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Quantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor,aging,and Parkinson’s disease

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Nano Research 2023年第5期16卷 7119-7133页

作者： Alexander V.Romashchenko Dmitrii V.Petrovskii Sergey Yu.Trotsky Ksenia N.morozova Nina B.Illarionova maria V.Zhukova Elena V.Kiseleva marina B.Sharapova Daniil S.Zuev Konstantin E.Kuper Sergey Yu.Taskaev Anna I.Kasatova Dmitrii A.Kasatov Olga I.Solovieva Ivan A.Razumov Ludmila A.Gerlinskaya mikhail P.moshkin yuri m.moshkin The Federal Research Center Institute of Cytology and Genetics SB RASAcademician Lavrentiev Avenue10Novosibirsk 630090Russia International tomography center Institutskaya st.3ANovosibirsk 630090Russia G.K.Boreskov Institute of Catalysis SB RASAcademician Lavrentiev Avenue5Novosibirsk 630090Russia The Federal Research Center Budker Institute of Nuclear Physics SB RASAcademician Lavrentiev Avenue11Novosibirsk 630090Russia Institute of Computational Technologies Academician M.A.Lavrentiev avenue6Novosibirsk 630090Russia Institute of Gene Biology Russian Academy of SciencesMoscow 117334Russia Institute of molecular and Cellular Biology SB RASAcad.Lavrentiev Ave8/2Novosibirsk 630090Russia Federal Research Centre of Biological Systems and Agrotechnologies RASst.January 929Orenburg 460000Russia

Nanoparticles(NPs)can be transported via the nose-to-brain(N_(2)B)***,quantitative data on their spatiotemporal dynamics and regulation of the N_(2)B transport are largely *** surveyed metal oxide/hydroxide NPs as magnetic resonance imaging(mRI)contrasts for quantitative N_(2)B *** containing divalent transition metals were the only ones capable of N_(2)B *** T1-weighted(T1W)mRI,we showed that mn_(3)O_(4)-NPs were readily engulfed by olfactory receptor neurons(ORNs)without disrupting olfactory sensing,we mapped their N_(2)B *** neurons,the mn_(3)O_(4)-NPs were localized to the cytosol,mitochondria,vesicles,moved at mixed fast and slow axonal transport velocities intraand extra-vesicularly through *** NPs’axonal transport is dependent on neuronal activity and microtubule *** mn_(3)O_(4)-NPs were trans-synaptically transmitted through at least four synapses across the olfactory ***-synaptic transmission of the NPs was dependent on N-type Ca^(2+)channels and NmDA receptors but blocked by GABAB receptor activation.A five-parameter Weibull signal increase/decrease model fitted to the T1W mRI data allowed for estimating kinetic parameters of mn_(3)O_(4)-NP accumulation/*** and relative accumulation rates,but not elimination,correlated negatively with the number of synapses from ORNs,indicating a coupling of the NPs’N_(2)B transport with spontaneous neuronal ***,olfactory stimuli(2,5-dimethylpyrazine and acetophenone)significantly modulated and rerouted the mn_(3)O_(4)-NP N_(2)B transport odor ***,the NPs’trans-synaptic transmission was impaired by aging and the onset of Parkinson’s *** data suggest new approaches to diagnostics,functional neuroimaging,controlling N_(2)B drug delivery.

关键词： mn_(3)O_(4)nanoparticles magnetic resonance imaging(mRI) nose-to-brain transport trans-synaptic transmission olfactory stimulation

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Recovery of Brachiopod and Ammonoid Faunas Following the End-Permian Crisis:Additional Evidence from the Lower Triassic of the Russian Far East and Kazakhstan

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Journal of Earth Science 2014年第1期25卷 1-44页

作者： yuri D Zakharov Alexander m Popov Far Eastern Geological Institute Far Eastern BranchRussian Academy of Sciences

After the End-Permian mass extinction, ammonoids reached levels of taxonomic diver- sity higher than in the Changhsingian by the Dienerian Substage of the Induan. However, brachiopods exhibit a prolonged delay in recovery, and their taxonomic diversity had not recovered to Late Permian levels even by the Olenekian. The differential patterns of recovery between these two clades may reflect fundamental differences in physiology and behavior. Brachiopods were benthic organisms that were dependent on specific trophic sources, and their general reduction in size during the Early Triassic may have been a response to a relative paucity of food resources. In contrast, ammonoids were sluggish- nektic organisms that utilized a wider range of trophic sources and that suffered no comparable size decrease during the Early Triassic. Brachiopods may have been at a disadvantage also due to vulner- abilities associated with their larval stage, during which they had to locate a suitable substrate for set- tlement. In contrast, ammonoids had no larval stage and juveniles may have been dispersed widely into favorable habitats. These factors may account for differences in the relative success of ammonoids and brachiopods at high-latitude regions following the End-Permian mass extinction： ammonoids success- fully reeolonized the Boreal region during the Early Triassic whereas brachiopods did not.

