检索结果-南通市图书馆

Ab Initio Two-Phase Molecular Dynamics on the Melting Curve of SiO_2

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2010年第5期21卷 801-810页

作者： yusuke Usui Taku Tsuchiya Geodynamics Research Center Ehime University

Ab initio two-phase molecular dynamics simulations were performed on silica at pressures of 20-160 GPa and temperatures of 2 500-6 000 K to examine its solid-liquid phase boundary. Results indicate a melting temperature （Tin） of 5 900 K at 135 GPa. This is 1 100 K higher than the temperature considered for the core-mantle boundary （CMB） of about 3 800 K. The calculated melting temperature is fairly consistent with classical MD （molecular dynamics） simulations. For liquid silica, the O-O coordination number is found to be 12 along the Tm and is almost unchanged with increasing pressure. The self-diffusion coefficients of O and Si atoms are determined to be 1.3×10^-9-3.3×10^-9 m2/s, and the viscosity is 0.02-0.03 Pa＇s along the Tin. We find that these transport properties depend less on pressure in the wide range up of more than 135 GPa. The eutectic temperatures in the MgO-SiO2 systems were evaluated and found to be 700 K higher than the CMB temperature, though they would decrease considerably in more realistic mantle compositions.

关键词： Ab Initio Two-Phase Molecular Dynamics on the Melting Curve of SiO2 SiO CMB MgO than

The origin of high eccentricity planets:The dispersed planet formation regime for weakly magnetized disks

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2017年第2期8卷 233-245页

作者： yusuke Imaeda Toshikazu Ebisuzaki RIKEN 2-1Hirosawa351-0198Japan

In the tandem planet formation regime,planets form at two distinct sites where solid particles are densely accumulated due to the on/off state of the magnetorotational instability（MRI）.We found that tandem planet formation can reproduce the solid component distribution of the Solar System and tends to produce a smaller number of large planets through continuous pebble flow into the planet formation *** the present paper,we investigate the dependence of tandem planet formation on the vertical magnetic field of the protoplanetary *** calculated two cases of BZ 3.4 × 10^-3 G and BZ = 3.4 × 10^-5 G at 100 AU as well as the canonical case of BZ = 3.4 × 10^-4 *** found that tandem planet formation holds up well in the case of the strong magnetic field（BZ 3.4 × 10^-3 G）.On the other hand,in the case of a weak magnetic field（BZ= 3.4 × 10^-5 G） at 100 AU,a new regime of planetary growth is realized：the planets grow independently at different places in the dispersed area of the MRl-suppressed region of r-8-30 AU at a lower accretion rate of M 〈 10^-7.4M⊙yr^-*** call this the ＂dispersed planet formation＂ *** may lead to a system with a larger number of smaller planets that gain high eccentricity through mutual collisions.

关键词： Accretion disk Planet formation Magnetorotational instability

Tandem planet formation for solar system-like planetary systems

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2017年第2期8卷 223-231页

作者： yusuke Imaeda Toshikazu Ebisuzaki RIKEN 2-1Hirosawa351-0198Japan

We present a new united theory of planet formation,which includes magneto-rotational instability（MRl） and porous aggregation of solid particles in a consistent *** show that the ＂tandem planet formation＂ regime is likely to result in solar system-like planetary *** the tandem planet formation regime,planetesimals form at two distinct sites：the outer and inner edges of the MRl suppressed *** former is likely to be the source of the outer gas giants,and the latter is the source for the inner volatile-free rocky *** study spans disks with a various range of accretion rates,and we find that tandem planet formation can occur for M = 10^7.3- 10^-6.9Myr^-*** rocky planets form between 0.4-2 AU,while the icy planets form between 6-30 All;no planets form in 2-6 AU region for any accretion *** is consistent with the gap in the solid component distribution in the solar system,which has only a relatively small Mars and a very small amount of material in the main asteroid belt from 2-6 *** tandem regime is consistent with the idea that the Earth was initially formed as a completely volatile-free *** and other volatile elements came later through the accretion of icy material by occasional inward scattering from the outer *** between reductive minerals,such as schreibersite（Fe-jP）,and water are essential to supply energy and nutrients for primitive life on Earth.

