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Joint input–output identiﬁcation of unstable systems with kernel regularization

Control Theory and Technology 2024年第2期22卷 195-202页

作者： yusuke fujimoto Toshiharu Sugie Department of Environmental Engineering the University of Kitakyushu1-1HibikinoWakamatsu-kuKitakyushu 8080135FukuokaJapan Professor Emeritus Kyoto UniversityYoshida-HonmachiSakyo-kuKyoto 6068501KyotoJapan

This paper discusses closed-loop identiﬁcation of unstable *** particular,weﬁrst apply the joint input–output identiﬁcation method and then convert the identiﬁcation problem of unstable systems into that of stable systems,which can be tackled by using kernel-based regularization *** propose to identify two transfer functions by kernel regularization,the one from the reference signal to the input,and the one from the reference signal to the *** these transfer functions are stable,kernel regularization methods can construct their accurate *** the model of unstable system is constructed by ratio of these *** effectiveness of the proposed method is demonstrated by a numerical example and a practical experiment with a DC motor.

关键词： Closed-loop identification Kernel regularization Joint input-output identification

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Depth of invasion to the bladder wall as a prognostic factor and its association with circulating cell-free DNA levels in patients with muscle-invasive bladder cancer

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当代泌尿学（英文） 2023年第4期17卷 229-235页

作者： yusuke lemura Makito Miyake Shinji Fukui Tomomi Fujii Sayuri Ohnishi Shunta Hori Yosuke Morizawa Yasushi Nakai Kazumasa Torimoto Nobumichi Tanaka Kiyohide fujimoto Department of Urology Nara Medical UniversityKashiharaNaraJapan Department of Diagnostic Pathology Nara Medical UniversityKashiharaNaraJapan Department of Urology Nara Medical UniversityKashiharaNaraJapan Department of Prostate Brachytherapy Nara Medical UniversityKashiharaNaraJapan

Background:Radical cystectomy(RC)is the standard surgical treatment for patients with muscle-invasive bladder cancer,but the prognosis is not favorable,and new prognostic factors need to be *** investigated the potential of depth of invasion(DOI)as a prognostic factor in patients with muscle-invasive bladder cancer who underwent ***,we examined the asso-ciation between preoperative levels of circulating cell-free DNA and DOI.Materials and methods:We retrospectively reviewed patients who underwent RC between January 2007 and December 2017;those who received neoadjuvant chemotherapy were *** of invasion was measured using hematoxylin-eosin-stained RC specimens.Results:Of the 121 patients selected,41(33.9％)were eligible for *** median follow-up period was 14 months and mean DOI was 17 mm(range,2-75 mm).Long DOI(＞17 mm)was significantly associated with shorter progression-free survival(hazard ratio,14.5;95％confidence interval,3.9-53.97,p＜0.0001)and cancer-specific survival(hazard ratio,18.97;95％confidence interval,4.04-88.99,p=0.0002)compared with short *** analysis revealed that DOI was an independent risk factor for cancer-specific *** levels of circulating cell-free DNA were significantly higher in patients with a longer DOI than in those with short DOI(65 vs.20 ng/mL,respectively;p=0.028).Conclusions:Depth of invasion predicted with levels of circulating cell-free DNA and thus could be a useful prognostic factor.

关键词： Bladder cancer Cell-free DNA Depth of invasion

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经皮冠状动脉干预前静脉注射尼可地尔可以预防冠状动脉慢溢流现象

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首都食品与医药 2016年第24期23卷 116-118页

作者： yusuke Kawai Kenichi Hisamatsu Hiromi Matsubara Kazuhiro Dan Satoshi Akagi Katsumasa Miyaji Mitsuru Munemasa Yoshihisa fujimoto Kengo F.Kusano Tohru Ohe 高万峰北京四环科宝制药有限公司 100070

冠状动脉慢溢流(SCF)的现象是冠状动脉微血管紊乱,疾病的特点是对比度的延迟通道,不存在阻塞性心外膜冠状动脉的疾病。在经皮冠状动脉介入治疗(PCI)手术过程中发生慢溢流现象会导致严重的并发症。最近一些研究表明,对急性冠状动脉综合... 详细信息

冠状动脉慢溢流(SCF)的现象是冠状动脉微血管紊乱,疾病的特点是对比度的延迟通道,不存在阻塞性心外膜冠状动脉的疾病。在经皮冠状动脉介入治疗(PCI)手术过程中发生慢溢流现象会导致严重的并发症。最近一些研究表明,对急性冠状动脉综合征患者给予静脉或冠脉内给药尼可地尔(KATP钾离子通道开放剂和硝酸盐的混合物)可以减少这种现象的发生率。然而,至于尼克地尔不仅会对急性冠脉综合征患者,而且对于非急性冠脉综合征患者均能阻止慢溢流现象的使用方法尚不清楚。因此,我们评估了静脉给予尼可地尔对有急性冠状动脉综合症且经历首选PCI手术的患者以及无急性冠状动脉综合症且经历后续PCI手术的患者发生慢溢流现象的效应。

关键词：尼可地尔预防冠状动脉慢溢流

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