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Current and future perspectives on acute-on-chronic liver failure: Challenges of transplantation, machine perfusion, and beyond

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world Journal of Gastroenterology 2022年第48期28卷 6922-6934页

作者： Bianca della Guardia Amanda P C S Boteon Celso E l Matielo Guilherme Felga yuri l Boteon liver Unit Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil

Acute-on-chronic liver failure(AClF)is a syndrome that occurs in patients with chronic liver disease and is characterized by acute decompensation,organ failure and high short-term *** due to the lack of universal diagnostic criteria,the actual AClF prevalence remains unclear;nevertheless,it is expected to be a highly prevalent condition *** transplantation is an effective protective measure for selected AClF *** liver transplantation,diagnosing and treating precipitant events and providing supportive treatment for organ failures are currently the cornerstone of AClF *** new clinical specific therapies have been researched,more studies are necessary to assess safety and ***,future AClF management strategies must consider measures to improve access to liver transplantation because the time window for this life-saving therapy is frequently ***,an urgent and global discussion about allocation and prioritization for transplantation in critically ill AClF patients is needed because there is evidence suggesting that the current model may not portray their waitlist *** addition,while donor organ quality is meant to be a prognostic factor in the AClF setting,recent evidence suggests that machine perfusion of the liver may be a safe tool to improve the donor organ pool and expedite liver transplantation in this scenario.

关键词： Acute-on-chronic liver failure liver cirrhosis liver transplantation Machine perfusion Hypothermic oxygenated machine perfusion

cell2mol:encoding chemistry to interpret crystallographic data

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npj Computational Materials 2022年第1期8卷 1787-1794页

作者： Sergi Vela Ruben laplaza yuri Cho Clémence Corminboeuf laboratory for Computational Molecular design(lCMD) Institute of Chemical Sciences and Engineering(ISIC)École Polytechnique Fédérale de Lausanne(EPFL)CH-1015LausanneSwitzerland National Centre for Computational design and Discovery of Novel Materials(NCCR MARVEl) Ecole Polytechnique Fédérale de Lausanne1015LausanneSwitzerland National Centre for Competence in Research“Sustainable chemical processes through catalysis(NCCR Catalysis)” École Polytechnique Fédérale de Lausanne1015LausanneSwitzerland

The creation and maintenance of crystallographic data repositories is one of the greatest data-related achievements in *** such as the Cambridge Structural Database host what is likely the most diverse collection of synthesizable *** properly mined,they could be the basis for the large-scale exploration of new regions of the chemical space using quantum chemistry(QC).Yet,it is currently challenging to retrieve all the necessary information for QC codes based exclusively on the available structural data,especially for transition metal *** overcome this limitation,we present cell2mol,a software that interprets crystallographic data and retrieves the connectivity and total charge of molecules,including the oxidation state(OS)of metal *** demonstrate that cell2mol outperforms other popular methods at assigning the metal OS,while offering a comprehensive interpretation of the unit *** code is made available,as well as reliable QC-ready databases totaling 31k transition metal complexes and 13k ligands that contain incomparable chemical diversity.

关键词： offering overcome properly

Update on the management and treatment of viral hepatitis

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world Journal of Gastroenterology 2021年第23期27卷 3249-3261页

作者： Patricia Holanda Almeida Celso E l Matielo lilian A Curvelo Rodrigo A Rocco Guilherme Felga Bianca della Guardia yuri l Boteon liver Unit Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil

This review aims to summarize the current evidence on the treatment of viral hepatitis,focusing on its clinical ***,future treatment options and areas of potential research interest are *** and Scopus databases were searched for primary studies published within the last ten *** included hepatitis A virus,hepatitis B virus(HBV),hepatitis C virus,hepatitis D virus(HDV),hepatitis E virus,and *** reported in the studies were summarized,tabulated,and *** advances in viral hepatitis treatment were accomplished,such as the advent of curative therapies for hepatitis C and the development and improvement of hepatitis A,hepatitis B,and hepatitis E *** that cure hepatitis B,going beyond viral suppression,are so far unavailable;however,targeted antiviral drugs against HBV(immunomodulatory therapies and gene silencing technologies)are promising approaches to eradicating the ***,high vaccination coverage and large-scale test-and-treat programmes with high screening rates may eliminate viral hepatitis and mitigate their burden on health *** development of curative hepatitis C treatment renewed the enthusiasm for curing hepatitis B,albeit further investigation is *** therapeutic options targeting HDV life cycle are currently under clinical investigation.

