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Trilayer anisotropic structure versus randomly oriented structure in heart valve leaflet tissue engineering

Bio-Design and Manufacturing 2023年第4期6卷 423-438页

作者： yuriy snyder Soumen Jana Department of Bioengineering University of MissouriColumbiaMO 65211USA

It has been hypothesized that leaflet substrates with a trilayer structure and anisotropicmechanical properties could be useful for the production of functional and long-lasting tissue-engineered *** investigate the influence of the anisotropic structural and mechanical characteristics of a substrate on cells,in this study,we electrospun trilayer anisotropic fibrous substrates and randomly oriented isotropic fibrous substrates(used as controls)from polycaprolactone ***,the random substrates had higher radial and lower circumferential tensile properties than the trilayer substrates;however,they had similar flexural *** valvular interstitial cells cultured on both substrates produced random and trilayer cell-cultured constructs,*** trilayer cell-cultured constructs had more anisotropic mechanical properties,17%higher cellular proliferation,14%more extracellular matrix(i.e.,collagen and glycosaminoglycan)production,and superior gene and protein expression,suggesting that more cells were in a growth state in the trilayer constructs than in the random ***,the random and radial layers of the trilayer constructs had more vimentin,collagen,transforming growth factor-beta 1(TGF-ß1),transforming growth factor-beta 3(TGF-ß3)gene expression than in the circumferential layer of the *** study verifies that the differences in structural,tensile,and anisotropic properties of the trilayer and random substrates influence the characteristics of the cells and ECM in the constructs.

关键词： Heart valve leaflet Trilayer Tissue engineering Fiber Electrospinning

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