关键词： Lower Triassic South Primorye Kazakhstan brachiopod ammonoid biotic recovery.

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Numerical investigation of full scale coaxial main rotor aerodynamics in hover and vertical descent

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Chinese Journal of Aeronautics 2021年第5期34卷 666-683页

作者： Pavel V.mAKEEV yuri m.IGNATKIN Alexander I.SHOmOV Department of Helicopter Design Moscow Aviation Institute(National Research University)Moscow 125993Russia

The original free vortex wake model was used for numerical *** of the aerodynamic characteristics in hover and vertical descent modes in the range of vertical descent speed of 0–30 m/s including the Vortex Ring State(VRS)area was *** calculations were carried out under the condition of variable blade pitch angle values providing a fixed timeaverage thrust *** data of free vortex wake shapes,flow structures,and velocity fields were obtained and *** time-dependences of the rotor’s thrust and torque coefficients were obtained and *** obtained data allows determining the boundaries of the VRS area by various criteria such as rotor thrust and torque pulsations,growth of rotor power consumption relative to the hover,growth of rotor induced velocities relative to the hover,and growth of the required rotor blade pitch angles *** results of the study are compared with experimental and calculated data of other authors and can significantly supplement the available results of experimental and computational studies in this area.

关键词： Aerodynamic characteristics Coaxial rotor Free wake model Hover and vertical descent Vortex ring state mode

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Approximations of the Fractional Integral and Numerical Solutions of Fractional Integral Equations

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Communications on Applied mathematics and Computation 2021年第3期3卷 545-569页

作者： yuri Dimitrov Department of mathematics and Physics University of Forestry1756 SofiaBulgaria Institute of mathematics and Informatics Bulgarian Academy of Sciences1113 SofiaBulgaria

In the present paper,we derive the asymptotic expansion formula for the trapezoidal approximation of the fractional *** use the expansion formula to obtain approximations for the fractional integral of ordersα,1+α,2+α,3+αand 4+α.The approximations are applied for computation of the numerical solutions of the ordinary fractional relaxation and the fractional oscillation equations expressed as fractional integral equations.

关键词： Fractional integral Trapezoidal approximation Fractional integral equation Finite-difference scheme

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Nitrogen and Carbon Isotope Data of Olenekian to Anisian Deposits from Kamenushka/South Primorye, Far-Eastern Russia and Their Palaeoenvironmental Significance

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Journal of Earth Science 2018年第4期29卷 837-853页

作者： yuri D Zakharov micha Horacek Alexander m Popov Liana G Bondarenko Far Eastern Geological Institute of Russian Academy of Sciences (Far Eastern Branch) Stoletiya Prospect 159 Vladivostok 690022 Russia BLT Wieselburg Research Center HBLFA Francisco-Josephinum Wieselburg 3250 Austria Institute of Lithospheric Research Vienna University Vienna 1090 Austria

The Kamenushka Formation, exposed in the northern part of South Primorye （Kamennshka-1 and Kamenushka-2 sections）, is one of the few localities in the world with richly fossiliferous Lower-Upper Olenekian sedimentary successions. Lower to middle Triassic ammonoid-, brachiopod- and conodont-bearing silty-clayey deposits of the Kamenushka-1 and Kamenushka-2 sections have been isotope-geochemically investigated in detail. As a result, these sections, together with the previously investigated Abrek Section, exposed in the southern part of South Primorye, provide almost complete ^15Non- and ^13Corg- records for the Lower Triassic of this region. Nine N- isotope intervals and the five negative C-isotope excursions, reflecting, apparently, unstable climatic and hydrological conditions, have been distinguished in the Lower Triassic of South Primorye. On the basis of the new C-isotope data the mesohedenstroemia bosphorensis Zone （upper part）, Shimanskyites shimanskyi and Neocolumbites insignis zones of South Primorye are correlated now with the Lower Smithian part of the Yinkeng Formation, the Upper Smithian part of the Helongshan Formation and the middle Spathian part of the Nanlinghu Formation in South China, respectively, as has been observed in the Abrek, Kamenushka-2, West Pingdingshan and majiashan sections.

关键词： Triassic N- and C-isotopes palaeoclimatology bio- and chemostratigraphy Pri- morye Russia.

