检索结果-南通市图书馆

Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2019年第1期7卷 66-75页

作者： yuta Nakai Kazuo Okamoto Asuka Terashima Shogo Ehata Jun Nishida Takeshi Imamura Takashi Ono Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyoJapan Department of Orthodontic Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityYushima 1-5-45Bunkyo-kuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyoJapan Department of Molecular Pathology Graduate School of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyoJapan Department of Molecular Medicine for Pathogenesis Ehime University Graduate School of MedicineShitsukawaToonEhimeJapan

Bone is one of the preferred sites for the metastasis of malignant tumours,such as breast cancer,lung cancer and malignant *** cells colonizing bone have the capacity to induce the expression of receptor activator of nuclear factor-κB ligand(RANKL),which promotes osteoclast differentiation and ***-induced osteoclastic bone resorption leads to a vicious cycle between tumours and bone cells that fuels osteolytic tumour growth,causing bone pain and ***,RANKL contributes to bone metastasis by acting as a chemoattractant to bone for tumour cells that express its receptor,*** inhibition of the RANKL–RANK pathway is a promising treatment for bone metastasis,and a human monoclonal anti-RANKL antibody,denosumab,has been used in the ***,orally available drugs targeting RANKL must be developed to increase the therapeutic benefits to *** we report the efficacy of the small-molecule RANKL inhibitor AS2676293 in treating bone metastasis using mouse *** administration of AS2676293 markedly inhibited bone metastasis of human breast cancer cells MDA-MB-231-5a-D-Luc2 as well as tumour-induced ***2676293 suppressed RANKLmediated tumour migration in the transwell assay and inhibited bone metastasis of the murine cell line B16F10,which is known not to trigger osteoclast *** on the results from this study,RANKL inhibition with a small-molecule compound constitutes a promising therapeutic strategy for treating bone metastasis by inhibiting both osteoclastic bone resorption and tumour migration to bone.

关键词： Bone tumours metastasis

维普期刊数据库

Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第10期15卷 1267-1272页

作者： Takayuki Kogure Yoshiyuki Ueno Satoshi Sekiguchi Kazuyuki Ishida Takehiko Igarashi yuta Wakui Takao Iwasaki Tooru Shimosegawa Division of Gastroenterology Graduate School of MedicineTohoku UniversitySendai 980-8574Japan Division of Advanced Surgical Science and Technology Graduate School of MedicineTohoku University Sendai 980-8574Japan Department of Pathology Tohoku University HospitalSendai 980-8574Japan Division of Gastroenterology Osaki Citizen Hospital Furukawa 989-6183Japan

A liver tumor 35 mm in diameter was found incidentally in a 40-year-old woman who had no history of liver diseases or the use of oral *** diagnostics showed the typical findings of liver cell adenoma(LCA).Dynamic computed tomography revealed that the tumor showed a homogenous enhancement in the arterial phase and almost the same enhancement as the surrounding liver parenchyma in the delayed *** tumor was found to contain fat on magnetic resonance imaging.A benign fat containing liver tumor was ***,radiological findings altered,which caused us to suspect that a welldifferentiated hepatocellular carcinoma(HCC)containing fat was becoming *** hepatectomy was performed and the pathological findings showed the typical findings of *** case was an extremely rare LCA,which had no background of risk for LCA and developed the sequential alteration of the radiological findings to suspect well-differentiated HCC.

关键词： Liver cell adenoma Hepatocellularcarcinoma Diagnosis Hepatectomy

Detection accuracy for epithelial dysplasia using an objective autofluorescence visualization method based on the luminance ratio

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2017年第4期9卷 200-209页

作者： nanami yamamoto koji kawaguchi hisako fujihara mitsuhiko hasebe yuta kishi masaaki yasukawa kenichi kumagai yoshiki hamada department of oral and maxillofacial surgery school of dental medicinetsurumi universityYokohamaJapan department of oral hygiene tsurumi junior collegeYokohamaJapan

