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Immunological effect of local ablation combined with immunotherapy on solid malignancies

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Chinese Journal of Cancer 2017年第6期36卷 252-257页

作者： yusuke takahashi Noriyuki Matsutani Takashi Nakayama Hitoshi Dejima Hirofumi Uehara Masafumi Kawamura Department of General Thoracic Surgery Teikyo University School of Medicine

Recent comprehensive investigations clarified that immune microenvironment surrounding tumor cells are deeply involved in tumor progression,metastasis,and response to ***,several immunotherapeutic trials have achieved successful results,and the immunotherapeutic agents are available in clinical *** enhance their demonstrated efficacy,combination of immunotherapy and ablation has begun to *** ablations have considerable advantages as an alternative therapeutic option,especially its minimal *** addition,local ablations have shown immune-regulatory effect in preclinical and clinical *** the corresponding mechanisms are still unclear,the local ablations combined with immunotherapy have been suggested in the treatment of several solid *** article aims to review the published data on the immune-regulatory effects of local ablations including stereotactic body radiotherapy,cryoablation,radiofrequency ablation,and high-intensityfocused *** also discuss the value of local ablations combined with *** ablations have the potential to improve future patient outcomes;however,the effectiveness and safety of local ablations combined with immunotherapy should be further investigated.

关键词：免疫治疗剂免疫效应实体瘤免疫调节作用高强度聚焦超声肿瘤细胞临床实践综合调查

Genetic diversity in Japanese populations of the Eurasian Collared Dove

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Avian Research 2020年第2期11卷 133-138页

作者： Kazuya Nagai yusuke takahashi Ken‑ichi Tokita Tomomi Anzai Kiyoshi Uchida Fumihito Nakayama Faculty of Agriculture Iwate UniversityMoriokaIwate 020‑8550Japan Research and Education Centre for Natural Sciences Keio UniversityYokohamaKanagawa 223‑8521Japan Japan Wildlife Research Centre KotoTokyo 130‑8606Japan Satoyama Natural History Study Group AbikoChiba 270‑1153Japan.

Background:Eurasian Collared Dove(Streptopelia decaocto)is a species distributed in the Eurasian continent and North Africa,and inhabiting mainly in Saitama Prefecture in *** Collared Dove is one of the most prosper-ous invaders in the world,and Japanese Eurasian Collared Dove has also been introduced from *** Japa-nese population has declined to one-hundredth over 30 years and is being *** this study,we analyzed its genetic diversity in order to understand the genetic differences between wild populations of Eurasian Collared Dove and those bred in ***:A sequence of about 1.9 kb mtDNA was determined for 20 wild Eurasian Collared Doves living in Saitama,Japan and 20 zoo-bred Eurasian Collared Doves,and population genetic analysis was ***:In the COI gene,778 bp had the same sequence in all the 40 individuals examined,and no mutation sites could be *** the control region,two base substitution sites were confirmed in 1140 bp long *** haplotypes were detected in 20 individuals in wild,whereas all 20 zoo-bred individuals possessed the same haplotypes possessed in the wild ***:Haplotypes of zoo-bred individuals were also retained among the wild individuals,confirming that no genetic problems could occur if the zoo-bred individuals were released to the wild for the Japanese Eurasian Collared Dove propagation program.

关键词： COI Control region Eurasian Collared Dove Genetic diversity mtDNA Phylogeography

Thermochemical Nonequilibrium 2D Modeling of Nitrogen Inductively Coupled Plasma Flow

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Plasma Science and Technology 2015年第9期17卷 749-760页

作者： YU Minghao yusuke takahashi Hisashi KIHARA Ken-ichi ABE Kazuhiko YAMADA Takashi ABE Satoshi MIYATANI Department of Aeronautics and Astronautics Kyushu University Division of Mechanical and Space Engineering Hokkaido University Institute of Space and Astronautical Science Japan Aerospace Exploration Agency Department of Aeronautics and Astronautics The University of Tokyo

