检索结果-南通市图书馆

The association between recurrence pattern and impaired blood flow around the resection cavity due to the glioblastoma surgery

在线全文

cnki会议

学校读者我要写书评

暂无评论

The association between recurrence pattern and impaired bloo...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Takuya FURUTA Mitsutoshi NAKADA yutaka hayashi Jun-ichiro HAMADA Department of Neurosurgery Kanazawa University

＜正＞PURPOSE: Initial treatment for glioblastoma multiforme （GBM） is tumor resection. In the acute stage after GBM surgery, hyperintensity lesion around the resection cavity caused by the impairment of vessels is c...

关键词：

Relation of surgical extent of glioblastoma resection to survival in the standard therapy

在线全文

cnki会议

学校读者我要写书评

暂无评论

Relation of surgical extent of glioblastoma resection to sur...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Shingo Tanaka Mitsutoshi Nakada yutaka hayashi Jun-ichiro Hamada Department of Neurosurgery Kanazawa University

＜正＞Introduction: It remains to be elucidated whether the extent of glioblastoma （GBM） resection is associated with patient survival although the extent of surgical resection tends

关键词：

The expression level of sphingosine-1-phosphate receptor type 1 is related to MIB-1 labeling index and predicts survival of glioblastoma patients

在线全文

cnki会议

学校读者我要写书评

暂无评论

The expression level of sphingosine-1-phosphate receptor typ...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Yuya Yoshida Mitsutoshi Nakada Tomoya Harada Shingo Tanaka Takuya Furuta Yasuhiko hayashi Daisuke Kita Naoyuki Uchiyama yutaka hayashi Jun-ichiro Hamada Department of Neurosurgery Graduate School of Medical ScienceKanazawa University13-1 Takara-machiKanazawa 920-8641Japan

Although there are many reports on the clinical use of the MIB-1 labeling index（LI）,which is a measure of proliferative activity in astrocytomas;its significance varies between *** are no known molecules that are directly linked to the MIB-1 LI in *** evaluated the clinical value of the MIB-1 LI in our human glioblastoma cases and determined the molecules that possibly influenced the MIB-1 *** immunohistochemical study of the MIB-1 protein was performed and MIB-1 LIs of 38 glioblastomas were *** the same cases,epidermal growth factor receptor（EGFR）,plateletderived growth factor receptor-a（PDGFRA）,and sphingosine-1-phosphate receptor type 1（S1P1）,which are known regulators of glioma cell proliferation,were detected and quantified by quantitative real-time-PCR or western ***-Meier survival curves for 38 patients with glioblastomas showed that a high MIB-1 LI correlated with poor survival（P ＜ 0.05）.Among the molecules tested,only the low expression of S1P1 was significantly correlated with the high MIB-1 LI in glioblastomas（P ＜ 0.05）.Multivariate analysis revealed that the S1P1 expression level was a significant prognostic *** results indicate that the MIB-1 LI is an important prognostic factor in human ***,downregulation of S1P1 expression increases proliferative activity,and thus enhances the malignancy of glioblastomas,resulting in a poor survival.

关键词： Glioblastoma MIB-1 labeling index S1P1 receptor Survival Cell proliferation

Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival

在线全文

cnki会议

学校读者我要写书评

暂无评论

Sphingosine-1-phosphate receptor type 1 regulates glioma cel...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Yuya Yoshida Mitsutoshi Nakada Naotoshi Sugimoto Tomoya Harada Yasuhiko hayashi Daisuke Kita Naoyuki Uchiyama yutaka hayashi Akihiro Yachie Yoh Takuwa Jun-ichiro Hamada Department of Neurosurgery Graduate School of Medical ScienceKanazawa University Department of Physiology Graduate School of Medical ScienceKanazawa UniversityKanazawaJapan Department of Pediatrics Graduate School of Medical ScienceKanazawa UniversityKanazawaJapan

Sphingosine-1-phosphate（S1P） is a bioactive lipid that signals through a family of G protein-coupled receptors consisting of 5 members termed S1P1-5,and it regulates cellular proliferation,migration and *** investigated the expression and role of S1P receptors in *** glioma expressed S1P1,S1P2,S1P3,and S1P5 by quantitative real-time PCR *** of the S1P1 was significantly lower in glioblastoma than in the normal brain（p ＜ 0.01） and diffuse astrocytoma（p ＜ 0.05）.Immunoblotting showed that normal brain expressed more S1P1 protein than did *** showed that S1P1 was localized predominantly in the astrocytes in the normal brain,but no staining was observed in *** of S1P1 expression correlated with poor survival of patients with glioblastoma（p ＜ 0.05）.S1P1 small interfering RNA promoted cell proliferation in high-expressor glioma cell lines（T98G,G112）.Cell proliferation was promoted by the pertussis toxin,which deactivates Gi/o type of G proteins;the S1P1 is exclusively coupled to these *** expression of the S1P1 in low-expressor cell lines（U87,U251） resulted in decreased cell growth and led to suppressed tumor growth in transplanted gliomas in ***,we found a significant association between the S1P1 expression and early growth response-1,a transcriptional factor that exhibits tumor suppression in glioblastoma cells（p ＜ 0.05）.These data indicate that the downregulation of S1P1 expression enhances the malignancy of glioblastoma by increasing cell proliferation and correlates with the shorter survival of patients with glioblastoma.

