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Mediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults

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World Journal of Psychiatry 2025年第1期15卷 137-144页

作者： Juan Fang Li-Hui Li Ming-Qian He Yue ji Dong-Yan Lu Li-Bing Zhang jin-Lan Yao School of Medicine Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty has become a significant public health *** recent increase in the number of frail older adults has led to increased attention being paid to psycho-logical care services in *** social isolation of pre-frail older adults can impact their psychological *** To explore the mediating effect of health literacy between social isolation and psychological distress among communitydwelling older adults with *** This descriptive cross-sectional study was conducted with 254 pre-frail older individuals aged 60 years and *** isolation,health literacy,and psycholo-gical distress were comprehensively measured using the Lubben Social Network Scale-6,12-item Short-Form Health Literacy Questionnaire,and the Kessler Psy-chological Distress *** were evaluated using the SPSS 27.0 package program and the PROCESS macro *** statistical analyses,correlation analyses,and bootstrap mediation tests were used to assess associations between the *** The results showed that social isolation had an effect on health literacy among pre-frail older adults(β=0.240,P<0.001),social isolation impact on psycho-logical distress pre-frail older adults(β=-0.415,P<0.001);health literacy was identified effect on psychological distress among pre-frail older persons(β=-0.307,P<0.001).Health literacy partially mediated the relationship between social isolation and psychological distress among community-dwelling older adults with pre-frailty,with a mediation effect of-0.074,accounting for 17.83%of the total effect.

关键词： Frail Ageing Psychological distress Health literacy Social isolation

二仙丸加减方含药血清抑制巨噬细胞焦亡的物质基础和作用机制

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中国组织工程研究 2025年第19期29卷 4029-4037页

作者：李思源王瑜茹徐烨郭地南楠刘杨赵杰郝慧琴山西中医药大学第三临床学院山西省晋中市030619 山西中医药大学中西医结合基础实验室山西省晋中市030619 经方扶阳山西省重点实验室山西省太原市030013

背景:课题组前期研究发现二仙丸加减方可以缓解胶原诱导性关节炎大鼠炎症反应,但其作用机制尚需进一步验证。目的:分析二仙丸加减方入血成分,观察二仙丸加减方含药血清对J774A.1巨噬细胞焦亡的影响。方法:①二仙丸加减方入血成分分析:... 详细信息

背景:课题组前期研究发现二仙丸加减方可以缓解胶原诱导性关节炎大鼠炎症反应,但其作用机制尚需进一步验证。目的:分析二仙丸加减方入血成分,观察二仙丸加减方含药血清对J774A.1巨噬细胞焦亡的影响。方法:①二仙丸加减方入血成分分析:采用超高效液相色谱-高分辨质谱(UHPLC-HRMS)对二仙丸加减方及入血成分进行检测和鉴定。②二仙丸加减方含药血清对J774A.1巨噬细胞焦亡的影响:采用分子对接技术对二仙丸加减方入血成分倍半萜类化合物与NLRP3进行初步验证。将J774A.1巨噬细胞随机分为空白对照组、脂多糖+三磷酸腺苷组及脂多糖+三磷酸腺苷+二仙丸加减方含药血清低(2.5%)、中(5%)、高(10%)剂量组。根据试剂盒说明书检测各组细胞上清液中乳酸脱氢酶释放情况;ELISA检测各组细胞上清液中白细胞介素1β、白细胞介素18水平;Hoechst/PI染色法检测各组细胞膜受损情况;Western blot检测各组细胞中NLRP3、Caspase-1、GSDMD及GSDMD-N蛋白表达水平。结果与结论:①共鉴定出二仙丸加减方药效成分32个,入血成分21个,其中入血成分主要包括多种倍半萜类化合物;②分子对接结果显示3-O-Acetyl-13-deoxyphomenone、Incensol oxide、Atractylenolide Ⅲ、Rupestonic acid、3,7-Dihydroxy-9,11-eremophiladien-8-one与NLRP3之间结合活性较好;③与空白对照组相比,脂多糖+三磷酸腺苷组细胞上清中乳酸脱氢酶活性及白细胞介素1β、白细胞介素18水平均显著升高(P<0.001),Hoechst/PI染色可见PI阳性细胞数量显著增加。脂多糖+三磷酸腺苷+二仙丸加减方含药血清各组上述指标均显示不同程度降低;④与空白对照组相比,脂多糖+三磷酸腺苷组NLRP3、Caspase-1、GSDMD及GSDMD-N蛋白表达显著升高(P<0.05);与脂多糖+三磷酸腺苷组相比,脂多糖+三磷酸腺苷+二仙丸加减方含药血清各组细胞中NLRP3、Caspase-1、GSDMD及GSDMD-N蛋白表达均有不同程度降低(P<0.05),且具有一定的剂量依赖性。结果表明:二仙丸加减方含药血清可能通过调控NLRP3/Caspase-1/GSDMD通路抑制J774A.1巨噬细胞焦亡。