The autofluorescence visualization method （AVM） uses blue excitation light to assist in the diagnosis of epithelial dysplasia. It detects epithelial dysplasia as a black area, which is known as fluorescence visualization loss （FVL）. In this study, we evaluated the detection accuracy for epithelial dysplasia of the tongue using the objective AVM and assessed its possible clinical utility. Seventy-nine tongue specimens clinically suspected to have leukoplakia or squamous cell carcinoma （SCC） were analyzed. First, the AVM was subjectively performed using the Visually Enhanced Lesion scope （VELscope）, and the iodine-staining method was then performed. After biopsy, the histopathological results and the luminance ratio between the lesion and healthy tissue were compared, and a receiver operating characteristic curve was created. The cutoff value for the objective AVM was determined; the lesion was considered FVL-positive or -negative when the luminance ratio was higher or lower than the cutoff value, respectively. The histopathological diagnoses among the 79 specimens were SCC （n = 30）, leukoplakia with dysplasia （n = 34）, and leukoplakia without dysplasia （n= 15）. The cutoff value of the luminance ratio was 1.62, resulting in 66 FVL-positive and 13 FVL-negative specimens. The luminance ratio was significantly higher in the epithelial dysplasia-positive than -negative group （P〈O.O00 1）. The objective AVM showed much higher consistency between histopathological results than did the two methods （kappa statistic = 0.656）. In conclusion, objective autofluorescence visualization has a potential as an auxiliary method for diagnosis of epithelial dysplasia.

关键词： autofluorescence epithelial dysplasia oral cancer Visually Enhanced Lesion scope

维普期刊数据库

MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第3期32卷 463-476页

作者： Hur SUN MASANORI KAWANO TATSUYA IWASAKI ICHRO ITONAGA yuta KUBOTA HROSHI TSUMURA KAZUHRO TANAKA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

An important factor in the emergence and progre sion of osteosarcoma(OS)is the dysregulated expression of microRNAs(miRNAs).Transcription factor 7-like 1(TCF7LI),a member of the T cell factor/lymphoid enhancer factor(TCF/LEF)transcription factor family,interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding *** study sought to elucidate the impact of the interaction between miR 3293p and TCF7L1 *** growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of ***329-3p was significantly downregulated,while TCF7L1 was considerably up-regulated in all examined OS cell ***,a clinical comparison study was performed using the TCGA ***,the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo *** miR 329-3p was transfected into the OS cell line,the expression of TCF7L1 decreased,the proliferation of OS cells was inhibited,the cytoskeleton disintegrated,and the nucleus condensed to fom apoptotic *** expression of proteins that indicate apoptosis increased *** cell cycle was arrested in the G0/G1 phase,and the G1/S transition was *** introduction of miR 3293p also inhibited downstream Cyclin D1 of the Wnt *** experiments indicated that the overexpression of miR-329-3p signi ficanly inhibited the growth of OS xenografts in nude mice,and the expression of TCF7L1 and C-Myc in tumor tssues *** 329-3p was significantly reduced in OS cells and played a suppressive role in tumorigenesis and proliferation by targeting TCF7L1 both in vitro and in *** cell cycle arrest and pathway inhibition were observed upon the regulation of TCF7LI by miR *** these results,it can be inferred that miR.3293p exerts anticancer efects in osteosarcom

关键词： MiR-329-3p TCF7L1 Wnt/β-catenin pathway Osteosarcoma Proliferation

Patellar dislocation following distal femoral replacement after extraarticular knee resection for bone sarcoma:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第11期10卷 3561-3572页

作者： yuta Kubota Kazuhiro Tanaka Masashi Hirakawa Tatsuya Iwasaki Masanori Kawano Ichiro Itonaga Hiroshi Tsumura Orthopaedic Surgery Oita UniversityYufu City 879-5593OitaJapan

BACKGROUND For the treatment of bone sarcoma in the distal femur,wide-margin resection and knee reconstruction with tumor endoprosthesis are standard *** knee resection is required in cases of tumor invasion of the knee joint;however,the incidence of complications,such as aseptic loosening,prosthesis infection,and implant failure,is higher than that following intra-articular knee *** the best of our knowledge,there are three reports of patellar dislocations after replacement of a tumor *** SUMMARY A 36-year-old man with no significant past medical history was admitted to our institution with continuous pain in his left knee for 4 *** open biopsy was performed,and the patient was diagnosed with a left distal femoral malignant bone ***-articular knee resection and knee reconstruction with a tumor endoprosthesis were *** the alignment of the tumor prosthesis was acceptable,knee instability was noticed *** axial radiographic view of the patellar and computed tomography showed lateral patellar dislocation at 4 wk *** patient had to undergo a lateral release and proximal *** could perform his daily activities at 9 mo *** revealed no patellar *** Proximal realignment may be considered during primary surgery if there is an imbalance in the forces controlling the patellar tracking.

