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Neurohumoral,cardiac and inflammatory markers in the evaluation of heart failure severity and progression

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Journal of Geriatric Cardiology 2021年第1期18卷 47-66页

作者： Ekaterina A Polyakova Evgeny N Mikhaylov Dmitry L Sonin yuri V Cheburkin Mikhail M Galagudza Almazov National Medical Research Centre Saint-PetersburgRussia

Heart failure is common in adult population,accounting for substantial morbidity and mortality *** main risk factors for heart failure are coronary artery disease,hypertension,obesity,diabetes mellitus,chronic pulmonary diseases,family history of cardiovascular diseases,cardiotoxic *** main factor associated with poor outcome of these patients is constant progression of heart *** the current review we present evidence on the role of established and candidate neurohumoral biomarkers for heart failure progression management and diagnostics.A growing number of biomarkers have been proposed as potentially useful in heart failure patients,but not one of them still resembles the characteristics of the"ideal biomarker."A single marker will hardly perform well for screening,diagnostic,prognostic,and therapeutic management ***,the pathophysiological and clinical significance of biomarkers may depend on the presentation,stage,and severity of the *** authors cover main classification of heart failure phenotypes,based on the measurement of left ventricular ejection fraction,including heart failure with preserved ejection fraction,heart failure with reduced ejection fraction,and the recently proposed category heart failure with mid-range ejection *** could envisage specific sets of biomarker with different performances in heart failure progression with different left ventricular ejection fraction especially as concerns prediction of the future course of the disease and of left ventricular adverse/reverse *** article is intended to provide an overview of basic and additional mechanisms of heart failure progression will contribute to a more comprehensive knowledge of the disease pathogenesis.

关键词： cardiac and inflammatory markers in the evaluation of heart failure severity and progression Neurohumoral

A sensing mechanism for the detection of carbon nanotubes using selective photoluminescent probes based on ionic complexes with organic dyes

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Light(Science & Applications) 2016年第1期5卷 686-694页

作者： Petro Lutsyk Raz Arif Jan Hruby Anatolii Bukivskyi Olexander Vinijchuk Mykola Shandura Viktor yakubovskyi yuri Kovtun Graham A Rance Michael Fay yuri Piryatinski Oleksiy Kachkovsky Anatoli Verbitsky Aleksey Rozhin Institute of Physics National Academy of Sciences of Ukraine46prospekt Nauky03680 KyivUkraine School of Engineering&Applied Science Aston UniversityAston TriangleB47ET BirminghamUK Physics Department Faculty of ScienceUniversity of SulaimaniP.O.Box 334SulaimaniIraq-Kurdistan Region Brno University of Technology CEITEC BUTTechnicka´3058/1061600 BrnoCzech Republic Institute of Organic Chemistry National Academy of Sciences of Ukraine5 Murmanska str.02660 KyivUkraine School of Chemistry University of NottinghamUniversity ParkNottinghamNG72RDUK Nottingham Nanotechnology and Nanoscience Centre University of NottinghamUniversity ParkNottinghamNG72RDUK

The multifunctional properties of carbon nanotubes(CNTs)make them a powerful platform for unprecedented innovations in a variety of practical *** a result of the surging growth of nanotechnology,nanotubes present a potential problem as an environmental pollutant,and as such,an efficient method for their rapid detection must be ***,we propose a novel type of ionic sensor complex for detecting CNTs–an organic dye that responds sensitively and selectively to CNTs with a photoluminescent *** complexes are formed through Coulomb attractions between dye molecules with uncompensated charges and CNTs covered with an ionic surfactant in *** demonstrate that the photoluminescent excitation of the dye can be transferred to the nanotubes,resulting in selective and strong amplification(up to a factor of 6)of the light emission from the excitonic levels of CNTs in the near-infrared spectral range,as experimentally observed via excitation-emission photoluminescence(PL)*** chirality of the nanotubes and the type of ionic surfactant used to disperse the nanotubes both strongly affect the amplification;thus,the complexation provides sensing selectivity towards specific ***,neither similar uncharged dyes nor CNTs covered with neutral surfactant form such *** model organic molecules,we use a family of polymethine dyes with an easily tailorable molecular structure and,consequently,tunable absorbance and PL *** provides us with a versatile tool for the controllable photonic and electronic engineering of an efficient probe for CNT detection.

