检索结果-南通市图书馆

Nano Research 2022年第4期15卷 3514-3532页

作者： Zhixi Li Jun guo Yue Wan yutian Qin Meiting Zhao Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistryInstitute of Molecular Aggregation ScienceTianjin UniversityTianjin 300072China School of Chemistry Tiangong UniversityTianjin 300387China

In the past decades,metal-organic frameworks(MOFs)and covalent organic frameworks(COFs)basically enjoy the coordination chemistry and covalent chemistry,respectively,and such uniqueness has become the major obstacle hampering their further scope diversity and application *** from the principle of organic retrosynthesis,combining coordination bond and covalent bond together offers additional opportunities for constructing novel MOFs,COFs and MOF@COF hybrids as well as confer on them superior performances in versatile application *** this review,we firstly classify and summarize the recently reported synthesis strategies based on the integration of metal-ligand coordination and dynamic covalent ***,the application performances of as-constructed MOFs,COFs as well as MOF@COF hybrids are discussed and highlighted in the fields of adsorption,separation,catalysis,biosensing,energy storage and so ***,our personal insights of the remaining challenges and further prospects are also provided,in order to trigger much more inspirations and endeavors for this hot research field.

关键词： metal-organic frameworks(MOFs) covalent organic frameworks(COFs) hybrids coordination chemistry covalent chemistry applications

Phase field simulation of dendrite growth under convection

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2010年第2期23卷 121-128页

作者： yutian DING Xun.fcng YUAN Tingbiao guo Yong HU State Key Laboratory of Gansu Advanced Non-Ferrous Metal Materials Lanzhou University of TechnologyLanzhou 730050 China

The phase-field model coupled with a flow field was used to simulate the solidification of pure materials by the finite difference method. The effects of initial crystal radius, the space step and the interface thickness on the dendrite growth were studied. Results indicate that the grain grows into an equiaxial dendrite during free flow and into a typical branched structure under forced flow. The radius of an initial crystal can affect the growth of side-branches but not the stability of the dendrite＇s tip when an appropriate value is assigned to it. With an increase in space steps, side-branches appear at the upstream of the longitudinal principal branch and they grow rapidly. With an increase in the interface thickness, the trunk of the longitudinal upstream and lateral principal branches grow longer and become more slender while the number of secondary branches increases.

关键词： Phase field method Forced flow Dendrite growth Simulation

在线全文

学校读者我要写书评

暂无评论

不同工艺皮康冲剂对黄芩甙含量的影响

时珍国药研究 1997年第2期8卷 146-147页

作者：金裕田章仲懿郭海飞南京市中医院南京中医药大学中药系

对不同工艺皮康冲剂中的黄芩甙含量应用ＨＰＬＣ进行比较。实验结果表明：黄芩甙的含量以黄连单独打细粉，于制粒前加入黄芩、大黄等煎液的稠膏中，制得的冲剂含量最高为５．３０％，而以黄芩、黄连等药合煎制得的冲剂黄芩甙的含量最低... 详细信息

对不同工艺皮康冲剂中的黄芩甙含量应用ＨＰＬＣ进行比较。实验结果表明：黄芩甙的含量以黄连单独打细粉，于制粒前加入黄芩、大黄等煎液的稠膏中，制得的冲剂含量最高为５．３０％，而以黄芩、黄连等药合煎制得的冲剂黄芩甙的含量最低为３．１９％。

关键词：皮康冲剂工艺黄芩甙含量

基于血清代谢标志物的甲状腺癌患者淋巴结转移风险的预测模型

在线全文

学校读者我要写书评

暂无评论

现代医学 2022年第5期50卷 581-588页

作者：李洪跃徐先发杨晓琦唐玲薄少军郭雨田北京大学民航临床医学院民航总医院耳鼻喉头颈外科北京100123

目的:探讨基于血清代谢标志物建立的预测模型对甲状腺癌(TC)患者淋巴结转移风险的预测价值。方法:选择2020年1月至2021年1月于我院确诊TC并行手术治疗的患者207例,通过随机数字表法选择20%作为验证集,剩余80%作为训练集进行比较并建立... 详细信息