关键词： glioblastoma S1P receptors S1P1 receptor proliferation survival

Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy

在线全文

cnki会议

学校读者我要写书评

暂无评论

Silencing of ferrochelatase enhances 5-aminolevulinic acid-b...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Lei Teng1,2,Mitsutoshi Nakada1,Shi-Guang Zhao2,yutaka hayashi1,and Jun-Ichiro Hamada1 1Department of Neurosurgery,Graduate School of Medical Science,Kanazawa University,Kanazawa,Ishikawa 920-8641,Japan 2Department of Neurosurgery,The First Clinical College of Harbin Medical University,Nangang Harbin 150001,People''s Republic of China

BACKGROUND:Recurrence of glioma frequently occurs within the marginal area of the surgical cavity due to invading residual cells.5-aminolevulinic acid（5-ALA） fluorescence-guided resection has been used as effective therapeutic modalities to improve discrimination of brain tumor margins and patient ***,the marginal areas of glioma usually show vague fluorescence,which makes tumor identification difficult,and the applicability of 5-ALA-based photodynamic therapy（PDT） is hampered by insufficient therapeutic efficacy in glioma ***:To overcome these issues,we assessed the expression of ferrochelatase（FECH） gene,which encodes a key enzyme that catalyzes the conversion of protoporphyrin IX（PpIX） to heme,in glioma surgical specimens and manipulated FECH in human glioma cell ***:Prominent down-regulation of FECH mRNA expression was found in glioblastoma tissues compared to normal brain tissues,suggesting that FECH is responsible for PpIX accumulation in glioblastoma *** of FECH by small interference RNA enhanced PpIX fluorescence after exposure to 5-ALA concomitant with increased intracellular PpIX accumulation in glioma *** of FECH caused marked growth inhibition and apoptosis induction by PDT in glioma ***:These results suggest that knockdown of FECH is a potential approach to enhancing PpIX fluorescent quality for optimizing the subjective discrimination of vague fluorescence and improving the effect of 5-ALA-PDT.

关键词： glioma ferrochelatase 5-aminolevulinic acid fluorescence photodynamic therapy

Savonius风力机叶片重叠比的风洞实验研究

在线全文

cnki会议

学校读者我要写书评

暂无评论

太阳能学报 2009年第2期30卷 226-231页

作者：李岩原丰林农东北农业大学工程学院哈尔滨150030 鸟取大学工学部日本鸟取6808552

为了探明其最佳重叠比,首先对具有3种典型重叠比(OL=0,0.2和0.5)的Savonius风力机进行了风洞实验,确认了OL=0.2的风力机具有较佳的性能。之后将OL设定在0.15～0.30之间,以0.025为间隔细分为7个模式,每一模式中又分为带有中心转轴和无转... 详细信息

为了探明其最佳重叠比,首先对具有3种典型重叠比(OL=0,0.2和0.5)的Savonius风力机进行了风洞实验,确认了OL=0.2的风力机具有较佳的性能。之后将OL设定在0.15～0.30之间,以0.025为间隔细分为7个模式,每一模式中又分为带有中心转轴和无转轴两种类型,分别进行了详细的风洞实验,对叶片重叠比以及转轴轴径对Savonius风力机的静态起动特性和动态功率输出特性的影响进行了研究。

关键词： Savonius风力机叶片重叠比风洞实验风力机转轴功率力矩

Clinical outcomes of enteroscopy using the double-balloon method for strictures of the small intestine

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第7期11卷 1087-1089页

作者： Keijiro Sunada Hironori Yamamoto Hiroto Kita Tomonori Yano Hiroyuki Sato Yoshikazu hayashi Tomohiko Miyata yutaka Sekine Akiko Kuno Michiko Iwamoto Hirohide Ohnishi Kenichi Ido Kentaro Sugano Department of Internal Medicine

AIM:To evaluate the clinical outcome of enteroscopy, using the double-balloon method, focusing on the involvement of neoplasms in strictures of the small intestine. METHODS: Enteroscopy, using the double-balloon method, was performed between December 1999 and December 2002 at Jichi Medical School Hospital, 3apan and strictures of the small intestine were found in 17 out of 62 patients. These 17 consecutive patients were subjected to analysis. RESULTS: The double-balloon enteroscopy contributed to the diagnosis of small intestinal neoplasms found in 3 out of 17 patients by direct observation of the strictures as well as biopsy sampling. Surgical procedures were chosen for these three patients, while balloon dilation was chosen for the strictures in four patients diagnosed with inflammation without involvement of neoplasm. CONCLUSION: Double-balloon enteroscopy is a useful method for the diagnosis and treatment of strictures in the small bowel.

