Engineering National University of Defense Technology Changsha 410073 China

A collimated light beam will be refracted if it propagates through a flow-field with index-of-refraction variations,and its wavefront will be *** we measure the deflection angle of the light beam,the gradient of the wavefront can be obtained using the Malus law,and the wavefront aberration can be computed with a reconstruction *** characteristics of background oriented schlieren(BOS) are conducive to wavefront aberration measurement:BOS can be used to measure the deflection angle of a light beam by measuring the displacement field between the reference image and the experiment ***,in a BOS system of Schlieren mode,only the ray perpendicular to the background image can be captured with a *** is helpful to measure wavefront aberrations that occur after a planar wavefront has passed through the *** on these characteristics of BOS of Schlieren mode,a new wavefront measurement technique,which is called the BOS-based wavefront technique(BOS-WT),is proposed in this *** works by constructing the relationship between the displacement of the background image and the aero-optical wavefront gradient and uses the Southwell wavefront reconstruction algorithm.A BOS-WT system was assembled,and its temporal resolution was found to be 6 ns,and its temporal-correlation resolution reached 0.2 μs.A BOS-WT can measure the time-correlation transient wavefront *** is simple and easy to *** this paper,we also present a study of the aero-optical performance of supersonic mixing layer based on our BOS-WT transient wavefronts at an interval of 5 μ*** results showed the wavefront was transient and distorted after it had passed through the mixing *** the analysis of the data at the 5 μs interval,the temporal evolution of wavefront can be obtained.

关键词：波前像差测量技术气动光学超音速混合层时间分辨率应用背景图像折射指数

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Aero-optical aberration measuring method based on NPLS and its application

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Chinese Science Bulletin 2010年第31期55卷 3545-3549页

作者： YI ShiHe TIAN LiFeng ZHAO yuxin HE lin CHEN Zhi College of Aerospace and Material Engineering National University of Defense Technology Changsha 410073 China

The existing methods for measuring aero-optical aberration suffer from several problems,such as low spatiotemporal resolution,sensitivity to environment,and integral effects.A new method for measuring aero-optical aberration of supersonic flow is *** on the self-developed measuring method of supersonic density field,the wavefront aberration induced by a cross-section of supersonic flow field could be measured by *** with other methods,the present one has three significant innovations:(1) high spatiotemporal *** time resolution is 6 ns,and the spatial resolution can reach up to micrometers;(2) it can avoid the integral effects and study the wavefront aberration induced by the flow field of interest locally;(3) it can also avoid the influence from the test section wall boundary layers and environmental *** present method was applied to supersonic flow around an optical bow *** results of high spatiotemporal resolution reveal fine wavefront structures,and show that shock waves,expansion waves and turbulent boundary layers have different impacts on the wavefront aberration.

关键词：测量方法光学畸变不良贷款气动应用时空分辨率超音速流动超声速流场

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Multivariate competing endogenous RNA network characterization for cancer microRNA biomarker discovery:a novel bioinformatics model with application to prostate cancer metastasis

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Precision Clinical Medicine 2022年第1期5卷 2-12页

作者： yuxin lin Xin Qi Jing Chen Bairong Shen Institutes for Systems Genetics Frontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610212China Department of Urology the First Affiliated Hospital of Soochow UniversitySuzhou 215000China Center for Systems Biology Soochow UniversitySuzhou 215006China School of Chemistry and Life Sciences Suzhou University of Science and TechnologySuzhou 215011China