关键词： Accretion disk Planet formation Magneto-rotational instability Origin of life

Single planet formation regime in the high-ionization environment:Possible origin of hot Jupiters and super-Earths

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2018年第4期9卷 1023-1031页

作者： yusuke Imaeda Toshikazu Ebisuzaki RIKEN

We studied the particle growth in a protoplanetary disk in a high-ionization environment and found that icy planet formation is inactive for a disk with an ionization rate 100 times higher than that of the present Solar System. In particular, in the case of M 〈 10^（-7.4）M_☉yr^（-1）, only rocky planet formation occurs. In such a case, all the solid materials in the disk drift inward, eventually reach the inner MRI front,and accumulate there. They form a dense, thin sub-disk of solid particles, which undergoes gravitational instability to form rocky planetesimals. The planetesimals rapidly grow into a planet through pebble accretion. Consequently, rocky planets tend to be much larger than planets formed through other regimes（tandem planet formation regime and dispersed planet formation regime）, in which icy planet formation actively takes place. These rocky planets may evolve into hot Jupiters if they grow fast enough to the critical core mass of the runaway gas accretion before the dispersal of the disk gas, or they may evolve into super-Earths if the gas dispersed sufficiently early.

关键词： Accretion disk Planet formation Magneto-rotational instability Galactic cosmic rays Hot Jupiter Super-Earth

Detection of Adhesion Molecules on Inflamed Macrophages at Early-Stage Using SERS Probe Gold Nanorods

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2017年第1期9卷 113-121页

作者： Dakrong Pissuwan yusuke Hattori World Premier International Immunology Frontier Research Center Osaka UniversityOsaka 5650871Japan Materials Science and Engineering Program Multidisciplinary UnitFaculty of ScienceMahidol UniversityBangkok 10400Thailand Research Institute of Pharmaceutical Sciences Musashino UniversityTokyo 2028585Japan

In recent years, it has been shown that inflammatory biomarkers can be used as an effective signal for disease diagnoses. The early detection of these signals provides useful information that could prevent the occurrence of severe diseases. Here, we employed surface-enhanced Raman scattering(SERS) probe gold nanorods(GNRs) as a tool for the early detection of inflammatory molecules in inflamed cells. A murine macrophage cell line(Raw264.7) stimulated with lipopolysaccharide(LPS) was used as a model in this study. The prepared SERS probe GNRs containing 4-mercaptobenzoic acid as a Raman reporter to generate SERS signals were used for detection of intracellular adhesion molecule-1(ICAM-1) in macrophages after treatment with LPS for varying lengths of time. Our results show that SERS probe GNRs could detect significant differences in the expression of ICAM-1 molecules in LPS-treated macrophages compared to those in untreated macrophages after only 1 h of LPS treatment. In contrast, when using fluorescent labeling or enzyme-linked immunosorbent assays(ELISA) to detect ICAM-1, significant differences between inflamed and un-inflamed macrophages were not seen until the cells had been treated with LPS for 5 h. These results indicate that our SERS probe GNRs provide a higher sensitivity for detecting biomarker molecules in inflamed macrophages than the conventional fluorescence and ELISA techniques, and could therefore be useful as a potential diagnostic tool for managing disease risk.

关键词： Gold nanorod SERS Inflamed cell Macrophage ICAM-1

Study on the Rotor Design Method for a Small Propeller-Type Wind Turbine

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2016年第4期25卷 355-362页

作者： Yasuyuki Nishi yusuke Yamashita Terumi Inagaki Department of Mechanical Engineering Ibaraki University Graduate School of Science and Engineering Ibaraki University

Small propeller-type wind turbines have a low Reynolds number,limiting the number of usable airfoil ***,their design method is not sufBciently established,and their performance is often *** ultimate goal of this research is to establish high-performance design guidelines and design methods for small propeller-type wind *** that end,we designed two rotors:Rotor A,based on the rotor optimum design method from the blade element momentum theory,and Rotor B,in which the chord length of the tip is extended and the chord length distribution is *** examined performance characteristics and flow fields of the two rotors through wind tunnel experiments and numerical *** results revealed that the maximum output tip speed ratio of Rotor B shifted lower than that of Rotor A,but the maximum output coefficient increased by approximately 38.7%.Rotors A and B experienced a large-scale separation on the hub side,which extended to the mean in Rotor *** difference in separation had an impact on the significant decrease in Rotor A's output compared to the design value and the increase in Rotor B's output compared to Rotor A.

