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Highly efficient gene silencing and bioimaging based on fluorescent carbon dots in vitro and in vivo

Nano Research 2017年第2期10卷 503-519页

作者： Seongchan Kim yuri Choi Ginam Park Cheolhee Won Young-Joon Park Younghoon Lee Byeong-Su Kim DaI-Hee Min Center for RNA Research Institute for Basic Sciences (IBS) Department of Chemistry Seoul National University Seou108826 Republic of Korea Department of Energy Engineering and Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Republic of Korea Institute of Nanobio Convergence Technology Lemonex Inc. Seou108826 Republic of Korea College of Pharmacy Ajou University Worldcuplo 206 Yeongtong-gu Suwon 16499 Republic of Korea Department of Chemistry Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea

Small interfering RNA （siRNA） is an attractive therapeutic candidate for sequence- specific gene silencing to treat incurable diseases using small molecule drugs. However, its efficient intracellular delivery has remained a challenge. Here, we have developed a highly biocompatible fluorescent carbon dot （CD）, and demonstrate a functional siRNA delivery system that induces efficient gene knockdown in vitro and in vivo. We found that CD nanoparticles （NPs） enhance the cellular uptake of siRNA, via endocytosis in tumor cells, with low cytotoxicity and unexpected immune responses. Real-time study of fluorescence imaging in live cells shows that CD NPs favorably localize in cytoplasm and successfully release siRNA within 12 h. Moreover, we demonstrate that CD NP-mediated siRNA delivery significantly silences green fluorescence protein （GFP） expression and inhibits tumor growth in a breast cancer cell xenograft mouse model of tumor-specific therapy. We have developed a multifunctional siRNA delivery vehicle enabling simultaneous bioimaging and efficient downregulation of gene expression, that shows excellent potential for gene therapy.

关键词： bioimaging carbon dot gene delivery RNA interference targeted cancer therapy

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植被冠层立体结构与叶片倾角的偏振光效应

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遥感学报 2018年第6期22卷 935-946页

作者：杨彬晏磊 yuri Knyazikhin 刘思远湖南大学电气与信息工程学院长沙410082 北京大学空间信息集成与3S工程应用北京市重点实验室北京100871 北京大学地球与空间科学学院遥感与地理信息系统研究所北京100871 波士顿大学地球与环境系波士顿MA02215

植被偏振特性研究对于植被监测与组分定量反演具有极其重要的作用。植被冠层的反射辐射具有偏振特性,这种特性与入射辐射和植被冠层结构相关。本文分析了偏振对光子—叶片—冠层之间细微相互作用及其变化的有效探测能力,并利用研究型扫... 详细信息

植被偏振特性研究对于植被监测与组分定量反演具有极其重要的作用。植被冠层的反射辐射具有偏振特性,这种特性与入射辐射和植被冠层结构相关。本文分析了偏振对光子—叶片—冠层之间细微相互作用及其变化的有效探测能力,并利用研究型扫描式偏振辐射仪RSP(Research Scanning Polarimeter)数据系统对比分析了偏振对不同叶倾角分布的估测。通过上述研究得出以下结论:(1)偏振观测能够对光线在冠层立体结构中的透射反射再出射过程给出精细刻画,若不用偏振手段对这一过程进行甄别并去除,则直接测算的植被散射系数会产生高达140%的误差;(2)利用偏振手段可以为高精度大倾角、多时相遥感观测提供可能,以此可改变目前光学遥感小角度、垂直观测的较严格约束;(3)偏振辐射呈现出随波长的稳定特性(相关系数>0.96),使得利用偏振手段可以更好地研究冠层结构;(4)不同叶倾角分布对入射辐射存在不同的偏振反射,为利用多角度偏振信息进行遥感植被精细分类提供了新的途径。本文详细描述冠层结构和植被偏振特性的相互作用,通过对冠层立体结构与叶倾角的研究,刻画了植被定量遥感的方向性信息与高精度实现,为高分辨率遥感定量化的有效信息挖掘提供了新手段。

关键词：入射观测几何冠层立体结构叶倾角偏振光效应 RSP 高分辨率遥感

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X-波段电子顺磁共振的微观有序宏观无序谱分析

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光谱学与光谱分析 2007年第2期27卷 209-212页

