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World Journal of Gastroenterology 2007年第35期13卷 4699-4706页

作者： yutaka kohgo Katsuya Ikuta Takaaki Ohtake Yoshihiro Torimoto Junji Kato Division of Gastroenterology and Hematology/Oncology Department of MedicineAsahikawa Medical CollegeMidorigaoka-higashi 2-1Asahikawa 078-8510Japan Fourth Department of Internal Medicine Sapporo Medical UniversitySouth-1West-14ChuokuSapporo 060-0030Japan

There are several cofactors which affect body iron metabolism and accelerate iron overload. Alcohol and hepatic viral infections are the most typical examples for clarifying the role of cofactors in iron overload. In these conditions, iron is deposited in hepatocytes and Kupffer cells and reactive oxygen species （ROS） produced through Fenton reaction have key role to facilitate cellular uptake of transferrin-bound iron. Furthermore, hepcidin, antimicrobial peptide produced mainly in the liver is also responsible for intestinal iron absorption and reticuloendothelial iron release. In patients with ceruloplasmin deficiency, anemia and secondary iron overload in liver and neurodegeneration are reported. Furthermore, there is accumulating evidence that fatty acid accumulation without alcohol and obesity itself modifies iron overload states. Ineffective erythropoiesis is also an important factor to accelerate iron overload, which is associated with diseases such as thalassemia and myelodysplastic syndrome. When this condition persists, the dietary iron absorption is increased due to the increment of bone marrow erythropoiesis and tissue iron overload will thereafter occurs. In porphyria cutanea tarda, iron is secondarily accumulated in the liver.

关键词： Iron overload Cofactors Alcohol Chronic hepatic C Non-alcoholic steatohepatitis Insulin resistance Hepatocellular carcinoma

Efficacy and adverse events of cold vs hot polypectomy: A meta-analysis

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World Journal of Gastroenterology 2016年第23期22卷 5436-5444页

作者： Mikihiro Fujiya Hiroki Sato Nobuhiro Ueno Aki Sakatani Kazuyuki Tanaka Tatsuya Dokoshi Shugo Fujibayashi Yoshiki Nomura Shin Kashima Takuma Gotoh Junpei Sasajima Kentaro Moriichi Jiro Watari yutaka kohgo Division of Gastroenterology and Hematological Oncology Department of MedicineAsahikawa Medical University Hyogo College of Medicine Division of GastroenteroelogyDepartment of Internal Medicine

AIM: To compare previously reported randomized controlled studies (RCTs) of cold and hot polypectomy, we systematically reviewed and clarify the utility of cold polypectomy over hot with respect to efficacy and adverse ***: A meta-analysis was conducted to evaluate the predominance of cold and hot polypectomy for removing colon polyps. Published articles and abstracts from worldwide conferences were searched using the keywords “cold polypectomy”. RCTs that compared either or both the effects or adverse events of cold polypectomy with those of hot polypectomy were collected. The patients’ demographics, endoscopic procedures, No. of examined lesions, lesion size, macroscopic and histologic findings, rates of incomplete resection, bleeding amount, perforation, and length of procedure were extracted from each study. A forest plot analysis was used to verify the relative strength of the effects and adverse events of each procedure. A funnel plot was generated to assess the possibility of publication ***: Ultimately, six RCTs were selected. No significant differences were noted in the average lesion size (less than 10 mm) between the cold and hot polypectomy groups in each study. Further, the rates of complete resection and adverse events, including delayed bleeding, did not differ markedly between cold and hot polypectomy. The average procedural time in the cold polypectomy group was significantly shorter than in the hot polypectomy ***: Cold polypectomy is a time-saving procedure for removing small polyps with markedly similar curability and safety to hot polypectomy.

关键词： Cold polypectomy Hot polypectomy Colon adenoma Conventional polypectomy Colon neoplasm Endoscopic mucosal resection Bleeding

Epiploic appendagitis as an uncommon cause of lower abdominal pain

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Open Journal of Gastroenterology 2012年第2期2卷 31-32页

作者： Toshikatsu Okumura Masumi Ohhira Yoshihiro Tsuchiya Yoko Kikuchi yutaka kohgo Shinsuke Yoshihara Hirofumi Okabe Tsukasa Nozu Department of General Medicine Asahikawa Medical University Asahikawa Japan Department of Medicine Asahikawa Medical University Asahikawa Japan Department of Regional Medicine and Education Asahikawa Medical University Asahikawa Japan

Epiploic appendagitis should be considered to be an uncommon cause of lower abdominal pain. To diagnose accurately, typical CT findings are needed, and total colonoscopy should be done later to rule out the possibilit... 详细信息