关键词：二仙丸加减方含药血清细胞焦亡 J774A.1巨噬细胞倍半萜类

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-jie Quan Hao Liang Yong-Hong Tang Li jiang Xiong-Ying ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

Formation of advanced glycation end products in raw and subsequently boiled broiler muscle:biological variation and effects of postmortem ageing and storage

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Food Science and Human Wellness 2022年第2期11卷 255-262页

作者： Suhong Huang Xiaoli Dong Yali Zhang yuru Chen Yajie Yu Ming Huang Yuandong Zheng Nanjing Innovation Center of Meat Products Processing Jiangsu Collaborative Innovation Center of Meat Production and ProcessingQuality and Safety Controland College of Food Science and TechnologyNanjing Agricultural UniversityNanjingJiangsu 210095China Nanjing Huangjiaoshou Food Science Technology Co. Ltd.National R&D Center for Poultry Processing TechnologyNanjingJiangsu 210095China Henan Province Qi County Yongda Food Industry Co. Ltd.HebiHenan 458000China

The study aimed to investigate and compare the contents of carboxymethyllysine(CML)in two kinds of broilers during postmortem ageing and *** contents of CML in raw and boiled(100℃,30 min)broiler briskets and legs which were from white feather broilers(n=8)and yellow feather broilers(n=8)with ageing and storage at 4℃for 0-168 h were *** ageing and storage had a significant(P0.05)change,while that in boiled brisket meat significantly(P0.05)effect on the CML contents in raw/boiled yellow feather ***,CML contents in white feather broilers were much higher than that in yellow feather ***,white feather broilers can be selected as the research object to study the mechanism of ageing and storage on CML content in the postmortem broiler in the future.

关键词： Carboxymethyllysine Broiler Postmortem ageing Storage Heating

A NONLOCAL KRONECKER-BASIS-REPRESENTATION METHOD FOR LOW-DOSE CT SINOGRAM RECOVERY

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Journal of Computational Mathematics 2024年第4期42卷 1080-1108页

作者： jian Lu Huaxuan Hu yuru Zou Zhaosong Lu Xiaoxia Liu Keke Zu Lin Li Shenzhen Key Laboratory of Advanced Machine Learning and Applications College of Mathematics and StatisticsShenzhen UniversityShenzhen 518060China National Center for Applied Mathematics Shenzhen(NCAMS) Shenzhen 518055China Department of Industrial and Systems Engineering University of Minnesota Twin CitiesMinneapolisMN55455USA Department of Applied Mathematics The Hong Kong Polytechnic UniversityHong Kong SARChina School of Electronic Engineering Xidian UniversityXi'an 710071China

