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Novel Biomaterial for NCT - “Rigid” Particles of (DNA-gadolinium) Liquid-Crystalline Dispersions

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Journal of Biomaterials and Nanobiotechnology 2011年第3期2卷 281-292页

作者： yuri m. Yevdokimov Victor I. Salyanov Sergey V. Akulinichev Vladimir m. Skorkin Pavel V. Spirin Nataliya N. Orlova Vladimir I. Popenko Vladimir S. Prassolov 不详

The formation and physico-chemical properties of biomaterial, based on double-stranded (ds) DNA molecules and bearing high concentration of gadolinium, is described. This “rigid” biomaterial demonstrate a few unique properties: (i) the ds DNA molecules forming complexes with gadolinium are fixed in the spatial structure of “rigid” particles, (ii) an abnormal negative band in the circular dichroism spectrum permits to follow the formation of this biomaterial;(iii) local concentration gadolinium in the content of biomaterial can reach 40%. These properties show that we are dealing with a novel type of biomaterial strongly enriched by gadolinium. This opens a gateway for practical application of this biomaterial for neutron-capture reactions. A first attempt to apply this material for neutron-capture reaction in combination with neutron generator of thermal neutron flux was performed. Positive result obtained at destruction of CHO cells allows one to state that the advantages of this biomaterial are a simple manipulation with it, a possibility to adjust its gadolinium content, long-term stability of its physico-chemical properties, as well as a reduced cost of neutron-capture experiment.

关键词： Liquid-Crystalline DNA Dispersions Cholesterics Circular Dichroism Spectrum Gadolinium Neutron-Capture Therapy

Electrically-Conductive Composite Nanomaterial with multi-Walled Carbon Nanotubes

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materials Sciences and Applications 2013年第5期4卷 1-7页

作者： Levan Ichkitidze Vitally Podgaetsky Sergei Selishchev Eugenie Blagov Vyacheslav Galperin yuri Shaman Alexander Pavlov Eugenie Kitsyuk Institute of Nanotechnology of microelectronics RAS Moscow Russia National Research University of Electronic Technology (mIET) Moscow Russia Scientific manufacturing Complex “Technological Centre” Moscow Russia

Specific conductivity of the composite nanomaterial layers with micron and submicron dimensions, consisting of carboxymethyl cellulose (CmC) and multiwalled carbon nanotubes (mWCNT) was investigated. Ultradispersed aqueous suspension was deposited on soft (aluminum foil, plates made from polyester and polyimide, cotton fabric, office paper) and solid (coverslip, silicon wafers with silicon oxide layer) substrates by silk-screen printing. Electrical resistance was measured by four-probe method and by the method of square on surface from which the conductivity and conductivity per square of surface were calculated taking into account layer’s geometric dimensions. Specific conductivity of the layers with thickness range 0.5 - 5 μm was? ~1.2×104÷4×104 S/m, and max conductivity per square was ~ 0.2 S. Investigated nanomaterial is attractive to electronic and biomedical applications.

关键词： multiwalled Carbon Nanotubes Electroconductive Nanomaterial Substrates Carboxymethyl Cellulose Electroconductive Gel Electroconductive Layers

Quantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor,aging,and Parkinson’s disease

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Nano Research 2023年第5期16卷 7119-7133页

作者： Alexander V.Romashchenko Dmitrii V.Petrovskii Sergey Yu.Trotsky Ksenia N.morozova Nina B.Illarionova maria V.Zhukova Elena V.Kiseleva marina B.Sharapova Daniil S.Zuev Konstantin E.Kuper Sergey Yu.Taskaev Anna I.Kasatova Dmitrii A.Kasatov Olga I.Solovieva Ivan A.Razumov Ludmila A.Gerlinskaya mikhail P.moshkin yuri m.moshkin The Federal Research Center Institute of Cytology and Genetics SB RASAcademician Lavrentiev Avenue10Novosibirsk 630090Russia International tomography center Institutskaya st.3ANovosibirsk 630090Russia G.K.Boreskov Institute of Catalysis SB RASAcademician Lavrentiev Avenue5Novosibirsk 630090Russia The Federal Research Center Budker Institute of Nuclear Physics SB RASAcademician Lavrentiev Avenue11Novosibirsk 630090Russia Institute of Computational Technologies Academician M.A.Lavrentiev avenue6Novosibirsk 630090Russia Institute of Gene Biology Russian Academy of SciencesMoscow 117334Russia Institute of molecular and Cellular Biology SB RASAcad.Lavrentiev Ave8/2Novosibirsk 630090Russia Federal Research Centre of Biological Systems and Agrotechnologies RASst.January 929Orenburg 460000Russia