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mollisols Properties and Changes in Ukraine and China

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Chinese Geographical Science 2011年第3期21卷 257-266页

作者： yuri S KRAVCHENKO ZHANG Xingyi LIU Xiaobing SONG Chunyu Richard m CRUSE Key Laboratory of mollisols Agroecology Northeast Institute of Geography and Agroecology Chinese Academy of Sciences Harbin 150081 China National University of Life and Environmental Sciences of Ukraine Kyiv 03041 Ukraine Department of Agronomy Iowa State University Ames 500011 IA USA

Soils are the foundation of civilizations and the basis for human food *** in Ukraine and Northeast China are two out of the four major mollisol regions in the *** natural areas from which mollisols developed are the prairies and steppes that experience temperate and freezing *** review paper introduces the general climate,vegetation,and topography of mollisols regions in Ukraine and Northeast China,analyzes their properties,including soil texture,soil organic matter content,soil bulk density,pH,cation exchange capacity and other chemical properties,and compares the property changes and management practices of mollisols in relation to sustainable grain production.

关键词： mollisols soil properties soil organic matter tillage mollisols management

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Neurohumoral,cardiac and inflammatory markers in the evaluation of heart failure severity and progression

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Journal of Geriatric Cardiology 2021年第1期18卷 47-66页

作者： Ekaterina A Polyakova Evgeny N mikhaylov Dmitry L Sonin yuri V Cheburkin mikhail m Galagudza Almazov National medical Research Centre Saint-PetersburgRussia

Heart failure is common in adult population,accounting for substantial morbidity and mortality *** main risk factors for heart failure are coronary artery disease,hypertension,obesity,diabetes mellitus,chronic pulmonary diseases,family history of cardiovascular diseases,cardiotoxic *** main factor associated with poor outcome of these patients is constant progression of heart *** the current review we present evidence on the role of established and candidate neurohumoral biomarkers for heart failure progression management and diagnostics.A growing number of biomarkers have been proposed as potentially useful in heart failure patients,but not one of them still resembles the characteristics of the"ideal biomarker."A single marker will hardly perform well for screening,diagnostic,prognostic,and therapeutic management ***,the pathophysiological and clinical significance of biomarkers may depend on the presentation,stage,and severity of the *** authors cover main classification of heart failure phenotypes,based on the measurement of left ventricular ejection fraction,including heart failure with preserved ejection fraction,heart failure with reduced ejection fraction,and the recently proposed category heart failure with mid-range ejection *** could envisage specific sets of biomarker with different performances in heart failure progression with different left ventricular ejection fraction especially as concerns prediction of the future course of the disease and of left ventricular adverse/reverse *** article is intended to provide an overview of basic and additional mechanisms of heart failure progression will contribute to a more comprehensive knowledge of the disease pathogenesis.

关键词： cardiac and inflammatory markers in the evaluation of heart failure severity and progression Neurohumoral

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Unique marine Olenekian-Anisian Boundary Section from South Primorye, Russian Far East

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Journal of China University of Geosciences 2005年第3期16卷 219-230页

作者： yuri D Zakharov Alexander m Popov Galina I Buryi Far Eastern Geological Institute Russian Academy of Sciences (Far Eastern Branch) Stoletiya Prospect 159 Vladivostok 690022 RussiaFar Eastern Geological Institute Russian Academy of Sciences (Far Eastern Branch) Stoletiya Prospect 159 Vladivostok 690022 Russia Far Eastern Geological Institute Russian Academy of Sciences (Far Eastern Branch) Stoletiya Prospect 159 Vladivostok 690022 Russia

To show paleontological characteristics of the Olenekian-Anislan boundary beds in the Russian Far East, a review of new data on the Upper Olenekian and Lower Anisian biostratigraphy of South Primorye is given on the basis of five sections： Golyi Cape, Petrovka River, Zhitkov Peninsula, Tchernyschew Bay and Atlasov Cape, using new ammonoid, brachiopod and conodont findings. The most representative ammonoid assemblage at the base of the Anisian was discovered in the Ussuriphyllites amurensis Zone （10.6 m thick） of the Atlasov Cape Section： Parasageceras sp. nov., Prionitidae gen. et sp. nov. , Ussuriphyllites amurensis （Kiparisova）（dominant）, megaphyllites atlasoviensis Zakharov, Leiophyllites praematurus Kiparisova, Leiophyllites sp. , Ussurites sp. , Paradanubites sp. indet., Paracrochordiceras sp. nov., Prohungarites popowi Kiparisova, Arctohungarites primoriensis Zakharov, A. solimani （Toula）, Salterites sp. indet. （gigantic shell）, and Tropigastrites sublachontanus Zakharov. Conodonts Neospathodus cf. homeri （Bender） were found in the lower part of the Ussuriphyllites amurensis Zone of the Atlasov Cape. The Atlasov Cape seems to be one of the very promising sections of the Russian Far East for detailed investigation of the Olenekian-Anisian boundary.

