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Health benefits of Grifola frondosa polysaccharide on intestinal microbiota in type 2 diabetic mice

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Food Science and Human Wellness 2022年第1期11卷 68-73页

作者： Xiaoxiang Gao Dan Liu Luying Gao Yuezhen Ouyang yuxi wen Chao Ai Yuqing Chen Chao Zhao College of Food Science Fujian Agriculture and Forestry UniversityFuzhou 350002China Department of Pediatrics Nanjing First HospitalNanjing Medical UniversityNanjing 210006China School of Food Science and Engineering South China University of TechnologyGuangzhou 510641China Department of Food Science&Technology National University of SingaporeSingapore 117543Singapore Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition Ministry of Education Fuzhou 350002China

Grifola frondosa polysaccharide(GFP)as the natural compounds have been reported to exert diverse *** aim of this study was to investigate the regulatory effects of GFP on intestinal microbiota in type 2 diabetic *** changes of microbiota in faeces of the diabetic mice upon high fat diet were determined and the V3 region of the 16S rRNA was sequenced by Illumina MiSeq high-throughput sequencing *** operational taxonomic unit were identified to be shared by all samples,and the quality and richness of sequencing were assessed via rarefaction and rank abundance *** diversity of gut flora was slightly improved in diabetic mice after GFP *** composition and relative abundance of gut microbiota at phylum and genus levels were altered by *** abundance of Robinsoniella,Flavonifractor,Anaerotruncus,and Desulfvibrio were found to concentrate on diabetic mice through LEfSe ***,Alloprevotella and Burkholderia had strong relevancy with other gut *** on the findings,GFP might be a desired candidate on ameliorating the intestinal unbalance in diabetes.

关键词： Maitake Grifola frondosa polysaccharide Diabetes Gut microbiota

Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies

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Cancer Communications 2024年第3期44卷 408-432页

作者： Lu Tang Huan Zhang Fen Zhou Qiuzhe Wei Mengyi Du Jianghua Wu Chenggong Li wenjing Luo Jie Zhou Xindi Wang Zhaozhao Chen Yinqiang Zhang Zhongpei Huang Zhuolin Wu yuxi wen Huiwen Jiang Danying Liao Haiming Kou Wei Xiong Heng Mei Yu Hu Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Hubei Clinical Medical Center of Cell Therapy For Neoplastic Disease WuhanHubeiP.R.China Key Laboratory of Biological Targeted Therapy the Ministry of EducationWuhanHubeiP.R.China Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Hubei Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China

Background:Chimeric antigen receptor T(CAR-T)therapy has substantially revolutionized the clinical outcomes of patients with hematologic malignan-cies,but the cancer-intrinsic mechanisms underlying resistance to CAR-T cells remain yet to be fully *** study aims to explore the molecular deter-minants of cancer cell sensitivity to CAR-T cell-mediated killing and to provide a better understanding of the underlying mechanisms and potential modulation to improve clinical ***:The human whole-genome CRISPR/Cas9-based knockout screening was conducted to identify key genes that enable cancer cells to evade CD19 CAR-T-cell-mediated *** in vitro cytotoxicity assays and evaluation of tumor tissue and bone marrow specimens were further conducted to confirm the role of the key genes in cancer cell susceptibility to CAR-T *** addition,the specific mechanisms influencing CAR-T cell-mediated cancer clearance were elucidated in mouse and cellular ***:The CRISPR/Cas9-based knockout screening showed that the enrich-ment of autophagy-related genes(ATG3,BECN1,and RB1CC1)provided protec-tion of cancer cells from CD19 CAR-T cell-mediated *** findings were further validated by in vitro cytotoxicity assays in cells with genetic and pharmacological inhibition of ***,higher expression of the three autophagy-related proteins in tumor samples was correlated with poorer respon-siveness and worse survival in patients with relapsed/refractory B-cell lymphoma after CD19 CAR-T *** RNA sequencing analysis of bone marrow samples from B-cell leukemia patients also suggested the clinical relevance of autophagy to the therapeutic response and relapse after CD19 CAR-T cell *** inhibition of autophagy and knockout of RB1CC1 could dramatically sensitize tumor cells to CD19 CAR-T cell-mediated killing in mouse models of both B-cell leukemia and ***,our study revealed that cancer-intrinsic