作者：吴雪 Edmund Howard yuri Nesmelov David D Thomas 南开大学物理学院南开大学生物活性材料教育部重点实验室天津300071 Department of Biochemistry Molecular Biology and BiophysicsUniversity of Minnesota

相关时间和序参量是表征自旋探针标记大分子运动与分布的两个重要参数。用合适的物理模型,通过线型分析同时确定这些参数在电子顺磁共振谱的解析中非常有意义。文章应用微观有序宏观无序(MO-MD)模型,在X-波段对具有轴对称磁参量自旋探针... 详细信息

相关时间和序参量是表征自旋探针标记大分子运动与分布的两个重要参数。用合适的物理模型,通过线型分析同时确定这些参数在电子顺磁共振谱的解析中非常有意义。文章应用微观有序宏观无序(MO-MD)模型,在X-波段对具有轴对称磁参量自旋探针的EPR谱进行了模拟计算,测量了波形的实验参数,比较了与经验公式分析的误差。对于MOMD谱,作者提出了分辨标准来筛选实验参数进行线型分析,以此确定了同时解析相关时间及内部序参量的有效区间。

关键词： EPR模拟 MOMD模型相关时间序参量

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Tunable chemical complexity to control atomic diffusion in alloys

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npj Computational Materials 2020年第1期6卷 1360-1367页

作者： yuri Osetsky Alexander V.Barashev Laurent K.Béland Zhongwen Yao Keyvan Ferasat Yanwen Zhang Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Nuclear Engineering and Radiological Sciences University of MichiganAnn ArborMI 48109USA Department of Mechanical and Materials Engineering Queen’s UniversityKingstonON K7L 3N6Canada Department of Materials Science and Engineering University of TennesseeKnoxvilleTN 37996USA

In this paper we report a new fundamental understanding of chemically-biased diffusion in Ni–Fe random alloys that is tuned/controlled by the intrinsic quantifiable chemical *** of radiation-tolerant alloys has been a long-standing *** we show how intrinsic chemical complexity can be utilized to guide the atomic diffusion and suppress radiation *** influence of chemical complexity is shown by the example of interstitial atom(IA)diffusion that is the most important defect in radiation *** useμs-scale molecular dynamics to reveal sluggish diffusion and percolation of IAs in concentrated Ni–Fe *** develop a mean field diffusion model to take into account the effect of migrating defect energy properties on diffusion percolation,which is verified by a new kinetic Monte Carlo approach addressing detailed *** demonstrate that the local variations in the ground state energy of IA configurations in alloys,reflecting the chemical difference between alloying components,drives the percolation effects for atomic ***,chemically-biased and sluggish diffusion are phenomena that are directly related to the chemical complexity intrinsically to multicomponent alloys.

关键词： alloys alloying diffusion

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Inverse Problem of Astrodynamics

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World Journal of Mechanics 2015年第12期5卷 249-256页

作者： yuri Menshikov Department of Mechanics and Mathematics Dnepropetrovsk University Dnepropetrovsk Ukraine

We consider the problem of determining the center of mass of an unknown gravitational body, using the disturbances in the motion of observed celestial bodies. In this paper an universal approach to obtain the approximate and stable estimate of problem solution is suggested. This approach can be used in other fields of Science. For example, it can be applied for investigation of interactions between fields of forces and elementary particles using known trajectories of elementary particles motions.

关键词： Astrodynamics Le Verrier Problem Regularization Main Hypothesis

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A Simplified Approach to the Problems of Room-Temperature Superconductivity

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Journal of Modern Physics 2015年第4期6卷 396-402页

作者： yuri Prazdnikov Faculty of Physics Moscow State University Moscow Russia

An attempt to simplify the approach to the problems of room-temperature superconductors was done. The key factor has been highlighted—a giant spin-orbit interaction as a result of specific geometry of crystal. Considering oriented carbyne as an example, it was shown that maximal value of SOC was attained in low-dimensional systems. A qualitative model of superconductivity in the localized phase with “pseudo-magnetic field” and “Rashba effective field” as parameters was presented. Their correlation was shown via geometry of electric microfields of crystal. Oriented carbyne was presented as localized phase of room-temperature superconductor and the recipe of its transformation to macroscopic superconductivity was given.