Nanoparticles(NPs)can be transported via the nose-to-brain(N_(2)B)***,quantitative data on their spatiotemporal dynamics and regulation of the N_(2)B transport are largely *** surveyed metal oxide/hydroxide NPs as magnetic resonance imaging(mRI)contrasts for quantitative N_(2)B *** containing divalent transition metals were the only ones capable of N_(2)B *** T1-weighted(T1W)mRI,we showed that mn_(3)O_(4)-NPs were readily engulfed by olfactory receptor neurons(ORNs)without disrupting olfactory sensing,we mapped their N_(2)B *** neurons,the mn_(3)O_(4)-NPs were localized to the cytosol,mitochondria,vesicles,moved at mixed fast and slow axonal transport velocities intraand extra-vesicularly through *** NPs’axonal transport is dependent on neuronal activity and microtubule *** mn_(3)O_(4)-NPs were trans-synaptically transmitted through at least four synapses across the olfactory ***-synaptic transmission of the NPs was dependent on N-type Ca^(2+)channels and NmDA receptors but blocked by GABAB receptor activation.A five-parameter Weibull signal increase/decrease model fitted to the T1W mRI data allowed for estimating kinetic parameters of mn_(3)O_(4)-NP accumulation/*** and relative accumulation rates,but not elimination,correlated negatively with the number of synapses from ORNs,indicating a coupling of the NPs’N_(2)B transport with spontaneous neuronal ***,olfactory stimuli(2,5-dimethylpyrazine and acetophenone)significantly modulated and rerouted the mn_(3)O_(4)-NP N_(2)B transport odor ***,the NPs’trans-synaptic transmission was impaired by aging and the onset of Parkinson’s *** data suggest new approaches to diagnostics,functional neuroimaging,controlling N_(2)B drug delivery.

关键词： mn_(3)O_(4)nanoparticles magnetic resonance imaging(mRI) nose-to-brain transport trans-synaptic transmission olfactory stimulation

Transient GUS and GFP Expression in Spanish Red Cedar(Cedrela odorata L.)Somatic *** of Bombardment Conditions and Evaluation of Selective Agent Lethal Dose

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Open Journal of Forestry 2012年第2期2卷 54-58页

作者： yuri J.Pena-Ramírez max m.Apolinar-Hernández Oscar A.Gomez-y-Gomez Luisa A.Lopez-Ochoa Aileen O’Connor-Sánchez Instituto Tecnologico Superior de Acayucan AcayucanMexico Centro de Investigacion Científica de Yucatán MéridaMexico

Cedrela odorata is a tropical tree widely appreciated for its wood. Commercial plantations are frequently hampered by the attack of the meliacea borer, Hypsipyla grandella, and the lack of resistant varieties. C. odorata traditional breeding would consume very long periods of time, thus direct transfer of entomotoxic coding genes to generate resistant varieties is a promising alternative. There are two prerequisites for gene manipulation of this species: 1) to set the conditions for transgene delivery and 2) to have a way to select regenerating transformed plants. In this paper, we report the optimal biolistics conditions for transient expression of uidA and gfp reporter genes in C. odorata somatic embryos and the selective doses for kanamycin, spectinomycin, phosphinotrycin and hygromycin to screen transformed cells.

关键词： Biolistics Genetic Transformation Tree Genetic modification Tropical Wood

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多毛细管柱色谱

生命科学仪器 2007年第2期5卷 11-14页

作者： yuri P. Belov marina m. Ulyanova Vlandimir N. Sidelnikov Dr. Belov is Vice President ChromBA Inc. 123 Coal Alley State College PA 16801 U.S.A Dr. Ulyanova is Postdoetoral Fellow State Public Health Labs Anchorage AK U.S.A Dr. Sidelnikov is Senior Researcher The Boreskov Institute of Catalysis Russian Academy of Sciences Novosibirsk Russia.