关键词： CAR-T resistance Autophagy Immune evasion Apoptosis Chemotaxis

裸藻非水溶性和水溶性多糖的化学组成及抗氧化活性分析

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食品工业科技 2022年第5期43卷 105-113页

作者：文愉熙黄晓舟林晓思泉州师范学院海洋与食品学院福建泉州362000 福建农林大学食品科学学院福建福州350002 福建省海洋藻类活性物质制备与功能开发重点实验室福建泉州362000

目的:研究比较裸藻非水溶性和水溶性多糖抗氧化活性,并分析其主要结构特征,为后续研究裸藻多糖的结构与活性关系提供实验基础。方法:以裸藻为原料,提取裸藻中的非水溶性和水溶性多糖,经分离纯化后,采用紫外-可见吸收光谱、红外光谱、凝... 详细信息

目的:研究比较裸藻非水溶性和水溶性多糖抗氧化活性,并分析其主要结构特征,为后续研究裸藻多糖的结构与活性关系提供实验基础。方法:以裸藻为原料,提取裸藻中的非水溶性和水溶性多糖,经分离纯化后,采用紫外-可见吸收光谱、红外光谱、凝胶色谱、离子色谱等技术对多糖的基本结构进行分析;进一步以维生素C(VC)为对照,考察它们对DPPH和OH自由基的清除能力及还原能力。结果:裸藻非水溶性多糖(EGP-1)、裸藻水溶性多糖(EGP-2A-1和EGP-2B-1)的相对分子质量分别为1.01×10^(4)、2.91×10^(6)和1.70×10^(6)Da。EGP-1是一种含有β-糖苷键和吡喃葡萄糖环的多糖,EGP-2A-1和EGP-2B-1是含有α-和β-糖苷键的吡喃葡萄糖环形式的多糖。EGP-1主要单糖为葡萄糖、甘露糖、岩藻糖和鼠李糖;EGP-2A-1和EGP-2B-1均由岩藻糖、鼠李糖、阿拉伯糖、盐酸氨基葡萄糖、半乳糖、葡萄糖、木糖、甘露糖和葡萄糖醛酸组成。体外抗氧化活性结果显示,3种组分多糖均具有抗氧化活性,其抗氧化能力为V_(C)>EGP-2A-1>EGP-2B-1>EGP-1。结论:从裸藻中分离得到的多糖均具有抗氧化能力,且水溶性多糖的抗氧化活性强于非水溶性多糖,其中EGP-2A-1组分活性最佳。

关键词：裸藻多糖提取结构抗氧化活性

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嵌入式系统在智能家居中的应用研究

仪器仪表用户 2024年第9期31卷 50-52+55页

作者：闻玉玺郑州大学国际学院

随着网络技术与计算机技术的深度融合，智能化系统的发展已成为现代生活不可或缺的一部分。文中首先探讨了智能家居的当前发展态势，随后深入分析了嵌入式系统的基本概念及其独特优势。在此基础上，文中详细论述了嵌入式系统在智能家居... 详细信息

随着网络技术与计算机技术的深度融合，智能化系统的发展已成为现代生活不可或缺的一部分。文中首先探讨了智能家居的当前发展态势，随后深入分析了嵌入式系统的基本概念及其独特优势。在此基础上，文中详细论述了嵌入式系统在智能家居设计中的核心要素，并探讨了其在提升生活质量和效率方面的实际应用。通过研究，为智能家居领域的进一步发展提供理论支持和实践指导。

