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生物节律因素对体外循环心脏手术后AKI发生的影响：回顾性队列研究

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中华麻醉学杂志 2024年第9期44卷 1093-1096页

作者：李小东文静徐小廖先建宋雨汐段家翔鲁开智易斌甯交琳陆军军医大学第一附属医院麻醉科重庆

目的评价生物节律因素对体外循环心脏手术后急性肾损伤(AKI)发生的影响。方法本研究为回顾性队列研究。收集2018年6月至2019年12月体外循环心脏手术患者的病例资料, 按照实施麻醉手术的时间分为2组(n=125):上午节律组(Ⅰ组)8:00至12:00... 详细信息

目的评价生物节律因素对体外循环心脏手术后急性肾损伤(AKI)发生的影响。方法本研究为回顾性队列研究。收集2018年6月至2019年12月体外循环心脏手术患者的病例资料, 按照实施麻醉手术的时间分为2组(n=125):上午节律组(Ⅰ组)8:00至12:00实施麻醉手术;下午节律组(Ⅱ组)14:00至18:00实施麻醉手术。记录患者术后AKI及术后其他相关并发症(肺部感染、脓毒症、脑梗死)发生情况。结果与Ⅱ组相比, Ⅰ组术后AKI发生率升高(P0.05)。结论生物节律因素影响体外循环心脏手术后AKI发生, 下午较上午实施手术有助于降低术后AKI发生。

关键词：生物节律体外循环急性肾损伤队列研究心脏手术

基于风云气象和高分静止卫星数据的四川省凉山地区森林火灾遥感监测研究

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四川林业科技 2024年第4期45卷 54-63页

作者：黄云文军葛翔宇李晓玥宋雨曦成都信息工程大学大气科学学院/高原大气与环境四川省重点实验室四川成都610225

森林火灾不仅会对区域生态环境造成严重破坏,还可能导致人类生命财产遭受巨大损失,因此研究有效的火灾监测算法至关重要。在此背景下,利用我国风云四号卫星数据开展研究,通过对比确定了适用于凉山地区的森林火灾监测算法。采用高分四号... 详细信息

森林火灾不仅会对区域生态环境造成严重破坏,还可能导致人类生命财产遭受巨大损失,因此研究有效的火灾监测算法至关重要。在此背景下,利用我国风云四号卫星数据开展研究,通过对比确定了适用于凉山地区的森林火灾监测算法。采用高分四号卫星中波红外扫描仪数据,成功确定了火点的大小和位置,并提取了火烧迹地面积,优选了最适宜于凉山地区的方法。研究结果表明,上下文算法在凉山地区的森林火灾监测中效果最佳,漏判率最低,可准确检测到小火点的位置,算法的综合指标达到了0.7以上,为凉山地区的森林火灾扑救工作提供了科学参考。通过将高分四号卫星红外扫描仪数据的阈值设置为330 K,进一步确定火点的大小和位置,弥补了风云四号卫星空间分辨率的不足,为森林火灾监测提供更好的技术支持。基于高分四号卫星数据对比不同方法的灰度衰减图时,红外波段的衰减变化最为明显,其次为全球环境监测植被指数和归一化植被指数,过火区识别指数的衰减变化不明显,根据红外波段的灰度衰减图可准确提取出火烧迹地面积范围。

关键词： FY-4A GF-4 火灾监测火烧迹地

The essential roles of m^(6)A modification in osteogenesis and common bone diseases

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Genes & Diseases 2024年第1期11卷 335-345页

作者： yuxi Gu Yidan song Yihua Pan Jun Liu State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases Department of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China

N6-methyladenosine(m^(6)A)is the most prevalent modification in the eukaryotic transcriptome and has a wide range of functions in coding and noncoding *** affects the fate of the modified RNA,including its stability,splicing,and translation,and plays an important role in post-transcriptional *** play a key role in supporting and pro-tecting muscles and other organs,facilitating the movement of the organism,ensuring blood production,*** diseases such as osteoarthritis,osteoporosis,and bone tumors are serious public health *** processes of bone development and osteogenic differen-tiation require the precise regulation of gene expression through epigenetic mechanisms including histone,DNA,and RNA *** a reversible dynamic epigenetic mark,m^(6)A modifications affect nearly every important biological process,cellular component,and molecular function,including skeletal development and *** recent years,studies have shown that m^(6)A modification is involved in osteogenesis and bone-related *** this review,we summarized the proteins involved in RNA m^(6)A modification and the latest progress in elucidating the regulatory role of m^(6)A modification in bone formation and stem cell direc-tional *** also discussed the pathological roles and potential molecular mech-anisms of m^(6)A modification in bone-related diseases like osteoporosis and osteosarcoma and suggested potential areas for new strategies that could be used to prevent or treat bone de-fects and bone diseases.