关键词： carbon nanotubes ionic surfactant organic dye photoluminescence sensor

Neurogenic potential of NG2 in neurotrauma:a systematic review

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Neural Regeneration Research 2024年第12期19卷 2673-2683页

作者： yuri R.Rigo Radharani Benvenutti Luis V.Portela Nathan R.Strogulski Departamento de Bioquímica Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreBrazil School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health SciencesDublinIreland School of Biochemistry and Immunology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Regenerative approaches towards neuronal loss following traumatic brain or spinal cord injury have long been considered a dogma in neuroscience and remain a cutting-edge area of *** is reflected in a large disparity between the number of studies investigating primary and secondary injury as therapeutic to rgets in spinal co rd and traumatic brain *** advances in biotechnology may have the potential to reshape the current state-of-the-art and bring focus to primary injury neurotrauma *** studies using neural-glial factor/antigen 2(NG2)cells indicate that they may differentiate into neurons even in the developed *** these cells show great potential to play a regenerative role,studies have been conducted to test various manipulations in neurotrauma models aimed at eliciting a neurogenic response from *** the present study,we systematically reviewed the experimental protocols and findings described in the scientific literature,which were peer-reviewed original research articles(1)describing preclinical experimental studies,(2)investigating NG2 cells,(3)associated with neurogenesis and neurotrauma,and(4)in vitro and/or in vivo,available in PubMed/MEDLINE,Web of Science or SCOPUS,from 1998 to ***,we have reviewed a total of 1504 papers,and summarized findings that ultimately suggest that NG2 cells possess an inducible neurogenic potential in animal models and in *** also discriminate findings of NG2 neurogenesis promoted by different pharmacological and genetic approaches over functional and biochemical outcomes of traumatic brain injury and spinal co rd injury models,and provide mounting evidence for the potential benefits of manipulated NG2 cell ex vivo transplantation in primary injury *** findings indicate the feasibility of NG2 cell neurogenesis strategies and add new players in the development of therapeutic alternatives for neurotrauma.

关键词： neural-glial antigen 2 neural-glial factor 2 neuron differentiation NG2 cell regeneration spinal cord injury(SCI) traumatic brain injury(TBI)

Unique Marine Olenekian-Anisian Boundary Section from South Primorye, Russian Far East

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Journal of China University of Geosciences 2005年第3期16卷 219-230页

作者： yuri D Zakharov Alexander M Popov Galina I Buryi Far Eastern Geological Institute Russian Academy of Sciences (Far Eastern Branch) Stoletiya Prospect 159 Vladivostok 690022 RussiaFar Eastern Geological Institute Russian Academy of Sciences (Far Eastern Branch) Stoletiya Prospect 159 Vladivostok 690022 Russia Far Eastern Geological Institute Russian Academy of Sciences (Far Eastern Branch) Stoletiya Prospect 159 Vladivostok 690022 Russia

To show paleontological characteristics of the Olenekian-Anislan boundary beds in the Russian Far East, a review of new data on the Upper Olenekian and Lower Anisian biostratigraphy of South Primorye is given on the basis of five sections： Golyi Cape, Petrovka River, Zhitkov Peninsula, Tchernyschew Bay and Atlasov Cape, using new ammonoid, brachiopod and conodont findings. The most representative ammonoid assemblage at the base of the Anisian was discovered in the Ussuriphyllites amurensis Zone （10.6 m thick） of the Atlasov Cape Section： Parasageceras sp. nov., Prionitidae gen. et sp. nov. , Ussuriphyllites amurensis （Kiparisova）（dominant）, Megaphyllites atlasoviensis Zakharov, Leiophyllites praematurus Kiparisova, Leiophyllites sp. , Ussurites sp. , Paradanubites sp. indet., Paracrochordiceras sp. nov., Prohungarites popowi Kiparisova, Arctohungarites primoriensis Zakharov, A. solimani （Toula）, Salterites sp. indet. （gigantic shell）, and Tropigastrites sublachontanus Zakharov. Conodonts Neospathodus cf. homeri （Bender） were found in the lower part of the Ussuriphyllites amurensis Zone of the Atlasov Cape. The Atlasov Cape seems to be one of the very promising sections of the Russian Far East for detailed investigation of the Olenekian-Anisian boundary.