Background:MicroRNAs(miRNAs)are post-transcriptional regulators with potential as biomarkers for cancer *** competing endogenous RNA(ceRNA)network modeling is an effective way to decipher the complex interplay between miRNAs and ***,there are currently no general rules for ceRNA network-based biomarker *** and results:In this study,a novel bioinformatics model was developed by integrating gene expression with multivariate miRNA-target data for ceRNA network-based biomarker *** with traditional methods,the structural vulnerability in the human long non-coding RNA(lncRNA)–miRNA–messenger RNAs(mRNA)network was comprehensively analyzed,and the single-line regulatory or competing mode among miRNAs,lncRNAs,and mRNAs was characterized and quantified as statistical evidence for miRNA biomarker *** application of this model to prostate cancer(PCa)metastasis identified a total of 12 miRNAs as putative biomarkers from the metastatic PCa-specific lncRNA–miRNA–mRNA network and nine of them have been previously reported as biomarkers for PCa *** receiver operating characteristic curve and cell line qRT-PCR experiments demonstrated the power of miR-26b-5p,miR-130a-3p,and miR-363-3p as novel candidates for predicting PCa ***,PCa-associated pathways such as prostate cancer signaling,ERK/MAPK signaling,and TGF-βsignaling were significantly enriched by targets of identified miRNAs,indicating the underlying mechanisms of miRNAs in PCa ***:A novel ceRNA-based bioinformatics model was proposed and applied to screen candidate miRNA biomarkers for PCa *** validations using human samples and clinical data will be performed for future translational studies on the identified miRNAs.

关键词： miRNA biomarker competing endogenous RNA network characterization single-line regulation prostate cancer metastasis

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Translational Informatics for Parkinson’s Disease:from Big Biomedical Data to Small Actionable Alterations

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Genomics, Proteomics & Bioinformatics 2019年第4期17卷 415-429页

作者： Bairong Shen yuxin lin Cheng Bi Shengrong Zhou Zhongchen Bai Guangmin Zheng Jing Zhou Institutes for Systems Genetics West China HospitalSichuan UniversityChengdu 610041China Center for Systems Biology Soochow UniversitySuzhou 215006China Center for Translational Biomedical Informatics Guizhou University School of MedicineGuiyang 550025China

Parkinson’s disease(PD)is a common neurological disease in elderly people,and its morbidity and mortality are increasing with the advent of global *** traditional paradigm of moving from small data to big data in biomedical research is shifting toward big data-based identification of small actionable *** highlight the use of big data for precision PD medicine,we review PD big data and informatics for the translation of basic PD research to clinical *** emphasize some key findings in clinically actionable changes,such as susceptibility genetic variations for PD risk population screening,biomarkers for the diagnosis and stratification of PD patients,risk factors for PD,and lifestyles for the prevention of *** challenges associated with the collection,storage,and modelling of diverse big data for PD precision medicine and healthcare are also *** perspectives on systems modelling and intelligent medicine for PD monitoring,diagnosis,treatment,and healthcare are discussed in the end.

关键词： Parkinson’s disease Healthcare Disease biomarker Translational informatics Systems modelling

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Utilization of aggregation-induced emission materials in urinary system diseases

Aggregate

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Aggregate 2024年第5期5卷 135-158页

作者： Haodong Xu Xin Chen He Wang Chaozhong Wang Yunjie Guo yuxin lin Yuhua Huang Jianquan Hou Xuedong Wei Department of Urology The First Afﬁliated Hospital of Soochow UniversitySuzhouChina Department of Urology Dushu Lake Hospital Afﬁliated to Soochow UniversityMedical Center of Soochow UniversitySuzhou Dushu Lake HospitalSuzhouChina

With the development of aggregation-induced emission(AIE)materials,the draw-backs of conventionalﬂuorescence materials subjected to aggregation-caused quenching(ACQ)have been *** has allowed for the improvement of novel AIEﬂuorescent materials that exhibit enhanced photostability,a higher signal-to-noise ratio,and better imaging ***,the enhanced phototherapeutic effect of AIE materials has garnered widespread attention in the realm of tumor *** distinct physiological and anatomical characteristics of the urinary system make it suitable for the use of AIE ***,AIE-based pho-totherapy provides a superior solution to deal with the weaknesses of conventional treatments for urologic *** this review,the scientiﬁc advancement on the use of AIE materials in urinary system diseases since the emergence of the AIE con-cept is reviewed in *** review highlights the promise of AIE materials for biomarkers detection,ﬂuorescence imaging(FLI)in vivo and in vitro,AIE-based phototherapy,and synergistic therapy from both diagnostic and therapeutic *** isﬁrmly believed that AIE materials hold immense untapped potential for the diagnosis and treatment of urologic disease,as well as all diseases of the human body.