关键词： Bone tumor Distal femoral replacement Lateral release Patellar dislocation Proximal realignment Case report

Feasibility of initial endoscopic common bile duct stone removal in patients with acute cholangitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2017年第7期5卷 280-285页

作者： Akira Yamamiya Katsuya Kitamura Yu Ishii yuta Mitsui Tomohiro Nomoto Hitoshi Yoshida Division of Gastro- enterology Department of MedicineShowa University School of Medicine

AIM To investigate the feasibility of initial endoscopic common bile duct(CBD) stone removal in patients with acute cholangitis(AC).METHODS A single-center,retrospective study was conducted between April 2013 and December 2014 and was approved by the Medical Ethics Committee at our *** informed consent was obtained from each patient prior to the *** cohort comprised 31 AC patients with CBD stones who underwent endoscopic biliary drainage(EBD) for na?ve papilla within 48 h after AC *** retrospectively divided the participants into two groups: 19 patients with initial endoscopic CBD stone removal(initial group) and 12 patients with delayed endoscopic CBD stone removal(delayed group).We evaluated the feasibility of initial endoscopic CBD stone removal in patients with *** We observed no significant differences between the groups regarding patient *** to the assessments based on the Tokyo Guidelines,the AC severity of patients with initial endoscopic CBD stone removal was mild to *** use of antithrombotic agents before EBD was less frequent in the initial group than in the delayed group(11% vs 58%,respectively; P = 0.004).All the patients underwent successful endoscopic CBD stone removaland adverse events did not differ significantly between the *** number of endoscopic retrograde cholangiopancreatography procedures was significantly lower in the initial group than in the delayed group [median(interquartile range) 1(1-1) vs 2(2-2),respectively; P < 0.001].The length of hospital stay was significantly shorter for the initial group than for the delayed group [10(9-15) vs 17(14-20),respectively; P = 0.010].CONCLUSION Initial endoscopic CBD stone removal in patients with AC may be feasible when AC severity and the use of antithrombotic agents are carefully considered.

关键词： Acute cholangitis Common bile duct stone Feasibility Initial endoscopic common bile stone removal Endoscopic retrograde cholangiopancreatography

Emerging trends in organ-on-a-chip systems for drug screening

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第6期13卷 2483-2509页

作者： Yanping Wang Yanfeng Gao Yongchun Pan Dongtao Zhou yuta Liu Yi Yin Jingjing Yang Yuzhen Wang Yujun Song College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China Sino-French Engineer School Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Flexible Electronics&Institute of Advanced Materials Jiangsu National Synergistic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing 211816China

New drug discovery is under growing pressure to satisfy the demand from a wide range of domains, especially from the pharmaceutical industry and healthcare services. Assessment of drug efficacy and safety prior to human clinical trials is a crucial part of drug development, which deserves greater emphasis to reduce the cost and time in drug discovery. Recent advances in microfabrication and tissue engineering have given rise to organ-on-a-chip, an in vitro model capable of recapitulating human organ functions in vivo and providing insight into disease pathophysiology, which offers a potential alternative to animal models for more efficient pre-clinical screening of drug candidates. In this review, we first give a snapshot of general considerations for organ-on-a-chip device design. Then, we comprehensively review the recent advances in organ-on-a-chip for drug screening. Finally, we summarize some key challenges of the progress in this field and discuss future prospects of organ-on-a-chip development. Overall,this review highlights the new avenue that organ-on-a-chip opens for drug development, therapeutic innovation, and precision medicine.