关键词： South Primorye Triassic Olenekian-Anisian boundary ammonoid conodont

Development of waste-to-energy through integrated sustainable waste management:the case of ABREN WtERT Brazil towards changing status quo in Brazil

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Waste Disposal and Sustainable Energy 2023年第3期5卷 295-308页

作者： yuri Schmitke Almeida Belchior Tisi Flavio Arantes Matos Maria Luisa N.M.Carneiro Waste to Energy Research and Technology Council—WtERT Brasil Distrito FederalBrasília71316-109Brazil Waste to Energy Research and Technology Council—WtERT Brasil Ribeirão PretoSão PauloBrazil Waste to Energy Research and Technology Council—WtERT Brasil Rio de JaneiroBrazil

In the context of circular economy,it is known that once waste is generated,it should be subject to proper treatment for recovering material or energy before being *** countries worldwide,especially developing countries such as Brazil,have been struggling to effectively apply sustainable waste management in municipalities and still rely on dumpsites and unsuitable ***,a weak legal framework,lack of financial resources and poor infra-structure as well as pressure from organizations profiting from the expansion of landfills are some factors contributing to the preservation of the negative status quo:the“landfill culture”.Material recovery,i.e.,recycling and composting,is applied to less than 5%of Brazilian municipal waste,while 95%is disposed of in landfills or *** this context,ABREN WtERT(Waste-to-Energy Research and Technology Council)Brazil was created in 2019 as the first permanent organization formed to promote the development of energy and material recovery from waste focused on the waste-to-energy(WTE)*** this paper,the strategy proposed and implemented by the organization towards changing the status quo in Brazil through an integrated sustainable waste management approach is *** proposed strategy integrates the concepts of Sustainability and Circular Economy for minimizing landfill disposal(avoiding methane emissions)and maximizing material/energy *** others,the approach focuses on changing the public opinion regarding thermal treatment facilities,mainly incinerators,which has been wrongly linked to pollution,excessive public expenditures and considered a harm to the recycling *** activities performed by ABREN include engaging public and private institutions,enhancing education,leading the publication of research and business studies,gathering industry members and academy experts,as well as creating strategic alliances with players around the *** a result,within a few years,major

关键词： Integrated Sustainable Waste Management(ISWM) Waste-to-energy(WTE) Municipal solid waste(MSW) Energy recovery

Correlation between surface charge and hydration on mineral surfaces in aqueous solutions: A critical review

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International Journal of Minerals,Metallurgy and Materials 2020年第7期27卷 857-871页

作者： Hong-liang Li Wen-nan Xu Fei-fei Jia Jian-bo Li Shao-xian Song yuri Nahmad College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G2V4Canada School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China Instituto de Fiscia Universidad Autonoma de San Luis PotosiAv.Sierra LeonaSan Luis Potosi 78000Mexico

Surface charges and hydration are predominant properties of colloidal particles that govern colloidal stability in aqueous *** properties usually coexist and interact with each *** correlation between the surface charge and hydration of minerals is summarized on the basis of innovative experimental,theoretical,and molecular dynamics simulation *** factors affecting the adsorption behavior of ions and water molecules,such as ion concentration,ion hydration radius and valence,and surface properties,are *** example,the hydration and adsorption states completely differ between monovalent and divalent *** ions of the same valence,the effect of surface charge on the hydration force follows the Hofmeister adsorption *** concentration exerts a significant effect on the hydration force at high ion ***,the ion correlations in high-concentration electrolyte systems become long *** interfacial water structure largely depends on surface *** hydration layer between different surfaces shows large qualitative differences.

关键词： surface hydration surface charged ion mineral water molecule

Current application of neurofilaments in amyotrophic lateral sclerosis and future perspectives

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Neural Regeneration Research 2021年第10期16卷 1985-1991页

作者： yuri Matteo Falzone Tommaso Russo Teuta Domi Laura Pozzi Angelo Quattrini Massimo Filippi Nilo Riva Neuropathology Unit Institute of Experimental NeurologyDivision of NeuroscienceSan Raffaele Scientific InstituteMilanItaly Neurology and Neurorehabilitation Unit IRCCS SanRaffaele Scientific InstituteMilanItaly Neurophysiology Unit IRCCS San Raffaele Scientific InstituteMilanItaly Neuroimaging Research Unit Institute of Experimental NeurologyDivision of NeuroscienceIRCCS San Raffaele Scientific InstituteMilanItaly Vita-Salute San Rafaele University MilanItaly