Low-dose computed tomography(LDCT)contains the mixed noise of Poisson and Gaus-sian,which makes the image reconstruction a challenging *** order to describe the statistical characteristics of the mixed noise,we adopt the sinogram preprocessing as a stan-dard maximum a posteriori(MAP).Based on the fact that the sinogram of LDCT has non-local self-similarity property,it exhibits low-rank *** conventional way of solving the low-rank problem is implemented in matrix forms,and ignores the correlations among similar patch *** avoid this issue,we make use of a nonlocal Kronecker-Basis-Representation(KBR)method to depict the low-rank problem.A new denoising model,which consists of the sinogram preprocessing for data fidelity and the nonlocal KBR term,is developed in this *** proposed denoising model can better illustrate the generative mechanism of the mixed noise and the prior knowledge of the ***-merical results show that the proposed denoising model outperforms the state-of-the-art algorithms in terms of peak-signal-to-noise ratio(PSNR),feature similarity(FSIM),and normalized mean square error(NMSE).

关键词： Low-dose computed tomography Kronecker-basis-representation Low-rank imation.Noise-generating-mechanism

Haptic display for virtual reality: progress and challenges

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Virtual Reality & Intelligent Hardware 2019年第2期1卷 136-162页

作者： Dangxiao WANG Yuan GUO Shiyi LIU yuru ZHANG Weiliang XU jing XIAO State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100083China Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijing 100083China Peng Cheng Laboratory Shenzhen 518055China Department of Mechanical Engineering University of AucklandAuckland 1142New Zealand School of Computer Science and the Robotics Engineering Program Worcester Polytechnic InstituteWorcesterMA 01609-2280USA

Immersion, interaction, and imagination are three features of virtual reality (VR). Existing VR systems possess fairly realistic visual and auditory feedbacks, and however, are poor with haptic feedback, by means of which human can perceive the physical world via abundant haptic properties. Haptic display is an interface aiming to enable bilateral signal communications between human and computer, and thus to greatly enhance the immersion and interaction of VR systems. This paper surveys the paradigm shift of haptic display occurred in the past 30 years, which is classified into three stages, including desktop haptics, surface haptics, and wearable haptics. The driving forces, key technologies and typical applications in each stage are critically reviewed. Toward the future high-fidelity VR interaction, research challenges are highlighted concerning handheld haptic device, multimodal haptic device, and high fidelity haptic rendering. In the end, the importance of understanding human haptic perception for designing effective haptic devices is addressed.

关键词： Haptic display Virtual reality Desktop haptics Surface haptics Wearable haptics Multimodal haptics

Modulation of the plasma uniformity by coil and dielectric window structures in an inductively coupled plasma

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Plasma Science and Technology 2021年第9期23卷 111-122页

作者： Xiaoyan SUN yuru ZHANG jing YE Younian WANG jianxin HE Textile and Garment Industry of Research In stitute Zhongyuan University of Tech no logyZhengzhou 450007.People's Republic of China Key Laboratory of Materials Modification by Laser Ion and Electron Beams(Ministry of Education)School of PhysicsDalian University of TechnologyDalian 116024People's Republic of China School of Textiles Zhongyuan University of Technology.Zhengzhou 450007People's Republic of China

The effects of coil and dielectric window structures on the plasma distribution are examined in a cylindrically symmetric planar inductively coupled plasma(ICP).A two-dimensional(2 D)fluid model is employed to investigate the design issues of ICP source for *** the gradient coil structure is applied at 400 W and 20 mTorr,the ionization rate caused by the power deposition decreases at the reactor center as compared to that in a reactor with a planar coil above the planar dielectric window,and a rather uniform plasma is ***,for the vertical coil geometry,all the coils move to the position of the outermost coil,and the peaks of the power deposition and ionization rate appear at the radial edge of the *** this case,the plasma density is characterized by an edge-high ***,it is observed that the plasma uniformity is improved by increasing the source power under a gas pressure of 20 mTorr and becomes better when the gas pressure increases to 30 mTorr with the source power being fixed at400 W in the gradient coil configuration,but the uniformity of plasma worsens with the rising source power or pressure due to the strong localization in the vertical coil ***,when the discharge is sustained in a reactor with a stepped dielectric window at r=0.135 m,the best plasma uniformity is obtained at 400 W and 20 m Torr because the ionization rate is enhanced at the outermost coil,and the dielectric window at r=0.135 m blocks the diffusion of plasma towards the *** addition,higher source power and lower gas pressure produce more uniform plasma for the designs with a stepped window near the symmetry *** the dielectric window is stepped at r=0.135 m,the non-uniformity of plasma initially decreases and then increases with the increase in source power or gas *** the dielectric window is stepped at the radial edge of the chamber,the plasma uniformity is improved by increasing the source power and gas pressure due t

