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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1593-1616页

作者： Rania Saadah Mohammed Amleh Ahmad Qazza Shrideh Al-Omari Ahmet ocak Akdemir Department of Mathematics Faculty of ScienceZarqa UniversityZarqa13110Jordan Department of Mathematics Faculty of ScienceAl-Balqa Applied UniversityAmman11134Jordan Department of Mathematics Faculty of Science and LettersAgri Ibrahim莈鏴n UniversityAgri04100Turkey

In this study,we aimto investigate certain triple integral transformand its application to a class of partial *** discuss various properties of the new transformincluding inversion, linearity, existence, scaling andshifting, etc. Then,we derive several results enfolding partial derivatives and establish amulti-convolution ***, we apply the aforementioned transform to some classical functions and many types of partial differentialequations involving heat equations,wave equations, Laplace equations, and Poisson equations ***,wedraw some figures to illustrate 3-D contour plots for exact solutions of some selected examples involving differentvalues in their variables.

关键词： ARA transform double ARA transform triple ARA transform partial differential equations integral transform

The use of fluoroscopy for detecting hypertensive lung edema due to prosthetic valve dysfunction: a case report

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World Journal of Emergency Medicine 2024年第4期15卷 313-315页

作者： yusuf Kantar Necmi Baykan Emergency Department Akçaabat Haçkalibaba State HospitalTrabzon 61060Turkiye Emergency Department Kayseri City HospitalKayseri 38080Turkiye

Heart valve diseases affect more than one hundred million people around the world,which are a serious cause of illness and mortality.[1]Among the valve diseases,mitral valve insufficiency ranks second in the list of valve diseases requiring surgical repair in Europe.[2]Prosthetic valve replacement is the standard treatment in cases where repair is not sufficient for valve diseases.[3]Mechanical and bioprosthetic valves can be preferred for replacement,mechanical valves are more durable and require lifelong use of *** disadvantage of bioprosthetic valves is early degeneration,and infective reoperation is required due to the formation of endocarditis.[4-5]The risk of thromboembolism,lifetime anticoagulant use and complications related to anticoagulation remain disadvantages of valve surgery.[3]The most important complication requiring urgent intervention is valve dysfunction due to *** usually occurs due to inappropriate use of the anticoagulants.[6]Surgical treatment is used for severe obstructions,such as thrombi larger than 10 *** therapy can be applied in small thrombi and in cases where surgical intervention is risky.

关键词： valve disadvantage lifetime

Metabologenomics and network pharmacology to understand the molecular mechanism of cancer research

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World Journal of Clinical Cases 2024年第3期12卷 474-478页

作者： yusuf Tutar Department of Basic Pharmaceutical Sciences Faculty of PharmacyDivision of BiochemistryUniversity of Health SciencesIstanbul 34668Turkey Health Sciences Faculty Recep Tayyip Erdogan UniversityRize 53350Turkey Molecular Oncology Division Health Sciences InstitutesUniversity of Health SciencesIstanbul 34668Turkey Molecular Medicine Division Health Sciences InstitutesUniversity of Health SciencesIstanbul 34668Turkey

In this editorial I comment on the article“Network pharmacological and molecular docking study of the effect of Liu-Wei-Bu-Qi capsule on lung cancer”published in the recent issue of the World Journal of Clinical Cases 2023 November 6;11(31):*** all living forms are able to manufacture particular chemicals-metabolites that enable them to differentiate themselves from one another and to overcome the unique obstacles they encounter in their natural *** methods for chemical warfare,communication,nutrition acquisition,and stress prevention are made possible by these specialized *** is a popular technique for collecting direct mea-surements of metabolic activity from many biological ***,con-fusing metabolite identification is a typical issue,and biochemical interpretation is frequently constrained by imprecise and erroneous genome-based estimates of enzyme *** annotation and gene integration uses a biochemical reaction network to obtain a metabolite-gene association so called *** network uses an approach that emphasizes metabolite-gene consensus via biochemical *** metabolomics and genomics data is ***,computer networking proposes that using meta-bolomics data may improve annotations in sequenced species and provide testable hypotheses for specific biochemical *** The genome and metabolites of biological organisms are not fully characterized with current ***,increasing high-throughput metabolomics and genomics data provide promising generation of paired data sets to understand the molecular mechanism of biochemical processes as well as determining targets for pharmaceutical drug *** network infrastructures to integrate omics analysis can provide molecular mechanism of biochemical ***,clinical data may be integrated to gene expression–metabolite expression by system genetics appr

关键词： Network pharmacology Metabologenomics Genome Pathways Cancer

Decoding 17-Beta-hydroxysteroid Dehydrogenase 13:A Multifaceted Perspective on Its Role in Hepatic Steatosis and Associated Disorders

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Journal of Clinical and Translational Hepatology 2024年第10期12卷 857-864页

作者： Coskun Ozer Demirtas yusuf Yilmaz Department of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkiye Institute of Gastroenterol-ogy Marmara UniversityistanbulTurkiye Department of Gastroenterology School of MedicineRecep Tayyip Erdogan UniversityRizeTurkiye The Global NASH Council WashingtonDCUSA