应用直径范围为5～50μm的毛细管色谱柱可以使分离速度最大化。然而它们所需要的样品量很小,以至于难以进样和检测。本文设计的多毛细管柱克服了单毛细管柱在流速、体积、样品容量等方面的限制,并且可以与所有的常规色谱设备兼容。

关键词：毛细管柱色谱毛细管色谱柱分离速度常规色谱样品量最大化

Treatment of Vulvovaginal Candidiasis with A Strategy Based on Phototherapy (m.A.C.^® Scar Acceleration method)

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modern Research in Inflammation 2024年第1期13卷 1-7页

作者： marcus Vinicius de mello Pinto Karin yuri Fernández Iturra Aline Ronis Sampaio maría Elena Silva Álvarez Esteban Fortuny Celulare Institute Petrópolis Brazil Bienus Clinic Santiago Chile Fisiocare Curicó Chile Universidad Finis Terrae Santiago Chile

Candidiasis, also known as candidiasis vulvovaginitis, is an infection caused by different types of Candida fungi, the most frequent being Candida albicans. The present study reports an effective strategy, which opens new avenues for the treatment of this public health problem. The mAC® methodology, conventional laser light-emitting (LLLT)/LED) methods are based on the biphasic response demonstrated many times in LLLT research and as with other forms of drugs, a “drug” (irradiation parameters) and a “dose” (irradiation times) and the “Arndt-Schulz Law” is often cited as a suitable model to describe the dose-dependent effects of LLLT. This method uses photopharmaceuticals, cell markers and the use of correct parameters for each case to induce the acceleration of tissue repair. The present study shows a case of a 32-year-old patient diagnosed with recurrent candidiasis 4 years ago. Eighteen sessions were performed (every other day) using a photoactivated component (methylene blue 1% + Clotrimazole 1%) and LED phototherapy (red, blue and violet) with emission times of 60 - 260 seconds for each applicator, according to the dose recommendations of the scar acceleration method (mAC®). At the sixth treatment session there was a noticeable decrease in the itching sensation reported by the patient. In session 11 she reported feeling a great improvement, indicating that she no longer felt itching in any area after 18 sessions. The present case demonstrates new methodologies to treat common problems in the population that have a positive impact on the quality of life. This methodology has a promising future because it is non-invasive and requires a great biological transformation for inflammatory, fungal and viral control.

关键词： Treatment of vulvovaginal Candidiasis Candidiasis Candida m.A.C. mAC®

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“中国威胁”论导致的后果与影响(上)

黑河学院学报 2016年第6期7卷 3-5页

作者： B.m.尤里臧颖俄罗斯科学院远东研究所俄罗斯莫斯科117997 哈尔滨市社会科学院黑龙江哈尔滨150010

随着中国国力日益增强,中国在国际政治、军事、经济领域的地位越来越高,这引起一些国家的担忧和猜忌,随之产生"中国威胁"的言论。在俄罗斯的媒体、报刊、杂志上也经常出现有关中国威胁论的文章和报导。本文作者通过列举俄罗斯某些知名... 详细信息

随着中国国力日益增强,中国在国际政治、军事、经济领域的地位越来越高,这引起一些国家的担忧和猜忌,随之产生"中国威胁"的言论。在俄罗斯的媒体、报刊、杂志上也经常出现有关中国威胁论的文章和报导。本文作者通过列举俄罗斯某些知名学者关于"中国威胁"的诸多代表言论,阐释这些言论缺乏充分的论证和不实之处,并指出不当的"中国威胁"论的肆意扩散,对中俄正常和良好关系的发展是极为不利的。

关键词：俄罗斯中国威胁论

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“中国威胁”论导致的后果与影响(二)

黑河学院学报 2016年第7期7卷 5-7页

作者： B.m.尤里臧颖俄罗斯科学院远东研究所俄罗斯莫斯科117997 哈尔滨社会科学院黑龙江哈尔滨150010

随着中国国力日益增强,中国在国际政治、军事、经济领域的地位越来越高,这引起一些国家的担忧和猜忌,随之产生"中国威胁"的言论。在俄罗斯的媒体、报刊上也经常出现有关中国威胁论的文章和报道。列举俄罗斯某些知名学者关于"中国威胁"... 详细信息

随着中国国力日益增强,中国在国际政治、军事、经济领域的地位越来越高,这引起一些国家的担忧和猜忌,随之产生"中国威胁"的言论。在俄罗斯的媒体、报刊上也经常出现有关中国威胁论的文章和报道。列举俄罗斯某些知名学者关于"中国威胁"的诸多代表言论,发现这些言论缺乏充分的论证和不实之处,这种不当的"中国威胁"论的肆意扩散,对中俄正常和良好关系的发展是极为不利的。