关键词： fluid simulation gradient coil vertical coil stepped dielectric window plasma uniformity

Haptic rendering for dental training system

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Science in China(Series F) 2009年第3期52卷 529-546页

作者： WANG DangXiao ZHANG yuru WANG Yong LU PeiJun ZHOU RenGe ZHOU WanLin State Key Laboratory of Virtual Reality Technology and Systems Beihang University Beijing 100191 China School and Hospital of Stomatology Peking University Beijing 100081 China

Immersion and interaction are two key features of virtual reality systems, which are especially important for medical applications. Based on the requirement of motor skill training in dental surgery, haptic rendering method based on triangle model is investigated in this paper. Multi-rate haptic rendering architecture is proposed to solve the contradiction between fidelity and efficiency requirements. Realtime collision detection algorithm based on spatial partition and time coherence is utilized to enable fast contact determination. Proxy-based collision response algorithm is proposed to compute surface contact point. Cutting force model based on piecewise contact transition model is proposed for dental drilling simulation during tooth preparation. Velocity-driven levels of detail haptic rendering algorithm is proposed to maintain high update rate for complex scenes with a large number of triangles. Hapticvisual collocated dental training prototype is established using half-mirror solution. Typical dental operations have been realized including dental caries exploration, detection of boundary within dental cross-section plane, and dental drilling during tooth preparation. The haptic rendering method is a fundamental technology to improve immersion and interaction of virtual reality training systems, which is useful not only in dental training, but also in other surgical training systems.

关键词： haptic rendering computer haptics haptic-visual collocation dental training hand-eye coordination

Supersaturated bridge-sulfur and vanadium co-doped MoS_(2) nanosheet arrays with enhanced sodium storage capability

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Nano Research 2021年第1期14卷 74-80页

作者： yuru Dong Zhengju Zhu Yanjie Hu Guanjie He Yue Sun Qilin Cheng Ivan P.Parkin Hao jiang Key Laboratory for Ultrafine Materials of Ministry of Education Shanghai Engineering Research Center of Hierarchical Nanomaterialsy School of Materials Science and EngineeringEast China University of Science&TechnologyShanghai 200237China Christopher Ingold Laboratory Department of ChemistryUniversity College London20 Gordon StreetLondon WC1H0AJUK

The low specific capacity and sluggish electrochemical reaction kinetics greatly block the development of sodium-ion batteries(SIBs).New high-performance electrode materials will enhance development and are urgently required for ***,we report the preparation of supersaturated bridge-sulfur and vanadium co-doped MoS2 nanosheet arrays on carbon cloth(denoted as V-MoS_(2+x)/CC).The bridge-sulfur in M0S2 has been created as a new active site for greater Na^(+)*** vanadium doping increases the density of carriers and facilitates accelerated electron *** synergistic dual-doping effects endow the V-MoS_(2+x)/CC anodes with high sodium storage *** optimized V-MoS_(2.49)/CC gives superhigh capacities of 370 and 214 mAh·g^(-1)at 0.1 and 10 A·g^(-1)within 0.4-3.0 V,*** cycling 3,000 times at 2 A·g^(-1),almost 83%of the reversible capacity is *** findings indicate that the electrochemical performances of metal sulfides can be further improved by edge-engineering and lattice-doping co-modification concept.

关键词： MoS_(2) bridge-sulfur high specific capacity sodium-ion battery cycle life