关键词： Wind Turbine Propeller-Type Horizontal Axis Blade Element Momentum Theory Rotor Design Method

A Simple Method for Synthesizing Ultra-high-molecular-weight Polystyrene through Emulsion Polymerization Using Alkyl-9-BBN as an Initiator

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2018年第5期36卷 592-597页

作者： Chao Zhao Ryuichi Sugimoto yusuke Naruoka School of Environmental Science and Engineering Kochi University of Technology

Styrene emulsion polymerization using an alkyl-9-BBN, synthesized by reacting 9-BBN（9-borabicyclo-[3.3.1]-nonane） and styrene, in an aqueous sodium dodecyl sulfate（SDS） solution was studied. Ultra-high-molecular-weight（〉 1.0 × 10~7） polystyrene was synthesized using a radical initiator formed through the aerobic oxidation of this alkyl-9-BBN in a high yield（〉 80%）. The kinetics of this emulsion polymerization of styrene with the alkyl-9-BBN was investigated. We confirmed that in the initial stage of the polymerization, the initial reaction rate followed first-order kinetics. The activation energy for this emulsion polymerization of styrene was approximately 56.2 kJ/mol.

关键词： Emulsion polymerization 9-BBN Ultra-high molecular weight polystyrene

Assessing the efficacy of health countermeasures on arrival time of infectious diseases

在线全文

学校读者我要写书评

暂无评论

Infectious Disease Modelling 2023年第2期8卷 603-616页

作者： yusuke Asai Disease Control and Prevention Center National Center for Global Health and Medicine1-21-1 ToyamaShinjuku-kuTokyo162-8655Japan

Public health measures to control the international spread of infectious diseases include strengthening quarantines and sealing *** these measures are effective in delaying the importation of infectious diseases,they also have a significant economic impact by stopping the flow of people and *** arrival time of infectious diseases is often used to assess quarantine *** the arrival time is highly dependent on the number of infected cases in the endemic country,direct comparisons have not yet been ***,this study derives an explicit relationship between the number of infected cases and arrival *** behavior is stochastic,and deterministic models are not always *** this study,random differential equations,which are differential equations with stochastic processes,were used to describe the dynamics of infection in an endemic ***,the flow of travelers from the endemic country was described in terms of survival time,and the arrival time in each country was calculated.A scenario in which PCR kits were distributed between endemic and diseasefree countries was also considered,and the impact of different distribution rates on arrival time was *** simulation results showed that increasing the distribution of PCR kits in the endemic country was more effective in delaying arrival times than using PCR kits in quarantine in disease-free *** was also found that increasing the proportion of identified infected persons in the endemic country,leading to isolation,was more important and effective in delaying arrival times than increasing the number of PCR tests.

关键词： Epidemic model Arrival time Health countermeasures Quarantine Random ODE

Personalized immunotherapy in cancer precision medicine

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2021年第4期18卷 955-965页

作者： Kazuma Kiyotani Yujiro Toyoshima yusuke Nakamura Project for Immunogenomics Cancer Precision Medicine CenterJapanese Foundation for Cancer ResearchTokyo 135-8550Japan

With the significant advances in cancer genomics using next-generation sequencing technologies,genomic and molecular profilingbased precision medicine is used as a part of routine clinical test for guiding and selecting the most appropriate treatments for individual cancer *** many molecular-targeted therapies for a number of actionable genomic alterations have been developed,the clinical application of such information is still limited to a small proportion of cancer *** this review,we summarize the current status of personalized drug selection based on genomic and molecular profiling and highlight the challenges how we can further utilize the individual genomic *** immunotherapies,including immune checkpoint inhibitors,would be one of the potential approaches to apply the results of genomic sequencing most *** cancer-specific antigens derived from somatic mutations,the so-called neoantigens,occurring in individual cancers have been in focus *** immunotherapies,which target neoantigens,could lead to a precise treatment for cancer patients,despite the challenge in accurately predicting neoantigens that can induce cytotoxic T cells in individual *** prediction of neoantigens should accelerate the development of personalized immunotherapy including cancer vaccines and T-cell receptor-engineered T-cell therapy for a broader range of cancer patients.

关键词： Personalized medicine cancer precision medicine neoantigen personalized immunotherapy immune checkpoint blockade cancer vaccine adoptive T cell therapy