关键词： aggregation-induced emission AIEgens cancer therapy ﬂuorescence imaging urinary system diseases

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Experiment Study on Active-passive Mode-locking Using Cr4+∶YAG as Saturable Absorber

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Chinese Journal of Lasers 2002年第1期11卷 2-5页

作者： LENG yuxin LU Haihe lin Lihuang XU Zhizhan (Shanghai Institute of Optics and Fine Mechanics, The Chinese Academy of Sciences, Shanghai 201800, China) Shanghai Institute of Optics and Fine Mechanics The Chinese Academy of Sciences 上海 201800

Cr 4+ ∶YAG crystal was used as a saturable absorber in an active-passive mode-locked Nd∶YAG laser. The stable and complete mode-locked pulse train was achieved at 1064 nm. The duration of ～0.8 ns to 2.4 ns for a single pulse was obtained by using Cr 4+ ∶YAG crystals with the different initial transmissions, and there was a shortest pulse width. The mode-locking dynamic process of Cr 4+ ∶YAG crystal was discussed to explain the experimental result, and the effect of excited-state absorption was considered.

关键词： Cr 4+ ∶YAG active-passive mode-locking excited-state absorption

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Design and Realization of 3D Management Information System for Ancient and Famous trees Based on Virtual Plant

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Chinese Forestry Science and Technology 2012年第3期11卷 66-67页

作者： Wang Jingjing Tang Liyu lin Ding lin yuxin Key Lab.of Spatial Data Mining and Information Sharing of Education Ministry Spatial Information Research Center of Fujian ProvinceFuzhou University Fuzhou linjingxing information Technology Co.Led.

The modernization and informatization management of ancient and famous trees’ management is an important standard with which the municipal public resource management level of a region or city can be *** and development of ancient and famous trees’three-dimensional management information system was realized based on virtual plant by using integrated techniques of virtual plants and Geographic Information *** system architecture design was developed on the basis of functional requirements,and the practical system was achieved in Visual Studio 2008 development tools and OpenGL graphics *** system has function of ancient trees archives management,three-dimensional reconstruction of the trees surrounding environment,individual tree information inquiry in three-dimensional scene,*** and dissemination of this system will greatly promote the management and protection of ancient and famous trees standardization,informalization and

关键词： virtual plant ancient and famous tree information management

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Establishment and application of a fibrosis/scar biospecimen repository and systematic research platform

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第4期6卷 199-205页

作者： Zhiyuan Zhou Ya Gao Chiakang Ho Dongsheng Wen Yangdan Liu Tingyu Tsai yuxin lin Qingfeng Li Yifan Zhang Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine

Fibrosis is a pathological outcome of a dysregulated repair response to injury, which can occur in any organ and have devastating effects on hundreds of millions of patients worldwide. However, challenges remain in delineating the complex and dynamic network regulating fibrosis, as well as translating this information into effective anti-fibrotic treatments. A comprehensive understanding of existing methodologies and the development of new research tools are essential for ensuring the transferability of findings from bench to bedside. In this review, we present a framework consisting of a large biospecimen repository that integrates diverse patient cohorts with corresponding clinical data, and a systematic research platform incorporating multiple layers of experimental strategies, primarily focused on skin fibrosis. We summarize current advancements and the applications of various tools for preclinical fibrosis research and examine the limitations of traditional methods used to simulate and investigate biomechanical signals in the fibrotic environment. Importantly, we highlight the strengths of research techniques and translational approaches of varying physiological relevance developed by us over the past ***, we emphasize a trend toward more faithfully replicating the functional, structural, and biological complexity of fibrosis while providing high spatio-temporal control over soluble cues and intricate *** comprehensive overview of methodology paves the way for minimizing batch-to-batch variation and improving the reproducibility of experimental systems.

关键词： Fibrosis Biospecimen repository Clinical cohort Research platform

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