关键词：嵌入式系统智能家居家庭设备

基于POA的高中英语教学融合中华优秀传统文化实践探究——以非谓语动词复习为例

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英语教师 2024年第16期24卷 122-126页

作者：温雨淅广东省中山市第一中学广东中山528400

阐释将中华优秀传统文化融入高中英语语法教学的背景,以及产出导向法的内涵。以非谓语动词复习为例,从双向融合设计分析、多维度目标设计、多样化学习活动设计和多维度评价融合等方面探讨基于产出导向法的高中英语教学融合中华优秀传统... 详细信息

阐释将中华优秀传统文化融入高中英语语法教学的背景,以及产出导向法的内涵。以非谓语动词复习为例,从双向融合设计分析、多维度目标设计、多样化学习活动设计和多维度评价融合等方面探讨基于产出导向法的高中英语教学融合中华优秀传统文化的实践模式,从而引导学生在掌握语言基础知识的同时树立正确的文化观,增强文化自信,提高传播中华优秀传统文化的意识和能力。

关键词： POA 高中英语中华优秀传统文化文化意识

基于指数滤波模型的青藏高原根系层土壤水分估算研究

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高原气象 2025年第1期44卷 134-149页

作者：宋雨曦苏建宾文军郑东海成都信息工程大学大气科学学院高原大气与环境四川省重点实验室四川成都610225 中国科学院青藏高原研究所青藏高原地球系统与资源环境全国重点实验室国家青藏高原科学数据中心北京100101

高精度、长时序的土壤水分数据对青藏高原陆-气相互作用研究十分重要。然而,当前青藏高原土壤水分研究大多聚焦表层土壤水分的卫星反演,根系层土壤水分的估算研究相对匮乏。基于青藏高原五个土壤水分观测网络(狮泉河、帕里、那曲、黑河... 详细信息

高精度、长时序的土壤水分数据对青藏高原陆-气相互作用研究十分重要。然而,当前青藏高原土壤水分研究大多聚焦表层土壤水分的卫星反演,根系层土壤水分的估算研究相对匮乏。基于青藏高原五个土壤水分观测网络(狮泉河、帕里、那曲、黑河上游、玛曲)数据,本文系统评估了指数滤波模型在青藏高原不同气候与下垫面区域估算根系层(10 cm/20 cm/40 cm)土壤水分的适用性,探讨了不同环境因素(土壤、气候、植被)对模型特征时长参数T值的影响,最后评估了利用三种方法(各观测网络或青藏高原站点最优T值(Topt)中位数、随机森林模型)获取的区域T值估算青藏高原根系层土壤水分的可靠性。研究发现:(1)随着土壤深度的增加,根系层与表层土壤水分的相关性降低,而其空间异质性增大,导致指数滤波模型的应用精度降低,而模型T值及其空间异质性增大;(2)空间上随着降水量和土壤含水量的增加,根系层与表层土壤水分的相关性增大,而其空间异质性降低,使得指数滤波模型的应用精度上升,而其在区域内不同站点应用精度的差异呈现降低趋势;(3)土壤性质尤其是砂土含量是控制青藏高原区域T值空间分布的主要因素;(4)T值的获取对指数滤波模型在青藏高原的应用精度影响较小,当前常用的区域Topt中位数和随机森林模型均能获取相对合理的区域T值和取得一致且相对准确的模拟结果。本研究的发现有望推动利用指数滤波模型基于卫星表层土壤水分资料准确获取青藏高原根系层土壤水分。

关键词：青藏高原指数滤波模型根系层土壤水分不同气候与下垫面区域

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Correction:Global seaweed farming and processing in the past 20 years

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Food Production, Processing and Nutrition 2022年第1期4卷 365-365页

作者： Lizhu Zhang Wei Liao Yajun Huang yuxi wen Yaoyao Chu Chao Zhao College of Food Science Fujian Agriculture and Forestry University350002 FuzhouChina College of Marine Sciences Fujian Agriculture and Forestry University350002 FuzhouChina Key Laboratory of Marine Biotechnology of Fujian Province Institute of OceanologyFujian Agriculture and Forestry UniversityFuzhouChina

https://***/articles/10.1186/*** the original publication of this article(Zhang et al.,2022),the author affiliations 1 and 2 need to be exchanged.