关键词： Bone diseases m^(6)A modification Osteogenesis Regulatory role Stem cells

Abiotic transformation of chlorinated organics at the active surface of iron-bearing minerals in soils and sediments

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Science China Technological Sciences 2024年第10期67卷 2991-3008页

作者： LI XuXin YAN Chen ZENG yuxi LI WenBin PENG TianWei song Biao ZHOU ChengYun College of Environmental Science and Engineering Hunan University Key Laboratory of Environmental Biology and Pollution Control (Hunan University) Ministry of Education

Chlorinated organic compounds are emerging pollutants of widespread concern because of their toxicity, bioaccumulation,persistence, and lack of adequate regulatory measures. Their abiotic transformation, facilitated by iron-bearing minerals, is critical to their natural dissipation in soils and sediments. However, further exploration is needed to understand their underlying mechanisms and potential engineering applications under different redox conditions. This paper reviews the abiotic transformation behaviors and mechanisms of chlorinated organics at the active surface of iron-bearing minerals under anoxic and oxic conditions and summarizes the strategies for enhancing the abiotic transformation efficiency of chlorinated organics. The abiotic transformation rate under oxic conditions can be a few orders of magnitude higher than that under anoxic conditions. Under anoxic conditions, chlorinated organics undergo reductive dechlorination through reductive elimination, hydrogenolysis, dehydrohalogenation, and nucleophilic substitution. A close relationship between the abiotic transformation of chlorinated organics and the production of hydroxyl radicals by iron-bearing minerals under oxic conditions was discovered. Synthetic active iron-bearing minerals, carbonaceous materials, and biological synergy can facilitate abiotic dechlorination under anoxic conditions. Meanwhile, the regulation of redox conditions, the introduction of ligands, and the utilization of coexisting anions are proposed to enhance oxidative degradation. This study is expected to improve the comprehension of the abiotic degradation of chlorinated organics mediated by iron-bearing minerals and provide the theoretical foundation for developing new approaches aimed at addressing chlorinated organic pollution.

关键词： chlorinated organic compounds iron-bearing minerals dechlorination degradation remediation

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CmMYB3-like negatively regulates anthocyanin biosynthesis and flower color formation during the post-flowering stage in Chrysanthemum morifolium

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Horticultural Plant Journal 2024年第1期10卷 194-204页

作者： Lijie Zhou Shenhui Liu Yiguang Wang yuxi Wang Aiping song Jiafu Jiang Sumei Chen Zhiyong Guan Fadi Chen State Key Laboratory of Crop Genetics and Germplasm Enhancement The Key Laboratory of LandscapingMinistry of Agriculture and Rural AffairsCollege of HorticultureNanjing Agricultural UniversityNanjingJiangsu 210095China

Color fading caused by a decrease in anthocyanin accumulation during the post-flowering stage significantly affects postharvest quality of ***,the underlying mechanism by which anthocyanin accumulation decreases during the post-flowering stage still unclear,which greatly restricts design of molecular breeding in ***,a chrysanthemum SG7 R2R3 MYB transcription factor(TF),CmMYB3-like,was identified to have a function in regulating anthocyanin biosynthesis during the post-flowering *** real time PCR(qRT-PCR)assays showed that the expression of CmMYB3-like was gradually downregulated when anthocyanin content increased during the flowering stage and was significantly upregulated during the post-flowering *** transformation of chrysanthemum and dual-luciferase assays in *** leaves showed that CmMYB3-like suppressed anthocyanin accumulation by inhibiting the transcription of CmCHS and CmANS directly and that of CmF3H ***,overexpression or suppression of CmMYB3-like did not affect the biosynthesis of flavones or *** transformation of chrysanthemum revealed that the overexpression of CmMYB3-like inhibited anthocyanin accumulation,but its suppression prevented the decrease in anthocyanin accumulation during the post-flowering *** results revealed a crucial role of CmMYB3-like in regulating the color of petals during the post-flowering stage and provided a target gene for molecular design breeding to improve the postharvest quality of chrysanthemum.

关键词： Post-flowering stage Color fading Anthocyanins CmMYB3-like Chrysanthemum Molecular breeding

Early Warning System of Risk in Dairy Cows with Inactive Ovaries

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Journal of Biosciences and Medicines 2018年第11期6卷 74-88页

作者： Chang Zhao Shi Shu Jiang Zhang Yunlong Bai Shuhan Sun yuxi song Cheng Xia College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University Daqing China

The incidence of Inactive ovaries of dairy cows in China is relatively high. There is no complete early warning system for the occurrence of ovarian quiescence in clinical cows. This test provides early warning indicators for clinical prediction of ovary cessation in dairy cows. This experiment selected blood samples of dairy cows from 60 to 90 days postpartum in the inactive ovaries group and control group. Differential proteins were selected on the basis of proteomics, three energy indexes: AST, Glu, NEFA. Four reproductive hormones: E2, P4, FSH, LH, and four differentially expressed proteins: IGFBP-2, AHSG, APO-A4, and RBP-4. Key enzyme activities: ALDOB, LDHB, ITIH3, GPX3, SPAM1, PKM2. The ELISA test kit was used to detect the content and activity of the above markers in the test bovine serum. Through correlation analysis, binary logistic regression modeling and ROC analysis, a single indicator early warning technique for APOA4 and ITIH3 was established. The early warning values were APOA4 > 28.825 μg/L and ITIH3 > 195.07 ng/L. A multi-index early warning system based on potential biomarkers of APOA4 + ITIH3 and APOA4 + ITIH3 + E2 was established. The former had an early warning value of: APOA4 > 19.55 μg/I;ITIH3 > 191.14 ng/L;the latter has an early warning value: APOA4 > 47.56 μg/L, ITIH4 > 187.80 ng/L, E2 < 69.63 ng/L.