关键词： South Primorye Triassic Olenekian-Anisian boundary ammonoid conodont

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Development of waste-to-energy through integrated sustainable waste management:the case of ABREN WtERT Brazil towards changing status quo in Brazil

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Waste Disposal and Sustainable Energy 2023年第3期5卷 295-308页

作者： yuri Schmitke Almeida Belchior Tisi Flavio Arantes matos maria Luisa N.m.Carneiro Waste to Energy Research and Technology Council—WtERT Brasil Distrito FederalBrasília71316-109Brazil Waste to Energy Research and Technology Council—WtERT Brasil Ribeirão PretoSão PauloBrazil Waste to Energy Research and Technology Council—WtERT Brasil Rio de JaneiroBrazil

In the context of circular economy,it is known that once waste is generated,it should be subject to proper treatment for recovering material or energy before being *** countries worldwide,especially developing countries such as Brazil,have been struggling to effectively apply sustainable waste management in municipalities and still rely on dumpsites and unsuitable ***,a weak legal framework,lack of financial resources and poor infra-structure as well as pressure from organizations profiting from the expansion of landfills are some factors contributing to the preservation of the negative status quo:the“landfill culture”.material recovery,i.e.,recycling and composting,is applied to less than 5%of Brazilian municipal waste,while 95%is disposed of in landfills or *** this context,ABREN WtERT(Waste-to-Energy Research and Technology Council)Brazil was created in 2019 as the first permanent organization formed to promote the development of energy and material recovery from waste focused on the waste-to-energy(WTE)*** this paper,the strategy proposed and implemented by the organization towards changing the status quo in Brazil through an integrated sustainable waste management approach is *** proposed strategy integrates the concepts of Sustainability and Circular Economy for minimizing landfill disposal(avoiding methane emissions)and maximizing material/energy *** others,the approach focuses on changing the public opinion regarding thermal treatment facilities,mainly incinerators,which has been wrongly linked to pollution,excessive public expenditures and considered a harm to the recycling *** activities performed by ABREN include engaging public and private institutions,enhancing education,leading the publication of research and business studies,gathering industry members and academy experts,as well as creating strategic alliances with players around the *** a result,within a few years,major

关键词： Integrated Sustainable Waste management(ISWm) Waste-to-energy(WTE) municipal solid waste(mSW) Energy recovery

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A NUmERICAL mETHOD FOR THE SImULATION OF FREE SURFACE FLOWS OF VISCOPLASTIC FLUID IN 3D

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Journal of Computational mathematics 2011年第6期29卷 605-622页

作者： Kirill D. Nikitin maxim A. Olshanskii Kirill m. Terekhov yuri V. Vassilevski Institute of Numerical mathematics Russian Academy of Sciences Moscow Russia Department of mechanics and mathematics Moscow State University Moscow Russia

In this paper we study a numerical method for the simulation of free surface flows of viscoplastic （Herschel-Bulkley） fluids. The approach is based on the level set method for capturing the free surface evolution and on locally refined and dynamically adapted octree cartesian staggered grids for the discretization of fluid and level set equations. A regu- larized model is applied to handle the non-differentiability of the constitutive relations. We consider an extension of the stable approximation of the Newtonian flow equations on staggered grid to approximate the viscoplastic model and level-set equations if the free boundary evolves and the mesh is dynamically refined or coarsened. The numerical method is first validated for a Newtonian case. In this case, the convergence of numerical solutions is observed towards experimental data when the mesh is refined. Further we compute several 3D viscoplastic Herschel-Bulkley fluid flows over incline planes for the dam-break problem. The qualitative comparison of numerical solutions is done versus experimental investigations. Another numerical example is given by computing the freely oscillating viscoplastic droplet, where the motion of fluid is driven by the surface tension forces. Altogether the considered techniques and algorithms （the level-set method, compact discretizations on dynamically adapted octree cartesian grids, regularization, and the surface tension forces approximation） result in efficient approach to modeling viscoplastic free-surface flows in possibly complex 3D geometries.

关键词： Free surface flows Viscoplastic fluid Adaptive mesh refinement Oetree meshes.

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