Two-dimensional（2D） numerical simulations of thermochemical nonequilibrium inductively coupled plasma（ICP） flows inside a 10-kW inductively coupled plasma wind tunnel（ICPWT） were carried out with nitrogen as the working *** axisymmetric NavierStokes（N-S） equations coupled with magnetic vector potential equations were solved.A fourtemperature model including an improved electron-vibration relaxation time was used to model the internal energy exchange between electron and heavy *** third-order accuracy electron transport properties（3rd AETP） were applied to the simulations.A hybrid chemical kinetic model was adopted to model the chemical nonequilibrium *** flow characteristics such as thermal nonequilibrium,inductive discharge,effects of Lorentz force were made clear through the present *** was clarified that the thermal nonequilibrium model played an important role in properly predicting the temperature *** prediction accuracy can be improved by applying the 3rd AETP to the simulation for this ICPWT.

关键词： inductively coupled plasma nonequilibrium electron transport properties,magnetic vector potential

A novel role of LRP5 in tubulointerstitial fibrosis through activating TGF-β/Smad signaling

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1967-1978页

作者： Xuemin He Rui Cheng Chao Huang yusuke takahashi Yanhui Yang Siribhinya Benyajati Yanming Chen Xin AZhang Jian-xing Ma Department of Endocrinology&Metabolism The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510630China Department of Physiology College of MedicineUniversity of Oklahoma Health Sciences CenterOklahoma CityOK 73104USA Harold Hamm Diabetes Center University of Oklahoma Health Sciences CenterOklahoma CityOK 73104USA NHC Key Laboratory of Hormones and Development(Tianjin Medical University) Tianjin Key Laboratory of Metabolic DiseasesTianjin Medical University Chu Hsien-I Memorial Hospital&Tianjin Institute of EndocrinologyTianjin 300134China

Previous studies by us and others demonstrated that activation of Wnt/β-catenin signaling plays a pathogenic role in chronic kidney diseases(CKD).Wnt co-receptor LRP5 variants are reported to associate with autosomal dominant polycystic kidney disease;but their exact roles in this disease and renal fibrosis have not been ***,we observed the upregulation of LRP5 in the renal tubules of both type 1 and type 2 diabetic models and of an obstructive nephropathy *** the obstructed kidneys,Lrp5 knockout significantly ameliorated tubulointerstitial fibrosis and tubular injury without changing Wnt/β-catenin ***,decreased levels of TGF-β1 and TGF-βreceptors(TβRs)were detected in Lrp5 knockout kidneys,followed by attenuated activation and nuclear translocation of Smad2/3 in the renal tubules,suggesting a regulatory effect of LRP5 on TGF-β/Smad *** consistent with this hypothesis,LRP5 overexpression resulted in enhanced TGF-β/Smad signaling activation in renal tubule epithelial ***,LRP5 was co-immunoprecipitated with TβRI and TβRII,and its extracellular domain was essential for interacting with TβRs and for its pro-fibrotic *** addition to stabilizing TβRs,LRP5 increased the basal membrane presentation and TGF-β1-induced internalization of these ***,TGF-β1 also induced LRP5 *** findings indicate that LRP5 promotes tubulointerstitial fibrosis,at least partially,via direct modulation of TGF-β/Smad signaling,a novel,Wnt-independent function.

关键词： LRP5 Smad2/3 finding

Anomalous Proton Conductivity in Chitin-Chitosan Mixed Compounds

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Materials Sciences and Applications 2020年第1期11卷 1-11页

作者： Takashi Kawabata yusuke takahashi Yasumitsu Matsuo Department of Life Science Faculty of Science & Engineering Setsunan University Ikeda-Nakamachi Neyagawa Osaka Japan

In order to investigate a key factor for the appearance of proton conductivity in chitin-chitosan mixed compounds, the chitin-chitosan mixed compounds (chitin)x(chitosan)1-x were prepared and these proton conductivities have been investigated. DC proton conductivity σ is obtained from Nyquist plot of impedance measurement data, and the relationship between σ and mixing ratio x has been made clear. It was found that the x dependence of σ is non-monotonous. That is, σ shows the anomalous behavior, and has peaks around x = 0.4 and 0.75. This result indicates that there exist optimal conditions for the realization of high-proton conductivity in the chitin-chitosan mixed compound in which the number of acetyl groups is different. From the FT-IR measurement, we have found that the behavior of proton conductivity in (chitin)x(chitosan)1-x is determined by the amount of water content changed by x. Using these results, proton conductivity, which is important for the application of conducting polymers in chitin-chitosan mixed compounds, will be able to be easily controlled by adjusting the mixing ratio x.