关键词： Inactive Ovaries of Dairy Cows APOA4 ITIH3 E2 ROC

Enhancing solar-driven overall water splitting via both sacrifice and noble metal free photocatalysis:copper cluster/boron-doped carbon nitride catalysts

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Science China Chemistry 2024年

作者： Yun-Dong Cao yuxi Zhang Jian song Hong Liu Zhiyuan song Lin-Lin Fan Cai-Li Lv Guang-Gang Gao School of Materials Science and Engineering University of Jinan

The major impediment to the additional industrialization of water splitting is the high cost of the co-catalyst made of noble metals and the sacrificial reagent.A binary photocatalytic system,consisting of B-doped g-C3N4nanosheets (Cu20@BCN-X) and atomically accurate copper clusters,is designed in this *** copper clusters serve as co-catalysts for H2evolution and exhibit Pt-like activity,whereas the nanosheets serve as carriers and semiconductor components for *** binary system,created using simple techniques,demonstrates hydrogen bonding interactions that promote synergistic effects and efficient binding and charge transfer across the interface between the two *** position manipulation of carbon nitride nanosheets demonstrates a Z-scheme charge transfer mechanism between the nanosheets and copper *** photocatalytic system can accomplish the photocatalytic overall water splitting process (259.9μmol g-1h-1of H2and129.4μmol g-1h-1of O2) without using sacrificial agents or noble metal *** work lays the foundation for the design of overall water splitting catalysts by precisely manipulating the energy levels,and it also paves the way for commercialized photocatalytic catalysts that do not require noble metals or sacrificial chemicals.

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粗检漏试验标准问题的研究及建议

半导体技术 2010年第11期35卷 1099-1101页

作者：宋玉玺李巍国家半导体器件质量监督检验中心石家庄050051

有些外形较小或内腔腔体体积较小并且检漏合格的电子产品,进行水汽含量测定时有时会出现样品水汽含量超标现象。为证明现行国家标准中粗检漏试验方法(高温氟油加压检漏法)会对产品出现误判的问题,通过一系列试验和研究,证明了外形较小... 详细信息

有些外形较小或内腔腔体体积较小并且检漏合格的电子产品,进行水汽含量测定时有时会出现样品水汽含量超标现象。为证明现行国家标准中粗检漏试验方法(高温氟油加压检漏法)会对产品出现误判的问题,通过一系列试验和研究,证明了外形较小或内腔腔体体积较小存在漏孔的电子产品,严格按照现行的粗检漏试验方法中规定的样品在空气中干燥有效时间(2±1)min内进行试验,试验得到了多种结果,进而对产品形成误判,为此对标准中的该试验方法提出了一些新的建议。

关键词：粗检漏干燥时间标准水汽含量误判

通智测试——基于动态具身物理社会交互环境的通用人工智能测试

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Engineering 2024年第3期34卷 12-22页

作者： Yujia Peng Jiaheng Han Zhenliang Zhang Lifeng Fan Tengyu Liu Siyuan Qi Xue Feng yuxi Ma Yizhou Wang song-Chun Zhu National Key Laboratory of General Artificial Intelligence Beijing Institute for General Artificial IntelligenceBeijing 100086China Institute for Artificial Intelligence Peking UniversityBeijing 100871China Beijing Key Laboratory of Behavior and Mental Health School of Psychological and Cognitive SciencesPeking UniversityBeijing 100871China School of Intelligence Science and Technology Peking UniversityBeijing 100871China School of Computer Science Peking UniversityBeijing 100871China

The release of the generative pre-trained transformer(GPT)series has brought artificial general intelligence(AGI)to the forefront of the artificial intelligence(AI)field once ***,the questions of how to define and evaluate AGI remain *** perspective article proposes that the evaluation of AGI should be rooted in dynamic embodied physical and social interactions(DEPSI).More specifically,we propose five critical characteristics to be considered as AGI benchmarks and suggest the Tong test as an AGI evaluation *** Tong test describes a value-and ability-oriented testing system that delineates five levels of AGI milestones through a virtual environment with DEPSI,allowing for infinite task *** contrast the Tong test with classical AI testing systems in terms of various aspects and propose a systematic evaluation system to promote standardized,quantitative,and objective benchmarks and evaluation of AGI.

关键词： Artificial general intelligence Artificial intelligence benchmark Artificial intelligence evaluation Embodied artificial intelligence Value alignment Turing test Causality