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Development of Water Resources

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Development of Water Resources

中医综合疗法配合PFNA治疗老年人股骨粗隆间骨折疗效观察

作者： Wang Hao Wang Jianhua Gan Hong Zhang Haitao Yan Denghua xiao yuquan

＜正＞In recent years,breakthrough progress has been made in China in the fields of water resources research such as basic theories and evolutionary regulari- ties of water resources,macro-level water strategies,water...

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中国社区医师 2020年第1期36卷 96-96,98页

作者：肖玉权贵州省普定县人民医院

目的:探讨中医综合疗法配合防旋型股骨近端髓内钉(PFNA)治疗股骨粗隆间骨折的效果。方法:2016年2月-2018年2月收治股骨粗隆间骨折患者40例,随机分为两组,各20例。对照组采用PFNA内固定法治疗,观察组采用PFNA内固定法联合中医综合疗法治... 详细信息

目的:探讨中医综合疗法配合防旋型股骨近端髓内钉(PFNA)治疗股骨粗隆间骨折的效果。方法:2016年2月-2018年2月收治股骨粗隆间骨折患者40例,随机分为两组,各20例。对照组采用PFNA内固定法治疗,观察组采用PFNA内固定法联合中医综合疗法治疗。比较两组治疗效果。结果:观察组患者平均住院时间及骨折愈合时间短于对照组,治疗总有效率高于对照组,差异均有统计学意义(P<0.05)。结论:采用中医综合疗法配合PFNA治疗股骨粗隆间骨折疗效显著,有利于促进患者快速恢复。

关键词：股骨粗隆间骨折中医综合疗法防旋型股骨近端髓内钉

60例冠心病患者血清载脂蛋白A1和B的检测分析

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现代医院 2009年第3期9卷 84-85页

作者：肖育权许丽娇河源市中医院广东河源517000

目的探讨载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)及ApoA1与ApoB比值对冠心病(CHD)的诊断价值。方法以冠心病病人为研究对象,健康体检者作为对照组。空腹采血,测定血清中ApoA1、ApoB的含量。结果冠心病病人ApoA1、ApoB含量及ApoA1/ApoB的比... 详细信息

目的探讨载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)及ApoA1与ApoB比值对冠心病(CHD)的诊断价值。方法以冠心病病人为研究对象,健康体检者作为对照组。空腹采血,测定血清中ApoA1、ApoB的含量。结果冠心病病人ApoA1、ApoB含量及ApoA1/ApoB的比值与对照组相比有非常显著性差异。结论可供进一步研究冠心病病人载脂蛋白的代谢情况,为冠心病病人的诊断治疗提供了更有意义的预测指标。

关键词：冠心病载脂蛋白A1 载脂蛋白B 载脂蛋白A1/载脂蛋白B

等离子体直读光谱分析法在土壤环境样品分析中的应用

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福建分析测试 2003年第3期12卷 1795-1800页

作者：肖毓铨陈晓秋谢芳福建省环境监测中心站福建福州350003 福建省地质测试研究中心福建福州350002

采用电感耦合等离子体原子发射光谱法(ICP-AES)测定土壤环境样品中的Ba等20种元素。该法灵敏度高、检出限低、简单、快速,完全满足多目标地球化学品测试的需要。

关键词：等离子体直读光谱分析法电感耦合等离子体原子发射光谱仪光谱干扰土壤环境样品分析

Resilience effects for household food expenditure and dietary diversity in rural western China

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Journal of Integrative Agriculture 2024年第2期23卷 384-396页

作者： xiao Han Kaiyu Lyu Fengying Nie yuquan Chen Institute of Agricultural Economics and Development Chinese Academy of Agricultural SciencesBeijing 100081China Agricultural Information Institute Chinese Academy of Agricultural SciencesBeijing 100081China Academy of Global Food Economics and Policy China Agricultural UniversityBeijing 100083China