关键词： Microfluidics Drug discovery In vitro models Microphysiological systems Toxicity assessment Bioprinting Drug safety Human-on-a-chip

维普期刊数据库

Numerical investigation of the effect of seasonal variations of depthof-closure on shoreline evolution

在线全文

学校读者我要写书评

暂无评论

International Journal of Sediment Research 2021年第1期36卷 1-16页

作者： Xuan Tinh Nguyen Minh Thanh Tran Hitoshi Tanaka Trung Viet Nguyen yuta Mitobe Cong Dien Duong Department of Civil Engineering Tohoku University

The current study presents the effects of seasonal variations in the depth-of-closure（D;） on shoreline evolution using a numerical,one-line shoreline *** erosion of the southern beach of the Nha Trang Coast,which is located in south central of Vietnam,is selected as the study *** study area is immensely influenced by the tropical monsoon climate that has a clear pattern of large waves in the northeast monsoon season and calm waves in the non-monsoon *** analysis of the long-term measured shoreline variations from a video-camera system has found a strong correlation of these variations to the monsoon-dominated wave characteristics in the Nha Trang ***,a new approach for determining the depth-of-closure with consideration of the seasonal wave climate changes is purposed in the current *** implementing this new approach into a numerical,one-line shoreline model,it is found that the seasonal variations of D;appear to better describe the periodical shoreline evolution due to the monsoon-dominated wave characteristics for the Nha Trang *** important findings are considered to commonly apply for monsoon-dominated coastal regions in *** findings are useful information not only for scientific readers but also for the coastal authorities and managers in order to make better countermeasure plans against this kind of erosion mechanism in the future.

关键词： Video camera Shoreline change One-line theory Nha Trang Beach Depth-of-closure Monsoon wave climate

Alcohol,postprandial plasma glucose,and prognosis of hepatocellular carcinoma

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第1期19卷 78-85页

作者： Hiroshi Abe yuta Aida Haruya Ishiguro Kai Yoshizawa Tamihiro Miyazaki Munenori Itagaki Satoshi Sutoh Yoshio Aizawa Division of Gastroenterology and Hepatology Department of Internal MedicineJikei University School of Medicine Katsushika Medical CenterTokyo 125-8506Japan

AIM:To identify factors associated with prognosis of hepatocellular carcinoma(HCC) after initial ***:A total of 377 HCC patients who were newly treated at Katsushika Medical Center,Japan from January 2000 to December 2009 and followed up for > 2 years,or died during follow-up,were *** factors related to survival were first analyzed in 377 patients with HCC tumor stage T1-T4 using multivariate Cox proportional hazards regression analysis.A similar analysis was performed in 282 patients with tumor stage ***,factors associated with the period between initial and subsequent therapy were examined in 144 patients who did not show local ***,214 HCC stage T1-T3 patients who died during the observation period were classified into four groups according to their alcohol consumption and postprandial glucose levels,and differences in their causes of death were ***:On multivariate Cox proportional hazards regression analysis,the following were significantly associated with survival:underlying liver disease stage [non-cirrhosis/Child-Pugh A vs B/C,hazard ratio(HR):0.603,95% CI:0.417-0.874,P = 0.0079],HCC stage(T1/T2 vs T3/T4,HR:0.447,95% CI:0.347-0.576,P < 0.0001),and mean postprandial plasma glucose after initial therapy(< 200 vs ≥ 200 mg/dL,HR:0.181,95% CI:0.067-0.488,P = 0.0008).In T1-T3 patients,uninterrupted alcohol consumption after initial therapy(no vs yes,HR:0.641,95% CI:0.469-0.877,P = 0.0055) was significant in addition to underlying liver disease stage(non-cirrhosis/Child-Pugh A vs B/C,HR:0649,95% CI:0.476-0.885,P = 0.0068),HCC stage(T1 vs T2/T3,HR:0.788,95% CI:0.653-0.945,P = 0.0108),and mean postprandial plasma glucose after initial therapy(< 200 mg/dL vs ≥ 200 mg/dL,HR:0.502,95% CI:0.337-0.747,P = 0.0005).In patients without local recurrence,time from initial to subsequent therapy for newly emerging HCC was significantly longer in the "postprandial glucose within 200 mg/dL group" than the "postprandial

关键词： Hepatocellular carcinoma Prognosis Alcohol consumption Diabetes mellitus Postprandial plasma glucose level Initial therapy Local recurrence Survival