关键词： Viral hepatitis Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus

Assessing workability of greased bearings after long-term storage

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Friction 2019年第5期7卷 489-496页

作者： Michael VARENBERG yuri KlIGERMAN Grigory HAlPERIN Saad NAKAD Haytam KASEM George w.woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA30332USA department of Mechanical Engineering Technion-Israel Institute of TechnologyHaifa32000Israel department of Mechanical Engineering Azrieli College of EngineeringJerusalem9103501Israel

Here, we developed a technique to assess the workability of sealed-for-life greased rolling bearings after a long-term storage. In this framework, we devised a model of equivalent transition between the conditions of natural ageing under daily and seasonally fluctuating temperature, and the conditions of accelerated thermal ageing at a constant high temperature. The tested bearings were thermally aged, and then their steady state friction and outer ring temperature were examined in a custom high-speed spindle. These results were compared to the performance of a reference new bearing tested under the same loading conditions. Our findings suggest that long-term storage can significantly degrade the performance of sealed-for-life greased rolling bearings. However, a proper running-in can substantially deter the ageing-driven degradation of the bearings.

关键词： grease lubrication ball bearings thermal ageing lubricant degradation

维普期刊数据库

Energy Harvesting Based on Magnetic Dispersion for Three-Phase Power System

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Energy and Power Engineering 2013年第3期5卷 20-23页

作者： Tarcisio Oliveira de Moraes Júnior yuri Percy Molina Rodriguez Ewerton Cleudson de sousa Melo Maraiza Prescila dos Santos Cleonilson Protásio de Souza Federal Institute of Paraíba-IFPB CajazeirasBrazil department of Electrical Engineering Federal University of Paraíba-UFPBJoao PessoaBrazil

This paper presents a comparative study on Magnetic-Dispersion based Energy Harvesting Systems (MD-EHS) on electrical conductors that supply power for a three-phase AC motor. It introduces two MD-EHS which are based on magnetic cores of different material, named, nanocrystalline, ferrite and iron powder. The first one consists of harvesting energy from magnetic flux through three symmetrical magnetic cores installed on each power conductors of a three-phase AC motor. The second one consists of a single magnetic core for harvesting energy from magnetic flux of only one of these conductors. Both ones have an AC/DC converter and a variable resistor based load. Experimental results have agreed with the theoretical analysis and show that the first proposed MD-EHS is capable of supplying 14 times more energy than the second MD-EHS, considering nanocrystalline cores and phase current of 3 A, and 7.5 times more energy, considering ferrite cores and phase current of 9 A. Such energy can be applied to various low-power devices, especially in wireless sensor network.

关键词： Energy Harvesting Magnetic Dispersion Magnetic Cores

In Silico Evaluation of the Potential Interference of Boceprevir, Calpain Inhibitor II, Calpain Inhibitor XII, and GC376 in the Binding of SARS-CoV-2 Spike Protein to Human Nanobody Nb20

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Open Journal of Biophysics 2023年第3期13卷 35-49页

作者： yuri Alves de Oliveira Só Marcelo lopes Pereira Junior wiliam Ferreira Giozza Rafael Timóteo de sousa Junior Ricardo Gargano luiz Antônio Ribeiro Júnior Institute of Physics University of Brasília Brasília Brazil department of Electrical Engineering University of Brasília Brasília Brazil

Virtual screening can be a helpful approach to propose treatments for COVID-19 by developing inhibitors for blocking the attachment of the virus to human cells. This study uses molecular docking, recovery time and dynamics to analyze if potential inhibitors of main protease (Mpro) of SARS-CoV-2 can interfere in the attachment of nanobodies, specifically Nb20, in the receptor binding domain (RBD) of SARS-CoV-2. The potential inhibitors are four compounds previously identified in a fluorescence resonance energy transfer (FRET)-based enzymatic assay for the SARS-CoV-2 Mpro: Boceprevir, Calpain Inhibitor II, Calpain Inhibitor XII, and GC376. The findings reveal that Boceprevir has the higher affinity with the RBD/Nb20 complex, followed by Calpain Inhibitor XII, GC376 and Calpain Inhibitor II. The recovery time indicates that the RBD/Nb20 complex needs a relatively short time to return to what it was before the presence of the ligands. For the RMSD the Boceprevir and Calpain Inhibitor II have the shortest interaction times, while Calpain Inhibitor XII shows slightly more interaction, but with significant pose fluctuations. On the other hand, GC376 remains stably bound for a longer duration compared to the other compounds, suggesting that they can potentially interfere with the neutralization process of Nb20.