关键词： Oriented Carbyne Topological Insulator High-Temperature Superconductivity Pseudo-Magnetic Field

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Optical properties and phase-matching in LiInS2

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Chinese Optics Letters 2003年第4期1卷 237-240页

作者：黄金哲任德明胡孝勇曲彦臣 yuri Andreev Pavel Geiko Anna Shaiduko Sergey Grechin Institute of Opto-Electronics Harbin Institute of TechnologyHarbin 150001 Institute of Optical Monitoring SB RAS Tomsk 634055 Russia SRIRL Bauman Moscow State Technical University Moscow 107005 Russia

Investigation results on linear and non-linear optical properties, damage threshold and potential efficiencies of biaxial negative LiInS2 crystal are represented. It shows that the crystal has phase-matching and group-velocity matching in wide spectral range for second harmonic, sum- and difference-frequency generation of visible, near and middle IR lasers. The possibilities of designing middle IR optical parametric oscillator (OPO) pumped by Nd:YAG and dye lasers and specially possibility of frequency conversion with 3 um range femtosecond erbium lasers are given.

关键词： Crystals Optical frequency conversion Optically pumped lasers

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The Gulf Stream and the Californian Current as Factors Affecting the Behavior and Health of Americans

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Journal of Human Physiology 2021年第2期3卷 51-56页

作者： yuri Pivovarenko Research and Training Center‘Physical and Chemical Materials Science’Under Kyiv Taras Shevchenko University and NAS of Ukraine KievUkraine

Due to the existence of the Earth's geomagnetic field,Lorentz’s forces constantly act on all sea *** forces distribute the charges of sea currents in both vertical and horizontal *** particular,this distribution manifests itself in the electric polarization of sea currents in directions perpendicular to ***,earlier it was shown that the same Lorentz forces cause negative electrization of the Sargasso *** is also shown here that the positive electrization of the western edge of the Gulf Stream and,consequently,the eastern coast of the United States is also caused by the Lorentz force arising from the interaction of this sea current with the vertical component of the geomagnetic *** is also shown here that the positive electrization of east edge of California Current together with west coast of USA is also caused due to the similar *** this allows us to conclude that an increased concentration of positive air ions is constantly retained in the air both in the east and in the west of the United *** situation has caused the need for an analysis of how the predominantly positive electrization of the air affects both human health and their physical and mental *** results of this analysis are presented *** is also shown that these results can be useful for residents of some other countries.

关键词： Environment Electrization Gulfstream Metabolism Stroke Thrombogenesis Alzheimer's disease Viral infections Feng Shui

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Superinjection from Oriented Carbyne as the Result of Landau Quantization in Giant Pseudo-Magnetic Field

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Journal of Modern Physics 2013年第7期4卷 994-999页

作者： yuri Prazdnikov Faculty of Physics Moscow State University Moscow Russia

The qualitative explanation of the earlier published experimental data was obtained within new energetic model of oriented carbyne. The conductivity spectrum and the superinjection effect feature Landau quantization in a giant pseudomagnetic field. The relativistic dispersion of carriers and non-dissipative character of their motion cause the effect of superinjection where carriers go upwards on an energetic ladder. Raman-spectra and other data point out to the fact that the plane of carriers’ motion is close to the carbyne-insulator interface. Quantum effects and on-surface conductivity allow considering oriented carbyne as an analogue of topological insulator.

关键词： Carbyne Superinjection Pseudo-Magnetic Field Topological Insulator

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Design Procedure for Semi Interlocking Masonry

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Journal of Civil Engineering and Architecture 2015年第5期9卷 517-525页

作者： yuri Totoev Centre for Infrastructure Performance and Reliability The University of Newcastle Callaghan 2308 Australia

SIM （semi interlocking masonry） is a kind of innovative building system for mortar-less walls. It utilizes a special method of interlocking SIM bricks that allows relative sliding of brick courses in-plane of a wall and prevents out-of-plane relative movement of bricks. It has increased capacity to dissipate earthquake energy through friction between bricks compared with traditional masonry. It can be used in earthquake resistant frame structures as infill panels, which also act as EDD （energy dissipation devices）. However, as a mortar-less system, it is not covered by masonry design standards. The purpose of this paper is to introduce S1M and also to develop an analytical design procedure for this innovative masonry system.

关键词： Semi interlocking masonry mortar-less system earthquake resistance EDD.

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