关键词： Double-balloon enteroscopy Strictures Small intestine

Proposed criteria to differentiate heterogeneous eosinophilic gastrointestinal disorders of the esophagus, including eosinophilic esophageal myositis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第13期23卷 2414-2423页

作者： Hiroki Sato Nao Nakajima Kazuya Takahashi Go Hasegawa Ken-ichi Mizuno Satoru Hashimoto Satoshi Ikarashi Kazunao hayashi yutaka Honda Junji Yokoyama Yuichi Sato Shuji Terai Division of Gastroenterology and Hepatology Niigata University Medical and Dental Hospital Division of Gastroenterology and Hepatology Saiseikai Niigata Daini Hospital Division of Cellular and Molecular Pathology Department of Cellular FunctionNiigata University Graduate School of Medical and Dental Sciences

AIM To define clinical criteria to differentiate eosinophilic gastrointestinal disorder(Eo GD) in the esophagus. METHODS Our criteria were defined based on the analyses of the clinical presentation of eosinophilic esophagitis(Eo E), subepithelial eosinophilic esophagitis(s Eo E) and eosinophilic esophageal myositis(Eo EM), identified by endoscopy, manometry and serum immunoglobulin E levels(s-Ig E), in combination with histological and polymerase chain reaction analyses on esophageal tissue *** In five patients with Eo E, endoscopy revealed longitudinal furrows and white plaques in all, and fixed rings in two. In one patient with s Eo E and four with Eo EM, endoscopy showed luminal compression only. Using manometry, failed peristalsis was observed in patients with Eo E and s Eo E with some variation, while Eo EM was associated with hypercontractile or hypertensive peristalsis, with elevated s-Ig E. Histology revealed the following eosinophils per high-power field values. Eo E = 41.4 ± 7.9 in the epithelium and 2.3 ± 1.5 in the subepithelium; s Eo E = 3 in the epithelium and 35 in the subepithelium(conventional biopsy); Eo EM = none in the epithelium, 10.7 ± 11.7 in the subepithelium(conventional biopsy or endoscopic mucosal resection) and 46.8 ± 16.5 in the muscularis propria(peroral esophageal muscle biopsy). Presence of dilated epithelial intercellular space and downward papillae elongation were specific to Eo E. Eotaxin-3, IL-5 and IL-13 were overexpressed in Eo *** Based on clinical and histological data, we identified criteria, which differentiated between Eo E, s Eo E and Eo EM, and reflected a different pathogenesis between these esophageal Eo GDs.

关键词： Eosinophilic esophagitis Eosinophilic esophageal myositis Peroral endoscopic myotomy Jackhammer esophagus Achalasia Peroral esophageal muscle biopsy

Non-steroidal anti-inflammatory drug-induced small bowel injuries identified by double-balloon endoscopy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第31期11卷 4861-4864页

作者： Yoshikazu hayashi Hironori Yamamoto Hiroto Kita Keijiro Sunada Hiroyuki Sato Tomonori Yano Michiko Iwamoto yutaka Sekine Tomohiko Miyata Akiko Kuno Takaaki Iwaki Yoshiyuki Kawamura Hironari Ajibe Kenichi Ido Kentaro Sugano Department of Internal Medicine

AIM： To clarify clinical features of the NSAID-induced sma bowel lesions using a new method of endoscopy. METHODS： This is a retrospective study and we analyzed seven patients with small bowel lesions while taking NSAIDs among 61 patients who had undergone doubleballoon endoscopy because of gastro-intestinal bleeding or anemia between September 2000 and March 2004, at .lichi Medical School Hospital in Japan. Neither conventional EGD nor colonoscopy revealed any lesions of potential bleeding sources including ulcerations. Double-balloon endoscopy was carried out from oral approach in three patients, from anal approach in three patients, and from both approaches in one patient. RESULTS： Ulcers or erosions were observed in the ileum in six patients and in the jejunum in one patient, respectively. The ulcers were multiple in all the patients with different features from tiny punched out ulcers to deep ulcerations with oozing hemorrhage or scar. All the patients recovered uneventfully and had full resolution of symptoms after suspension of the drug. CONCLUSION： NSAIDs can induce injuries in the small bowel even in patients without any lesions in both the stomach and colon.

关键词： Double-balloon endoscopy NSAIDS-inducedsmall bowel injuries