Motor neuron disease includes a heterogeneous group of relentless progressive neurological disorders defined and characterized by the degeneration of motor *** lateral sclerosis is the most common and aggressive form of motor neuron disease with no effective treatment so ***,diagnostic and prognostic biomarkers are lacking in clinical *** are fundamental structural components of the axons and neurofilament light chain and phosphorylated neurofilament heavy chain can be measured in both cerebrospinal fluid and *** light chain and phosphorylated neurofilament heavy chain levels are elevated in amyotrophic lateral sclerosis,reflecting the extensive damage of motor neurons and ***,neurofilaments are now increasingly recognized as the most promising candidate biomarker in amyotrophic lateral *** potential usefulness of neurofilaments regards various aspects,including diagnosis,prognosis,patient stratification in clinical trials and evaluation of treatment *** this review paper,we review the body of literature about neurofilaments measurement in amyotrophic lateral *** also discuss the open issues concerning the use of neurofilaments clinical practice,as no overall guideline exists to date;finally,we address the most recent evidence and future perspectives.

关键词： amyotrophic lateral sclerosis biomarkers motor neuron disease neurofilament light chain phosphorylated neurofilament heavy chain

The first results of observations of lunar occultations in different spectral ranges at the 6-m telescope of the SAO RAS

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Research in Astronomy and Astrophysics 2020年第11期20卷 231-234页

作者： Ekaterina Shmaylova Vladimir Dyachenko Andrea Richichi Anatoly Beskakotov AleksandrMaksimov Arina Mitrofanova yuri Balega Special Astrophysical Observatory Russian Academy of SciencesNizhniy ArkhyzKarachai-Cherkessian RepublicRussia 369167 Astronomical Institute St.Petersburg State UniversityUniversitetskij Pr.28Petrodvorets198504St.PetersburgRussia INAF-Osservatorio Astrofisico di Arcetri Largo E.Fermi 550125FirenzeItaly

Observations by the method of lunar occultations at the 6-m telescope of the SAO RAS reach a resolution limit better than *** have devised a new method of observation,which allows obtaining the curves of lunar occultations simultaneously in different ranges of the visible part of the spectrum,and conducted the first observations using amodified optical *** January 2019,applying the newmethod,the magnitude differences of the components of the binary star HD 36524 in the R and I bands were measured,which were 1.5 and 1.3mag,respectively,in good agreement with values calculated from the Gaia *** to the obtained data,it was determined that with this method it is possible to reach a signal-to-noise ratio of about 5–10 for stars of 10th *** discuss the applicability of the proposed optical scheme for the study of binary stars.

关键词： star binaries general instrumentation high angular resolution methods observational

Room-temperature lasing from nanophotonic topological cavities

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Light(Science & Applications) 2020年第1期9卷 823-830页

作者： Daria Smirnova Aditya Tripathi Sergey Kruk Min-Soo Hwang Ha-Reem Kim Hong-Gyu Park yuri Kivshar Nonlinear Physics Center Research School of PhysicsAustralian National UniversityCanberraACT 2601Australia Institute of Applied Physics Russian Academy of ScienceNizhny Novgorod 603950Russia Department of Physics Indian Institute of TechnologyDelhi 110016India Department of Physics Korea UniversitySeoul 02841Republic of Korea

The study of topological phases of light underpins a promising paradigm for engineering disorder-immune compact photonic devices with unusual *** with an optical gain,topological photonic structures provide a novel platform for micro-and nanoscale lasers,which could benefit from nontrivial band topology and spatially localized gap ***,we propose and demonstrate experimentally active nanophotonic topological cavities incorporating Ⅲ-Ⅴ semiconductor quantum wells as a gain medium in the *** observe room-temperature lasing with a narrow spectrum,high coherence,and threshold *** emitted beam hosts a singularity encoded by a triade cavity mode that resides in the bandgap of two interfaced valley-Hall periodic photonic lattices with opposite parity *** findings make a step towards topologically controlled ultrasmall light sources with nontrivial radiation characteristics.

关键词： lasing singularity narrow