目的:探讨基于血清代谢标志物建立的预测模型对甲状腺癌(TC)患者淋巴结转移风险的预测价值。方法:选择2020年1月至2021年1月于我院确诊TC并行手术治疗的患者207例,通过随机数字表法选择20%作为验证集,剩余80%作为训练集进行比较并建立预测模型。根据影像学资料及术中标本病理检查结果按是否发生淋巴结转移将所有患者分为转移组及未转移组。收集所有患者临床、实验室检查及影像学检查资料,并于术前抽取患者外周静脉血检测3-羟基丁酸(BHB)、二十二碳六烯酸(DHA)及孕二醇-3-葡糖醛酸(PdG)含量。通过Logistic模型分析上述资料中与淋巴结转移相关的因素,并通过列线图建立预测模型并验证预测效果。结果:转移组患者年龄大于未转移组,桥本甲状腺炎病史占比高于未转移组,差异具有统计学意义(P<0.05)。转移组患者促甲状腺释放激素(TSH)、甲状腺球蛋白抗体(TGAb)、BHB、DHA高于未转移组,而PdG则低于未转移组,差异具有统计学意义(P<0.05)。转移组患者肿瘤最大直径大于未转移组,两组患者肿瘤数目、形态、与被膜关系、血流情况比较,差异具有统计学意义(P<0.05)。结果显示年龄、BHB、DHA、PdG、肿瘤最大直径、与被膜关系是影响TC淋巴结转移的相关因素(P<0.05)。列线图模型预测发生TC淋巴结转移的C-index为0.924(95%CI 0.901~0.974),校正曲线显示列线图模型预测可能性绝对误差为0.025,一致性良好。结论:基于血清代谢学指标建立的模型对于TC淋巴结转移的预测具有一定价值,可对临床确诊及手术方式的选择提供参考。

关键词：血清代谢标志物甲状腺癌淋巴结转移列线图

在线全文

学校读者我要写书评

暂无评论

肢端肥大症患者79例临床治疗分析

中华神经外科疾病研究杂志 2009年第2期8卷 157-160页

作者：潘绵顺孙海辉王鹏汪业汉郭裕天黄润生武警上海总队医院伽玛刀中心上海201103 安徽省立医院神经外科安徽合肥230001 解放军第117医院伽玛刀中心浙江杭州310021

目的探讨使用长效生长抑素类似物结合神经外科切除或伽玛刀治疗后激素变化和影像学复查来评价肢端肥大症患者治疗疗效。方法肢端肥大症患者79例,其中男性51例,女性28例,分为长效生长抑素(兰瑞肽lanreotideTM)结合神经外科切除治疗(A组)... 详细信息

目的探讨使用长效生长抑素类似物结合神经外科切除或伽玛刀治疗后激素变化和影像学复查来评价肢端肥大症患者治疗疗效。方法肢端肥大症患者79例,其中男性51例,女性28例,分为长效生长抑素(兰瑞肽lanreotideTM)结合神经外科切除治疗(A组)和长效生长抑素(兰瑞肽lanreotideTM)结合伽玛刀治疗组(B组),所有患者均给予肌注长效生长抑素,在药物使用结束4w后对患者进行临床评估并施行经蝶窦手术切除肿瘤或者接受伽玛刀治疗。随访瘤体体积变化及内分泌水平变化。结果多数患者的临床症状得到显著改善。与垂体微腺瘤组相比,药物治疗对垂体大腺瘤组体积缩小有更明显的作用。手术组微腺瘤组明显优于大腺瘤组;放射外科组结果:肿瘤缩小概率随随访时间的延长会明显提高,而且随着随访时间的延长,生长激素(GH)和胰岛素生长因子(IGF-I)值降至正常的概率明显提高。结论生长抑素类似物(兰瑞肽lanreotideTM)结合神经外科切除或伽玛刀治疗肢端肥大症患者可以获得较好的临床疗效,远期疗效有待于进一步观察。

关键词：伽玛刀兰瑞肽肢端肥大

Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2022年第3期14卷 48-60页

作者： yutian Zhang Ya Kong Haoran guo Yun Liu Yi Zang Jia Li University of Chinese Academy of Sciences Beĳing 100049China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Drug ScreeningChina Pharmaceutical UniversityNanjing 210009China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Open Studio for Druggability Research of Marine Natural Products Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

The nuclear envelope comprises the outer nuclear membrane,inner nuclear membrane(INM),and ***∼60 INM proteins have been identified,only a few of them have been well characterized,revealing their crucial *** group focused on the INM protein transmembrane protein 201(TMEM201),whose role in cellular function remains to be *** this study,we investigated the role of TMEM201 in endothelial cell migration and *** of TMEM201 expression by short hairpin RNA-mediated interference impeded human umbilical vein endothelial cell(HUVEC)angiogenic behavior in tube formation and fibrin gel bead sprouting ***,TMEM201-deficient HUVECs exhibited impaired migration *** next explored the underlying mechanism and found that the N-terminal of TMEM201 interacted with the linker of nucleoskeleton and cytoskeleton complex and was required for regulating endothelial cell migration and *** in vitro findings were further confirmed by using in vivo *** Tmem201-knockout mice,retinal vessel development was arrested and aortic ring sprouting was *** addition,loss of tmem201 impaired zebrafish intersegmental vessel *** summary,TMEM201 was shown to regulate endothelial cell migration and control the process of *** study is the first to reveal the role of INM proteins in the vascular system and angiogenesis.