A more resilient livelihood is increasingly recognized as an efficient way to improve vulnerable households’food security and optimize their dietary *** study quantifies rural household resilience in western China,identifies the three pillars(absorptive capacity,adaptive capacity,and transformative capacity)contribution to resilience,and then establishes the estimated Resilience Capacity Index(RCI)linked with food security and dietary diversity supported by the multiple indicator multiple cause(MIMIC)*** show that,despite geographical heterogeneity,the RCI consistently increased from 2015 to *** with a higher RCI inheriting better capacity to deal with risk and shocks are significantly and positively correlated with increasing food expenditure and diversifying food *** can be because resilient households will allocate more money to food expenditure instead of saving for livelihood ***,policymakers can provide more incentives for rural households to adopt more dynamic and effective risk management ***,in turn,could yield positive spillover effects by preventing human capital loss associated with dietary-related chronic diseases and mortality.

关键词： resilience food expenditure dietary diversity China risk management

Wind tunnel test on the effect of metal net fences on sand flux in a Gobi Desert, China

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Journal of Arid Land 2017年第6期9卷 888-899页

作者： WANG Tao QU Jianjun LING yuquan XIE Shengbo xiao Jianhua Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and Resources Chinese Academy of. Sciences Lanzhou 730000 China Breeding Base for State Key Laboratory of Land Degradation and Ecological Restoration in Northwest China Ningxia. University Yinchuan 750021 China Dunhuang" Gobi and Desert" Ecology and Environment Research Station Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Dunhuang 736200 China University of Chinese Academy of Sciences Beijing 100049 China

The Lanzhou-Xinjiang High-speed Railway runs through an expansive windy area in a Gobi Desert, and sand-blocking fences were built to protect the railway from destruction by wind-blown sand. However, the shielding effect of the sand-blocking fence is below the expectation. In this study, effects of metal net fences with porosities of 0.5 and 0.7 were tested in a wind tunnel to determine the effectiveness of the employed two kinds of fences in reducing wind velocity and restraining wind-blown sand. Specifically, the horizontal wind velocities and sediment flux densities above the gravel surface were measured under different free-stream wind velocities for the following conditions： no fence at all, single fence with a porosity of 0.5, single fence with a porosity of 0.7, double fences with a porosity of 0.5, and double fences with a porosity of 0.7. Experimental results showed that the horizontal wind velocity was more significantly decreased by the fence with a porosity of 0.5, especially for the double fences. The horizontal wind velocity decreased approximately 65% at a distance of 3.25 m（i.e., 13 H, where H denotes the fence height） downwind the double fences, and no reverse flow or vortex was observed on the leeward side. The sediment flux density decreased exponentially with height above the gravel surface downwind in all tested fences. The reduction percentage of total sediment flux density was higher for the fence with a porosity of 0.5 than for the fence with a porosity of 0.7, especially for the double fences. Furthermore, the decreasing percentage of total sediment flux density decreased with increasing free-stream wind velocity. The results suggest that compared with metal net fence with a porosity of 0.7, the metal net fence with a porosity of 0.5 is more effective for controlling wind-blown sand in the expansive windy area where the Lanzhou-Xinjiang High-speed Railway runs through.

关键词： wind-blown sand wind tunnel experiment porous fence flow field sediment flux density Lanzhou-Xinjiang High-speed Railway Gobi Desert

气相色谱与电感耦合等离子体质谱联用测定海产品中有机锡的研究

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福建分析测试 2008年第1期17卷 40-43页

作者：俞是聃肖毓铨陈晓秋林丽钦傅彦斌福建省环境监测中心站福州350003

本文报道用气相色谱和电感耦合等离子体质谱联用法测定海产品中的有机锡。经色谱柱分离进样,用等离子体质谱仪在线耦合测定了三氯丁基锡、二丁基锡二氯化物、氯化三丁基锡,并对影响测定的各种因素进行了研究探讨。用该联用方法测定三氯... 详细信息