关键词：俄罗斯中国威胁论

Notes for genera:basal clades of Fungi(including Aphelidiomycota,Basidiobolomycota,Blastocladiomycota,Calcarisporiellomycota,Caulochytriomycota,Chytridiomycota,Entomophthoromycota,Glomeromycota,Kickxellomycota,monoblepharomycota,mortierellomycota,mucoromycota,Neocallimastigomycota,Olpidiomycota,Rozellomycota and Zoopagomycota)

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Fungal Diversity 2018年第5期92卷 43-129页

作者： Nalin N.Wijayawardene Julia Pawłowska Peter m.Letcher Paul m.Kirk Richard A.Humber Arthur Schüßler marta Wrzosek Anna muszewska Alicja Okrasińska Łukasz Istel Aleksandra Gęsiorska Paul mungai Adebola Azeez Lateef Kunhiraman C.Rajeshkumar Rajshree V.Singh Renate Radek Grit Walther Lysett Wagner Christopher Walker D.Siril A.Wijesundara moslem Papizadeh Somayeh Dolatabadi Belle D.Shenoy yuri S.Tokarev Saisamorn Lumyong Kevin D.Hyde Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of molecular Phylogenetics and Evolution Institute of BotanyFaculty of BiologyBiological and Chemical Research CenterUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland Department of Biological Sciences The University of AlabamaTuscaloosaAL 35487USA Royal Botanic Gardens KewRichmondSurrey TW93DSUK USDA-ARS Emerging Pests and Pathogens Research Robert W.Holley Center for Agriculture and HealthTower RoadIthacaNY 14853-2901USA Symbiosis and Plant-microbe Association Research Laboratory SYMPLANTA GmbH&Co.KG64287 DarmstadtGermany Institute of Biochemistry and Biophysics Polish Academy of SciencesPawinskiego 5A02-106 WarsawPoland Ecological monitoring Unit Biodiversity Research and Monitoring DivisionKenya Wildlife ServiceP.O.Box 40241Nairobi 00100Kenya Department of Plant Biology Faculty of Life SciencesUniversity of IlorinIlorinNigeria National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology(Fungi)GroupAgharkar Research InstitutePuneMaharashtra 411004India Evolutionary Biology Institute for Biology/ZoologyFreie Universität Berlin14195 BerlinGermany National Reference Center for Invasive mycoses(NRZmyk) Leibniz Institute for Natural Product Research and Infection Biology–Hans Knoell InstituteJenaGermany School of Agriculture and Environment Faculty of ScienceUniversity of Western Australia35 Stirling HighwayCrawleyWA 6009Australia Royal Botanic Garden Edinburgh 20A Inverleith RowEdinburgh EH35LRUK National Institute of Fundamental Studies Hantane RoadKandySri Lanka Department of microbiology Pasteur Institute of IranTehranIran Faculty of Engineering Sabzevar University of New TechnologySabzevarIran CSIR-National Institute of Oceanography Regional

Compared to the higher fungi(Dikarya),taxonomic and evolutionary studies on the basal clades of fungi are fewer in ***,the generic boundaries and higher ranks in the basal clades of fungi are poorly *** DNA based taxonomic studies have provided reliable and accurate *** is therefore necessary to compile all available information since basal clades genera lack updated checklists or ***,Tedersoo et al.(mycoKeys 13:1–20,2016)accepted Aphelidiomycota and Rozellomycota in Fungal ***,we regard both these phyla as members in Kingdom *** accept 16 phyla in basal clades ***,Basidiobolomycota,Blastocladiomycota,Calcarisporiellomycota,Caulochytriomycota,Chytridiomycota,Entomophthoromycota,Glomeromycota,Kickxellomy-cota,monoblepharomycota,mortierellomycota,mucoromycota,Neocallimastigomycota,Olpidiomycota,Rozellomycota and ***,611 genera in 153 families,43 orders and 18 classes are provided with details of classification,synonyms,life modes,distribution,recent literature and genomic ***,Catenariaceae Couch is proposed to be conserved,Cladochytriales mozl.-*** emended and the family Nephridiophagaceae is introduced.

关键词： Invalid genera Nephridiophagaceae fam.nov. Outline Phylogeny Validation