关键词： transmembrane protein 201 inner nuclear membrane LINC complex endothelial cell migration angiogenesis

KNbO_3倍频产生488.5nm ps蓝光

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国激光 1991年第2期18卷 114-116页

作者：邹群耿兆华赵庆春陆雨田董景元郭晶华何慧娟南京大学物理系 210008 中国科学院上海光机所激光技术开放实验室 201800

用6.9×5.3×3.3mm^3的KNbO_3晶体对光学参量放大系统输出的波长连续可调近红外光进行倍频,产生485～493nm连续可调的ps蓝光。488.5nm的能量转换效率为2.6％,峰值功率大于2kW。

关键词： KNbo3晶体倍频 PS蓝光

Monitoring the delicate operations of surgical robots via ultra-sensitive ionic electronic skin

在线全文

学校读者我要写书评

暂无评论

National Science Review 2022年第12期9卷 163-176页

作者： Danyang Wei Jiajie guo Yuqi Qiu Shaoyu Liu Jiangyan Mao yutian Liu Zhenbing Chen Hao Wu Zhouping Yin State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and Technology Department of Hand Surgery Union Hospital Tongji Medical CollegeHuazhong University of Science and Technology

The arrival of surgical robots in high-end medical equipment is a landmark,and the realization of tactile sensation a major challenge in this important cutting-edge research *** to address this issue,we present ultra-sensitive ionic electronic skin in the form of flexible capacitive pressure sensors,which incorporate multistage bionic microstructures in ion gels for the purpose of monitoring the delicate operations of surgical ***,the ionic skin exhibits an ultra-high sensitivity of 9484.3 kPa-1(<15 kPa),and the sensitivity remains higher than 235 kPa-1in the wide range of 15-155 *** device has also achieved a detection limit as low as 0.12 Pa or,equivalently,0.31 mg,fast response within 24 ms,and high robustness(loading/unloading for 5000 cycles without fatigue).The sensor facilitates the challenging task of tele-operated robotic threading,which exceeds the human tactile perception limit when threading a *** have also confirmed that ionic skin can be used in robot-assisted invasive surgery,such as incision/resection of tissues and suturing of wounds,providing tactile information to surgeons to improve operation success *** flexible ionic skin is capable of conforming to the various shapes of robotic manipulators,thus has great promise for applications in robotic dexterous manipulation,prosthetics and human-machine interfaces.

关键词： surgical robots delicate operations ultra-sensitive ionic electronic skin tactile sensing

Journal of Genetics and Genomics in 2023:progresses and beyond

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第1期51卷 1-2页

作者： Xiu-Fen Song Xiaoxuan guo Jing Zhao yutian Zhang Yuan Qin Jianru Zuo Journal of Genetics and Genomics Institute of Genetics and Developmental BiologyChinese Academy of Sciences&the Genetics Society of ChinaBeijing 100101China

Journal of Genetics and Genomics(JGG),launched in 1974,celebrates its 50th birthday in *** continuous support from our authors,reviewers,readers,and the editorial board,JGG has made remarkable progress in the past year by publishing 122 papers covering major disciplines in life sciences and medical genetics with exciting *** is worthwhile to note that we have recruited 66 young talents to join JGG as junior editors,resulting in significant improvement in manuscript evaluation and journal ***,we summarize major progresses reported in JGG in 2023 fromaneditorial view.

关键词： journal beyond promotion

Recent advances in flexible self-oscillating actuators

在线全文

学校读者我要写书评

暂无评论

eScience 2024年第5期4卷 91-109页

作者： Jingjing Li Wenjin guo Weiqiang Zhao yutian Zhu Jie Bai Zhigang Xia Xiang Zhou Zunfeng Liu School of Textile Science and Engineering State Key Laboratory of New Textile Materials and Advanced Processing TechnologiesWuhan Textile UniversityWuhan 430200China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer MaterialsTianjin Key Laboratory of Functional Polymer MaterialsSmart Sensing Interdisciplinary Science CenterCollege of ChemistryNankai UniversityTianjin 300350China College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationKey Laboratory of Organosilicon Material TechnologyHangzhou Normal UniversityHangzhou 311121China College of Chemistry and Chemical Engineering Inner Mongolia Univ TechnolChem Engn CollHohhot 010051China Department of Science China Pharmaceutical UniversityNanjing 211198China

Soft actuators are constituted by a type of intelligent materials,and they can generate reversible mechanical motions under external *** usually achieve continuous actuation by manual turning on or off the power supply,which significantly increases the operation *** contrast,self-oscillating actuators can achieve autonomous motions under constant stimuli,and have recently attained great advancements,as well as promoted the development of autonomous soft *** this review,the latest achievements of soft oscillators are ***,the self-oscillating mechanisms mainly including oscillating chemical reactions and self-shadowing-induced mechanical negative feedback loops are *** oscillators constructed with various materials and configurations,driven by different stimuli and applied in different fields are then presented in ***,the difficulties and hopes of oscillators are ***,self-oscillating actuators are in the stage of vigorous development,and we believe that in the future,they will be used in various fields and make many scenarios more intelligent and autonomous.

关键词： Oscillating actuator Artificial muscles Polymer composite Biomimetic Smart materials