关键词： Epiploic Appendagitis Lower Abdominal Pain CT

Isoleucine, an Essential Amino Acid, Induces the Expression of Human <i>β</i>Defensin 2 through the Activation of the G-Protein Coupled Receptor-ERK Pathway in the Intestinal Epithelia

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Food and Nutrition Sciences 2012年第4期3卷 548-555页

作者： Youkou Konno Toshifumi Ashida Yuhei Inaba Takahiro Ito Hiroki Tanabe Atsuo Maemoto Tokiyoshi Ayabe Yusuke Mizukami Mikihiro Fujiya yutaka kohgo Division of Gastroenterology and Hematology/Oncology Department of Medicine Asahikawa Medical University Asahikawa Japan IBD Center Sapporo Higashi Tokushukai Hospital Sapporo Japan Innate Immunity Laboratory Department of Cellular Life Science Faculty of Advanced Life Science Hokkaido University Sapporo Japan

Anti-microbial peptides are essential for the intestinal innate immunity that protects the intestinal epithelia from attacks by foreign pathogens. Human β-defensin (HBD) is one of the pivotal anti-microbial peptides that are expressed in the colonic epithelia. This study investigated the effect and the signaling mechanism of inducible β-defensin HBD2 by an essential amino acid, isoleucine (Ile) in colonic epithelial cells. Here we examined the expression level of HBD2 on induction of Ile in epithelial cells, and checked this pathway. HBD2 mRNA was induced by co-incubation with IL-1α and Ile in Caco2 cells, but not by Ile alone. An inhibitor of either ERK or Gi, a subunit of G-proteins, reduced the induction of HBD2 mRNA by Ile. The treatment with Ile also increased the intracellular calcium ion concentration, thus suggesting that the GPCR and ERK signaling pathway mediate the effects of Ile. These results indicate that an essential amino acid, Ile, enhances the expression of an inducible β-defensin, namely HBD2, by IL-1α through the activation of GPCRs and ERK signaling pathway. The administration of Ile may therefore represent a possible option to safely treat intestinal inflammation.

关键词： Isoleucine Human β-Defensin G-Protein Coupled Receptor Extracellular Signal-Regulated Kinases Pathway Inflammatory Bowel Disease Crohn’s Disease

Effect of <i>Lactobacillus brevis</i>SBC8803 on Gamma-Glutamyl Transferase in Japanese Habitual Drinkers: A Double-Blind, Placebo-Controlled Study

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Food and Nutrition Sciences 2012年第5期3卷 678-684页

作者： Yoshihisa Wakita Hajime Kanda Chikako Shimizu Yasukazu Nakakita Hirotaka Kaneda Shuichi Segawa Moeko Ozaki Tatsuro Shigyo Takaaki Ohtake Mikihiro Fujiya yutaka kohgo Corporate Planning Department Sapporo Holdings Ltd. Tokyo Japan Division of Gastroenterology and Hematology/Oncology Department of Medicine Asahikawa Medi- cal University Hokkaido Japan Frontier Laboratories of Value Creation Sapporo Breweries Ltd. Shizuoka Japan

A randomized, double-blind, placebo-controlled clinical trial in Japanese habitual drinkers was conducted to evaluate the efficacy of Lactobacillus brevis SBC8803 to alleviate adverse effect of alcohol. Subjects who drank habitually and had moderately higher levels of gamma-glutamyl transferase (GGT) (50 - 100 IU/L) were enrolled. The levels of transaminases in these subjects were almost within normal levels (aspartate transaminase (AST) <30 IU/L and alanine transaminase (ALT) <40 IU/L). Either the capsules containing placebo (n = 23) or 130 mg (4.0 × 1010 colony-forming units) of live L. brevis SBC8803 (n = 22) per day were administered for the continuous eight weeks (56 days). During the period, the subjects both in test group and placebo groups have kept each drinking behavior as usual. Regarding lipid metabolism, triacylglycerol (TG) levels in the male test group significantly decreased at week 4 as compared with week 0. Biomarkers of hepatocytes-damage;AST and ALT levels showed no significant differences between the pla- cebo and test groups at both weeks 4 and 8. Oxidative stress marker;GGT at weeks 4 was significantly lower in the test group than that in the placebo group (p = 0.017), but not at weeks 8. However, taking a reduced rate of GGT at weeks 8 comparing with that at week 0, that in the test group showed larger value comparing with that in the placebo group. These data about TG and GGT suggest that, although efficacy of L. brevis SBC8803 is limited in this study, intake of the probiotic may alleviate alcoholic influence in lipid metabolism and oxidative stress.

关键词： Lactobacillus brevis Gamma-Glutamyl Transferase Alcoholic Related Disorder Double-Blind Placebo-Controlled Study