本文报道用气相色谱和电感耦合等离子体质谱联用法测定海产品中的有机锡。经色谱柱分离进样,用等离子体质谱仪在线耦合测定了三氯丁基锡、二丁基锡二氯化物、氯化三丁基锡,并对影响测定的各种因素进行了研究探讨。用该联用方法测定三氯丁基锡、二丁基锡二氯化物、氯化三丁基锡,可以在14分钟内分离完全。仪器检出限分别为:0.1μg/L-1。线性范围从1.0μg/L-1到200μg/L-1。本实验方法应用于海产品中三氯丁基锡、二丁基锡二氯化物、氯化三丁基锡的测定,结果较为满意。

关键词：气相色谱电感耦合等离子体质谱三氯丁基锡二丁基锡二氯化物三丁基锡

PEG400-mediated nanocarriers improve the delivery and therapeutic efficiency of mRNA tumor vaccines

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Chinese Chemical Letters 2024年第5期35卷 314-319页

作者： Wen xiao Fazhan Wang Yangzhuo Gu Xi He Na Fan Qian Zheng Shugang Qin Zhongshan He yuquan Wei Xiangrong Song Department of Critical Care Medicine Frontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Medical Research Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450000China

Dendritic cell(DC)-targeted delivery of mRNA is a prominent method to boost the efficacy of mRNA tumor *** targeting ligands are often modified on nanocarriers by polyethylene glycol(PEG)linker in mRNA delivery *** the PEG linker length influences the targeting delivery efficiency of mRNA nanocarrier in vivo remains ***,we designed and constructed DC-targeted mRNA delivery systems modified by mannose via different PEG linker lengths(100/400/1000/2000)(MPn-LPX).The top candidate MP_(400)-LPX(the linker was PEG400)showed the optimal mRNA expression and antigen presentation owing to the highly efficient uptake by ***,MP_(400)-LPX could better inhibited tumor growth and extended survival in the E.G7-OVA lymphoma and TC-1 cervical tumor mouse ***,these results demonstrated that PEG400 was the optimal linker for the PEGylated DC-targeted mRNA *** findings provided a new platform for the rational design of targeted mRNA nanovaccines with shorter-length PEG.

关键词： Cancer immunotherapy mRNA vaccines DC-targeted delivery PEGylated liposomes Cellular uptake

Sodium alginate coating simultaneously increases the biosafety and immunotherapeutic activity of the cationic mRNA nanovaccine

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Acta Pharmaceutica Sinica B 2023年第3期13卷 942-954页

作者： Xing Duan Yi Zhang Mengran Guo Na Fan Kepan Chen Shugang Qin Wen xiao Qian Zheng Hai Huang Xiawei Wei yuquan Wei Xiangrong Song Department of Critical Care Medicine Department of Clinical PharmacyFrontiers Science Center for Disease-related Molecular NetworkState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China West China Hospital Sichuan UniversityChengdu 610041China

The extraordinary advantages associated with mRNA vaccines,including their high efficiency,relatively low severity of side effects,and ease of manufacture,have enabled them to be a promising immunotherapy approach against various infectious diseases and ***,most mRNA delivery carriers have many disadvantages,such as high toxicity,poor biocompatibility,and low efficiency in vivo,which have hindered the widespread use of mRNA *** further characterize and solve these problems and develop a new type of safe and efficient mRNA delivery carrier,a negatively charged SA@DOTAP-mRNA nanovaccine was prepared in this study by coating DOTAP-mRNA with the natural anionic polymer sodium alginate(SA).Intriguingly,the transfection efficiency of SA@DOTAP-mRNA was significantly higher than that of DOTAP-mRNA,which was not due to the increase in cellular uptake but was associated with changes in the endocytosis pathway and the strong lysosome escape ability of SA@*** addition,we found that SA significantly increased the expression of LUC-mRNA in mice and achieved certain spleen ***,we confirmed that SA@DOTAP-mRNA had a stronger antigen-presenting ability in E.G7-OVA tumor-bearing mice,dramatically inducing the proliferation of OVA-specific CLTs and ameliorating the antitumor ***,we firmly believe that the coating strategy applied to cationic liposome/mRNA complexes is of potential research value in the field of mRNA delivery and has promising clinical application prospects.

关键词： Negatively charged mRNA vaccine Sodium alginate Cationic liposome DOTAP Lysosomes escape Cancer Immunotherapy Toxicity