Chronic liver disease(CLD)represents a significant global health burden,with hepatic steatosis-associated disorders—such as metabolic dysfunction-associated steatohepatitis(MASH),alcoholic liver disease,and hepatitis C virus infection—being major *** genome-wide association studies have identified the rs72613567:TA variant in the 17-beta-hydroxysteroid dehydrogenase 13(HSD17B13)gene as a protective factor against the development and progression of these *** this review,we summarized the current evidence surrounding the HSD17B13 rs72613567 variant,aiming to elucidate its impact on CLD risk and outcomes,and to explore the potential mechanisms behind its hepatoprotective *** rs72613567:TA variant induces a splice donor site mutation,resulting in a truncated,nonfunctional HSD17B13 *** studies have demonstrated that this loss-of-function mutation confers protection against the development of cirrhosis and hepatocellular carcinoma(HCC)in patients with MASH,alcoholic liver disease,and hepatitis C virus ***,the rs72613567:TA variant has been associated with reduced liver enzyme levels and improved survival in HCC *** this variant into genetic risk scores has shown promise in predicting the progression of fatty liver disease to cirrhosis and ***,inhibiting HSD17B13 expression through RNA interference and small molecule inhibitors has emerged as a potential therapeutic strategy for ***,the precise molecular mechanisms underlying the hepatoprotective effects of the HSD17B13 rs72613567 variant remain to be fully *** research should focus on clarifying the structure-function relationship of HSD17B13 and its role in liver pathophysiology to facilitate the development of targeted therapies for CLD associated with hepatic steatosis.

关键词： 17-Beta-hydroxysteroid dehydrogenase 13 Chronic liver disease Polymorphism Genetics Risk factor Hepatocellular carcinoma Metabolic dysfunction-associated steatohepatitis

A Comparative Study of Metaheuristic Optimization Algorithms for Solving Real-World Engineering Design Problems

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 1039-1094页

作者： Elif Varol Altay Osman Altay yusuf Ovik Department of Software Engineering Manisa Celal Bayar UniversityManisa45400Turkey

Real-world engineering design problems with complex objective functions under some constraints are relatively difficult problems to *** design problems are widely experienced in many engineering fields,such as industry,automotive,construction,machinery,and interdisciplinary ***,there are established optimization techniques that have shown effectiveness in addressing these types of *** research paper gives a comparative study of the implementation of seventeen new metaheuristic methods in order to optimize twelve distinct engineering design *** algorithms used in the study are listed as:transient search optimization(TSO),equilibrium optimizer(EO),grey wolf optimizer(GWO),moth-flame optimization(MFO),whale optimization algorithm(WOA),slimemould algorithm(SMA),harris hawks optimization(HHO),chimp optimization algorithm(COA),coot optimization algorithm(COOT),multi-verse optimization(MVO),arithmetic optimization algorithm(AOA),aquila optimizer(AO),sine cosine algorithm(SCA),smell agent optimization(SAO),and seagull optimization algorithm(SOA),pelican optimization algorithm(POA),and coati optimization algorithm(CA).As far as we know,there is no comparative analysis of recent and popular methods against the concrete conditions of real-world engineering ***,a remarkable research guideline is presented in the study for researchersworking in the fields of engineering and artificial intelligence,especiallywhen applying the optimization methods that have emerged *** research can rely on this work for a literature search on comparisons of metaheuristic optimization methods in real-world problems under similar conditions.

关键词： Metaheuristic optimization algorithms real-world engineering design problems multidisciplinary design optimization problems

Detecting early changes in choroidal vascularity and thickness using optical coherence tomography in patients with corneal crosslinking for keratoconus

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1267-1272页

作者： selim Doganay Mehmet Omer Kiristioglu Derya Doganay Elif Kacmaz Department of Ophthalmology Bursa Uludag University School of MedicineBursa 16059Turkey Department of Ophthalmology University of Health Sciences Bursa Yuksek Ihtisas Training and Research HospitalBursa 16310Turkey

AIM:To investigate changes in choroidal thickness and vascularity in keratoconus patients treated with corneal ***:This study evaluated 28 eyes of 22 patients with keratoconus who underwent corneal *** choroidal thicknesses were evaluated on enhanced depth imaging optical coherence tomography at the preoperative and postoperative 3d,1,and *** thickness in the four cardinal quadrants and the fovea were *** choroidal vascularity index was also ***:There was no significant difference in central choroidal thickness between the preoperative and postoperative 3d,1mo(P>0.05).There was a significant increase in the 3mo(P=0.034)and a significant decrease in the horizontal choroidal vascularity index on the postoperative 3d(P=0.014),there was no statistically significant change in vertical axes and other visits in horizontal sections(P>0.05).CONCLUSION:This study sheds light on choroidal changes in postoperative corneal crosslinking for *** it suggests the procedure’s relative safety for submacular choroid,more extensive research is necessary to confirm these findings and their clinical significance.