关键词： SARS-CoV-2 Main protease Mpro Boceprevir Calpain Inhibitor II Calpain Inhibitor XII GC376 Nanobody Nb20 In Silico

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Pedosphere 2017年第4期27卷 747-757页

作者： Alba l.A.SKORUPA Sérgio H.G.SIlVA Giovana C.POGGERE Diego TASSINARI leundro C.PINTO yuri l.ZINN Nilton CURI departamento de Ciéncia do Solo Universidade Federal de LavrasCampusLavras MG 37200-000Brazil

Soils result from the interaction of five independent formation *** one factor varies,while the others remain constant,different soils can be ***,we demonstrated an opposing trend,wherein two soils were similar,despite considerable differences in all factors of soil *** sampled two Inceptisols(Oxic Dystrudepts) formed on different parent materials(gneiss *** schist),climate(tropical altimontane ***,drier plateau),topography(1 650 m,45% slope vs.1 000 m,8% slope),time(rejuvenated ***,stable surface),and vegetation(rainforest *** savanna).The two soils had similar chemical properties,whereas the soil on mica schist had finer particle size distribution,lower porosity,and lower saturated hydraulic *** properties were related to a coarser blocky microstructure compared to the soil on *** soils presented active mineral weathering and pronounced pedoplasmation,demonstrated by clay contents>300 g kg^(-1),although only the Dystrudept on gneiss possessed coarse rock *** C horizons of both soils presented fragmented clay coatings suggestive of argilluviation,likely relict,because they were not observed in the B *** similarities in many properties of the two Dystrudepts,despite contrasting factors of soil formation,suggest converging evolution and that soil classification at the subgroup level was efficient in grouping similar formative processes in tropical ***,this work revealed that similar pedogenic processes acting on different factors of soil formation can result in similar soil properties,at least for Inceptisols where further soil development is hindered by topographic limitations.

关键词： mineral weathering, Oxic Dystrudept, pedogenic process, soil genesis, soil micromorphology, soil property, soil taxonomy

维普期刊数据库

A Clustering Algorithm for Planning the Integration Process of a large Number of Conceptual Schemas

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Journal of Computer Science & Technology 2015年第1期30卷 214-224页

作者： Carlo Batini: Paola Bonizzoni Marco Comerio Riccardo Dondi yuri Pirola Prancesco Salandra department of Informatics Systems and Communication University of Milano-Bicocca Milan 20126 Italy department of Human and Social Sciences University of Bergamo Bergamo 24129 Italy

when tens and even hundreds of schemas are involved in the integration process, criteria are needed for choosing clusters of schemas to be integrated, so as to deal with the integration problem through an efficient iterative process. Schemas in clusters should be chosen according to cohesion and coupling criteria that are based on similarities and dissimilarities among schemas. In this paper, we propose an algorithm for a novel variant of the correlation clustering approach that addresses the problem of assisting a designer in integrating a large number of conceptual schemas. The novel variant introduces upper and lower bounds to the number of schemas in each cluster, in order to avoid too complex and too simple integration contexts respectively. we give a heuristic for solving the problem, being an NP hard combinatorial problem. An experimental activity demonstrates an appreciable increment in the effectiveness of the schema integration process when clusters are computed by means of the proposed algorithm w.r.t, the ones manually defined by an expert.

关键词： conceptual schema schema integration clustering

High resolution imaging using scanning ion conductance microscopy with improved distance feedback control

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Progress in Natural Science:Materials International 2008年第6期18卷 671-677页

作者： Nicholas Johnson Victor Ostanin Andrew Shevchuk yuri Korchev David Klenerman department of Chemistry University of CambridgeLensfield RoadCambridge CB2 1EWUnited Kingdom Division of Medicine Imperial College LondonMRC Clinical Sciences CentreHammersmith CampusLondon W12 0NNUnited Kingdom

Microscopy is an essential technique for observation on living *** is currently great interest in applying scanning probe microscopy to image-living biological cells in their natural environment at the nanometer *** ion conductance microscopy is a new form of scanning probe microscopy,which enables non-contact high-resolution imaging of living biological *** on a scanned nanopipette in physiological buer,the distance feedback control uses the ion current to control the distance between the pipette tip and the sample ***,this feedback control has diculties over slopes on convoluted cell surfaces,which limits its *** this study,we present an improved form of feedback control that removes the contribution of up to the third-order slope from the ion current signal,hence providing a more accurate signal for controlling the *** show that this allows faster and lower noise topographic high-resolution imaging.

关键词： living biological cells Scanning ion conductance microscopy Distance feedback control