关键词： Chitin Chitosan Mixed Compounds Proton Conductor Biomaterial

Poly (ethylene terephthalate) synthesis with catalysts derived from chrysotile asbestos

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Natural Science 2010年第6期2卷 557-562页

作者： Shigeki Habaue yusuke takahashi Yu Hosogoe Hiroshi Yamashita Meisetsu Kajiwara Faculty of Health and Nutrition Shubun University Department of Chemistry and Chemical Enginerring Graduate School of Science and Engineering Yamagata University

The chrysotile asbestos was converted to the forsterite-type compounds by calcination at 740 and 800oC (F7-740 and F7-800), which were used as a catalyst for the polycondensation of bis(hydroxyethyl) terephthalate affording poly (ethylene terephthalate). The obtained forsterite-type compounds did not show any catalytic activity. However, the products obtained by simply treating them with acetic acid significantly promoted the polymerization that produced a THFinsoluble polymer. It was found that the polymer prepared with the acetic acid-treated F7-740 at 160oC for 2 h showed a 93% yield and the number average molecular weight of 6.4 × 103. The observed catalytic activity was higher than that for the acetic acid-treated magnesium oxide, as well as the typical polycondensation catalysts, such as magnesium acetate and antimony oxide.

关键词： Chrysotile Asbestos Forsterite Polycondensation Poly (Ethylene Terephthalate) Recycling

在机械搅拌溶池中粒子层厚度对捕获粒子的影响

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现代冶金（内蒙古） 2010年第1期 10-12,24页

作者： yusuke takahashi[日本] 日本

1引言按照先前KR脱磷工艺水模的研究，通过采取将圆柱棒轻微浸入溶池内偏心位置的方法，可使最初位于机械搅拌水池表面的低密度粒子被有效卷入溶池内部。

关键词：机械搅拌溶池粒子捕获厚度子层脱磷工艺偏心位置

局部消融术联合免疫治疗对实体恶性肿瘤的免疫效应

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癌症 2018年第10期37卷 439-446页

作者： yusuke takahashi Noriyuki Matsutani Takashi Nakayama Hitoshi Dejima Hirofumi Uehara Masafumi Kawamura Department of General Thoracic Surgery Teikyo University School of Medicine

最近的综合研究表明肿瘤细胞周围的免疫微环境与肿瘤的进展、转移和对治疗的反应密切相关。而且,一些免疫治疗试验已取得了成功的结果,用于临床实践的免疫治疗药物也可以获得。为了增强其已证实的疗效,免疫治疗和消融术的联合使用已开... 详细信息

最近的综合研究表明肿瘤细胞周围的免疫微环境与肿瘤的进展、转移和对治疗的反应密切相关。而且,一些免疫治疗试验已取得了成功的结果,用于临床实践的免疫治疗药物也可以获得。为了增强其已证实的疗效,免疫治疗和消融术的联合使用已开始出现。局部消融作为一种替代治疗方案具有相当大的优势,尤其是其微侵袭特性。此外,局部消融在临床前和临床研究中也显示出免疫调节作用。虽然相应的机制尚不清楚,但局部消融结合免疫治疗已被建议用于治疗几种实体恶性肿瘤。本文对局部消融的免疫调节效应方面发表的文献进行了综述,包括立体定向放射治疗、冷冻消融、射频消融和高强度聚焦超声。我们还讨论了局部消融与免疫治疗联合使用的价值。局部消融有改善未来患者预后的潜力,但局部消融与免疫治疗联合使用的有效性和安全性有待进一步研究。

关键词：免疫疗法实体恶性肿瘤冷冻手术放射治疗立体定向放射治疗

Poly (ethylene terephthalate) synthesis with catalysts derived from chrysotile asbestos

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