关键词： keratoconus corneal crosslinking choroidal vascularity index enhanced depth imaging optical coherence tomography

Prediction of Damping Capacity Demand in Seismic Base Isolators via Machine Learning

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2899-2924页

作者： Ayla ocak Umit Isıkdag Gebrail Bekdas Sinan Melih Nigdeli Sanghun Kim ZongWoo Geem Department of Civil Engineering Istanbul University-CerrahpasaIstanbul34320Turkey Department of Informatics Mimar Sinan Fine Arts UniversityIstanbul34427Turkey Department of Civil and Environmental Engineering Temple UniversityPhiladelphiaPA19122USA Department of Smart City Gachon UniversitySeongnam13120Korea

Base isolators used in buildings provide both a good acceleration reduction and structural vibration control *** base isolators may lose their damping capacity over time due to environmental or dynamic *** deterioration of them requires the determination of the maintenance and repair needs and is important for the long-termisolator *** this study,an artificial intelligence prediction model has been developed to determine the damage and maintenance-repair requirements of isolators as a result of environmental effects and dynamic factors over *** the developed model,the required damping capacity of the isolator structure was estimated and compared with the previously placed isolator capacity,and the decrease in the damping property was tried to be *** this purpose,a data set was created by collecting the behavior of structures with single degrees of freedom(SDOF),different stiffness,damping ratio and natural period isolated from the foundation under far fault *** data is divided into 5 different damping classes varying between 10%and 50%.Machine learning model was trained in damping classes with the data on the structure’s response to random seismic *** a result of the isolator behavior under randomly selected earthquakes,the recorded motion and structural acceleration of the structure against any seismic vibration were examined,and the decrease in the damping capacity was estimated on a class *** performance loss of the isolators,which are separated according to their damping properties,has been tried to be determined,and the reductions in the amounts to be taken into account have been determined by *** the developed prediction model,using various supervised machine learning classification algorithms,the classification algorithm providing the highest precision for the model has been *** the results are examined,it has been determined that the damping of the isolator structure with the

关键词： Vibration control base isolation machine learning damping capacity

On the interaction phenomena to the nonlinear generalized Hietarinta-type equation

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Journal of Ocean Engineering and Science 2024年第1期9卷 89-97页

作者： Usman Younas T.A.Sulaiman Jingli Ren A.yusuf State Key Laboratory of Power Grid Environmental Protection/Henan Academy of Big Data Zhengzhou UniversityZhengzhou 450001China Faculty of Science Federal University DutseJigawaNigeria Department of Computer Engineering Biruni University IstanbulTurkey

In this paper,we describe the nonlinear behavior of a generalized fourth-order Hietarinta-type equa-tion for dispersive waves in(2+1)*** various wave formations are retrieved by using Hirota’s bilinear method(HBM)and various test function *** Hirota method is a widely used and robust mathematical tool for finding soliton solutions of nonlinear partial differential equa-tions(NLPDEs)in a variety of disciplines like mathematical physics,nonlinear dynamics,oceanography,engineering sciences,and others requires bilinearization of nonlinear *** different wave structures in the forms of new breather,lump-periodic,rogue waves,and two-wave solutions are *** addi-tion,the physical behavior of the acquired solutions is illustrated in three-dimensional,two-dimensional,density,and contour profiles by the assistance of suitable *** on the obtained results,we can assert that the employed methodology is straightforward,dynamic,highly efficient,and will serve as a valuable tool for discussing complex issues in a diversity of domains specifically ocean and coastal *** have also made an important first step in understanding the structure and physical be-havior of complex structures with our findings *** believe this research is timely and relevant to a wide range of engineering *** results obtained are useful for comprehending the fundamental scenarios of nonlinear sciences.

关键词： Hirota’s bilinear method Lump-periodic solutions Breather waves Rouge waves Multi-waves

New lump interaction complexitons to the(2+1)-dimensional Korteweg-de Vries equation with electrostatic wave potential in plasmas

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Journal of Ocean Engineering and Science 2024年第2期9卷 173-177页

作者： Tukur Abdulkadir Sulaiman Abdullahi yusuf Alrazi Abdeljabbar Mustafa Bayram Department of Computer Engineering Biruni UniversityIstanbulTurkey Department of Mathematics Federal University DutseJigawaNigeria Department of Mathematics Near East University TRNCMersin 10Turkey Department of Mathematics Khalifa University for Science and TechnologyAbu DhabiUAE

A soliton is a packet of self-reinforcing waves that maintains its structure when moving at a constant *** are caused by the cancellation of the medium’s nonlinear and dispersive *** plas-mas,the bilinear form of Hirota will be utilized to investigate the(2+1)-dimensional Korteweg-de Vries equation with electrostatic wave *** for complexiton lump interaction have been *** throw further light on the physical qualities of the recorded data,certain 3-dimensional and contour plots are presented to illustrate the interaction elements of these solutions.

关键词： (2+1)-dimensional Korteweg-de Vries equation Multi waves solutions Brether waves solutions Numerical simulations