关键词： farming processing Global

Secondary Frequency Control Considering Optimized Power Support From Virtual Power Plant Containing Aluminum Smelter Loads Through VSC-HVDC Link

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Journal of Modern Power Systems and Clean Energy 2023年第1期11卷 355-367页

作者： Peng Bao wen Zhang yuxi Zhang Key Laboratory of Power System Intelligent Dispatch and Control of the Ministry of Education Shandong UniversityJinan 250061China

The growing number of renewable energy replacing conventional generators results in a loss of the reserve for frequency control in power systems,while many industrial power grids often have excess energy supply due to abundant wind and solar energy *** paper proposes a secondary frequency control(SFC)strategy that allows industrial power grids to provide emergency high-voltage direct current(HVDC)power support(EDCPS)for emergency to a system requiring power support through a voltage source converter(VSC)HVDC *** architecture including multiple model predictive control(MPC)controllers with periodic communication is designed to simultaneously obtain optimized EDCPS capacity and minimize adverse effects on the providing power support(PPS)***,a model of a virtual power plant(VPP)containing aluminum smelter loads(ASLs)and a high penetration of wind power is established for the PPS *** flexibility and controllability of the VPP are improved by the demand response of the *** uncertainty associated with wind power is considered by chance *** effectiveness of the proposed strategy is verified by simulation results using the data of an actual industrial power grid in Inner Mongolia,*** DC voltage of the VSCs and the DC in the potlines of the ASLs are also investigated in the simulation.

关键词： Secondary frequency control power support voltage source converter(VSC) high-voltage direct current(HVDC) model predictive control(MPC) virtual power plant(VPP) demand response

Constraint on nuclear symmetry energy imposed by f-mode oscillation of neutron stars

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Communications in Theoretical Physics 2021年第11期73卷 122-130页

作者： Jing Zhang Dehua wen yuxi Li School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510641China

Due to improvements in the sensitivity of gravitational wave(GW)detectors,the detection of GWs originating from the fundamental quasi-normal mode(f-mode)of neutron stars has become *** future detection of GWs originating from the f-mode of neutron stars will provide a potential way to improve our understanding of the nature of nuclear matter inside neutron *** this work,we investigate the constraint imposed by the f-mode oscillation of neutron stars on the symmetry energy of nuclear matter using Bayesian analysis and parametric *** is shown that if the frequency of the f-mode of a neutron star of known mass is observed precisely,the symmetry energy at twice the saturation density(E_(sym)(2_(ρ0)))of nuclear matter can be constrained within a relatively narrow *** example,when all the following parameters are within the given intervals:220≤K0≤260 Me V,28≤E_(sym)(ρ0)≤36 Me V,30≤L≤90 Me V,-800≤J0≤400 Me V,-400≤K_(sym)≤100 Me V,-200≤Jsym≤800 Me V,E_(sym)(2ρ0)will be constrained to within-+48.***.56.6 Me V if the f-mode frequency of a canonical neutron star(1.4 M■)is observed to be 1.720 k Hz with a 1%relative ***,if only f-mode frequency detection is available,*** is no stellar mass measurement,a precisely detected f-mode frequency can also impose an accurate constraint on the symmetry *** example,given the same parameter space and the same assumed observed f-mode frequency mentioned above,and assuming that the stellar mass is in the range of 1.2–2.0 Me,E_(sym)(2ρ0)will be constrained to within 49.5■*** addition,it is shown that a higher slope of 69≤L≤143 Me V will give a higher posterior distribution of E_(sym)(2ρ0),53.8■MeV.

关键词： f-mode Bayesian analysis nuclear symmetry energy neutron star